BRPI0810396A2 - Nanopartícula que compreende um polímero biodegradável, uma ciclodextrina ou um derivado desta, composição farmacêutica e processo para produzir nanopartículas - Google Patents
Nanopartícula que compreende um polímero biodegradável, uma ciclodextrina ou um derivado desta, composição farmacêutica e processo para produzir nanopartículasInfo
- Publication number
- BRPI0810396A2 BRPI0810396A2 BRPI0810396-8A2A BRPI0810396A BRPI0810396A2 BR PI0810396 A2 BRPI0810396 A2 BR PI0810396A2 BR PI0810396 A BRPI0810396 A BR PI0810396A BR PI0810396 A2 BRPI0810396 A2 BR PI0810396A2
- Authority
- BR
- Brazil
- Prior art keywords
- cyclodextrin
- nanoparticle
- derivative
- pharmaceutical composition
- biodegradable polymer
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title 2
- 229920000858 Cyclodextrin Polymers 0.000 title 1
- 229920002988 biodegradable polymer Polymers 0.000 title 1
- 239000004621 biodegradable polymer Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200701074A ES2310122B1 (es) | 2007-04-20 | 2007-04-20 | Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones. |
| PCT/ES2008/000269 WO2008129106A2 (es) | 2007-04-20 | 2008-04-18 | Nanopartículas que comprenden una ciclodextrina y una molécula biológicamente activa y sus aplicaciones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0810396A2 true BRPI0810396A2 (pt) | 2014-11-04 |
Family
ID=39643881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810396-8A2A BRPI0810396A2 (pt) | 2007-04-20 | 2008-04-18 | Nanopartícula que compreende um polímero biodegradável, uma ciclodextrina ou um derivado desta, composição farmacêutica e processo para produzir nanopartículas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9522197B2 (pt) |
| EP (1) | EP2153826B1 (pt) |
| JP (1) | JP5847397B2 (pt) |
| CN (1) | CN101686949A (pt) |
| AU (1) | AU2008240545B2 (pt) |
| BR (1) | BRPI0810396A2 (pt) |
| CA (1) | CA2684560C (pt) |
| ES (2) | ES2310122B1 (pt) |
| MX (1) | MX2009011247A (pt) |
| RU (1) | RU2460518C2 (pt) |
| WO (1) | WO2008129106A2 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8372877B2 (en) * | 2010-04-16 | 2013-02-12 | Cumberland Pharmaceuticals | Stabilized statin formulations |
| AU2014277744B2 (en) * | 2010-04-16 | 2017-01-19 | Cumberland Pharmaceuticals, Inc. | Stabilized Statin Formulations |
| EA016410B1 (ru) * | 2010-11-13 | 2012-04-30 | Ооо "Нпк Наносистема" | Фармацевтическая композиция на основе наночастиц циклодекстрина, содержащих рифабутин, способ ее получения, способ лечения микобактериоза и геликобактерной инфекции (варианты) |
| US20140017330A1 (en) * | 2011-04-04 | 2014-01-16 | Board Of Regents Of The University Of Nebraska | Activated Nucleoside Analog Conjugates and Methods of Use Thereof |
| EP2510930A1 (en) | 2011-04-15 | 2012-10-17 | Bionanoplus, S.L. | Nanoparticles comprising half esters of poly (methyl vinyl ether-co-maleic anhydride) and uses thereof |
| JP5391229B2 (ja) * | 2011-04-27 | 2014-01-15 | 富士フイルム株式会社 | 木構造抽出装置および方法ならびにプログラム |
| CN102670513B (zh) * | 2012-02-22 | 2014-03-19 | 河南碧云天动物药业有限公司 | 氧氟沙星分子包合纳米制剂及其制备方法 |
| CN104244986B (zh) * | 2012-03-13 | 2016-11-16 | 浦项工科大学校产学协力团 | 可控释的药物递送缀合物及其应用 |
| CN102579402B (zh) * | 2012-03-26 | 2013-07-03 | 山东大学 | 一种负载紫杉醇的囊泡的制备方法 |
| US8916697B2 (en) * | 2012-03-30 | 2014-12-23 | Purdue Research Foundation | Nucleic acid complexes |
| EP2919801B1 (en) * | 2012-10-26 | 2020-04-29 | Lupin Atlantis Holdings, SA | Stable pharmaceutical composition of the tnfr:fc fusion protein etanercept |
| FR3000080B1 (fr) * | 2012-12-20 | 2015-01-30 | Oreal | Polycondensat de cyclodextrine insoluble dans l'eau ; utilisations comme agent de capture |
| CN103142499B (zh) * | 2013-03-21 | 2014-10-01 | 青岛正大海尔制药有限公司 | 一种依托泊苷颗粒 |
| CN103705987B (zh) * | 2014-01-02 | 2015-10-07 | 东南大学 | 一种具有ct造影功能的葡聚糖栓塞微球的制备方法 |
| RU2546535C1 (ru) * | 2014-04-09 | 2015-04-10 | Федеральное государственное бюджетное учреждение науки Институт химии твердого тела и механохимии Сибирского отделения Российской академии наук (ИХТТМ СО РАН) | Противопаразитарное средство на основе альбендазола и способ его использования для лечения гельминтозов млекопитающих |
| KR20170023173A (ko) * | 2014-07-03 | 2017-03-02 | 화이자 인코포레이티드 | 표적화된 치료 나노입자 및 그의 제조 및 사용 방법 |
| CN104387592B (zh) * | 2014-11-29 | 2017-09-26 | 沈阳药科大学 | 环糊精‑甲基乙烯基醚/马来酸酐共聚物及其自组装纳米粒在口服药物传递中应用 |
| WO2016087340A1 (en) | 2014-12-01 | 2016-06-09 | Innoup Farma, S.L. | Nanoparticles for encapsulating compounds, the preparation and uses thereof |
| CN105194687A (zh) * | 2015-10-22 | 2015-12-30 | 浙江医药高等专科学校 | 沙喹那韦或其甲磺酸盐的环糊精包合物制备方法 |
| CN105561406A (zh) * | 2016-02-15 | 2016-05-11 | 丹阳纳瑞康纳米科技有限公司 | 一种含复合药物涂层的血管支架 |
| CN105695148B (zh) * | 2016-02-24 | 2018-11-02 | 江阴市佐恩精品衣物洗涤护理有限公司 | 一种环保型固体清洗剂组合物 |
| US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
| EP3554562A4 (en) | 2016-12-14 | 2020-11-04 | Janssen Biotech, Inc. | DOMAINS OF TYPE III FIBRONECTIN BINDING TO CD8A |
| US10800817B2 (en) | 2016-12-19 | 2020-10-13 | Morehouse School Of Medicine | Compositions and methods for treating diseases by inhibiting exosome release |
| US12064517B1 (en) | 2018-12-03 | 2024-08-20 | Hui Xie | Polymer nanoparticle |
| CN109602724B (zh) * | 2019-02-21 | 2022-02-11 | 江苏省中医药研究院 | 一种牛蒡子苷元口服纳米制剂及其制备方法 |
| WO2021076574A2 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| CN119119240A (zh) | 2019-10-14 | 2024-12-13 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
| CN110898015A (zh) * | 2019-12-31 | 2020-03-24 | 上海汉维生物医药科技有限公司 | 一种伊曲康唑制剂的制备方法 |
| AU2022258584A1 (en) | 2021-04-14 | 2023-10-12 | Aro Biotherapeutics Company | Fn3 domain-sirna conjugates and uses thereof |
| BR112023021325A2 (pt) | 2021-04-14 | 2023-12-19 | Aro Biotherapeutics Company | Domínios de fibronectina tipo iii de ligação a cd71 |
| CN113777100B (zh) * | 2021-08-27 | 2022-11-01 | 厦门大学 | 一种基于主客体作用的定量物质控释系统及方法 |
| CN114053229B (zh) * | 2022-01-17 | 2022-04-22 | 山东国邦药业有限公司 | 一种盐酸沙拉沙星水溶性颗粒剂及其制备方法 |
| CN118490645B (zh) * | 2024-07-17 | 2024-09-20 | 中国农业科学院农业环境与可持续发展研究所 | 一种氟苯尼考纳米粉及其制备方法和应用 |
| CN119700682B (zh) * | 2024-12-16 | 2025-10-31 | 山东大学 | 一种聚环糊精/二甲氧乙二酰甘氨酸复合纳米颗粒及其制备方法与应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU213200B (en) * | 1993-05-12 | 1997-03-28 | Chinoin Gyogyszer Es Vegyeszet | The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production |
| US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| FR2775435B1 (fr) * | 1998-02-27 | 2000-05-26 | Bioalliance Pharma | Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs |
| WO2002041829A2 (en) | 2000-11-20 | 2002-05-30 | Pr Pharmaceuticals, Inc. | Oral nanosphere delivery |
| ES2178961B1 (es) | 2001-03-06 | 2004-07-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Fabricacion de nanoparticulas a base del copolimero de metil vinil eter y anhidrido maleico para la administracion de farmacos de naturaleza hidrofilica, en particular de bases puricas y pirimidinicas. |
| FR2830017B1 (fr) * | 2001-09-27 | 2005-11-04 | Centre Nat Rech Scient | Materiau compose d'au moins un polymere biodegradable et de cyclodextrines |
| GB0127677D0 (en) * | 2001-11-19 | 2002-01-09 | Vianex S A | Inclusion complex |
| ES2246694B1 (es) * | 2004-04-29 | 2007-05-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A. | Nanoparticulas pegiladas. |
| ES2277743B2 (es) | 2005-06-02 | 2008-12-16 | Universidade De Santiago De Compostela | Nanoparticulas que comprenden quitosano y ciclodextrina. |
-
2007
- 2007-04-20 ES ES200701074A patent/ES2310122B1/es active Active
-
2008
- 2008-04-18 JP JP2010503534A patent/JP5847397B2/ja active Active
- 2008-04-18 WO PCT/ES2008/000269 patent/WO2008129106A2/es not_active Ceased
- 2008-04-18 AU AU2008240545A patent/AU2008240545B2/en not_active Ceased
- 2008-04-18 US US12/596,664 patent/US9522197B2/en active Active
- 2008-04-18 BR BRPI0810396-8A2A patent/BRPI0810396A2/pt not_active Application Discontinuation
- 2008-04-18 CA CA2684560A patent/CA2684560C/en active Active
- 2008-04-18 RU RU2009142806/15A patent/RU2460518C2/ru active
- 2008-04-18 CN CN200880017440A patent/CN101686949A/zh active Pending
- 2008-04-18 ES ES08761515.9T patent/ES2684554T3/es active Active
- 2008-04-18 MX MX2009011247A patent/MX2009011247A/es active IP Right Grant
- 2008-04-18 EP EP08761515.9A patent/EP2153826B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010524902A (ja) | 2010-07-22 |
| ES2310122A1 (es) | 2008-12-16 |
| WO2008129106A2 (es) | 2008-10-30 |
| CA2684560C (en) | 2016-06-14 |
| WO2008129106A3 (es) | 2009-03-05 |
| MX2009011247A (es) | 2010-01-29 |
| RU2460518C2 (ru) | 2012-09-10 |
| EP2153826B1 (en) | 2018-06-27 |
| AU2008240545B2 (en) | 2013-06-06 |
| CN101686949A (zh) | 2010-03-31 |
| JP5847397B2 (ja) | 2016-01-20 |
| EP2153826A2 (en) | 2010-02-17 |
| RU2009142806A (ru) | 2011-05-27 |
| ES2684554T3 (es) | 2018-10-03 |
| US9522197B2 (en) | 2016-12-20 |
| US20100136129A1 (en) | 2010-06-03 |
| AU2008240545A1 (en) | 2008-10-30 |
| CA2684560A1 (en) | 2008-10-30 |
| ES2310122B1 (es) | 2009-10-30 |
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