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BRPI0819932A2 - composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável. - Google Patents

composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável.

Info

Publication number
BRPI0819932A2
BRPI0819932A2 BRPI0819932A BRPI0819932A BRPI0819932A2 BR PI0819932 A2 BRPI0819932 A2 BR PI0819932A2 BR PI0819932 A BRPI0819932 A BR PI0819932A BR PI0819932 A BRPI0819932 A BR PI0819932A BR PI0819932 A2 BRPI0819932 A2 BR PI0819932A2
Authority
BR
Brazil
Prior art keywords
composition
nebulizer
inhaler
processes
producing
Prior art date
Application number
BRPI0819932A
Other languages
English (en)
Inventor
Basran Amrik
Sparks Catherine
D Brewis Neil
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0724331.4A external-priority patent/GB0724331D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0819932A2 publication Critical patent/BRPI0819932A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável a presente invenção diz respeito a métodos de administração pulmonar direta de polipeptídeos, por exemplo, de anticorpos de domínio, e a composições polipeptídicas particulares adequadas para administração pulmonar direta. a invenção também diz respeito ao uso de tais composições na medicina, por exemplo, para o tratamento e diagnóstico de doença pulmonar, por exemplo, para tratar doença pulmonar obstrutiva crônica (copd) e asma.
BRPI0819932A 2007-12-13 2008-12-11 composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável. BRPI0819932A2 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB0724331.4A GB0724331D0 (en) 2007-12-13 2007-12-13 Compositions for pulmonary delivery
BD1272008 2008-05-22
BD1302008 2008-05-22
BD1282008 2008-05-22
BD1292008 2008-05-22
PCT/GB2008/050399 WO2008149143A2 (en) 2007-06-06 2008-06-03 Methods for selecting protease resistant polypeptides
PCT/GB2008/050400 WO2008149144A2 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists
PCT/GB2008/050403 WO2008149146A2 (en) 2007-06-06 2008-06-03 Polypeptides, antibody variable domains and antagonists
PCT/EP2008/067295 WO2009074634A2 (en) 2007-12-13 2008-12-11 Compositions for pulmonary delivery

Publications (1)

Publication Number Publication Date
BRPI0819932A2 true BRPI0819932A2 (pt) 2019-07-30

Family

ID=61230984

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819932A BRPI0819932A2 (pt) 2007-12-13 2008-12-11 composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável.

Country Status (13)

Country Link
US (1) US20100260853A1 (pt)
EP (1) EP2220115A2 (pt)
JP (1) JP2011506396A (pt)
KR (1) KR20100098697A (pt)
CN (1) CN102131827A (pt)
AU (1) AU2008334605B2 (pt)
BR (1) BRPI0819932A2 (pt)
CA (1) CA2707986A1 (pt)
EA (1) EA201000785A1 (pt)
SG (1) SG185286A1 (pt)
TW (1) TW200938222A (pt)
WO (1) WO2009074634A2 (pt)
ZA (1) ZA201004093B (pt)

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EP2301967A3 (en) 2002-11-08 2011-07-13 Ablynx N.V. Single domain antibodies for nasal administration
US20060034845A1 (en) 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
EP2386858B1 (en) 2006-04-04 2015-07-15 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
NZ580530A (en) * 2007-06-06 2012-04-27 Domantis Ltd Anti vegf polypeptides, antibody variable domains and antagonists
WO2010037818A1 (en) * 2008-10-02 2010-04-08 Ablynx Nv Amino acid sequences directed against il-15 and/or the il-15 receptor and polypeptides comprising the same for the treatment of diseases and disorders associated with il-15 mediated signalling
KR20110092328A (ko) * 2008-11-26 2011-08-17 글락소 그룹 리미티드 Il-13에 결합하는 리간드
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
MX2012003939A (es) * 2009-09-30 2012-07-30 Glaxo Group Ltd Fusiones y conjugados de farmaco.
CA2787718C (en) 2010-02-11 2018-05-15 Ablynx Nv Methods and compositions for the preparation of aerosols
TW201215405A (en) 2010-08-25 2012-04-16 Hoffmann La Roche Antibodies against IL-18R1 and uses thereof
EP2635600B1 (en) * 2010-11-05 2017-06-21 F. Hoffmann-La Roche AG Optimized method for antibody capturing by mixed mode chromatography
AU2011336470B8 (en) 2010-12-01 2017-09-14 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
AU2012250872B2 (en) * 2011-05-02 2017-07-13 Millennium Pharmaceuticals, Inc. Formulation for anti-alpha4beta7 antibody
WO2012163519A1 (en) * 2011-05-27 2012-12-06 Dutalys Antibodies with improved folding stability
JP6292718B2 (ja) 2011-07-01 2018-03-14 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 凝集ポリペプチドから単量体ポリペプチドを分離するための方法
BR112014001855A2 (pt) * 2011-07-27 2017-02-21 Glaxo Group Ltd construto e proteína aglutinantes ao antígeno, dímero, composição farmacêutica, sequência de polinucleotídeo, célula hospedeira e, método para produção do construto
ES2813432T3 (es) 2011-08-17 2021-03-23 Glaxo Group Ltd Proteínas y péptidos modificados
AU2014233055B2 (en) 2013-03-15 2018-08-09 Board Of Regents, The University Of Texas System Inhibition of pulmonary fibrosis with nutlin-3a and peptides
DK3125942T3 (da) * 2014-04-03 2021-12-20 Csl Behring Ag Forstøvning af immunoglobulin
EP3198023B1 (en) 2014-09-26 2020-04-22 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
JP6866296B2 (ja) * 2015-02-27 2021-04-28 ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System ポリペプチド治療及びその使用
CN121159628A (zh) 2018-09-10 2025-12-19 莱恩治疗公司 Cav-1蛋白的修饰的肽片段及其在纤维化治疗中的用途
US20220025019A1 (en) * 2018-11-30 2022-01-27 Csl Behring Ag Methods and compositions for preventing or treating acute exacerbations with polyclonal immunoglobulin
JP2023512286A (ja) * 2020-01-31 2023-03-24 サノフイ 抗体の肺送達

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Also Published As

Publication number Publication date
CN102131827A (zh) 2011-07-20
TW200938222A (en) 2009-09-16
CA2707986A1 (en) 2009-06-18
KR20100098697A (ko) 2010-09-08
EP2220115A2 (en) 2010-08-25
WO2009074634A2 (en) 2009-06-18
WO2009074634A3 (en) 2010-09-23
US20100260853A1 (en) 2010-10-14
AU2008334605B2 (en) 2013-07-18
JP2011506396A (ja) 2011-03-03
EA201000785A1 (ru) 2011-02-28
SG185286A1 (en) 2012-11-29
ZA201004093B (en) 2011-11-30
AU2008334605A1 (en) 2009-06-18

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Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A, 8A, 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2536 DE 13-08-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]