[go: up one dir, main page]

BRPI0819690B8 - uso de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas - Google Patents

uso de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas

Info

Publication number
BRPI0819690B8
BRPI0819690B8 BRPI0819690A BRPI0819690A BRPI0819690B8 BR PI0819690 B8 BRPI0819690 B8 BR PI0819690B8 BR PI0819690 A BRPI0819690 A BR PI0819690A BR PI0819690 A BRPI0819690 A BR PI0819690A BR PI0819690 B8 BRPI0819690 B8 BR PI0819690B8
Authority
BR
Brazil
Prior art keywords
cysteamine
cystamine
composition
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
BRPI0819690A
Other languages
English (en)
Inventor
Schneider Jerry
Dohil Ranjan
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40679016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819690(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California filed Critical Univ California
Publication of BRPI0819690A2 publication Critical patent/BRPI0819690A2/pt
Publication of BRPI0819690B1 publication Critical patent/BRPI0819690B1/pt
Publication of BRPI0819690B8 publication Critical patent/BRPI0819690B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

uso de um produto de cisteamina, e, de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas. a revelação, no geral, diz respeito ao tratamento de desordens de gordura no fígado compreendendo administrar composições compreendendo produtos de cisteamina. a revelação fornece administração de composições de cisteamina entericamente revestidas para tratar desordens de gordura no fígado, tais como doença do fígado gorduroso não alcoólica (nafld) e esteatohepatite não alcoólica (nash).
BRPI0819690A 2007-11-30 2008-11-28 uso de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas BRPI0819690B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US99151707P 2007-11-30 2007-11-30
US60/991517 2007-11-30
US8539708P 2008-07-31 2008-07-31
US61/085397 2008-07-31
PCT/US2008/085064 WO2009070781A1 (en) 2007-11-30 2008-11-28 Methods of treating non-alcoholic steatohepatitis (nash) using cysteamine products

Publications (3)

Publication Number Publication Date
BRPI0819690A2 BRPI0819690A2 (pt) 2014-10-07
BRPI0819690B1 BRPI0819690B1 (pt) 2019-07-30
BRPI0819690B8 true BRPI0819690B8 (pt) 2021-05-25

Family

ID=40679016

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819690A BRPI0819690B8 (pt) 2007-11-30 2008-11-28 uso de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas

Country Status (25)

Country Link
US (5) US7994226B2 (pt)
EP (2) EP2636404B1 (pt)
JP (3) JP5583022B2 (pt)
KR (1) KR20100091219A (pt)
CN (2) CN101932238B (pt)
AR (1) AR069500A1 (pt)
AU (1) AU2008329628B2 (pt)
BR (1) BRPI0819690B8 (pt)
CA (1) CA2706768C (pt)
CL (1) CL2008003582A1 (pt)
CY (1) CY1114126T1 (pt)
DK (1) DK2214480T3 (pt)
ES (1) ES2417179T3 (pt)
HR (1) HRP20130590T1 (pt)
IL (2) IL205909B (pt)
MX (2) MX360827B (pt)
MY (1) MY156316A (pt)
NZ (1) NZ585732A (pt)
PL (1) PL2214480T3 (pt)
PT (1) PT2214480E (pt)
RU (1) RU2498795C2 (pt)
SG (1) SG10201403200RA (pt)
TW (2) TWI478710B (pt)
WO (1) WO2009070781A1 (pt)
ZA (1) ZA201003670B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3659588A1 (en) 2006-01-27 2020-06-03 The Regents of The University of California Enterically coated cysteamine and salts thereof
CN101932238B (zh) 2007-11-30 2015-04-08 加利福尼亚大学董事会 使用半胱胺制品治疗非酒精性脂肪性肝炎(nash)的方法
WO2011145340A1 (ja) * 2010-05-19 2011-11-24 興和株式会社 非アルコール性脂肪性肝炎の予防及び／又は治療剤
EP2580204B1 (en) * 2010-06-08 2017-03-08 Krisani Bioscience (P) Ltd. Cysteamine derivatives and their use in the treatment of nash
ES2565487T3 (es) * 2010-07-28 2016-04-05 Orchid Chemicals And Pharmaceuticals Ltd Compuestos de difeniléter para su uso en el tratamiento de enfermedades hepáticas
WO2014045293A1 (en) * 2012-09-24 2014-03-27 Krisani Bioscience (P) Ltd. Fatty acid amides with a cysteamine or an acetylated cysteamine group and uses thereof
US20130085075A1 (en) * 2011-06-06 2013-04-04 Meso Scale Technologies, Llc Diagnostic methods for liver disorders
MX360979B (es) 2011-09-16 2018-11-22 Galectin Therapeutics Inc Composiciones de galacto-ramnogalacturonato para el tratamiento de la esteatohepatitis no alcohólica y de la enfermedad del higado graso no alcohólico.
CA2853484C (en) 2011-10-26 2018-08-21 Seattle Children's Research Institute Cysteamine in the treatment of fibrotic disease
SG11201402472QA (en) * 2011-11-22 2014-06-27 Univ California Cysteamine and/or cystamine for treating ischemic injury
WO2013149148A2 (en) * 2012-03-29 2013-10-03 Halo Therapeutics, Llc Dosage forms of halofuginone and methods of use
AU2013271585B2 (en) 2012-06-06 2018-02-01 Galectin Therapeutics, Inc. Galacto-rhamnogalacturonate compositions for the treatment of diseases associated with elevated inducible nitric oxide synthase
US20140314841A1 (en) 2013-04-19 2014-10-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Use of Cysteamine and Derivatives Thereof to Suppress Tumor Metastases
TWI649100B (zh) * 2013-06-17 2019-02-01 地平線罕見醫學製藥有限責任公司 延遲釋放型半胱胺珠粒調配物，以及其製備及使用方法
US9682123B2 (en) 2013-12-20 2017-06-20 The Trustees Of Columbia University In The City Of New York Methods of treating metabolic disease
EP3132795B1 (en) * 2014-04-18 2020-10-21 LG Chem, Ltd. Composition for preventing or treating fatty liver diseases
JP6890536B2 (ja) * 2015-03-03 2021-06-18 三菱商事ライフサイエンス株式会社 非アルコール性脂肪肝改善又は予防組成物
RU2022103033A (ru) * 2015-07-02 2022-04-01 ХОРАЙЗОН ОРФАН ЭлЭлСи Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение
RU2595815C1 (ru) * 2015-07-13 2016-08-27 федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации Способ лечения больных неалкогольным стеатогепатитом на фоне метаболического синдрома
US10537528B2 (en) 2015-11-16 2020-01-21 The Regents Of The University Of California Methods of treating non-alcoholic steatohepatitis (NASH) using cysteamine compounds
US10143665B2 (en) 2015-11-17 2018-12-04 Horizon Orphan Llc Methods for storing cysteamine formulations and related methods of treatment
IL261756B2 (en) 2016-03-17 2023-11-01 Thiogenesis Therapeutics Inc Preparations for the controlled release of cysteamine and systemic treatment of disorders sensitive to cysteamine
ITUA20161799A1 (it) * 2016-03-18 2017-09-18 Recordati Ind Chimica E Farmaceutica S P A Composizione farmaceutica a rilascio prolungato comprendente cisteamina o un suo sale
JP7270979B2 (ja) * 2017-06-08 2023-05-11 エヌ－ジーン リサーチ ラボラトリーズ，アイエヌシー． Ｎａｓｈ治療方法及びｎａｓｈ誘発性ｈｃｃ予防方法
US10632092B2 (en) 2017-08-30 2020-04-28 First Fruits Business Ministry, Llc Composition for and method to increase serum adiponectin and reduce body fat
CN118924717A (zh) 2017-09-20 2024-11-12 硫创治疗公司 用于治疗半胱胺敏感性病症的方法
KR102177304B1 (ko) * 2018-07-23 2020-11-10 제이투에이치바이오텍 (주) 비알콜성 지방간염의 예방 또는 치료용 약학 조성물
CN111544426A (zh) * 2019-02-12 2020-08-18 复旦大学 炔丙基半胱氨酸及其在制备新靶点药物中的用途
US12391643B2 (en) 2019-03-26 2025-08-19 The Regents Of The University Of California Substituted amino-thiol and amino-disulfide compounds, and uses thereof
EP3998869A4 (en) * 2019-07-19 2023-09-06 Filtricine, Inc. Compositions, methods, kits and systems for cancer treatment and metabolic intervention therapy and other uses
CN111505099B (zh) * 2020-04-21 2023-07-04 上海市普陀区中心医院 Nash的诊断标志物及其应用
CN116546981A (zh) * 2020-12-18 2023-08-04 雀巢产品有限公司 使用至少一种甘氨酸或其衍生物和/或至少一种n-乙酰半胱氨酸或其衍生物以及至少一种百里酚和/或香芹酚的组合物和方法
CN118489805A (zh) * 2024-05-31 2024-08-16 杭州康德权饲料有限公司 半胱胺或其盐在制备预防和改善蛋鸡脂肪肝的饲料添加剂中的应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110441A (en) * 1974-04-29 1978-08-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Gamma-l-glutamyl cholamine phosphate
US4959306A (en) * 1986-11-28 1990-09-25 Sclavo, Inc. Labeling design for a binding assay reagent
US5668117A (en) * 1991-02-22 1997-09-16 Shapiro; Howard K. Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
US5639743A (en) * 1992-11-13 1997-06-17 University Of Georgia Research Foundation Compositions and methods for treating exocrine gland atrophy
JPH11302178A (ja) * 1998-02-17 1999-11-02 Otsuka Pharmaceut Factory Inc 脂肪肝予防及び治療剤
US20050059576A1 (en) * 1998-04-30 2005-03-17 Adamson J. Gordon Targeted delivery of antiviral compounds through hemoglobin bioconjugates
CA2236344A1 (en) * 1998-04-30 1999-10-30 Hemosol Inc. Hemoglobin-haptoglobin complexes
US6794414B1 (en) 1998-06-17 2004-09-21 Yeda Research And Development Co. Ltd. Method and compositions for treating diseases mediated by transglutaminase activity
UA73092C2 (uk) * 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
US20030137125A1 (en) * 2000-02-14 2003-07-24 Len Booysen Stabilizer unit
CN1144585C (zh) * 2000-12-13 2004-04-07 华扩达动物科学[I.P.2]有限公司 含有半胱胺或其盐类的促进动物快速生长的组合物及用途
US7449451B2 (en) * 2001-08-29 2008-11-11 Premier Micronutrient Corporation Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
GB2379854B (en) 2001-09-19 2006-04-19 Walcom Animal Science Dairy cow feed and the use thereof
JP2005510537A (ja) * 2001-11-29 2005-04-21 サウンド・ファーマシューティカルズ・インコーポレイテッド 化学療法の所望されない効果を改善する方法および組成物
WO2003057207A1 (en) * 2002-01-04 2003-07-17 Sound Pharmaceuticals Incorporated Methods for treating hearing loss
GB2386817B (en) 2002-02-20 2006-08-23 Walcom Animal Science Feed for fish and use therof
JP2004026716A (ja) 2002-06-25 2004-01-29 Ajinomoto Co Inc ＴＮＦα産生の抑制剤
US8017651B2 (en) 2002-11-22 2011-09-13 Bionexus, Ltd. Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia
GB2398497A (en) * 2003-02-19 2004-08-25 Walcom Animal Science Composition for improving immunity of animals
JP4966665B2 (ja) * 2003-11-19 2012-07-04 オメガ バイオ−ファーマ （アイ．ピー．１） リミテッド アルコール代謝を改善し、二日酔いの影響を軽減するための材料と方法
SG149814A1 (en) 2003-12-19 2009-02-27 Omega Bio Pharma Ip3 Ltd Compositions and methods for treating diabetes
US20050209441A1 (en) * 2004-03-22 2005-09-22 Lile Jackson D Process for promoting proper folding of human serum albumin using a human serum albumin ligand
BRPI0510613A (pt) 2004-05-03 2007-10-30 Omega Bio Pharma Ip3 Ltd cisteaminas para tratar complicações de hipercolesterolemia e diabete
EP1844006A2 (en) 2005-01-05 2007-10-17 Magd Ahmed Kotb Abdalla Taurine synthesis, production and utility as a medicine
CA2605631A1 (en) 2005-04-20 2006-10-26 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
EP1962835A2 (en) * 2005-12-21 2008-09-03 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or h3 receptor antagonist/inverse agonist
US20070172514A1 (en) * 2006-01-20 2007-07-26 Francis Chi Materials and methods for improving livestock productivity
EP3659588A1 (en) 2006-01-27 2020-06-03 The Regents of The University of California Enterically coated cysteamine and salts thereof
WO2007121545A1 (en) * 2006-04-20 2007-11-01 Universidade Estadual De Campinas-Unicamp S-nitrosothiols containing compositions for the treatment of fatty liver diseases, obesity and other diseases associated with the metabolic syndrome and the use of such compositions
US20090304704A1 (en) 2006-05-03 2009-12-10 Geisinger Clinic Methods for diagnosing and predicting non-alcoholic steatohepatitis (nash)
WO2008093764A1 (ja) 2007-02-02 2008-08-07 Kaneka Corporation 糖尿病予防または治療用組成物
CN101932238B (zh) * 2007-11-30 2015-04-08 加利福尼亚大学董事会 使用半胱胺制品治疗非酒精性脂肪性肝炎(nash)的方法

Also Published As

Publication number Publication date
AU2008329628A1 (en) 2009-06-04
TW201513855A (zh) 2015-04-16
DK2214480T3 (da) 2013-07-08
ZA201003670B (en) 2011-08-31
MX360827B (es) 2018-11-16
JP6121951B2 (ja) 2017-04-26
HK1141945A1 (en) 2010-11-26
MY156316A (en) 2016-02-11
TW200927093A (en) 2009-07-01
AR069500A1 (es) 2010-01-27
US9511038B2 (en) 2016-12-06
RU2498795C2 (ru) 2013-11-20
NZ585732A (en) 2012-02-24
EP2636404B1 (en) 2019-03-20
AU2008329628B2 (en) 2014-06-26
TWI478710B (zh) 2015-04-01
PL2214480T3 (pl) 2013-11-29
TWI535435B (zh) 2016-06-01
US20170304233A1 (en) 2017-10-26
IL205909B (en) 2018-05-31
CA2706768C (en) 2016-06-28
MX2010005921A (es) 2010-06-11
EP2214480A4 (en) 2010-09-29
EP2636404A2 (en) 2013-09-11
US9149448B2 (en) 2015-10-06
EP2636404A3 (en) 2013-10-16
KR20100091219A (ko) 2010-08-18
WO2009070781A1 (en) 2009-06-04
IL254586A0 (en) 2017-11-30
IL205909A0 (en) 2010-11-30
US8263662B2 (en) 2012-09-11
US20130183351A1 (en) 2013-07-18
CL2008003582A1 (es) 2009-04-03
CA2706768A1 (en) 2009-06-04
CY1114126T1 (el) 2016-07-27
US20120015005A1 (en) 2012-01-19
BRPI0819690B1 (pt) 2019-07-30
SG10201403200RA (en) 2014-10-30
CN104825430A (zh) 2015-08-12
CN104825430B (zh) 2018-05-04
US7994226B2 (en) 2011-08-09
US20160143865A1 (en) 2016-05-26
JP2014237670A (ja) 2014-12-18
RU2010126631A (ru) 2012-01-10
JP2017165735A (ja) 2017-09-21
PT2214480E (pt) 2013-07-23
JP2011505375A (ja) 2011-02-24
BRPI0819690A2 (pt) 2014-10-07
EP2214480A1 (en) 2010-08-11
US20100303870A1 (en) 2010-12-02
ES2417179T3 (es) 2013-08-06
JP5583022B2 (ja) 2014-09-03
CN101932238A (zh) 2010-12-29
HRP20130590T1 (en) 2013-08-31
CN101932238B (zh) 2015-04-08
EP2214480B1 (en) 2013-03-27
US10307386B2 (en) 2019-06-04

Similar Documents

Publication Publication Date Title
BRPI0819690B8 (pt) uso de uma composição compreendendo cisteamina ou cistamina, ou um sal farmaceuticamente aceitável das mesmas
BR112014006220A2 (pt) composições de galacto-ramnogalacturonato para o tratamento de esteatohepatite não alcoólica e de doença de gordura no fígado não alcoólica
BR112015020600A2 (pt) composição farmacêutica, método para o tratamento de e/ou melhorar doenças de gordura no fígado de origem não alcoólica e uso da composição
BR112018008805A8 (pt) proteínas de função dupla e composição farmacêutica que compreende a mesma
BR112014031394A2 (pt) composições e métodos para absorção transmucosa
ATE449602T1 (de) Arzneimittel mit dobesilat-calcium zur behandlung und prophylaxe von sehnenerkrankungen
BR112014032526A2 (pt) composto, e composição farmacêutica
FR2949044B1 (fr) Composition comprenant une fraction d&#39;insaponifiable
WO2012087742A3 (en) Methods and compositions suitable for managing blood glucose in animals
BRPI0507966A (pt) uso de meloxicam para o tratamento de doenças respiratórias em porcos
BR112014009097A2 (pt) composição para uso na promoção de crescimento de osso saudável e/ou na prevenção e/ou tratamento das doenças dos ossos
BR102013003570A8 (pt) Composições de plasma rico em plaquetas
PH12018000207B1 (en) A pharmaceutical composition for prevention of diet induced obesity
SG10201906400SA (en) Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
MY207469A (en) Therapeutic compounds
MY192494A (en) Vaginal composition and use thereof
MX2017006639A (es) Metodos y composiciones para preservar la masa corporal magra y promover la perdida de grasa durante la perdida de peso.
EA201692106A1 (ru) Пищевые продукты, системы, способы и наборы для замены электролитов
EP3852760A4 (en) MATERIAL OF COMPOSITION, SYNTHESIS, FORMULATION AND APPLICATION OF ANALOGS DERIVED AT POSITIONS 9 AND 7 ON THE FL118 PLATFORM FOR THE TREATMENT OF A HUMAN DISEASE
BRPI0712561B8 (pt) Uso de 3-oxo-3,4-diidro-2-pirazinacarboxamida
MX2022004382A (es) Metodos para promover la produccion de scfa por microbiota intestinal.
ZA202101688B (en) Pharmaceutical compositions suitable for articular delivery and use thereof in treatment of joint pain
BRPI0507482A (pt) combinação de (a) um inibidor de dna topoisomerase e (b) um inibidor de iap
RU2013133998A (ru) Способы и композиции для предотвращения и лечения остеоартрита
WO2018078599A3 (en) Composition for the preventive or curative treatment of liver disorders

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/07/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/11/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 13A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2646 DE 21-09-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.