BRPI0818893A2 - Compostos tropano - Google Patents

Compostos tropano

Info

Publication number: BRPI0818893A2
Authority: BR; Brazil
Prior art keywords: tropane compounds; tropane; compounds; formula; methods
Prior art date: 2007-10-25

Application number

Other languages

English (en)

Inventor

Kenneth D Rice

Naing Aay

Neel Kumar Anand

Arlyn Arcalas

Tae-Gon Baik

Charles M Blazey

Owen Joseph Bowles

Chris A Buhr

Joerg Bussenius

Simona Costanzo

Jeffry Kimo Curtis

Steven Charles Defina

Larisa Dubenko

Abigail R Kennedy

Angie Inyoung Kim

Catherine Lara

Sunghoon Ma

Jean-Claire Limun Manalo

Csaba J Peto

Tsze H Tsang

Longcheng Wang

Original Assignee

Exelixis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-25

Filing date

2008-10-27

Publication date

2015-05-05

2008-10-27 Application filed by Exelixis Inc filed Critical Exelixis Inc

2015-05-05 Publication of BRPI0818893A2 publication Critical patent/BRPI0818893A2/pt

2021-02-02 Publication of BRPI0818893B1 publication Critical patent/BRPI0818893B1/pt

2021-05-25 Publication of BRPI0818893B8 publication Critical patent/BRPI0818893B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Cardiology (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)

BRPI0818893A 2007-10-25 2008-10-27 compostos de tropano, suas composições farmacêuticas, seus usos e método in vitro de inibição de hsp90 em uma célula BRPI0818893B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68707P	2007-10-25	2007-10-25
US61/000,687		2007-10-25
PCT/US2008/012221 WO2009055077A1 (en)	2007-10-25	2008-10-27	Tropane compounds

Publications (3)

Publication Number	Publication Date
BRPI0818893A2 true BRPI0818893A2 (pt)	2015-05-05
BRPI0818893B1 BRPI0818893B1 (pt)	2021-02-02
BRPI0818893B8 BRPI0818893B8 (pt)	2021-05-25

Family

ID=40287869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818893A BRPI0818893B8 (pt)	2007-10-25	2008-10-27	compostos de tropano, suas composições farmacêuticas, seus usos e método in vitro de inibição de hsp90 em uma célula

Country Status (26)

Country	Link
US (1)	US8012956B2 (pt)
EP (1)	EP2074120B1 (pt)
JP (2)	JP5476307B2 (pt)
KR (1)	KR101578792B1 (pt)
CN (1)	CN101910168B (pt)
AT (1)	ATE459622T1 (pt)
AU (1)	AU2008317262B2 (pt)
BR (1)	BRPI0818893B8 (pt)
CA (1)	CA2703477C (pt)
CO (1)	CO6321232A2 (pt)
CY (1)	CY1110648T1 (pt)
DE (1)	DE602008000754D1 (pt)
DK (1)	DK2074120T3 (pt)
EA (1)	EA018999B1 (pt)
ES (1)	ES2342348T3 (pt)
HR (1)	HRP20100292T1 (pt)
IL (1)	IL205202A0 (pt)
MX (1)	MX2010004493A (pt)
NZ (1)	NZ585137A (pt)
PL (1)	PL2074120T3 (pt)
PT (1)	PT2074120E (pt)
RS (1)	RS51346B (pt)
SG (1)	SG2012079653A (pt)
SI (1)	SI2074120T1 (pt)
WO (1)	WO2009055077A1 (pt)
ZA (1)	ZA201002987B (pt)

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WO2009076631A1 (en) *	2007-12-12	2009-06-18	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds for metabolic disorders
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
UY32940A (es)	2009-10-27	2011-05-31	Bayer Cropscience Ag	Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
IN2012CN09242A (pt)	2010-04-05	2015-08-21	Shionogi & Co
WO2012068096A2 (en)	2010-11-15	2012-05-24	Exelixis, Inc.	Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
EP2740474A1 (en)	2012-12-05	2014-06-11	Instituto Europeo di Oncologia S.r.l.	Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
US20150352086A1 (en) *	2013-01-07	2015-12-10	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Heat shock protein (hsp) inhibition and monitoring effectiveness thereof
HK1225716A1 (zh)	2013-08-21	2017-09-15	Alios Biopharma, Inc.	抗病毒化合物
JP2016538574A (ja) *	2013-11-18	2016-12-08	デルマーファーマシューティカルズ	ジアンヒドロガラクチトール中の不純物のｈｐｌｃ分析
EP2949648A1 (en)	2014-05-30	2015-12-02	IEO - Istituto Europeo di Oncologia Srl	Cyclopropylamine derivatives as histone demethylase inhibitors
MX375102B (es)	2014-05-30	2025-03-06	Ieo St Europeo Di Oncologia S R L	Compuestos de ciclopropilamina como inhibidores de histona demetilasa
US20170224670A1 (en)	2014-10-14	2017-08-10	Exelixis, Inc.	Drug Combination to Treat Melanoma
AU2016294377A1 (en) *	2015-07-16	2018-02-15	Akuru Pharma Ab	Detection and treatment of renal cell carcinoma with a SLC6A3 ligand linked to a label, cytotoxic or immunomodulatory group
EP3588064B1 (en) *	2017-02-23	2022-09-07	IHI Corporation	Oh radical detection probe, oh radical measurement device, and oh radical measurement method
CN108164529B (zh) *	2017-12-25	2020-04-24	三峡大学	一种小分子抑制剂sld9059及其在制药中的应用
DK3737677T3 (da)	2018-01-10	2022-01-10	Allinky Biopharma	Tetrahydroisoquinolinforbindelser
CN111825702A (zh) *	2019-04-22	2020-10-27	成都科岭源医药技术有限公司	一种氮杂*并吲唑类衍生物及其制备方法和用途
CN110698395B (zh) *	2019-10-22	2021-05-25	杭州百诚医药科技股份有限公司	一种托吡司特的中间体的制备方法
CN112920078A (zh) *	2019-12-05	2021-06-08	武汉珈汇精化科技有限公司	一种制备4-氰基苯甲酸甲酯的方法和一种制备4-氰基苯甲酸的方法
TW202136238A (zh) *	2020-01-06	2021-10-01	大陸商廣東東陽光藥業有限公司	RORγt抑制劑及其製備方法和用途
CN116615422A (zh) *	2020-10-14	2023-08-18	珃诺生物医药科技(杭州)有限公司	用于靶向蛋白降解的方法和组合物
CN114591192B (zh) *	2020-12-04	2024-06-21	江西仰立新材料有限公司	一种n-环丙甲基苯胺类化合物的制备方法
WO2022132679A1 (en) *	2020-12-18	2022-06-23	Merck Sharp & Dohme Corp.	Amido-substituted pyridyl compounds and methods of use thereof for the treatment of herpesviruses
CN112707809B (zh) *	2020-12-30	2023-08-29	丽珠集团新北江制药股份有限公司	一种制备噁唑啉杀虫剂氟雷拉纳中间体的方法
JP7696490B2 (ja) *	2021-07-26	2025-06-20	ゾエティス・サービシーズ・エルエルシー	セロトニン５－ｈｔ２ｂ阻害化合物

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FR2738569B1 (fr)	1995-09-12	1997-11-28	Pf Medicament	Nouveaux derives naphtamide de 3 beta-amino azabicyclo octane ou nonane, leur procede de preparation, leur utilisation a titre de medicament antipsychotique
NZ326354A (en)	1996-01-15	1999-05-28	Janssen Pharmaceutica Nv	3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments
HUP0202001A2 (hu) *	2002-06-14	2005-08-29	Sanofi-Aventis	DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
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KR20060030482A (ko) *	2003-06-24	2006-04-10	뉴로서치 에이/에스	신규한 8-아자-바이사이클로[3.2.1]옥탄 유도체 및모노아민 신경전달물질 재흡수 억제제로서의 이의 용도
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DE602004010708T2 (de)	2003-10-03	2008-12-04	Pfizer Inc.	Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen
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JP2008526923A (ja)	2005-01-13	2008-07-24	ノイロサーチアクティーゼルスカブ	新規８−置換８−アザ−ビシクロ［３．２．１］オクタン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用
CN102127078A (zh) *	2005-07-14	2011-07-20	安斯泰来制药株式会社	Janus激酶3的杂环类抑制剂
CA2624558C (en) *	2005-10-06	2011-02-22	Nippon Soda Co., Ltd.	Cross-linked cyclic amine compounds and agents for pest control
CN101511818B (zh) *	2006-09-01	2013-05-08	大塚农业科技株式会社	N-吡啶基哌啶化合物、其制备方法及有害生物防治剂

2008
- 2008-10-27 JP JP2010531069A patent/JP5476307B2/ja not_active Expired - Fee Related
- 2008-10-27 RS RSP-2010/0220A patent/RS51346B/sr unknown
- 2008-10-27 SI SI200830024T patent/SI2074120T1/sl unknown
- 2008-10-27 AU AU2008317262A patent/AU2008317262B2/en not_active Ceased
- 2008-10-27 EP EP08832769A patent/EP2074120B1/en active Active
- 2008-10-27 KR KR1020107011444A patent/KR101578792B1/ko not_active Expired - Fee Related
- 2008-10-27 BR BRPI0818893A patent/BRPI0818893B8/pt not_active IP Right Cessation
- 2008-10-27 WO PCT/US2008/012221 patent/WO2009055077A1/en not_active Ceased
- 2008-10-27 DE DE602008000754T patent/DE602008000754D1/de active Active
- 2008-10-27 ES ES08832769T patent/ES2342348T3/es active Active
- 2008-10-27 AT AT08832769T patent/ATE459622T1/de active
- 2008-10-27 US US12/290,159 patent/US8012956B2/en active Active
- 2008-10-27 PT PT08832769T patent/PT2074120E/pt unknown
- 2008-10-27 HR HR20100292T patent/HRP20100292T1/hr unknown
- 2008-10-27 EA EA201070519A patent/EA018999B1/ru not_active IP Right Cessation
- 2008-10-27 CA CA2703477A patent/CA2703477C/en active Active
- 2008-10-27 NZ NZ585137A patent/NZ585137A/en not_active IP Right Cessation
- 2008-10-27 MX MX2010004493A patent/MX2010004493A/es active IP Right Grant
- 2008-10-27 DK DK08832769.7T patent/DK2074120T3/da active
- 2008-10-27 CN CN200880122860.5A patent/CN101910168B/zh not_active Expired - Fee Related
- 2008-10-27 PL PL08832769T patent/PL2074120T3/pl unknown
- 2008-10-27 SG SG2012079653A patent/SG2012079653A/en unknown
2010
- 2010-04-19 IL IL205202A patent/IL205202A0/en active IP Right Grant
- 2010-04-29 ZA ZA2010/02987A patent/ZA201002987B/en unknown
- 2010-05-24 CO CO10061824A patent/CO6321232A2/es not_active Application Discontinuation
- 2010-06-01 CY CY20101100483T patent/CY1110648T1/el unknown
2013
- 2013-12-13 JP JP2013257559A patent/JP5745021B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE459622T1 (de)	2010-03-15
KR101578792B1 (ko)	2015-12-21
BRPI0818893B1 (pt)	2021-02-02
PT2074120E (pt)	2010-06-15
CA2703477A1 (en)	2009-04-30
JP5476307B2 (ja)	2014-04-23
IL205202A0 (en)	2010-12-30
CN101910168B (zh)	2014-07-30
WO2009055077A1 (en)	2009-04-30
EP2074120A1 (en)	2009-07-01
JP2011500815A (ja)	2011-01-06
CA2703477C (en)	2016-10-11
PL2074120T3 (pl)	2010-08-31
HRP20100292T1 (hr)	2010-06-30
DE602008000754D1 (de)	2010-04-15
MX2010004493A (es)	2010-06-11
CN101910168A (zh)	2010-12-08
AU2008317262B2 (en)	2013-12-19
JP2014070077A (ja)	2014-04-21
SI2074120T1 (sl)	2010-06-30
HK1129390A1 (en)	2009-11-27
ES2342348T3 (es)	2010-07-05
EA201070519A1 (ru)	2010-12-30
JP5745021B2 (ja)	2015-07-08
EA018999B1 (ru)	2013-12-30
CO6321232A2 (es)	2011-09-20
BRPI0818893B8 (pt)	2021-05-25
US20090163471A1 (en)	2009-06-25
ZA201002987B (en)	2011-02-23
EP2074120B1 (en)	2010-03-03
DK2074120T3 (da)	2010-06-14
AU2008317262A1 (en)	2009-04-30
SG2012079653A (en)	2014-05-29
US8012956B2 (en)	2011-09-06
NZ585137A (en)	2012-07-27
KR20100090782A (ko)	2010-08-17
RS51346B (sr)	2011-02-28
CY1110648T1 (el)	2015-06-10

Publication	Publication Date	Title
ATE459622T1 (de)	2010-03-15	Tropanverbindungen
EA201100037A1 (ru)	2011-08-30	Органические соединения
EA201270254A1 (ru)	2012-07-30	Производные 5-фторпиримидинона
EA201070786A1 (ru)	2011-02-28	Бензофуропиримидиноны
UA107445C2 (uk)	2015-01-12	5-фторпіримідинові похідні як фунгіциди
SMP201100019B (it)	2012-01-18	Composti organici
EA201201377A1 (ru)	2013-04-30	Определенные аминопиридазины, композиции на их основе и способы их использования
BR112012018345A2 (pt)	2018-07-10	"compostos de heteroarila, bem como composições e usos dos mesmos"
MA32383B1 (fr)	2011-06-01	DÉRIVÉS D'INDAZOLES à SUBSTITUTIONS PHÉNYLE ET BENZODIOXYNYLE
CY1118199T1 (el)	2017-06-28	Ενωσεις υποκατεστημενης πυραζολο[1,5] πυριμιδινης ως ενδιαμεσα στη συνθεση αναστολεων κινασης trk
WO2010003133A3 (en)	2010-03-18	Cdk modulators
UA108101C2 (xx)	2015-03-25	Похідні n3-заміщених n1-сульфоніл-5-фторпіримідинонів
EA201170884A1 (ru)	2012-02-28	Производные пиперидина, пригодные в качестве антагонистов орексина
EA201270257A1 (ru)	2012-08-30	Производные n1-сульфонил-5-фторпиримидинона
MY146638A (en)	2012-09-14	Insecticidal aryl isoxazoline derivatives
PH12012501905A1 (en)	2015-10-19	Quinoline derivatives and their use as fungicides
ATE554066T1 (de)	2012-05-15	Entzündungshemmende substituierte cyclobutendionverbindungen
UA106889C2 (uk)	2014-10-27	Похідні n1-ацил-5-фторпіримідинону
EA201270256A1 (ru)	2012-07-30	Производные т1-замещенного 5-фтор-2-оксопиримидинон-1 (2h) -карбоксамида
NO20085317L (no)	2009-02-05	Imidazoazepinonforbindelser
EP2585446A4 (en)	2013-12-25	COMPOUNDS HAVING ANTAGONIST ACTIVITY OF TRPV1 AND USES THEREOF
ATE481395T1 (de)	2010-10-15	Cyclohexylderivate
ATE533477T1 (de)	2011-12-15	Pharmazeutische zusammensetzungen enthaltend irbesartan
UY30235A1 (es)	2007-10-31	Inhibidores de la adenilato ciclasa soluble
NZ590367A (en)	2012-08-31	9-Substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials

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