BRPI0818575A2 - Processo para a modificação do estado sólido de um composto e composições co-amorfas produzidas com o mesmo - Google Patents
Processo para a modificação do estado sólido de um composto e composições co-amorfas produzidas com o mesmoInfo
- Publication number
- BRPI0818575A2 BRPI0818575A2 BRPI0818575-1A2A BRPI0818575A BRPI0818575A2 BR PI0818575 A2 BRPI0818575 A2 BR PI0818575A2 BR PI0818575 A BRPI0818575 A BR PI0818575A BR PI0818575 A2 BRPI0818575 A2 BR PI0818575A2
- Authority
- BR
- Brazil
- Prior art keywords
- colorform
- modifying
- compound
- same
- solid state
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99948307P | 2007-10-17 | 2007-10-17 | |
| US99946207P | 2007-10-17 | 2007-10-17 | |
| US99944507P | 2007-10-17 | 2007-10-17 | |
| US12/252,458 US8173632B2 (en) | 2007-10-17 | 2008-10-16 | Process for the modification of the solid state of a compound and co-amorphous compositions produced with same |
| PCT/US2008/080095 WO2009052246A1 (en) | 2007-10-17 | 2008-10-16 | Process for the modification of the solid state of a compound and co-amorphous compositions produced with same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0818575A2 true BRPI0818575A2 (pt) | 2014-10-07 |
Family
ID=40567777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0818575-1A2A BRPI0818575A2 (pt) | 2007-10-17 | 2008-10-16 | Processo para a modificação do estado sólido de um composto e composições co-amorfas produzidas com o mesmo |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8173632B2 (pt) |
| EP (1) | EP2211611B1 (pt) |
| JP (1) | JP5596547B2 (pt) |
| CN (1) | CN101969766B (pt) |
| BR (1) | BRPI0818575A2 (pt) |
| CA (1) | CA2702903C (pt) |
| EA (1) | EA023338B1 (pt) |
| IL (1) | IL205155A (pt) |
| WO (1) | WO2009052246A1 (pt) |
| ZA (1) | ZA201003353B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8377989B2 (en) * | 2007-10-17 | 2013-02-19 | Todd F. Ovokaitys | Room temperature stable non-crystalline aspirin and method for the preparation thereof |
| EP2414529A2 (en) | 2009-04-01 | 2012-02-08 | Matrix Laboratories Ltd | Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe |
| EP2368543A1 (en) | 2010-03-25 | 2011-09-28 | KRKA, tovarna zdravil, d.d., Novo mesto | Method of preparing a granulated pharmaceutical composition comprising simvastatin and/or ezetimibe |
| CN103360357B (zh) * | 2013-08-07 | 2015-07-22 | 中国药科大学 | 辛伐他丁格列齐特共无定型物 |
| CN104415042A (zh) * | 2013-08-30 | 2015-03-18 | 天津药物研究院 | 一种共无定型系统及其制备方法 |
| CN103923049A (zh) * | 2014-05-05 | 2014-07-16 | 武汉远瞩医药科技有限公司 | 黄芩素咖啡因共无定型物 |
| US10202598B2 (en) | 2014-05-30 | 2019-02-12 | Todd Frank Ovokaitys | Methods and systems for generation, use, and delivery of activated stem cells |
| WO2015187974A1 (en) | 2014-06-06 | 2015-12-10 | Ovokaitys Todd Frank | Methods and compositions for increasing the bioactivity of nutrients |
| US10384985B2 (en) | 2014-06-06 | 2019-08-20 | B.K. Consultants, Inc. | Methods and compositions for increasing the yield of, and beneficial chemical composition of, certain plants |
| JP2016169198A (ja) * | 2015-03-13 | 2016-09-23 | 大原薬品工業株式会社 | ロスバスタチンカルシウムを含有する錠剤 |
| JP2017071559A (ja) * | 2015-10-05 | 2017-04-13 | 学校法人大阪医科薬科大学 | トラニラスト−ジフェンヒドラミンのコアモルファス |
| US11453840B2 (en) * | 2018-04-28 | 2022-09-27 | John Anton Broadhurst | Method for applying energy to cannabidiol |
| EP3991791A4 (en) * | 2019-06-25 | 2023-07-12 | Ajinomoto Co., Inc. | MIXTURE OF AMINO ACIDS WITH A CO-AMORPHIC STRUCTURE |
| EP4259162A4 (en) | 2020-12-08 | 2024-11-06 | Todd F. Ovokaitys | METHODS AND SYSTEMS FOR ENHANCED STEM CELL PRODUCTION |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9525103D0 (en) * | 1995-12-08 | 1996-02-07 | Strachan John S | Optical device and method of manufacture |
| US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
| GB9920351D0 (en) | 1999-08-28 | 1999-11-03 | Strachen John S | Sparse constructive node stimulation of cell surface molecular resonance in vivo |
| SI20814A (sl) * | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
| CZ292832B6 (cs) * | 2001-08-30 | 2003-12-17 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy silymarinu se zvýšenou rozpustností |
| EP1444041A2 (en) * | 2001-09-21 | 2004-08-11 | Solvias AG | Sealing system with flow channels |
| ES2878403T3 (es) * | 2002-02-01 | 2021-11-18 | Bend Res Inc | Método para preparar dispersiones de fármacos amorfas sólidas homogéneas secadas mediante pulverización utilizando aparatos de secado por pulverización modificados |
| WO2004071435A2 (en) * | 2003-02-10 | 2004-08-26 | Todd Ovokaitys | Enhanced Bioavailability Using Laser Resonant Homogenization |
| EA200800041A1 (ru) * | 2005-06-13 | 2008-04-28 | Элан Фарма Интернэшнл Лтд. | Составы с наночастицами клопидогреля, содержащие комбинацию клопидогреля и аспирина |
| WO2007100614A2 (en) * | 2006-02-24 | 2007-09-07 | Scidose, Llc | STABLE NON-CRYSTALLINE FORMULATION COMPRISING HMG-CoA REDUCTASE INHIBITOR |
-
2008
- 2008-10-16 WO PCT/US2008/080095 patent/WO2009052246A1/en not_active Ceased
- 2008-10-16 CN CN200880119828.1A patent/CN101969766B/zh not_active Expired - Fee Related
- 2008-10-16 CA CA2702903A patent/CA2702903C/en not_active Expired - Fee Related
- 2008-10-16 BR BRPI0818575-1A2A patent/BRPI0818575A2/pt not_active IP Right Cessation
- 2008-10-16 EA EA201070467A patent/EA023338B1/ru not_active IP Right Cessation
- 2008-10-16 EP EP08839613.0A patent/EP2211611B1/en not_active Not-in-force
- 2008-10-16 JP JP2010530098A patent/JP5596547B2/ja not_active Expired - Fee Related
- 2008-10-16 US US12/252,458 patent/US8173632B2/en active Active
-
2010
- 2010-04-18 IL IL205155A patent/IL205155A/en not_active IP Right Cessation
- 2010-05-12 ZA ZA2010/03353A patent/ZA201003353B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5596547B2 (ja) | 2014-09-24 |
| CN101969766A (zh) | 2011-02-09 |
| IL205155A (en) | 2017-12-31 |
| EP2211611A1 (en) | 2010-08-04 |
| JP2011500709A (ja) | 2011-01-06 |
| EP2211611A4 (en) | 2012-03-28 |
| WO2009052246A1 (en) | 2009-04-23 |
| IL205155A0 (en) | 2010-11-30 |
| CA2702903A1 (en) | 2009-04-23 |
| ZA201003353B (en) | 2011-12-28 |
| EP2211611B1 (en) | 2014-12-10 |
| CA2702903C (en) | 2016-01-19 |
| US20090131376A1 (en) | 2009-05-21 |
| EA023338B1 (ru) | 2016-05-31 |
| CN101969766B (zh) | 2015-05-06 |
| EA201070467A1 (ru) | 2011-06-30 |
| US8173632B2 (en) | 2012-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2484 DE 14-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |