BRPI0818350A2 - formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-triflúor-1-(3-metoxibifenil-4-il)etóxi)pirimidin-4-il)fenil)propanoico e processo para uso das mesmas - Google Patents

formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-triflúor-1-(3-metoxibifenil-4-il)etóxi)pirimidin-4-il)fenil)propanoico e processo para uso das mesmas

Info

Publication number: BRPI0818350A2
Authority: BR; Brazil
Prior art keywords: amino; methoxybiphenyl; pyrimidin; trifluoro; ethoxy
Prior art date: 2007-10-08

Application number

BRPI0818350A

Other languages

English (en)

Inventor

Li Hui-Yin

Mangzhu Zhao Matthew

Song Qiuling

Iimura Shinya

Wu Wenxue

Original Assignee

Lexicon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-08

Filing date

2008-10-07

Publication date

2017-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40344344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0818350(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-10-07 Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc

2017-10-10 Publication of BRPI0818350A2 publication Critical patent/BRPI0818350A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BRPI0818350A 2007-10-08 2008-10-07 formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-triflúor-1-(3-metoxibifenil-4-il)etóxi)pirimidin-4-il)fenil)propanoico e processo para uso das mesmas BRPI0818350A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US97830307P	2007-10-08	2007-10-08
PCT/US2008/079042 WO2009048864A1 (en)	2007-10-08	2008-10-07	Solid forms of (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and methods of their use

Publications (1)

Publication Number	Publication Date
BRPI0818350A2 true BRPI0818350A2 (pt)	2017-10-10

Family

ID=40344344

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818350A BRPI0818350A2 (pt)	2007-10-08	2008-10-07	formas sólidas de ácido (s)-2-amino-3-(4-(2-amino-6-((r)-2,2,2-triflúor-1-(3-metoxibifenil-4-il)etóxi)pirimidin-4-il)fenil)propanoico e processo para uso das mesmas

Country Status (20)

Country	Link
US (1)	US20090099206A1 (pt)
EP (1)	EP2231618A1 (pt)
JP (1)	JP2010540665A (pt)
KR (1)	KR20100066548A (pt)
CN (1)	CN101932563A (pt)
AR (1)	AR068837A1 (pt)
AU (1)	AU2008310979A1 (pt)
BR (1)	BRPI0818350A2 (pt)
CA (1)	CA2701904A1 (pt)
CL (1)	CL2008002980A1 (pt)
CO (1)	CO6270323A2 (pt)
EA (1)	EA201070455A1 (pt)
EC (1)	ECSP10010162A (pt)
IL (1)	IL204582A0 (pt)
MX (1)	MX2010003803A (pt)
PE (1)	PE20091213A1 (pt)
TW (1)	TW200932729A (pt)
UY (1)	UY31381A1 (pt)
WO (1)	WO2009048864A1 (pt)
ZA (1)	ZA201001870B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103265495B (zh)	2005-12-29	2016-11-16	莱西肯医药有限公司	多环氨基酸衍生物及其使用方法
US7855291B2 (en) *	2005-12-29	2010-12-21	Lexicon Pharmaceuticals, Inc.	Process for the preparation of substituted phenylalanines
US7897763B2 (en)	2005-12-29	2011-03-01	Lexicon Pharmaceuticals, Inc.	Process for the preparation of substituted phenylalanines
EA201070059A1 (ru) *	2007-06-26	2010-06-30	Лексикон Фармасьютикалз, Инк.	Композиции, содержащие ингибиторы триптофангидроксилазы
TWI439457B (zh)	2007-09-28	2014-06-01	Lexicon Pharmaceuticals Inc	（ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
CA2719505A1 (en)	2008-03-31	2009-10-08	The Trustees Of Columbia University In The City Of New York	Methods of diagnosing, preventing and treating bone mass diseases
WO2011063181A1 (en) *	2009-11-23	2011-05-26	Lexicon Pharmaceuticals, Inc.	Methods and assays for the treatment of irritable bowel syndrome
US20130303763A1 (en) *	2012-03-30	2013-11-14	Michael D. Gershon	Methods and compositions for the treatment of necrotizing enterocolitis
US11203597B2 (en) *	2018-11-14	2021-12-21	Altavant Sciences Gmbh	Crystalline spirocyclic compound, a dosage form containing, a method for using in treatment of disease, and a method for recrystallizing
TW202210462A (zh) *	2020-05-28	2022-03-16	中國大陸商杭州中美華東製藥有限公司	（ｓ）－２－胺基－３－（４－（２，３－二甲基吡啶－４－基）苯基丙酸甲酯及其鹽的製備方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7382793B1 (en) *	2002-01-17	2008-06-03	Juniper Networks, Inc.	Systems and methods for determining the bandwidth used by a queue
CN103265495B (zh) *	2005-12-29	2016-11-16	莱西肯医药有限公司	多环氨基酸衍生物及其使用方法
US7855291B2 (en) *	2005-12-29	2010-12-21	Lexicon Pharmaceuticals, Inc.	Process for the preparation of substituted phenylalanines
US7897763B2 (en) *	2005-12-29	2011-03-01	Lexicon Pharmaceuticals, Inc.	Process for the preparation of substituted phenylalanines
UA99270C2 (en) *	2006-12-12	2012-08-10	Лексикон Фармасьютикалз, Инк.	4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
EA201070059A1 (ru) *	2007-06-26	2010-06-30	Лексикон Фармасьютикалз, Инк.	Композиции, содержащие ингибиторы триптофангидроксилазы
WO2009002964A1 (en) *	2007-06-26	2008-12-31	Lexicon Pharmaceuticals, Inc.	Methods of treating serotonin-mediated diseases and disorders
EP2170397A1 (en) *	2007-07-11	2010-04-07	Lexicon Pharmaceuticals, Inc.	Methods and compositions for treating pulmonary hypertension and related diseases and disorders
CA2694443A1 (en) *	2007-07-26	2009-01-29	Lexicon Pharmaceuticals, Inc.	Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein

2008
- 2008-10-02 TW TW097137954A patent/TW200932729A/zh unknown
- 2008-10-07 UY UY31381A patent/UY31381A1/es not_active Application Discontinuation
- 2008-10-07 US US12/246,735 patent/US20090099206A1/en not_active Abandoned
- 2008-10-07 PE PE2008001736A patent/PE20091213A1/es not_active Application Discontinuation
- 2008-10-07 MX MX2010003803A patent/MX2010003803A/es not_active Application Discontinuation
- 2008-10-07 AU AU2008310979A patent/AU2008310979A1/en not_active Abandoned
- 2008-10-07 BR BRPI0818350A patent/BRPI0818350A2/pt not_active IP Right Cessation
- 2008-10-07 CN CN200880110755XA patent/CN101932563A/zh active Pending
- 2008-10-07 KR KR1020107007548A patent/KR20100066548A/ko not_active Withdrawn
- 2008-10-07 EA EA201070455A patent/EA201070455A1/ru unknown
- 2008-10-07 CA CA2701904A patent/CA2701904A1/en not_active Abandoned
- 2008-10-07 JP JP2010528220A patent/JP2010540665A/ja not_active Withdrawn
- 2008-10-07 EP EP08837474A patent/EP2231618A1/en not_active Withdrawn
- 2008-10-07 CL CL2008002980A patent/CL2008002980A1/es unknown
- 2008-10-07 WO PCT/US2008/079042 patent/WO2009048864A1/en not_active Ceased
- 2008-10-08 AR ARP080104405A patent/AR068837A1/es unknown
2010
- 2010-03-16 ZA ZA2010/01870A patent/ZA201001870B/en unknown
- 2010-03-18 IL IL204582A patent/IL204582A0/en unknown
- 2010-05-06 EC EC2010010162A patent/ECSP10010162A/es unknown
- 2010-05-07 CO CO10054926A patent/CO6270323A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZA201001870B (en)	2011-06-29
JP2010540665A (ja)	2010-12-24
PE20091213A1 (es)	2009-08-26
TW200932729A (en)	2009-08-01
KR20100066548A (ko)	2010-06-17
MX2010003803A (es)	2010-04-21
CA2701904A1 (en)	2009-04-16
UY31381A1 (es)	2009-04-30
AU2008310979A1 (en)	2009-04-16
CO6270323A2 (es)	2011-04-20
AR068837A1 (es)	2009-12-09
EP2231618A1 (en)	2010-09-29
CL2008002980A1 (es)	2009-03-20
IL204582A0 (en)	2010-11-30
ECSP10010162A (es)	2010-06-29
WO2009048864A1 (en)	2009-04-16
EA201070455A1 (ru)	2010-08-30
US20090099206A1 (en)	2009-04-16
CN101932563A (zh)	2010-12-29

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Legal Events

Date	Code	Title	Description
2017-10-31	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2018-02-20	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]