[go: up one dir, main page]

BRPI0815048B8 - derivados de fenóxi-pirrolidinas, seus usos e composições farmacêuticas - Google Patents

derivados de fenóxi-pirrolidinas, seus usos e composições farmacêuticas

Info

Publication number
BRPI0815048B8
BRPI0815048B8 BRPI0815048A BRPI0815048A BRPI0815048B8 BR PI0815048 B8 BRPI0815048 B8 BR PI0815048B8 BR PI0815048 A BRPI0815048 A BR PI0815048A BR PI0815048 A BRPI0815048 A BR PI0815048A BR PI0815048 B8 BRPI0815048 B8 BR PI0815048B8
Authority
BR
Brazil
Prior art keywords
phenoxy
pharmaceutical compositions
pyrrolidine derivatives
compound
pyrrolidine
Prior art date
Application number
BRPI0815048A
Other languages
English (en)
Inventor
Li Jin
Lee Kolosko Nicole
Original Assignee
Graceway Pharmaceuticals Llc
Medicis Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Graceway Pharmaceuticals Llc, Medicis Pharmaceutical Corp filed Critical Graceway Pharmaceuticals Llc
Publication of BRPI0815048A2 publication Critical patent/BRPI0815048A2/pt
Publication of BRPI0815048B1 publication Critical patent/BRPI0815048B1/pt
Publication of BRPI0815048B8 publication Critical patent/BRPI0815048B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

derivado de fenóxi-pirrolidinas e uso e composições do mesmo. a presente invenção refere-se ao composto 2-(4-(hidroximetil)-fenóxi)-1-(3-(2- (trifluorometil)-fenóxi)-pirrolidin-1-il)-etanona, uso do mesmo como um inibidor de estearoil coa dessaturase, e composições farmacêuticas que contêm este composto.
BRPI0815048A 2007-08-08 2008-07-28 derivados de fenóxi-pirrolidinas, seus usos e composições farmacêuticas BRPI0815048B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95459307P 2007-08-08 2007-08-08
US60/954,593 2007-08-08
PCT/IB2008/002028 WO2009019566A1 (en) 2007-08-08 2008-07-28 Phenoxy-pyrrolidine derivative and its use and compositions

Publications (3)

Publication Number Publication Date
BRPI0815048A2 BRPI0815048A2 (pt) 2016-04-05
BRPI0815048B1 BRPI0815048B1 (pt) 2020-09-29
BRPI0815048B8 true BRPI0815048B8 (pt) 2021-05-25

Family

ID=39870001

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815048A BRPI0815048B8 (pt) 2007-08-08 2008-07-28 derivados de fenóxi-pirrolidinas, seus usos e composições farmacêuticas

Country Status (14)

Country Link
US (3) US8242286B2 (pt)
EP (1) EP2173711B1 (pt)
JP (2) JP5239001B2 (pt)
KR (1) KR101189189B1 (pt)
CN (2) CN104292144B (pt)
AT (1) ATE488499T1 (pt)
AU (1) AU2008285255B2 (pt)
BR (1) BRPI0815048B8 (pt)
CA (1) CA2695664C (pt)
DE (1) DE602008003586D1 (pt)
ES (1) ES2352098T3 (pt)
MX (1) MX2010001485A (pt)
RU (1) RU2010107892A (pt)
WO (1) WO2009019566A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8242286B2 (en) 2007-08-08 2012-08-14 Medicis Pharmaceutical Corporation Phenoxy-pyrrolidine derivative and its use and compositions
FR2948939B1 (fr) 2009-08-05 2013-03-22 Pf Medicament Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine
FR2958935B1 (fr) 2010-04-19 2012-06-22 Pf Medicament Derives d'heterocycles azotes, leur preparation et leur application en therapeutique humaine
EP2579843A4 (en) 2010-06-11 2015-12-16 Avon Prod Inc USE OF ECLIPTA PROSTRATA AND OTHER PPAR GAMMA INHIBITORS IN COSMETICS AND COMPOSITIONS THEREOF
JP6254087B2 (ja) 2011-10-15 2017-12-27 ジェネンテック， インコーポレイテッド 癌を治療するためのｓｃｄ１アンタゴニスト
US9233102B2 (en) 2012-03-07 2016-01-12 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
US10405795B1 (en) 2013-03-15 2019-09-10 The Procter & Gamble Company Methods of classifying periorbital dyschromia and systems therefor
JP2016527307A (ja) * 2013-08-08 2016-09-08 ガルデルム セラピューティクス リミテッド 胆汁酸−脂肪酸抱合体を含む抗座瘡組成物
US9630896B2 (en) 2013-11-22 2017-04-25 Tansna Therapeutics, Inc. 2,5-dialkyl-4-H/halo/ether-phenol compounds
EP3808349B1 (en) 2014-08-07 2022-10-05 Mayo Foundation for Medical Education and Research Compounds and methods for treating cancer
KR20170000657U (ko) 2015-08-11 2017-02-21 김유호 골프연습기
EP3463277A4 (en) * 2016-06-06 2020-01-01 GDD Therapeutics, LLC FORMULATIONS FOR SUBSTITUTED 3-PYRROLIDINES, COMPOSITIONS THEREFOR AND USES THEREOF
JP2019533022A (ja) 2016-10-24 2019-11-14 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
ES3025460T3 (en) 2017-01-06 2025-06-09 Janssen Pharmaceutica Nv Scd inhibitor for the treatment of neurological disorders
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
EP3768269B1 (en) 2018-03-23 2025-08-20 Janssen Pharmaceutica NV Compounds and uses thereof
WO2020154571A1 (en) 2019-01-24 2020-07-30 Yumanity Therapeutics, Inc. Compounds and uses thereof
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
EP4294517A4 (en) * 2021-02-19 2024-12-04 Lipidio Pharmaceuticals, Inc. METHODS OF TREATING NONALCOHOLIC STEATOHEPATITIS WITH AN SCD-1 INHIBITOR

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH432495A (de) * 1964-02-04 1967-03-31 Geigy Ag J R Verfahren zur Herstellung neuer Aryloxyessigsäureamide
CA2067514A1 (en) 1991-05-10 1992-11-11 Sergiu Mircea Gorun Manganese oligomer containing main group elements
US6338144B2 (en) 1999-02-19 2002-01-08 Sun Microsystems, Inc. Computer system providing low skew clock signals to a synchronous memory unit
US20050119251A1 (en) 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
ATE556056T1 (de) 2003-07-29 2012-05-15 Xenon Pharmaceuticals Inc Pyridylderivate und deren verwendung als therapeutische mittel
US7605161B2 (en) 2003-07-30 2009-10-20 Xenon Pharmaceuticals Inc. Pyridyl derivatives and their use as therapeutic agents
PT1651620E (pt) 2003-07-30 2012-02-10 Xenon Pharmaceuticals Inc Derivados de piperizina e sua utilização como agentes terapêuticos
EP2316827B1 (en) 2003-07-30 2016-01-27 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
HUP0401526A2 (en) * 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet Aryloxy acetic acid amide derivatives, pharmaceutical compositions comprising thereof, methods for their preparation and their use
JP2009501733A (ja) * 2005-07-20 2009-01-22 メルク フロスト カナダ リミテツド ステアロイルコエンザイムａデルタ−９デサチュラーゼの阻害剤としてのヘテロ芳香族化合物
EP2032570A4 (en) * 2006-06-13 2010-10-27 Merck Frosst Canada Ltd AZACYCLOPENTATE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE
US8242286B2 (en) 2007-08-08 2012-08-14 Medicis Pharmaceutical Corporation Phenoxy-pyrrolidine derivative and its use and compositions

Also Published As

Publication number Publication date
KR101189189B1 (ko) 2012-10-10
US20120277280A1 (en) 2012-11-01
RU2010107892A (ru) 2011-09-27
CN104292144A (zh) 2015-01-21
JP5239001B2 (ja) 2013-07-17
BRPI0815048B1 (pt) 2020-09-29
CN101821234A (zh) 2010-09-01
CA2695664C (en) 2014-12-09
EP2173711B1 (en) 2010-11-17
US8242286B2 (en) 2012-08-14
MX2010001485A (es) 2010-06-01
CN104292144B (zh) 2017-05-17
JP2010535756A (ja) 2010-11-25
BRPI0815048A2 (pt) 2016-04-05
JP5805119B2 (ja) 2015-11-04
US20140045911A1 (en) 2014-02-13
EP2173711A1 (en) 2010-04-14
AU2008285255B2 (en) 2012-09-27
CA2695664A1 (en) 2009-02-12
ATE488499T1 (de) 2010-12-15
DE602008003586D1 (de) 2010-12-30
AU2008285255A1 (en) 2009-02-12
US8524761B2 (en) 2013-09-03
US20100247471A1 (en) 2010-09-30
JP2013100377A (ja) 2013-05-23
ES2352098T3 (es) 2011-02-15
WO2009019566A1 (en) 2009-02-12
KR20100040878A (ko) 2010-04-21
CN101821234B (zh) 2014-06-25
US8980936B2 (en) 2015-03-17

Similar Documents

Publication Publication Date Title
BRPI0815048B8 (pt) derivados de fenóxi-pirrolidinas, seus usos e composições farmacêuticas
CY1121144T1 (el) Ετεροκυκλικες ενωσεις και χρησεις αυτων
EA201100049A1 (ru) Органические соединения
BRPI0922073A2 (pt) Compostos de éter com heterociclo de 5 membros contendo nitrogênio e usos dos mesmos.
CL2011000846A1 (es) Compuestos heterociclicos sustituidos; composicion farmaceutica; y su uso para el tratamiento de la hepatitis c.
EA201070698A1 (ru) Твердые формы 3-(6-(1-(2,2-дифторбензо[d][1,3]-диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты
CL2010001428A1 (es) Compuestos derivados de amidas y tioamidas heteroaromaticas; agente que contiene al menos uno de dichos compuestos; procedimiento para combatir parasitos; y uso de dichos compuestos.
EA201270254A1 (ru) Производные 5-фторпиримидинона
SMT201300098B (it) Forme solide di N-(4-(7-azabiciclo[2.2.1]eptan-7-il)-2-(trifluorometil)fenil-4-osso-5-trifluorometil)-1,4-diidrochinolina-3-carbossammide
EA201001359A1 (ru) Гетероциклические соединения в качестве ингибиторов cxcr2
EA201270257A1 (ru) Производные n1-сульфонил-5-фторпиримидинона
BRPI1016219B8 (pt) composto indazol substituído com oxazol, e, composição farmacêutica
BRPI0915084B8 (pt) composto, e, composição farmacêutica
EA201290255A1 (ru) Способы и композиции для лечения рака
UY33397A (es) Forma sólida de un naftaleno carboxamida
EA201100427A1 (ru) Гетероциклические ингибиторы киназы
EA200900820A1 (ru) 2-замещенные 5-членные гетероциклы в качестве ингибиторов стеароил-соа-десатуразы (ссд)
EA201001315A1 (ru) ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ СТЕАРОИЛ-CoA-ДЕСАТУРАЗЫ
ATE516286T1 (de) 5-(ä1,3,4üoxadiazol-2-yl)-1h-indazol und 5-(ä1,3, 4üthiadiazol-2-yl)-1h-indazol derivate als sgk- inhibitoren zur behandlung von diabetes
CL2011002781A1 (es) Compuestos (e)-2-(4-(2-(5-(1-(3,5-dicloropiridin-4-il)etoxi)-1h-indazol-3-il)vinil)-1h-pirazol-1-il)etanol y (r)-(e)-2-(4-(2-(5-(1-(3,5-dicloropiridin-4-il)etoxi)-1h-indazol-3-il)vinil)-1h-pirazol-1-il)etanol; composicion farmaceutica que los comprende; y uso en el tratamiento del cancer.
DE602008005141D1 (de) 1,3-dihydroimidazol-2-thionderivate als inhibitoren von dopamin-beta-hydroxylase
EP2252671A4 (en) AZEOTROPARTIC COMPOSITION OF 1,1,1-TRIFLUOR-3-CHLOROPROPENE AND DIMETHOXYMETHANE
EA201170680A1 (ru) Ингибиторы акт и p70 s6-киназы
CL2016001023A1 (es) Compuesto n-(1-(4-(2-(4-cloro-2,6-dimetilpirimidin-5-il)etil)piperidin-1-il)-1-oxopropan-2-il)ciclopropanocarboxamida, estereoisomero, inhibidores de grelina o-aciltransferasa (goat); composición farmaceutica; y uso para reducir la ganancia de peso y para tratar la diabetes tipo 2.
UY30610A1 (es) Moduladores de mglur5

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: MEDICIS PHARMACEUTICAL CORPORATION (US)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/09/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/07/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25G Requested change of headquarter approved

Owner name: MEDICIS PHARMACEUTICAL CORPORATION (US)

B25A Requested transfer of rights approved

Owner name: THESAN PHARMACEUTICALS, INC. (US)