[go: up one dir, main page]

BRPI0814624A2 - Tratamento de doença neurodegenerativa progresiva com ibudilaste - Google Patents

Tratamento de doença neurodegenerativa progresiva com ibudilaste

Info

Publication number
BRPI0814624A2
BRPI0814624A2 BRPI0814624-1A2A BRPI0814624A BRPI0814624A2 BR PI0814624 A2 BRPI0814624 A2 BR PI0814624A2 BR PI0814624 A BRPI0814624 A BR PI0814624A BR PI0814624 A2 BRPI0814624 A2 BR PI0814624A2
Authority
BR
Brazil
Prior art keywords
progresive
ibudilast
treatment
neurodegenerative disease
neurodegenerative
Prior art date
Application number
BRPI0814624-1A2A
Other languages
English (en)
Inventor
Michael E Kalafer
Kenneth W Locke
Kazuko Matsuda
Richard E Gammans
Original Assignee
Medicinova Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicinova Inc filed Critical Medicinova Inc
Publication of BRPI0814624A2 publication Critical patent/BRPI0814624A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0814624-1A2A 2007-07-11 2008-07-08 Tratamento de doença neurodegenerativa progresiva com ibudilaste BRPI0814624A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92974507P 2007-07-11 2007-07-11
US4218108P 2008-04-03 2008-04-03
PCT/US2008/069417 WO2009009529A1 (en) 2007-07-11 2008-07-08 Treatment of progressive neurodegenerative disease with ibudilast

Publications (1)

Publication Number Publication Date
BRPI0814624A2 true BRPI0814624A2 (pt) 2015-01-27

Family

ID=39789775

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814624-1A2A BRPI0814624A2 (pt) 2007-07-11 2008-07-08 Tratamento de doença neurodegenerativa progresiva com ibudilaste

Country Status (14)

Country Link
US (10) US8138201B2 (pt)
EP (2) EP2567699A1 (pt)
JP (2) JP5468001B2 (pt)
CN (1) CN101848712B (pt)
AU (1) AU2008275148A1 (pt)
BR (1) BRPI0814624A2 (pt)
CA (2) CA2970273C (pt)
DK (1) DK2187882T3 (pt)
ES (1) ES2402175T3 (pt)
HR (1) HRP20130057T1 (pt)
PL (1) PL2187882T3 (pt)
PT (1) PT2187882E (pt)
TW (1) TW200918051A (pt)
WO (1) WO2009009529A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2442651T1 (sl) * 2009-06-19 2015-10-30 Teva Pharmaceutical Industries Ltd. Zdravljenje multiple skleroze z lakvinimodom
US8119657B2 (en) 2009-06-23 2012-02-21 Medicinova, Inc. Enantiomeric compositions of 2-amino-1-(2-isopropylpyrazolo[1,5-α]pyridin-3-yl)propan-1-one and related methods
KR20160148050A (ko) * 2009-07-30 2016-12-23 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 크론병의 치료
US9585878B2 (en) * 2009-08-10 2017-03-07 Teva Pharmaceutical Industries, Ltd. Treatment of BDNF-related disorders using laquinimod
EP2398488B1 (en) * 2010-01-04 2018-11-14 Mapi Pharma Limited Depot system comprising glatiramer acetate
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
KR20160129093A (ko) * 2010-03-03 2016-11-08 테바 파마슈티컬 인더스트리즈 리미티드 라퀴니모드를 이용한 루푸스 신장염의 치료
PH12012501741A1 (en) * 2010-03-03 2012-11-12 Teva Pharma Treatment of lupus arthritis using laquinimod
PH12012501740A1 (en) * 2010-03-03 2012-11-12 Teva Pharma Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate
EP2699317B1 (en) 2011-04-21 2016-08-10 Mapi Pharma Limited Random pentapolymer for treatment of autoimmune diseases
WO2013055907A1 (en) 2011-10-12 2013-04-18 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN104093310A (zh) 2012-02-03 2014-10-08 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
CN103255142B (zh) * 2012-02-21 2017-07-25 上海转基因研究中心 一种利用RNAi调控内源性朊蛋白表达的方法及其应用
TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
CN103505731A (zh) * 2012-06-15 2014-01-15 中国药科大学 1型半胱氨酰白三烯受体拮抗剂在制备用于治疗阿尔茨海默病的药物中的用途
FR3000746A1 (fr) 2013-01-04 2014-07-11 Centre Nat Rech Scient Peptide pour son utilisation dans le traitement des neuronopathies motrices
CA2900503A1 (en) * 2013-02-15 2014-08-21 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with laquinimod
JP2016517883A (ja) 2013-05-03 2016-06-20 オレゴン ヘルス アンド サイエンス ユニバーシティー Ｘ連鎖副腎白質ジストロフィーの処置におけるソベチロムの使用
HK1231413A1 (zh) 2014-04-29 2017-12-22 Teva Pharmaceutical Industries Ltd. 用於治疗具有高残疾状况的复发-缓解型多发性硬化症(rrms)的患者的拉喹莫德
US20150366847A1 (en) * 2014-06-20 2015-12-24 Medicinova, Inc. Combination of geranylgeranylacetone and ibudilast and methods of using same
EP3193870A4 (en) * 2014-09-16 2018-04-25 Teva Pharmaceutical Industries Ltd. Treatment of neurodegenerative diseases with combination of laquinimod and fingolimod
WO2016086000A1 (en) * 2014-11-26 2016-06-02 Medicinova, Inc. A combination of geranygeranylacetone, ibudilast, and riluzole and methods of using same
CN107205986A (zh) * 2014-11-26 2017-09-26 美迪诺亚公司 异丁司特和利鲁唑的组合及其使用方法
CN105395511A (zh) * 2015-12-07 2016-03-16 黑龙江省智诚医药科技有限公司 一种异丁司特缓释微丸及其制备方法
US20190151294A1 (en) * 2016-05-10 2019-05-23 Medicinova, Inc. Treatment of alcoholism and depression and/or dysphoric mood using ibudilast
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
AU2017319728B2 (en) 2016-08-31 2024-09-05 Mapi Pharma Ltd Depot systems comprising glatiramer acetate
WO2018119262A1 (en) * 2016-12-22 2018-06-28 Medicinova, Inc. Methods of treating glioblastoma multiforme using ibudilast
MX2019010174A (es) 2017-03-26 2019-10-15 Mapi Pharma Ltd Sistemas de deposito de glatiramer para el tratamiento de formas progresivas de esclerosis multiple.
EP3740205B1 (en) * 2018-02-12 2023-09-20 MediciNova, Inc. Methods of suppressing myeloid-derived suppressor cells in patients
CN112236140A (zh) * 2018-02-12 2021-01-15 美迪诺亚公司 用于癌症治疗的使用异丁司特和第二药剂的方法和剂量方案
CN112770748A (zh) * 2018-10-09 2021-05-07 美迪诺亚公司 异丁司特和干扰素-β的组合及其使用方法
CA3116577A1 (en) * 2018-10-19 2020-04-23 Medicinova, Inc. Methods of treating ophthalmic disease/disorder or injury with ibudilast
EP3894383A1 (en) 2018-12-12 2021-10-20 Autobahn Therapeutics, Inc. Novel thyromimetics
JP7580380B2 (ja) * 2019-02-26 2024-11-11 ウニベルシタット デ バレンシア―エストゥディ ジェネラル 運動ニューロン疾患を処置するための方法及び組成物
EP3931180A1 (en) 2019-03-01 2022-01-05 Autobahn Therapeutics, Inc. Novel thyromimetics
WO2020251748A1 (en) * 2019-06-11 2020-12-17 Yale University Novel treatment for wolfram syndrome
US11865214B2 (en) 2019-09-23 2024-01-09 Medicinova, Inc. Ibudilast oral formulations and methods of using same
CN115279359A (zh) 2019-11-29 2022-11-01 速通医疗公司 新型拟甲状腺素药
CN115335049A (zh) * 2020-04-06 2022-11-11 美迪诺亚公司 降低患者中巨噬细胞迁移抑制因子的血浆水平的方法
CN115916740A (zh) 2020-06-17 2023-04-04 速通医疗公司 拟甲状腺素药
JP2024506840A (ja) 2021-01-29 2024-02-15 メディシノバ・インコーポレイテッド 化学ガス曝露を処置する方法
JP2024528731A (ja) 2021-07-26 2024-07-30 メディシノバ・インコーポレイテッド 眼癌転移を予防するためのイブジラスト
JP2024535880A (ja) 2021-09-21 2024-10-02 メディシノバ・インコーポレイテッド 膠芽腫の治療における使用のための併用療法におけるイブジラスト
US12042485B2 (en) 2021-10-07 2024-07-23 Medicinova, Inc. Methods of minimizing cancer metastasis
WO2023150093A1 (en) 2022-02-01 2023-08-10 Medicinova, Inc. Ibudilast for use in the treatment of post-covid conditions
US20250179503A1 (en) * 2022-03-28 2025-06-05 Praxis Precision Medicines, Inc. Methods of using oligomeric compounds to treat scn2a-related disorders
CN119768153A (zh) 2022-07-13 2025-04-04 美迪诺亚公司 异丁司特的注射制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009127A1 (en) * 1998-08-10 2000-02-24 Kyorin Pharmaceutical Co., Ltd. Remedies for multiple sclerosis
CA2427430A1 (en) * 2000-11-02 2002-06-13 Research Foundation Of City University Of New York Methods for stimulating nervous system regeneration and repair by inhibition phosphodiesterase type 4
US20050043319A1 (en) * 2001-08-14 2005-02-24 Exonhit Therapeutics Sa Molecular target of neurotoxicity
WO2005051293A2 (en) 2003-11-21 2005-06-09 Combinatorx, Incorporated Methods and reagents for the treatment of inflammatory disorders
US7534806B2 (en) * 2004-12-06 2009-05-19 Avigen, Inc. Method for treating neuropathic pain and associated syndromes
AU2006304787A1 (en) * 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition

Also Published As

Publication number Publication date
US8138201B2 (en) 2012-03-20
US9114136B2 (en) 2015-08-25
DK2187882T3 (da) 2013-04-08
CA2970273C (en) 2020-04-14
CA2970273A1 (en) 2009-01-15
US20090062330A1 (en) 2009-03-05
US9314452B2 (en) 2016-04-19
EP2567699A1 (en) 2013-03-13
US11944607B2 (en) 2024-04-02
ES2402175T3 (es) 2013-04-29
US20150011581A1 (en) 2015-01-08
EP2187882B1 (en) 2013-01-09
PT2187882E (pt) 2013-04-17
CA2693697A1 (en) 2009-01-15
AU2008275148A1 (en) 2009-01-15
CN101848712A (zh) 2010-09-29
US11083713B2 (en) 2021-08-10
EP2187882A1 (en) 2010-05-26
TW200918051A (en) 2009-05-01
CN101848712B (zh) 2013-07-24
US20140171463A1 (en) 2014-06-19
US20170014390A1 (en) 2017-01-19
US8338453B2 (en) 2012-12-25
JP2010533193A (ja) 2010-10-21
JP5468001B2 (ja) 2014-04-09
PL2187882T3 (pl) 2013-05-31
HRP20130057T1 (hr) 2013-02-28
US20250073213A1 (en) 2025-03-06
US20200093805A1 (en) 2020-03-26
US20170020851A1 (en) 2017-01-26
CA2693697C (en) 2017-07-25
JP2014062118A (ja) 2014-04-10
WO2009009529A1 (en) 2009-01-15
US20220168283A1 (en) 2022-06-02
US20120214839A1 (en) 2012-08-23
US20130217718A1 (en) 2013-08-22

Similar Documents

Publication Publication Date Title
BRPI0814624A2 (pt) Tratamento de doença neurodegenerativa progresiva com ibudilaste
BRPI0917567A2 (pt) tratamento de doença respiratória
SMT201500186B (it) Autoanticorpi umani anti-alfa-sinucleina
BRPI0908026A2 (pt) Métodos para o tratamento de doenças do intestino
BRPI0811265A2 (pt) Tratamento de sinucleinopatias
BRPI0813908A2 (pt) Seringa com mecanismo de desativar
EP2296593A4 (en) MEDICAL HEAD COVER
BRPI0815551A2 (pt) Tratamento através de hucbc de doença beta-amiloide
BRPI0916931A2 (pt) agentes terapêuticos
IT1391555B1 (it) Apparato trattamento extracorporeo sangue
ME03508B (me) Kombinovana terapija za liječenje dijabetesa
EP2110789A4 (en) PAPER MONEY PROCESSOR
DK2627345T3 (da) Formuleringer til behandling af sygdomme i de øvre luftveje
BRPI0811919A2 (pt) Medicamento para tratamento do mal de alzheimer
DK2173831T3 (da) Brøndbehandling
BRPI0810559A2 (pt) Macadores de doenças
EP3381471C0 (en) PAIN TREATMENT
EP2368499A4 (en) TREATMENT INSTRUMENT
BRPI1011535A2 (pt) tratamento de distúrbios resistentes à insulina.
BRPI0820410A2 (pt) Lactans substituídos terapêuticos
BRPI1010516A2 (pt) Métodos de tratamento de edema relacionados à isquemia-reperfusão
BRPI0818598A2 (pt) agentes terapêuticos - 802
EP2146744A4 (en) THERAPEUTIC BETA-GLUCAN COMPOSITIONS
HRP20160577T1 (hr) Liječenje osteoartritisa
EP2319442A4 (en) TREATMENT INSTRUMENT FOR ENDOSCOPE

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]