BRPI0800573A2 - keratin based nutritional supplement - Google Patents

Abstract

NUTRITIONAL KERATIN-BASED SUPPLEMENT. The present invention pertains to the use of an ingestible composition containing keratin and at least one component having an antioxidant activity to stimulate metabolism, which results in an improvement of the physical and mental condition acting within the human body bringing benefits in the treatment of system diseases. respiratory tract of adults and children. The present invention pertains to the use of such a composition for the preparation of a food composition, in particular a human functional food or pet food product.

Description

"KERATIN-NUTRITIONAL SUPPLEMENT"

The present innovation pertains to the use of an ingestible composition containing keratin and at least one component having an antioxidative activity to stimulate metabolism.

The present invention relates to the use of such a composition for preparing a pharmaceutical composition or a foodstuff, in particular a functional foodstuff.

In general, to prevent deterioration or to improve health condition and / or performance, two approaches are known. The first approach is to apply directly ingested topical formulations, which may prove to be effective under certain circumstances. These formulations, however, suffer from deficiencies when contraindication symptoms deteriorate health.

A second approach to improving health involves the administration of ingestible compositions designed to act within the body. Various compositions have been proposed in the art, which, however, often contain rare and expensive starting materials.

The Jackson Laboratory (USA) reported that a reduction in dietary fat content may lead to a reduction in the incidence of specific skin diseases, such as dermatitis in certain mouse strains.

The reduction in dietary fat content will postpone, however, only skin disease and did not suppress ulcerative dermatitis. In addition, most of these compositions focus on individuals of a specific age, for example young people or older people, or just women, and are not adapted for long term consumption due to the ingredients they contain.

Due to the shortcomings of the prior art, the problem of the present invention is to provide a nutritional composition which can be employed for long term consumption and provides relief to all individuals, regardless of their age and / or gender, by improving their physical and mental condition. preventing diseases mainly from the respiratory system.

This problem has been resolved by employing an ingestible composition containing a mixture of keratin and at least one compound having an antioxidant activity to stimulate an individual's metabolism.

Even more surprisingly, this beneficial effect can be observed when a relatively high fat diet has been administered, which is essentially contrary to the general understanding in the art since a significant improvement in skin condition can be achieved by reducing the fat content of a subject's diet. This feature seems to be quite favorable as the normal diet in Western societies contains a high amount of fat.

The term "ingestible composition" as used herein encompasses any acceptable food composition. The term "improving health condition and preventing disease" includes not only improving physical and mental conditions and preventing and / or treating respiratory system diseases, but also balancing the processes that occur. A nutritional composition according to the present invention stimulates metabolism. Keratin is a protein synthesized by many animals to form various body structures. It is a secondary protein, three-dimensional form of α-helix (α-keratin) or β-pleated leaves (β-keratin), consisting of about amino acids, primarily a sulfur amino acid called cysteine.

These structures occur because keratin amino acids interact with each other via hydrogen bonds and covalent bisulfite bonds (-S-S-) called cysteid bonds.

Keratin is a fibrous protein because its three-dimensional structure gives it special characteristics: micro filaments with resistance, elasticity and impermeability to water.

Even dead, the keratinized cell layers stop the microbes and prevent dehydration of the cells below. This is because keratin is impervious to water. In addition, these dead cells prevent friction from harming living cells as a barrier. It is formed of permeable protein.

Keratin is synthesized in differentiated cells - keratinocytes - endowed with epithelial (skin) and epidermis invaginations to the dermis (like hair eunhas) of terrestrial animals. In birds, which have different evolutionary origins, feather cells synthesize keratin filaments of different molecular structures called β-keratin. It is two-dimensional as a-helice a-keratin or -b-pleated defoliation (b-keratin) consisting of about 15 amino acids, primarily a sulfur amino acid called cysteine. They are found in the epidermis and appendages of various terrestrial and aquatic animals. These compounds may be isolated from natural sources or chemically synthesized. The term "component having an antioxidant activity" or "antioxidant component" includes any acceptable food components having an antioxidant activity, such as vitamin C, vitamin E (tocopherols and tocotenenols) and derivatives thereof, such as, for example, devitamin E acetate, carotenoids (carotenes, lycopene, lutein, zeaxanthin), ubiquinones (eg COQ10), tea catechins (eg epigallocatechin gallate), coffee extracts containing polyphenols and / or diterpenes (eg kawheol and cafestol), ginkgo extracts biloba, grape, or econoanthocyanidin rich grape seed extracts, spice extracts (eg, rosemary), extracts containing soya containing isoflavones, phytoestrogens, compounds that over-regulate cell antioxidant defenses (eg, ursodeoxycholic acid for increased glutathione S-transferase, ursolic acid for increased catalase, ginseng and gingenosides for increased superoxide dismutase and natural sources such as medicinal herbs), compounds being a source of thiols, such as, for example, lipolytic acid, cysteine, cystine, methionine, S-adenosyl methionine, taurine, glutathione, natural sources of these, or compounds over-regulating their biosynthesis in vivo. as well as mixtures of antioxidant components such as, for example, mixtures of the above antioxidant components.

The amount of keratin to be administered daily to an individual is at least 1 mg per kg body weight per day, and is preferably in the range of 1 mg to 1 g per kg body weight per day, and most preferably in the range of 5 mg to 250 mg. per kg of body weight per day. Especially for humans, keratin may be chosen in an amount of from 7 to 70 mg per kg of body weight per day, in particular from 29 to 31 mg per kg of body weight per day. For pets, such as dogs and cats, keratin may be chosen in an amount of 21 to 210 mg per kg body weight per day, in particular from 19 to 21 mg per kg body weight per day. In the case of keratin derivatives, the corresponding amounts are varied based on the molecular weight of the compound.

A complete nutritional composition of a substantially dry food or mammalian food may comprise, for example, up to 1800 to 2200 ppm (parts per million) of keratin or a derivative thereof, more preferably up to 750 ppm of keratin or derivative thereof, even more preferably 510 to 750 ppm keratin or derivative thereof.

Nutritional compositions comprising an antioxidant decomposing amount (s) in an amount of, for example, at least 0.025 mg per kg body weight per day, preferably from 0.025 mg to 250 mg porkg body weight per day provided good results.

An example for a combination of antioxidant components is, for example, a combination of vitamin E (or derivatives thereof), with at least one additional antioxidant component, preferably an antioxidant component having greater water solubility compared to vitamin E, such as a combination of vitamin E and at least one, preferably two or three of the antioxidant components selected from the group consisting of Vitamin C, or derivatives thereof, grape seed extract, and cysteine. An example for vitamin E or a derivative thereof, for use in nutritional composition according to The present invention is, for example, alpha-tocopheryl acetate, in particular in the (ali rac) configuration, which is commercially available. Vitamin E or said derivative may be present in an amount corresponding to from 2 to 6 times, preferably from 4.5 to 5.5 times as recommended daily dose.

Vitamin C may be chosen in an amount from 1 to 4 times the amount of vitamin E, preferably from 1.5 to 3 times the amount of vitamin E, more preferably 1.7 to 2.3 times the amount of vitamin E, plus preferably 2 times the amount of vitamin E. An example for Vitamin C or a derivative thereof for use in nutritional composition according to the present invention is, for example, stabilized vitamin C commercially available from Roche.

An example for grape or grape seed extract rich in phoanthocyanidins for use in a nutritional composition according to the present invention are extracts of grape seed proanthocyanidins (GSPE) comprising catechin and tannin monomers and polymers, which are commercially available, for example. for example, under the name Grapemax (Burgundy Botanical Extract) or Soursop (Kikkoman). Grapemax contains, for example, 25% catechins, 45% oligomers (2 to 6mers) and 35% tannins. GSPE may be included, for example, in an amount from 0.02 to 100 mg per kg body weight, but preferably from 2.5 to 40 mg per kg body weight as daily doses in a nutritional composition according to the present invention. Especially for humans 2.5 to 10 mg GSPE per kg bodyweight, and especially for pets, e.g. cats and dogs, 7.5 to 30 mg per kg body weight may be employed in daily doses.

Fish oils are a suitable source of eicosapentaenoic acid and exanoic acid while borage oil, blackcurrant oil and onage oil are suitable sources of gamma linoleic acid.

Rapeseed oil, soybean oil, flaxseed oil and walnut oil are all suitable sources of alpha linoleic acid. Safflower oils, sunflower oils, corn oils and soybean oils are suitable sources of linoleic acids.

Olive oil, rapeseed oil are sources of high oleic acid, sunflower oil, turmeric, peanuts, and rice bran are suitable sources of monounsaturated fatty acids.

The nutritional composition according to the present invention may also be supplemented with a food acceptable carbohydrate source and / or a protein source, amino acids, and / or peptides. For example, carbohydrate source may be flour, grains or starches, for example rice, barley, sorghum, millet, oats, corn. Sugars, in particular di- and oligosaccharides, such as sucrose, glucose and corn syrup may also be employed. Additionally, appropriate fibers may also be added. The amount of carbohydrate provided by the carbohydrate source can be selected as desired. For example, the feed may contain up to about 65 wt% carbohydrate, more preferably 45 to 60 wt% carbohydrate, based on the total weight of the nutritional composition. A suitable protein source for the nutritional composition according to the present invention may be be selected from any source of animal protein, eg muscle or skeletal meat, meat and bone meal, household meal, fish meal, milk protein, corn gluten, wheat gluten, soy flour, soy protein, soy protein isolates, egg proteins, dietary proteins such as whey, casein, gluten, and the like. Amount of protein, peptides, and amino acids (regardless of the amount of keratin) can be selected as desired. For example, the nutritional composition may contain from about 12 wt% to about 70 wt% protein based on dry weight of the total composition.

The choice of carbohydrate, protein, peptide, amino acid sources can be selected based on your consumer's nutritional needs, palatability considerations, and the types of products produced. In addition, various other ingredients, for example salts, seasonings, seasonings, vitamin, minerals, flavoring agents, gums, prebiotic microorganisms and probiotic may also be incorporated into the nutritional composition as desired.

One or more food grade emulsifiers may be incorporated into the nutritional composition, if desired, for example, mono- and di-glyceride, lecithin and mono- and di-glyceride diacetyl tartaric acid esters.

Similarly, suitable salts and stabilizers may be included.

The nutritional composition may be employed for humans and / or mammals, in particular animals, such as cats and dogs, and will be adapted to the specific nutritional requirements of the respective target mammal. Said composition may be administered to the individual as a normal dietary supplement or as a component of a nutritionally complete food. The food composition may likewise be a nutritionally balanced and complete food. In one embodiment, a nutritionally complete feed or animal feed may be prepared. Nutritionally complete feed or animal feed may be in any suitable form, for example in dry form, semi-wet form or wet form, it may be a shelf stable or chilled animal feed product. These foods or pet foods can be produced as conventional. Apart from the nutritional composition according to the present invention, these foods or pet foods may include any one or more of a carbohydrate source, a protein source and a lipid source.

For dry foods or dry pet foods a suitable process is extrusion cooking, although baking and other suitable processes may be employed. When pet food is cooked by extrusion, dry pet food is usually provided in the form of a shredder.

Nutritional compositions for human consumption may be, for example, a complete nutritional formula, a dairy product, a shelf or cold drink, soup, a dietary supplement, a meal replacement, a nutritional bar or a confectionery.

The nutritional composition may be administrable, for example, as a powder, a liquid concentrate, or a ready-to-drink beverage. If it is desired to produce a powdered nutritional formula, the homogenized mixture is transferred to a suitable drying apparatus.

In addition, also a usual food product such as, for example, fermented milk, yogurt, fresh cheese, curdled milk, a confectionery bar, morning cereal bars or flakes, beverages, milk powder, Soybeans, milk-free fermented products or clinical nutritional nutrition supplements may likewise be enriched with a nutritional composition according to the present invention.

Preferably, the amount of the food composition to be consumed by the human and / or mammal to obtain a beneficial effect will depend upon its size, type, and age and may be chosen according to general knowledge in the art by a skilled person.

The present innovation consists in the oral intake of a keratin-based food supplement, a constituent protein in poultry feathers. Whose molecular formula is: <formula> formula see original document page 12 </formula>

Claims (5)

1.) "NUTRITIONAL DEQUERATIN-BASED SUPPLEMENT", characterized by the use of keratin and at least one component having an antioxidant activity to prepare an ingestible composition for stimulating the metabolism of a human or animal. 2.) "NUTRITIONAL DEQUERATIN-BASED SUPPLEMENT", characterized by the use according to claim 1 for keratin to act within the body bringing benefits in the treatment of diseases of the respiratory system of adults and children and / or animals, assisting in physical development. Emmental. 3. "NUTRITIONAL DEQUERATIN-BASED SUPPLEMENT", characterized by the use according to any of the preceding claims, wherein the component exhibiting an antioxidant activity is selected from the group consisting of vitamin E; Vitamin C; carotenoids; ubiquinones; tea catechins; coffee extracts containing polyphenols and / or diterpenes; deginkgo biloba extracts; proanthocyanidin-rich grape or grape seed extracts; flavoring extracts; soy extracts containing isoflavones, phytoestrogens; oxycholic acid; ursolic acid; ginseng and gingenosides and natural sources thereof: a source of thiols, preferably lipoic acid, cysteine, cystine, methionine, S-adenosylmethionine, taurine, glutathione or natural sources thereof; or mixtures thereof. 4.) "NUTRITIONAL DEQUERATIN-BASED SUPPLEMENT", characterized by the use according to any of the preceding claims, wherein the ingestible composition is a food or functional food, a nutritionally complete human or animal food or a dietary supplement. 5.) "NUTRITIONAL DEQUERATIN-BASED SUPPLEMENT", characterized by the ingestible composition selected from a food, a functional food, a complete human or animal nutritional food, comprising keratin and at least one component having an antioxidant activity.