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BRPI0808600A2 - "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética" - Google Patents

"método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética"

Info

Publication number
BRPI0808600A2
BRPI0808600A2 BRPI0808600A BRPI0808600A BRPI0808600A2 BR PI0808600 A2 BRPI0808600 A2 BR PI0808600A2 BR PI0808600 A BRPI0808600 A BR PI0808600A BR PI0808600 A BRPI0808600 A BR PI0808600A BR PI0808600 A2 BRPI0808600 A2 BR PI0808600A2
Authority
BR
Brazil
Prior art keywords
isobutanol
host cell
acetolactate
recombinant host
genetic construct
Prior art date
Application number
BRPI0808600A
Other languages
English (en)
Inventor
Liao Der-Ing
J Nelson Mark
G Bramucci Michael
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of BRPI0808600A2 publication Critical patent/BRPI0808600A2/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

método para converter acetolactato em dihidroxijsovalerato, método para produzir jsobutanol, célula hospedeira recombinante e método para identificar e isolar uma construção genética a presente invenção fornece métodos para a produção fermentativa de isobutanol pelo crescimento fermentativo de um microorganismo recombinante expressando uma enzima cetol-ácido redutoisomerase altamente ativa, além de outras enzimas necessárias para a conversão da glicose em isobutanol.
BRPI0808600A 2007-04-18 2008-04-16 "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética" BRPI0808600A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91249107P 2007-04-18 2007-04-18
PCT/US2008/060466 WO2008130995A2 (en) 2007-04-18 2008-04-16 Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes

Publications (1)

Publication Number Publication Date
BRPI0808600A2 true BRPI0808600A2 (pt) 2018-12-26

Family

ID=39872591

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808600A BRPI0808600A2 (pt) 2007-04-18 2008-04-16 "método para a conversão de acetolactato em dihidroxi-isovalerato, método para a produção de isobutanol, célula hospedeira recombinante e método para a identificação e isolameno de uma construção genética"

Country Status (13)

Country Link
US (2) US7910342B2 (pt)
EP (2) EP2134849B1 (pt)
JP (2) JP5582576B2 (pt)
KR (1) KR101573775B1 (pt)
CN (1) CN101680007A (pt)
AU (1) AU2008242978B2 (pt)
BR (1) BRPI0808600A2 (pt)
CA (1) CA2683898C (pt)
ES (1) ES2426070T3 (pt)
MX (1) MX2009011192A (pt)
NZ (1) NZ579780A (pt)
WO (1) WO2008130995A2 (pt)
ZA (1) ZA200906811B (pt)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
CN101688175A (zh) * 2007-02-09 2010-03-31 加利福尼亚大学董事会 利用重组微生物生产生物燃料
JP5551448B2 (ja) 2007-03-16 2014-07-16 ジェノマティカ・インコーポレイテッド １，４−ブタンジオールおよびその前駆体の生合成のための組成物および方法
WO2008124523A1 (en) * 2007-04-04 2008-10-16 The Regents Of The University Of California Butanol production by recombinant microorganisms
CN101680007A (zh) 2007-04-18 2010-03-24 纳幕尔杜邦公司 使用高活性酮醇酸还原异构酶来发酵生产异丁醇
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
CA2702361A1 (en) * 2007-10-12 2009-04-16 The Regents Of The University Of California Microorganism engineered to produce isopropanol
EP2225351A4 (en) 2007-12-03 2016-11-09 Gevo Inc RENEWABLE COMPOSITIONS
US8193402B2 (en) 2007-12-03 2012-06-05 Gevo, Inc. Renewable compositions
EP2240593A4 (en) * 2007-12-10 2014-05-21 Synthetic Genomics Inc METHYLBUTANOL AS IMPROVED BIOCARBURANT
EP2262901B1 (en) 2008-03-05 2018-11-21 Genomatica, Inc. Primary alcohol producing organisms
CN106119112B (zh) 2008-03-27 2021-07-13 基因组股份公司 用于产生己二酸和其他化合物的微生物
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
AU2009242615A1 (en) * 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
US8876924B2 (en) 2010-06-16 2014-11-04 Butamax Advanced Biofuels Llc Oxygenated butanol gasoline composition having good driveability performance
BRPI0909989A2 (pt) 2008-06-05 2021-06-22 Butamax Advanced Biofuels Llc célula de levedura recombinante e método para a produção de um produto
EP3514242A3 (en) 2008-09-10 2019-08-28 Genomatica, Inc. Microrganisms for the production of 1,4-butanediol
CN102186983A (zh) 2008-09-29 2011-09-14 布特马斯先进生物燃料有限责任公司 酵母中提高的异源Fe-S酶活性
CN102186973B (zh) * 2008-09-29 2017-08-15 布特马斯先进生物燃料有限责任公司 细菌的[2Fe‑2S]二羟酸脱水酶的鉴定和用途
CA2736420A1 (en) * 2008-09-29 2010-04-01 Butamaxtm Advanced Biofuels Llc Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
US8465964B2 (en) 2008-11-13 2013-06-18 Butamax (TM) Advanced Biofules LLC Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
US8828694B2 (en) * 2008-11-13 2014-09-09 Butamax Advanced Biofuels Llc Production of isobutanol in yeast mitochondria
WO2010068821A1 (en) 2008-12-10 2010-06-17 Synthetic Genomics, Inc. Production of branched-chain alcohols by photosynthetic microoraganisms
CA2746952A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
US20120045809A1 (en) * 2008-12-23 2012-02-23 Gevo, Inc. Engineered Microorganisms for the Production of One or More Target Compounds
US8455225B2 (en) * 2008-12-29 2013-06-04 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
US8795992B2 (en) * 2008-12-29 2014-08-05 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving cell wall integrity pathway
US8557562B2 (en) * 2008-12-29 2013-10-15 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving filamentous growth response
US8614085B2 (en) * 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
JP2012523245A (ja) * 2009-04-13 2012-10-04 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 抽出発酵を用いてブタノールを生成するための方法
AU2010245687A1 (en) 2009-05-07 2011-11-24 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
SG176654A1 (en) 2009-06-04 2012-01-30 Genomatica Inc Process of separating components of a fermentation broth
BRPI1010581A2 (pt) 2009-06-04 2016-11-08 Genomatica Inc micro-organismos para a produção de 1,4-butanodiol e métodos relacionados
WO2011019894A1 (en) * 2009-08-12 2011-02-17 Gevo, Inc. Cytosolic isobutanol pathway localization for the production of isobutanol
WO2011041402A1 (en) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved flux to acetolactate-derived products in lactic acid bacteria
IN2012DN02227A (pt) * 2009-09-29 2015-08-21 Butamax Tm Advanced Biofuels
US9260708B2 (en) * 2009-09-29 2016-02-16 Butamax Advanced Biofuels Llc Yeast production host cells
US20110195505A1 (en) * 2009-10-08 2011-08-11 Butamax(Tm) Advanced Biofuels Llc Bacterial strains for butanol production
MX2012004291A (es) * 2009-10-13 2012-08-17 Genomatica Inc Microorganismos para la produccion de 1,4-butanoidol, 4-hidroxibutanal, 4-hidroxibutiril-coa, putrescina y compuestos y metodos relacionados con los mismos.
EP2504447A2 (en) * 2009-11-23 2012-10-03 ButamaxTM Advanced Biofuels LLC Method for producing butanol using extractive fermentation with osmolyte addition
CN102656272A (zh) * 2009-11-23 2012-09-05 布特马斯先进生物燃料有限责任公司 使用添加电解质的萃取发酵来生产丁醇的方法
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
US20110137088A1 (en) * 2009-12-03 2011-06-09 Bp Corporation North America Inc. Methods and Apparatuses for Producing Renewable Materials From Inhibiting Compounds
CN102762722B (zh) 2009-12-29 2015-05-20 布特马斯先进生物燃料有限责任公司 用于发酵生产低级烷基醇的醇脱氢酶(adh)
JP2013515507A (ja) 2009-12-29 2013-05-09 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 組換え宿主細胞におけるヘキソースキナーゼの発現
CN102770397A (zh) 2010-01-08 2012-11-07 格沃股份有限公司 制备可再生的化学品的整合方法
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
US8574406B2 (en) * 2010-02-09 2013-11-05 Butamax Advanced Biofuels Llc Process to remove product alcohol from a fermentation by vaporization under vacuum
KR20130027063A (ko) 2010-02-17 2013-03-14 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 Ｆｅ-ｓ 클러스터 요구성 단백질의 활성 향상
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
CN102906053B (zh) 2010-03-15 2015-06-03 道达尔研究技术弗吕公司 通过异丁醇在酸性催化剂上同时脱水和骨架异构化之后易位生产丙烯
EP2374781A1 (en) 2010-04-09 2011-10-12 Total Petrochemicals Research Feluy Simultaneous dehydration and skeletal isomerisation of isobutanol on acid catalysts
EA025806B1 (ru) 2010-03-15 2017-01-30 Тотал Ресерч Энд Текнолоджи Фелюи Одновременная дегидратация и скелетная изомеризация изобутанола на кислотных катализаторах
EP2374780A1 (en) 2010-04-09 2011-10-12 Total Petrochemicals Research Feluy Production of propylene via simultaneous dehydration and skeletal isomerisation of isobutanol on acid catalysts followed by metathesis
US8373012B2 (en) 2010-05-07 2013-02-12 Gevo, Inc. Renewable jet fuel blendstock from isobutanol
EP2582774B1 (en) 2010-06-16 2018-03-28 Butamax(tm) Advanced Biofuels LLC Oxygenated butanol gasoline composition having good driveability performance
CA2801576A1 (en) 2010-06-17 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Yeast production culture for the production of butanol
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
CA2801209A1 (en) 2010-06-18 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Extraction solvents derived from oil for alcohol removal in extractive fermentation
US9012190B2 (en) 2011-06-15 2015-04-21 Butamax Advanced Biofuels Llc Use of thiamine and nicotine adenine dinucleotide for butanol production
US9040263B2 (en) 2010-07-28 2015-05-26 Butamax Advanced Biofuels Llc Production of alcohol esters and in situ product removal during alcohol fermentation
HUE044304T2 (hu) 2010-06-18 2019-10-28 Butamax Tm Advanced Biofuels Olajból nyert oldószerek kivonása alkoholeltávolításra extraháló fermentációban
EP2601157B1 (en) 2010-08-03 2019-03-06 Total Research & Technology Feluy Combined process to make olefins from isobutanol
CN103153921A (zh) 2010-08-03 2013-06-12 道达尔研究技术弗吕公司 由甲醇和异丁醇制造烯烃的方法
BR112013002359B1 (pt) 2010-08-03 2019-10-08 Total Research & Technology Feluy Processo para produzir olefinas a partir de isobutanol
ES2493141T3 (es) 2010-08-03 2014-09-11 Total Research & Technology Feluy Procedimiento de preparación olefinas a partir de isobutanol
WO2012027642A1 (en) * 2010-08-27 2012-03-01 Gevo, Inc. Balanced four-step pathways to renewable butanols
BR112013005386A2 (pt) 2010-09-07 2016-06-07 Butamax Advanced Biofuels Llc célula hospedeira recombinante, método, composição e uso de uma célula hospedeira
CN103228599A (zh) 2010-09-24 2013-07-31 道达尔研究技术弗吕公司 由异丁醇制造异戊二烯
WO2012071121A1 (en) * 2010-11-24 2012-05-31 Gevo, Inc. Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
FR2969147B1 (fr) 2010-12-21 2013-01-04 Total Raffinage Marketing Production d'additifs pour carburant par deshydratation et isomerisation squelettique simultanee d'isobutanol sur des catalyseurs acides suivies par une etherification
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
KR20140092759A (ko) 2011-03-24 2014-07-24 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 숙주 세포 및 아이소부탄올의 제조 방법
EP2699618A4 (en) 2011-04-19 2014-12-17 Gevo Inc VARIATIONS OF A PRINS REACTION FOR THE PREPARATION OF 2,5-DIMETHYLHEXADIENE FROM ISOBUTANOL
US20140295512A1 (en) * 2011-06-16 2014-10-02 California Institute Of Technology Ketol-Acid Reductoisomerases With Improved Performance Properties
BR112013032319A2 (pt) 2011-06-17 2016-12-20 Butamax Advanced Biofuels Llc métodos da geração de coprodutos de destilação, coprodutos de destilação, método para atenuar o impacto de contaminantes de fermentação, método para a redução da contaminação por micotoxinas, método para a redução da variabilidade do teor de lipídeos, método para aumento do teor de triglicerídeos, método de produção de um coproduto de destilação para o combustível e método de produção de um coproduto destilação para o biodiesel
BR112014001943A2 (pt) 2011-07-28 2018-08-07 Butamax Advanced Biofuels Llc método de converter alfa-cetoisovalerato a isobutiraldeído e método de produção de isobutanol
WO2013086222A2 (en) 2011-12-09 2013-06-13 Butamax(Tm) Advanced Biofuels Llc Process to remove product alcohols from fermentation broth
EP2798072A2 (en) 2011-12-30 2014-11-05 Butamax Advanced Biofuels LLC Fermentative production of alcohols
MX2014008073A (es) 2011-12-30 2014-10-06 Butamax Advanced Biofuels Llc Cambios geneticos para la produccion de butanol.
WO2013142338A1 (en) 2012-03-23 2013-09-26 Butamax(Tm) Advanced Biofuels Llc Acetate supplemention of medium for butanologens
JP6321631B2 (ja) 2012-05-11 2018-05-09 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー ケトール酸レダクトイソメラーゼ酵素及び使用方法
WO2013184602A2 (en) 2012-06-04 2013-12-12 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
US20140024064A1 (en) 2012-07-23 2014-01-23 Butamax(Tm) Advanced Biofuels Llc Processes and systems for the production of fermentative alcohols
WO2014018837A1 (en) 2012-07-26 2014-01-30 Cheng Cecilia Butanol purification
US10233467B2 (en) 2012-08-17 2019-03-19 Easel Biotechnologies, Llc Two-stage production of higher alcohols
WO2014031831A1 (en) 2012-08-22 2014-02-27 Butamax Advanced Biofuels Llc Production of fermentation products
BR112015005439A8 (pt) 2012-09-12 2022-01-11 Butamax Advanced Biofuels Llc Método para recuperar um produto alcoólico de um caldo de fermentação e sistema
US9249076B2 (en) 2012-09-21 2016-02-02 Butamax Advanced Biofuels Llc Recyclable extractant compositions
WO2014047421A1 (en) 2012-09-21 2014-03-27 Butamax(Tm) Advanced Biofuels Llc Production of renewable hydrocarbon compositions
CA2886157A1 (en) 2012-09-26 2014-04-03 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
CA2884876A1 (en) 2012-09-28 2014-04-03 Butamax Advanced Biofuels Llc Production of fermentation products
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
BR112015008077A2 (pt) 2012-10-11 2017-12-05 Butamax Advanced Biofuels Llc métodos para a produção de um produto de fermentação
WO2014081848A1 (en) 2012-11-20 2014-05-30 Butamax Advanced Biofuels Llc Butanol purification
US10300464B2 (en) 2012-12-07 2019-05-28 Evernu Technology, Llc Catalytic conversion of bio-mass derivable aliphatic alcohols to valuable alkenes or oxygenates
US9650624B2 (en) 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
WO2014105840A1 (en) 2012-12-31 2014-07-03 Butamax Advanced Biofuels Llc Fermentative production of alcohols
WO2014130352A1 (en) 2013-02-21 2014-08-28 Butamax Advanced Biofuels Llc Recovery of thermal energy as heat source in the production of butanol from a fermentation process
WO2014159309A1 (en) 2013-03-12 2014-10-02 Butamax Advanced Biofuels Llc Processes and systems for the production of alcohols
US9267158B2 (en) 2013-03-14 2016-02-23 Intrexon Corporation Biological production of multi-carbon compounds from methane
ES2735024T3 (es) 2013-03-14 2019-12-13 Du Pont Glicerol-3-fosfato deshidrogenasa para la producción de butanol
US9580705B2 (en) 2013-03-15 2017-02-28 Butamax Advanced Biofuels Llc DHAD variants and methods of screening
WO2014144643A1 (en) 2013-03-15 2014-09-18 Butamax Advanced Biofuels Llc Method for producing butanol using extractive fermentation
US9771602B2 (en) 2013-03-15 2017-09-26 Butamax Advanced Biofuels Llc Competitive growth and/or production advantage for butanologen microorganism
WO2014151645A1 (en) 2013-03-15 2014-09-25 Butamax Advanced Biofuels Llc Process for maximizing biomass growth and butanol yield by feedback control
BR112015020685A2 (pt) 2013-03-15 2017-07-18 Butamax Advanced Biofuels Llc método para a recuperação do butanol, composição, métodos para a extração de álcool e de secagem
US9663759B2 (en) 2013-07-03 2017-05-30 Butamax Advanced Biofuels Llc Partial adaptation for butanol production
CN105722990B (zh) * 2013-09-22 2020-10-20 朗泽科技新西兰有限公司 发酵工艺
CN105722969A (zh) 2013-10-28 2016-06-29 丹尼斯科美国公司 大规模基因工程化活性干酵母
CN104195125B (zh) * 2014-07-01 2017-01-11 中国科学院广州能源研究所 一种α-酮酸脱羧酶KIVD-LL及其编码基因和应用
US10280438B2 (en) 2014-08-11 2019-05-07 Butamax Advanced Biofuels Llc Method for the production of yeast
US10472300B2 (en) 2014-12-31 2019-11-12 Total Research & Technology Feluy Process for preparing olefins by dehydrating alcohols with less side effects comprising addition of sulfur containing compounds
US10544067B2 (en) 2014-12-31 2020-01-28 Total Research & Technology Feluy Process for preparing olefins by dehydrating alcohols with less side effects comprising addition of organic acids
EP3162763A1 (en) 2015-10-30 2017-05-03 Total Research & Technology Feluy SA Simultaneous dehydration and skeletal isomerisation of isobutanol on ti-containing zeolite catalysts
US11326193B1 (en) 2016-03-03 2022-05-10 National Technology & Engineering Solutions Of Sandia, Llc Enrichment of amino acids from biomass residuum
KR101960501B1 (ko) 2017-09-15 2019-03-21 고려대학교 산학협력단 Ｎａｄｈ 친화적인 신규 케톨산 리덕토아이소머라제
CN111394325A (zh) * 2019-07-05 2020-07-10 成都高界科技有限公司 一种耐热乙酰乳酸异构还原酶
FR3115988A1 (fr) 2020-11-06 2022-05-13 Global Bioenergies Composition de maquillage à base d’isododécane biosourcé et son procédé de préparation
FR3157389A1 (fr) 2023-12-22 2025-06-27 Axens Procédé de production de bioalkylat ou d’essence biosourcée
WO2025226576A1 (en) 2024-04-25 2025-10-30 ExxonMobil Technology and Engineering Company Processes for producing isobutylene and isobutylene-based polymers

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4865973A (en) 1985-09-13 1989-09-12 Queen's University At Kingston Process for extractive fermentation
FR2696190B1 (fr) 1992-09-25 1994-12-09 Agronomique Inst Nat Rech Acide nucléique codant pour une alpha-acétolactate synthase et ses applications.
US6514733B1 (en) * 1999-08-18 2003-02-04 E. I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high titer
WO2001070955A2 (en) 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes
US6586229B1 (en) 2000-06-01 2003-07-01 North Carolina State University Method for the production of ρ-Hydroxybenzoate in species of pseudomonas and agrobacterium
EP1416050A4 (en) 2001-07-02 2004-12-22 Kaneka Corp METHOD FOR ENZYME MODIFICATION AND OXIDOREEDUCTASE VARIANT
MXPA05009553A (es) 2003-03-10 2006-03-17 Broin And Associates Inc Metodo para producir etanol utilizando almidon como materia prima.
SE526429C2 (sv) 2003-10-24 2005-09-13 Swedish Biofuels Ab Metod för att framställa syreinnehållande föreningar utgående från biomassa
CN101160405B (zh) 2005-04-12 2014-01-01 纳幕尔杜邦公司 处理生物质以获得目标化学物质
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8945899B2 (en) 2007-12-20 2015-02-03 Butamax Advanced Biofuels Llc Ketol-acid reductoisomerase using NADH
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
JP5276986B2 (ja) 2005-10-26 2013-08-28 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 四炭素アルコールの発酵性生産
US8828704B2 (en) 2006-05-02 2014-09-09 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
US7659104B2 (en) 2006-05-05 2010-02-09 E.I. Du Pont De Nemours And Company Solvent tolerant microorganisms and methods of isolation
US7541173B2 (en) 2006-06-15 2009-06-02 E.I. Du Pont De Nemours And Company Solvent tolerant microorganisms and methods of isolation
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
CN101688175A (zh) * 2007-02-09 2010-03-31 加利福尼亚大学董事会 利用重组微生物生产生物燃料
CN101680007A (zh) 2007-04-18 2010-03-24 纳幕尔杜邦公司 使用高活性酮醇酸还原异构酶来发酵生产异丁醇
EP2060632A1 (en) 2007-10-29 2009-05-20 Technische Universität Berlin Method of modifying a yeast cell for the production of ethanol
WO2009059253A2 (en) 2007-10-31 2009-05-07 Gevo, Inc. Methods for the economical production of biofuel from biomass
JP2010503379A (ja) 2007-12-17 2010-02-04 サントリーホールディングス株式会社 変異ｉｌｖ５遺伝子及びその用途
WO2009085953A2 (en) 2007-12-20 2009-07-09 E. I. Du Pont De Nemours And Company Ketol-acid reductoisomerase using nadh
US8372612B2 (en) 2007-12-21 2013-02-12 Butamax(Tm) Advanced Biofuels Llc Production of four carbon alcohols using improved strain
US8518678B2 (en) 2007-12-21 2013-08-27 Butamax(Tm) Advanced Biofuels Llc Strain comprising increased expression of a CFA coding region for butanol production
CA2710359C (en) 2007-12-23 2018-02-20 Gevo, Inc. Yeast organism producing isobutanol at a high yield
US8188250B2 (en) 2008-04-28 2012-05-29 Butamax(Tm) Advanced Biofuels Llc Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans
US8389252B2 (en) 2008-05-12 2013-03-05 Butamax(Tm) Advanced Biofuels Llc Yeast strain for production of four carbon alcohols
US8906666B2 (en) 2008-05-22 2014-12-09 Butamax Advanced Biofuels Llc Engineering resistance to aliphatic alcohols
BRPI0909989A2 (pt) 2008-06-05 2021-06-22 Butamax Advanced Biofuels Llc célula de levedura recombinante e método para a produção de um produto
CN102186973B (zh) 2008-09-29 2017-08-15 布特马斯先进生物燃料有限责任公司 细菌的[2Fe‑2S]二羟酸脱水酶的鉴定和用途
CN102186983A (zh) 2008-09-29 2011-09-14 布特马斯先进生物燃料有限责任公司 酵母中提高的异源Fe-S酶活性
CA2736420A1 (en) 2008-09-29 2010-04-01 Butamaxtm Advanced Biofuels Llc Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria
WO2010037119A1 (en) 2008-09-29 2010-04-01 Butamax™ Advanced Biofuels LLC Enhanced iron-sulfur cluster formation for increased dihydroxy-acid dehydratase activity in lactic acid bacteria
BRPI0913547A2 (pt) 2008-09-29 2020-08-18 Butamax Advanced Biofuels Llc célula bacteriana ácido-lática recombinante, método para a produção de 2-butanol e método para a produção de 2-butanona
AU2009320163B2 (en) 2008-10-27 2014-10-02 Butamax(Tm) Advanced Biofuels Llc Carbon pathway optimized production hosts for the production of isobutanol
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
US8828694B2 (en) 2008-11-13 2014-09-09 Butamax Advanced Biofuels Llc Production of isobutanol in yeast mitochondria
US8465964B2 (en) 2008-11-13 2013-06-18 Butamax (TM) Advanced Biofules LLC Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis
US8652823B2 (en) 2008-12-03 2014-02-18 Butamax(Tm) Advanced Biofuels Llc Strain for butanol production with increased membrane unsaturated trans fatty acids
US8557562B2 (en) 2008-12-29 2013-10-15 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving filamentous growth response
US8795992B2 (en) 2008-12-29 2014-08-05 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving cell wall integrity pathway
US8455225B2 (en) 2008-12-29 2013-06-04 Butamax Advanced Biofuels Llc Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20120058541A1 (en) 2009-05-22 2012-03-08 Butamax(Tm) Advanced Biofuels Llc Engineering resistance to aliphatic alcohols
WO2011019894A1 (en) 2009-08-12 2011-02-17 Gevo, Inc. Cytosolic isobutanol pathway localization for the production of isobutanol
WO2011041402A1 (en) 2009-09-29 2011-04-07 Butamax(Tm) Advanced Biofuels Llc Improved flux to acetolactate-derived products in lactic acid bacteria
IN2012DN02227A (pt) 2009-09-29 2015-08-21 Butamax Tm Advanced Biofuels
US9260708B2 (en) 2009-09-29 2016-02-16 Butamax Advanced Biofuels Llc Yeast production host cells
US20110195505A1 (en) 2009-10-08 2011-08-11 Butamax(Tm) Advanced Biofuels Llc Bacterial strains for butanol production
WO2011066356A1 (en) 2009-11-24 2011-06-03 Gevo, Inc. Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
JP2013515507A (ja) 2009-12-29 2013-05-09 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 組換え宿主細胞におけるヘキソースキナーゼの発現
CN102762722B (zh) 2009-12-29 2015-05-20 布特马斯先进生物燃料有限责任公司 用于发酵生产低级烷基醇的醇脱氢酶(adh)
ES2739894T3 (es) 2010-02-12 2020-02-04 Gevo Inc Microorganismos de levadura con una acumulación reducida de subproductos para una mejor producción de combustibles, productos químicos y aminoácidos
KR20130027063A (ko) 2010-02-17 2013-03-14 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 Ｆｅ-ｓ 클러스터 요구성 단백질의 활성 향상
CA2801576A1 (en) 2010-06-17 2011-12-22 Butamax(Tm) Advanced Biofuels Llc Yeast production culture for the production of butanol
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
BR112013005386A2 (pt) 2010-09-07 2016-06-07 Butamax Advanced Biofuels Llc célula hospedeira recombinante, método, composição e uso de uma célula hospedeira
KR20140092759A (ko) 2011-03-24 2014-07-24 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 숙주 세포 및 아이소부탄올의 제조 방법
US20120258873A1 (en) 2011-04-06 2012-10-11 Butamax(Tm) Advanced Biofuels Llc Reduction of 2,3-dihydroxy-2-methyl butyrate (dhmb) in butanol production
EP2721165A2 (en) 2011-06-17 2014-04-23 Butamax Advanced Biofuels LLC Lignocellulosic hydrolysates as feedstocks for isobutanol fermentation
BR112014001943A2 (pt) 2011-07-28 2018-08-07 Butamax Advanced Biofuels Llc método de converter alfa-cetoisovalerato a isobutiraldeído e método de produção de isobutanol
MX2014008073A (es) 2011-12-30 2014-10-06 Butamax Advanced Biofuels Llc Cambios geneticos para la produccion de butanol.
EP2798072A2 (en) 2011-12-30 2014-11-05 Butamax Advanced Biofuels LLC Fermentative production of alcohols
WO2013142338A1 (en) 2012-03-23 2013-09-26 Butamax(Tm) Advanced Biofuels Llc Acetate supplemention of medium for butanologens
JP6321631B2 (ja) 2012-05-11 2018-05-09 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー ケトール酸レダクトイソメラーゼ酵素及び使用方法
CA2886157A1 (en) 2012-09-26 2014-04-03 Butamax Advanced Biofuels Llc Polypeptides with ketol-acid reductoisomerase activity
US9273330B2 (en) 2012-10-03 2016-03-01 Butamax Advanced Biofuels Llc Butanol tolerance in microorganisms
US9650624B2 (en) 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
US20140186911A1 (en) 2012-12-28 2014-07-03 Butamax Advanced Biofuels Llc Recombinant host cells and methods for producing butanol
ES2735024T3 (es) 2013-03-14 2019-12-13 Du Pont Glicerol-3-fosfato deshidrogenasa para la producción de butanol
US9580705B2 (en) 2013-03-15 2017-02-28 Butamax Advanced Biofuels Llc DHAD variants and methods of screening

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