BRPI0712889A8 - composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica. - Google Patents

composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica.

Info

Publication number: BRPI0712889A8
Authority: BR; Brazil
Prior art keywords: compound; pharmaceutical composition; preparation; intermediate compound; substituted
Prior art date: 2006-07-14

Application number

BRPI0712889A

Other languages

English (en)

Portuguese (pt)

Inventor

Guglielmotti Angelo

Garofalo Barbara

Garrone Beatrice

Maugeri Caterina

Mangano Giorgina

Furlotti Guido

Coletta Isabella

Polenzani Lorenzo

Alessandra Alisi Maria

Cazzolla Nicola

Ombrato Rosella

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-14

Filing date

2007-06-14

Publication date

2018-01-02

2007-06-14 Application filed by Acraf filed Critical Acraf

2012-10-09 Publication of BRPI0712889A2 publication Critical patent/BRPI0712889A2/pt

2018-01-02 Publication of BRPI0712889A8 publication Critical patent/BRPI0712889A8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI0712889A 2006-07-14 2007-06-14 composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica. BRPI0712889A8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI2006A001368		2006-07-14
IT001368A ITMI20061368A1 (it)	2006-07-14	2006-07-14	Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
PCT/EP2007/055901 WO2008006663A1 (en)	2006-07-14	2007-06-14	2-arylindole derivatives as npges-i inhibitors

Publications (2)

Publication Number	Publication Date
BRPI0712889A2 BRPI0712889A2 (pt)	2012-10-09
BRPI0712889A8 true BRPI0712889A8 (pt)	2018-01-02

Family

ID=37895798

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0712889A BRPI0712889A8 (pt)	2006-07-14	2007-06-14	composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica.

Country Status (21)

Country	Link
US (1)	US8017644B2 (xx)
EP (1)	EP2049480B1 (xx)
JP (1)	JP5302191B2 (xx)
KR (2)	KR101440015B1 (xx)
CN (1)	CN101490000B (xx)
AR (1)	AR061973A1 (xx)
AU (1)	AU2007271865B2 (xx)
BR (1)	BRPI0712889A8 (xx)
CA (1)	CA2655750C (xx)
DK (1)	DK2049480T3 (xx)
EA (1)	EA015689B1 (xx)
ES (1)	ES2441594T3 (xx)
GE (1)	GEP20115166B (xx)
IL (1)	IL196000A (xx)
IT (1)	ITMI20061368A1 (xx)
MX (1)	MX2009000492A (xx)
PL (1)	PL2049480T3 (xx)
PT (1)	PT2049480E (xx)
SI (1)	SI2049480T1 (xx)
UA (1)	UA96759C2 (xx)
WO (1)	WO2008006663A1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2078711A1 (en)	2007-12-28	2009-07-15	AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.	(Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
US8410144B2 (en)	2009-03-31	2013-04-02	Arqule, Inc.	Substituted indolo-pyridinone compounds
WO2011077313A1 (en)	2009-12-22	2011-06-30	Pfizer Inc.	Piperidinecarboxamides as mpges - 1 inhibitors
MX348548B (es)	2011-08-18	2017-06-19	Nippon Shinyaku Co Ltd	Derivado heterociclico y farmaceutico.
WO2013038308A1 (en) *	2011-09-15	2013-03-21	Glenmark Pharmaceuticals S.A.	SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS
CN105636951B (zh)	2014-04-14	2018-05-15	上海恒瑞医药有限公司	酰胺类衍生物及其可药用盐、其制备方法及其在医药上的应用
EP3178810A4 (en) *	2014-08-08	2018-07-04	Kasuma Partners Inc.	Condensed heterocyclic compound
SMT202200134T1 (it)	2018-03-08	2022-05-12	Incyte Corp	Composti di amminopirazindiolo come inibitori di pi3k-y
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
CN114302874B (zh) *	2019-08-26	2025-02-25	国际药品株式会社	吲哚甲酰胺衍生物和包含吲哚甲酰胺衍生物的药物组合物
WO2021231474A1 (en) *	2020-05-12	2021-11-18	Pmv Pharmaceuticals, Inc.	METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004024655A2 (en) *	2002-09-12	2004-03-25	Avanir Pharmaceuticals	Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
WO2004069788A1 (ja) *	2003-02-07	2004-08-19	Ono Pharmaceutical Co., Ltd.	カルボン酸化合物
WO2005021508A1 (en) *	2003-09-03	2005-03-10	Pfizer Inc.	Phenyl or pyridyl amide compounds as prostaglandin e2 antagonists
ITTO20040125A1 (it) *	2004-03-01	2004-06-01	Rotta Research Lab	Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
GB0410121D0 (en)	2004-05-06	2004-06-09	Glaxo Group Ltd	Compounds

2006
- 2006-07-14 IT IT001368A patent/ITMI20061368A1/it unknown
2007
- 2007-06-14 SI SI200731381T patent/SI2049480T1/sl unknown
- 2007-06-14 WO PCT/EP2007/055901 patent/WO2008006663A1/en not_active Ceased
- 2007-06-14 PT PT77867406T patent/PT2049480E/pt unknown
- 2007-06-14 CN CN200780026647XA patent/CN101490000B/zh not_active Expired - Fee Related
- 2007-06-14 EP EP07786740.6A patent/EP2049480B1/en active Active
- 2007-06-14 BR BRPI0712889A patent/BRPI0712889A8/pt not_active IP Right Cessation
- 2007-06-14 PL PL07786740T patent/PL2049480T3/pl unknown
- 2007-06-14 DK DK07786740.6T patent/DK2049480T3/da active
- 2007-06-14 KR KR1020097003017A patent/KR101440015B1/ko not_active Expired - Fee Related
- 2007-06-14 UA UAA200814463A patent/UA96759C2/ru unknown
- 2007-06-14 JP JP2009518814A patent/JP5302191B2/ja not_active Expired - Fee Related
- 2007-06-14 CA CA2655750A patent/CA2655750C/en not_active Expired - Fee Related
- 2007-06-14 AU AU2007271865A patent/AU2007271865B2/en not_active Ceased
- 2007-06-14 EA EA200970124A patent/EA015689B1/ru not_active IP Right Cessation
- 2007-06-14 US US12/306,426 patent/US8017644B2/en not_active Expired - Fee Related
- 2007-06-14 ES ES07786740.6T patent/ES2441594T3/es active Active
- 2007-06-14 GE GEAP200711112A patent/GEP20115166B/en unknown
- 2007-06-14 KR KR1020147014551A patent/KR20140091569A/ko not_active Ceased
- 2007-06-14 MX MX2009000492A patent/MX2009000492A/es active IP Right Grant
- 2007-07-12 AR ARP070103095A patent/AR061973A1/es not_active Application Discontinuation
2008
- 2008-12-17 IL IL196000A patent/IL196000A/en active IP Right Grant

Also Published As

Publication number	Publication date
UA96759C2 (xx)	2011-12-12
ITMI20061368A1 (it)	2008-01-15
KR20140091569A (ko)	2014-07-21
EA200970124A1 (ru)	2009-06-30
US20090186922A1 (en)	2009-07-23
EP2049480B1 (en)	2013-10-30
KR20090054962A (ko)	2009-06-01
KR101440015B1 (ko)	2014-09-12
US8017644B2 (en)	2011-09-13
CN101490000B (zh)	2012-10-03
ES2441594T3 (es)	2014-02-05
AR061973A1 (es)	2008-08-10
IL196000A (en)	2013-10-31
EA015689B1 (ru)	2011-10-31
SI2049480T1 (sl)	2014-02-28
WO2008006663A1 (en)	2008-01-17
PL2049480T3 (pl)	2014-03-31
CA2655750A1 (en)	2008-01-17
BRPI0712889A2 (pt)	2012-10-09
MX2009000492A (es)	2009-01-27
DK2049480T3 (da)	2014-01-20
EP2049480A1 (en)	2009-04-22
GEP20115166B (en)	2011-02-25
PT2049480E (pt)	2013-12-16
JP5302191B2 (ja)	2013-10-02
IL196000A0 (en)	2009-09-01
CN101490000A (zh)	2009-07-22
JP2009543766A (ja)	2009-12-10
AU2007271865A1 (en)	2008-01-17
AU2007271865B2 (en)	2013-02-21
HK1124068A1 (en)	2009-08-07
CA2655750C (en)	2014-09-09

Publication	Publication Date	Title
BRPI0712889A8 (pt)	2018-01-02	composto, processo para a preparação de um composto, composto intermediário, e, composição farmacêutica.
BRPI0717970B8 (pt)	2020-12-01	composto inibidor de 11betahsd1, composição farmacêutica, e, uso do composto
BRPI0607455A2 (pt)	2009-09-01	composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica
BRPI0510410A (pt)	2007-10-23	compostos orgánicos
BRPI0606379A2 (pt)	2009-06-23	triazolftalazinas
BR122019010008B8 (pt)	2021-07-27	derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
BRPI0615705A2 (pt)	2016-08-23	processo para preparar um composto, e, composto
BRPI0609121B8 (pt)	2021-05-25	1h-benzimidazol-4-carboxamidas substituídas com um carbono quaternário na posição 2
AR061134A1 (es)	2008-08-06	Derivados de tioxantina
UY29886A1 (es)	2007-05-31	Derivados de pirazol novedosos, composiciones farmaccuticas que los contienen, procedimientos para la preparacinn de los mismos y aplicaciones
BRPI0712631B8 (pt)	2021-05-25	compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações
BRPI0515594A (pt)	2008-07-29	inibidores da interação entre mdm2 e p53
CY1113011T1 (el)	2016-04-13	Νεα κρυσταλλικη μορφη v της αγομελατινης, μεθοδος παρασκευης αυτης και φαρμακευτικες συνθεσεις που περιεχουν αυτην
BRPI0518758A2 (pt)	2008-12-02	compostos de acetamida como fungicidas
BR0314379A (pt)	2005-07-19	Quinazolinonas espirocondensadas e a sua utilização como inibidores de fosfodiesterase
BRPI0510412A (pt)	2007-10-23	compostos orgánicos
ECSP099413A (es)	2009-07-31	COMPUESTOS A BASE DE 4 - fenil - 6 - (2,2,2 - trifluoro - 1 - feniletoxi)pirimidina Y MÉTODOS PARA SU EMPLEO
MX2009005048A (es)	2009-05-25	Nuevo proceso para la preparacion de derivados de 2-imino-tiazolidin-4-ona.
BRPI0720525B8 (pt)	2021-05-25	inibidores de mapk/erk quinase
ECSP067110A (es)	2007-01-26	Derivados de 2-carbamida-4-feniltiazol, su preparación y su aplicación en terapéutica
BRPI0900983B8 (pt)	2021-05-25	composto de diometina, processo para a síntese do mesmo, composição farmacêutica e seu uso
CY1112960T1 (el)	2016-04-13	Παραγωγα ουριας, μεθοδοι για την παρασκευη τους και χρησεις αυτων
BRPI0817223B8 (pt)	2021-05-25	inibidores da interação entre mdm2 e p53, seu processo de preparação e seu uso, composição farmacêutica que os compreende e combinação
UY29648A1 (es)	2007-02-28	Derivados de piridopirimidina, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones
CR9391A (es)	2008-01-21	Derivados de indanil-piperazinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Legal Events

Date	Code	Title	Description
2018-01-16	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-24	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-04-09	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 12A ANUIDADE.
2019-07-30	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2518 DE 09-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.