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BRPI0712163A2 - composto, e, agente antimicrobiano - Google Patents

composto, e, agente antimicrobiano Download PDF

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Publication number
BRPI0712163A2
BRPI0712163A2 BRPI0712163-6A BRPI0712163A BRPI0712163A2 BR PI0712163 A2 BRPI0712163 A2 BR PI0712163A2 BR PI0712163 A BRPI0712163 A BR PI0712163A BR PI0712163 A2 BRPI0712163 A2 BR PI0712163A2
Authority
BR
Brazil
Prior art keywords
compound
substituted
analog
group
bond
Prior art date
Application number
BRPI0712163-6A
Other languages
English (en)
Inventor
Kiyoto Taro
Ando Junichi
Tanaka Tadashi
Tsutsui Yasuhiro
Yokotani Mai
Noguchi Toshiya
Ushiyama Fumihito
Urabe Hiroki
Horikiri Hiromasa
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of BRPI0712163A2 publication Critical patent/BRPI0712163A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTO, E, AGENTE ANTIMICROBIANO. Divulga-se um composto representada pela fórmula geral: [sendo que R^1^ representa um grupo arila ou heterocíclico que pode ser substituído ou análogo; X^1^ representa um grupo C~2~-C~4~ alquileno ou análogo; X^2^, X^3^ e X^5^ representam independentemente NH, uma ligação ou análogo; X^4^ representa um grupo alquileno inferior, uma ligação ou análogo; Y^1^representa um radical hidrocarboneto alicíclico divalente que pode ser substituído ou um radical amina alicíclico divalente que pode ser substituído; e Z^1^, Z^2^, Z^3^, Z^4^, Z^5^ e Z^6^ representam independentemente um átomo de nitrogênio, um grupo representado pela fórmula: CH, ou análogo, desde que pelo menos um de Z^3^ , Z^4^ , Z^5^ e Z^6^ represente um átomo de nitrogênio] ou um sal do mesmo, que é útil como um agente antibacteriano.
BRPI0712163-6A 2006-05-26 2007-05-24 composto, e, agente antimicrobiano BRPI0712163A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006-146588 2006-05-26
JP2006146588 2006-05-26
PCT/JP2007/060606 WO2007138974A1 (ja) 2006-05-26 2007-05-24 新規な複素環化合物またはその塩ならびにその中間体

Publications (1)

Publication Number Publication Date
BRPI0712163A2 true BRPI0712163A2 (pt) 2012-03-13

Family

ID=38778494

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0712163-6A BRPI0712163A2 (pt) 2006-05-26 2007-05-24 composto, e, agente antimicrobiano

Country Status (17)

Country Link
US (2) US8211908B2 (pt)
EP (1) EP2022793B1 (pt)
JP (1) JP5171618B2 (pt)
KR (1) KR101409261B1 (pt)
CN (1) CN101454319B (pt)
AU (1) AU2007268749B2 (pt)
BR (1) BRPI0712163A2 (pt)
CA (1) CA2652501C (pt)
ES (1) ES2476423T3 (pt)
IL (1) IL195346A (pt)
MX (1) MX2008014908A (pt)
NO (1) NO20084701L (pt)
NZ (1) NZ573032A (pt)
RU (1) RU2434868C2 (pt)
SG (1) SG164384A1 (pt)
WO (1) WO2007138974A1 (pt)
ZA (1) ZA200809782B (pt)

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US8329694B2 (en) 2005-06-24 2012-12-11 Toyama Chemical Co., Ltd. Quinoxalinones as antibacterial composition
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CA2652501C (en) 2006-05-26 2014-07-08 Toyama Chemical Co., Ltd. Novel heterocyclic compound or salt thereof and intermediate thereof
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EP1992628A1 (en) * 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
WO2008071962A1 (en) * 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
WO2008071964A1 (en) * 2006-12-15 2008-06-19 Astrazeneca Ab Naphthyridine bactericides
US20100144717A1 (en) * 2006-12-15 2010-06-10 Janelle Comita-Prevoir 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents
TW200831517A (en) * 2006-12-15 2008-08-01 Astrazeneca Ab Chemical compounds
JP5620636B2 (ja) * 2007-11-26 2014-11-05 富山化学工業株式会社 新規な複素環化合物またはその塩を含有する抗菌剤
PL2221309T3 (pl) 2007-11-26 2013-12-31 Toyama Chemical Co Ltd Monohydrat pochodnej naftyrydyny i sposób jego wytwarzania
EP2080761A1 (en) * 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
RU2501799C2 (ru) * 2008-02-22 2013-12-20 Актелион Фармасьютикалз Лтд Поизводные оксазолидинона
CN102046603B (zh) * 2008-06-03 2014-08-13 埃科特莱茵药品有限公司 作为抗细菌剂的[4-(1-氨基-乙基)-环己基]-甲基-胺及[6-(1-氨基-乙基)-四氢-吡喃-3-基]-甲基-胺衍生物
WO2010027002A1 (ja) * 2008-09-05 2010-03-11 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環モルホリン誘導体
JP5490809B2 (ja) * 2008-10-10 2014-05-14 アクテリオン ファーマシューティカルズ リミテッド オキサゾリジニル抗生物質
TW201022279A (en) * 2008-11-14 2010-06-16 Astrazeneca Ab Chemical compounds
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WO2011148962A1 (ja) * 2010-05-25 2011-12-01 大正製薬株式会社 新規な複素環化合物又はその塩
US8911427B2 (en) 2010-12-28 2014-12-16 Medtronic, Inc. Therapeutic agent reservoir delivery system
WO2012108376A1 (ja) 2011-02-07 2012-08-16 第一三共株式会社 アミノ基含有ピロリジノン誘導体
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US9029368B2 (en) 2011-11-30 2015-05-12 Actelion Pharmaceuticals Ltd. 3,7-disubstituted octahydro-2H-pyrido[4,3-E][1,3]oxazin-2-one antibiotics
ES2817448T3 (es) * 2013-03-14 2021-04-07 Icahn School Med Mount Sinai Compuestos de pirimidina como inhibidores de quinasas
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
JP2021505671A (ja) * 2017-12-08 2021-02-18 ザ ロックフェラー ユニバーシティＴｈｅ Ｒｏｃｋｅｆｅｌｌｅｒ Ｕｎｉｖｅｒｓｉｔｙ 中毒症、掻痒症、疼痛および炎症治療用ピラノ［３，４−ｂ］ピラジンカッパオピオイド受容体リガンド
CN111757879A (zh) * 2018-01-29 2020-10-09 卡地拉健康护理有限公司 用作抗菌剂的杂环化合物
CN109678793B (zh) * 2019-01-12 2020-08-04 上海卡洛化学有限公司 一种5-氟-3-氨基吡啶的制备方法

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CA2652501C (en) 2006-05-26 2014-07-08 Toyama Chemical Co., Ltd. Novel heterocyclic compound or salt thereof and intermediate thereof
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
WO2008071964A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Naphthyridine bactericides
WO2008071962A1 (en) 2006-12-15 2008-06-19 Astrazeneca Ab Pteridines and pyrimidinopyridines as antibacterial agents
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Also Published As

Publication number Publication date
AU2007268749A1 (en) 2007-12-06
US20120226035A1 (en) 2012-09-06
KR101409261B1 (ko) 2014-06-18
US8367831B2 (en) 2013-02-05
CN101454319B (zh) 2012-06-27
KR20090018976A (ko) 2009-02-24
EP2022793A4 (en) 2010-09-08
HK1133874A1 (en) 2010-04-09
RU2434868C2 (ru) 2011-11-27
NO20084701L (no) 2009-02-06
CN101454319A (zh) 2009-06-10
RU2008151754A (ru) 2010-07-10
CA2652501C (en) 2014-07-08
JPWO2007138974A1 (ja) 2009-10-08
EP2022793A1 (en) 2009-02-11
US8211908B2 (en) 2012-07-03
NZ573032A (en) 2010-12-24
AU2007268749B2 (en) 2012-07-26
IL195346A (en) 2013-02-28
IL195346A0 (en) 2009-08-03
WO2007138974A1 (ja) 2007-12-06
US20090198063A1 (en) 2009-08-06
ZA200809782B (en) 2010-02-24
JP5171618B2 (ja) 2013-03-27
SG164384A1 (en) 2010-09-29
MX2008014908A (es) 2009-05-13
EP2022793B1 (en) 2014-06-04
ES2476423T3 (es) 2014-07-14
CA2652501A1 (en) 2007-12-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]