BRPI0716884A2 - Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos - Google Patents

Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos

Info

Publication number: BRPI0716884A2
Authority: BR; Brazil
Prior art keywords: mucosal; osmolites; hydratation; treatment; sodium channel
Prior art date: 2006-09-07

Application number

BRPI0716884-5A2A

Other languages

English (en)

Inventor

Michael R Johnson

Richard C Boucher

Andrew J Hirsch

Original Assignee

Parion Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-07

Filing date

2007-09-07

Publication date

2013-10-15

2007-09-07 Application filed by Parion Sciences Inc filed Critical Parion Sciences Inc

2013-10-15 Publication of BRPI0716884A2 publication Critical patent/BRPI0716884A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Otolaryngology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Toxicology (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

BRPI0716884-5A2A 2006-09-07 2007-09-07 Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos BRPI0716884A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US84266906P	2006-09-07	2006-09-07
US84517106P	2006-09-18	2006-09-18
PCT/US2007/077880 WO2008031028A2 (en)	2006-09-07	2007-09-07	Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes

Publications (1)

Publication Number	Publication Date
BRPI0716884A2 true BRPI0716884A2 (pt)	2013-10-15

Family

ID=39158091

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0716884-5A2A BRPI0716884A2 (pt)	2006-09-07	2007-09-07	Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos

Country Status (12)

Country	Link
US (1)	US8058278B2 (pt)
EP (1)	EP2059237A4 (pt)
JP (1)	JP2010502738A (pt)
KR (1)	KR20090065508A (pt)
AR (1)	AR062741A1 (pt)
AU (1)	AU2007294547A1 (pt)
BR (1)	BRPI0716884A2 (pt)
CA (1)	CA2663041A1 (pt)
EA (1)	EA200970258A1 (pt)
MX (1)	MX2009002602A (pt)
TW (1)	TW200817343A (pt)
WO (1)	WO2008031028A2 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6858615B2 (en)	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenyl guanidine sodium channel blockers
WO2004073729A1 (ja)	2003-02-21	2004-09-02	Translational Research Ltd.	薬物の経鼻投与用組成物
AU2003220808B2 (en)	2003-03-27	2008-08-21	Bioactis Limited	Powder medicine applicator for nasal cavity
US7064129B2 (en) *	2003-08-18	2006-06-20	Parion Sciences, Inc.	Capped pyrazinoylguanidine sodium channel blockers
US8673360B2 (en)	2004-08-10	2014-03-18	Shin Nippon Biomedical Laboratories, Ltd.	Compositions that enable rapid-acting and highly absorptive intranasal administration
US7399766B2 (en) *	2004-08-18	2008-07-15	Parion Sciences, Inc.	Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7807834B2 (en)	2005-08-03	2010-10-05	Parion Sciences, Inc.	Capped pyrazinoylguanidine sodium channel blockers
JP5254961B2 (ja) *	2006-06-09	2013-08-07	パリオン・サイエンシィズ・インコーポレーテッド	ベータアゴニスト活性を有するフェニル置換ピラジノイルグアニジンナトリウムチャネル遮断薬
CA2653757A1 (en) *	2006-06-09	2007-12-21	Parion Sciences, Inc.	Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity
US7981898B2 (en) *	2006-09-07	2011-07-19	Parion Sciences, Inc.	Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
CN101668544B (zh)	2006-12-26	2013-04-24	株式会社新日本科学	经鼻投用制剂
US20080293740A1 (en) *	2007-04-03	2008-11-27	Parion Sciences, Inc.	Method of treating acid-sensing ion channel mediated pain, cough suppression, and central nervous system disorders
US8288391B2 (en) *	2007-04-03	2012-10-16	Parion Sciences, Inc.	Pyrazinoylguanidine compounds for use as taste modulators
DE102007040615A1 (de) *	2007-08-27	2009-03-05	Bitop Ag	Osmolyte zur Behandlung von allergisch oder viral bedingten Atemwegserkrankungen
EP2211956A4 (en)	2007-10-10	2014-07-09	Parion Sciences Inc	DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA
DE102007052380A1 (de) *	2007-10-31	2009-05-07	Bitop Ag	Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
WO2009139948A1 (en) *	2008-02-26	2009-11-19	Johnson Michael R	Poly aromatic sodium channel blockers
WO2009126695A2 (en) *	2008-04-08	2009-10-15	Dynamis Therapeutics, Inc.	Method for treating or preventing dry eye disorders using alkylamino-polyhydroxyalkanes
US20100074881A1 (en) *	2008-07-11	2010-03-25	Parion Sciences, Inc.	Multiple nebulizer systems
US9101539B2 (en)	2009-05-15	2015-08-11	Shin Nippon Biomedical Laboratories, Ltd.	Intranasal pharmaceutical compositions with improved pharmacokinetics
US8827946B2 (en) *	2009-07-31	2014-09-09	Shin Nippon Biomedical Laboratories, Ltd.	Intranasal granisetron and nasal applicator
JP6219271B2 (ja) *	2011-06-07	2017-10-25	パリオン・サイエンシィズ・インコーポレーテッド	治療の方法
US8945605B2 (en)	2011-06-07	2015-02-03	Parion Sciences, Inc.	Aerosol delivery systems, compositions and methods
HRP20171044T1 (hr)	2011-06-27	2017-10-06	Parion Sciences, Inc.	Kemijski i metabolički stabilni dipeptid s potentnom aktivnošću blokatora natrijevog kanala
AR086745A1 (es)	2011-06-27	2014-01-22	Parion Sciences Inc	3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112014029329A2 (pt) *	2012-05-29	2017-06-27	Parion Sciences Inc	aminoamidas semelhantes ao dendrímero possuindo atividade bloqueadora de canal de sódio para o tratamento de olho seco e outras doenças mucosais
WO2014036445A2 (en) *	2012-08-31	2014-03-06	Johnson Michael R	Novel mucolytic agents
EP2928532A4 (en) *	2012-12-07	2016-06-29	Parion Sciences Inc	NOSE CANNULA FOR THE ADMINISTRATION OF MEDICAMENTS IN AEROSOL FORM
ES2674665T3 (es) *	2012-12-17	2018-07-03	Parion Sciences, Inc.	Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
HUE032891T2 (hu) *	2012-12-17	2017-11-28	Parion Sciences Inc	Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
EP2931712B8 (en)	2012-12-17	2018-05-23	Parion Sciences, Inc.	3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
WO2015026601A2 (en)	2013-08-23	2015-02-26	Johnson Michael R	Dithiol mucolytic agents
US9102633B2 (en)	2013-12-13	2015-08-11	Parion Sciences, Inc.	Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
US20150376145A1 (en) *	2014-06-30	2015-12-31	Parion Sciences, Inc.	Stable sodium channel blockers
CN112321472A (zh)	2015-01-30	2021-02-05	帕里昂科学公司	新型单硫醇粘液溶解剂
AU2016255851A1 (en)	2015-04-30	2017-12-14	Parion Sciences, Inc.	Novel prodrugs of dithiol mucolytic agents
US11744967B2 (en)	2017-09-26	2023-09-05	Shin Nippon Biomedical Laboratories, Ltd.	Intranasal delivery devices

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4501729A (en) *	1982-12-13	1985-02-26	Research Corporation	Aerosolized amiloride treatment of retained pulmonary secretions
AU654979B2 (en) *	1990-10-05	1994-12-01	University Of North Carolina At Chapel Hill, The	Method of administering amiloride
AUPM411494A0 (en) *	1994-02-25	1994-03-24	Central Sydney Area Health Service	Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
US5656256A (en) *	1994-12-14	1997-08-12	The University Of North Carolina At Chapel Hill	Methods of treating lung disease by an aerosol containing benzamil or phenamil
WO2000023023A1 (en) *	1998-10-20	2000-04-27	The University Of North Carolina At Chapel Hill	Methods of hydrating mucosal surfaces
US6926911B1 (en) *	1998-12-22	2005-08-09	The University Of North Carolina At Chapel Hill	Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
PT1196396E (pt) *	1999-07-19	2008-05-14	Univ North Carolina	Compostos farmacologicamente activos com dois princípios activos covalentemente ligados (bloqueador dos canais do sódio/agonista do receptor p2y2) para o tratamento de superfícies mucosas
WO2001055390A1 (en) *	2000-01-28	2001-08-02	Human Genome Sciences, Inc.	Human serpin polynucleotides, polypeptides, and antibodies
US6858615B2 (en) *	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenyl guanidine sodium channel blockers
US6858614B2 (en) *	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenolic guanidine sodium channel blockers
US6903105B2 (en) *	2003-02-19	2005-06-07	Parion Sciences, Inc.	Sodium channel blockers
EP1670475A4 (en) *	2003-08-18	2009-04-15	Parion Sciences Inc	ALAPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
US7064129B2 (en) *	2003-08-18	2006-06-20	Parion Sciences, Inc.	Capped pyrazinoylguanidine sodium channel blockers
US20050090505A1 (en) *	2003-08-18	2005-04-28	Johnson Michael R.	Methods of reducing risk of infection from pathogens
EP1670474A4 (en) *	2003-08-18	2008-08-06	Parion Sciences Inc	BLOCKERS OF THE PYRAZINOYL-GUANIDINE SODIUM CHANNEL
US7745442B2 (en)	2003-08-20	2010-06-29	Parion Sciences, Inc.	Methods of reducing risk of infection from pathogens
US7399766B2 (en) *	2004-08-18	2008-07-15	Parion Sciences, Inc.	Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7807834B2 (en) *	2005-08-03	2010-10-05	Parion Sciences, Inc.	Capped pyrazinoylguanidine sodium channel blockers
US7981898B2 (en) *	2006-09-07	2011-07-19	Parion Sciences, Inc.	Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes

2007
- 2007-09-07 BR BRPI0716884-5A2A patent/BRPI0716884A2/pt not_active IP Right Cessation
- 2007-09-07 AR ARP070103971A patent/AR062741A1/es unknown
- 2007-09-07 US US11/851,803 patent/US8058278B2/en not_active Expired - Fee Related
- 2007-09-07 MX MX2009002602A patent/MX2009002602A/es unknown
- 2007-09-07 JP JP2009527584A patent/JP2010502738A/ja active Pending
- 2007-09-07 TW TW096133769A patent/TW200817343A/zh unknown
- 2007-09-07 AU AU2007294547A patent/AU2007294547A1/en not_active Abandoned
- 2007-09-07 EP EP07842049A patent/EP2059237A4/en not_active Withdrawn
- 2007-09-07 CA CA002663041A patent/CA2663041A1/en not_active Abandoned
- 2007-09-07 WO PCT/US2007/077880 patent/WO2008031028A2/en not_active Ceased
- 2007-09-07 KR KR1020097004814A patent/KR20090065508A/ko not_active Withdrawn
- 2007-09-07 EA EA200970258A patent/EA200970258A1/ru unknown

Also Published As

Publication number	Publication date
AU2007294547A2 (en)	2009-03-19
EP2059237A4 (en)	2010-06-30
WO2008031028A3 (en)	2008-11-13
CA2663041A1 (en)	2008-03-13
AU2007294547A1 (en)	2008-03-13
US8058278B2 (en)	2011-11-15
TW200817343A (en)	2008-04-16
AR062741A1 (es)	2008-12-03
MX2009002602A (es)	2009-05-28
US20080090841A1 (en)	2008-04-17
EA200970258A1 (ru)	2009-08-28
WO2008031028A2 (en)	2008-03-13
KR20090065508A (ko)	2009-06-22
JP2010502738A (ja)	2010-01-28
EP2059237A2 (en)	2009-05-20

Publication	Publication Date	Title
BRPI0716884A2 (pt)	2013-10-15	Método de intensificação de hidratação mucosal e clearance mucosal através de tratamento com bloqueadores do canal de sódio e osmolitos
EP2059239A4 (en)	2010-07-07	INCREASED SLIME HYDROGENATION AND SLIMMING SOLUTION BY TREATMENT WITH SODIUM CHANNEL BLOCKS AND OSMOLYTES
EP2083049A4 (en)	2009-09-23	HARDENABLE POLYORGANOSILOXANE COMPOSITION
BRPI0810206A2 (pt)	2014-10-21	Método de tratar câncer
BRPI0721052A2 (pt)	2014-12-23	Dispositivo de iluminação e método de iluminação
BRPI0913357A2 (pt)	2016-07-26	processo e instalação de fabricação de clínquer de cimento
PT2688350E (pt)	2014-11-10	Método de atribuição de canal
BRPI0716500A2 (pt)	2013-10-29	Projétil e método de direcionamento de projétil
EP2036350A4 (en)	2010-05-05	MEDIA CHANNEL MANAGEMENT
EP2030517A4 (en)	2012-11-28	SWIMSUIT AND METHOD OF MANUFACTURING THE SAME
BRPI0918290A2 (pt)	2015-12-22	reforço com design de canal
BRPI0820660A2 (pt)	2015-06-16	Acessório de iluminação e método
BRPI0921719A2 (pt)	2016-01-05	método de operação de um alto-forno e instalação de alto-forno
GB0813496D0 (en)	2008-08-27	Off-axis illumination assembly and method
BRPI0716528A2 (pt)	2013-09-17	mÉtodo de estabilizaÇço
PT2056675T (pt)	2019-05-09	Métodos de tratamento da mucosite oral
DE602007010225D1 (de)	2010-12-16	Synchronisationsverfahren und -anordnung
BR112012008166A2 (pt)	2017-10-10	método de tratamento de água e floculante de tratamento de água
BRPI0909144A2 (pt)	2015-08-04	Processo para o tratamento de água de descarga e instalação de tratamento de água de descarga
BRPI0818595A2 (pt)	2015-04-22	Método de produção de 2'-desóxi-5-azacitina (decitabina)
FI20060955A0 (fi)	2006-10-30	Sakeutuslaite ja -menetelmä
BRPI0717507A2 (pt)	2016-10-04	métodos para tratar, prevenir e diagnosticar infecção ttv de porcine
ZA200901452B (en)	2010-04-28	Treatment of vertigo with acetyl-L-leucine
GB0600692D0 (en)	2006-02-22	Well treatment
BRPI1013247A2 (pt)	2016-04-05	"método de otimização de designação de canal e aparelho de otimização de designação de canal."

Legal Events

Date	Code	Title	Description
2014-08-26	B08L	Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]	Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 5A, 6A E 7A ANUIDADES.
2020-11-10	B08I	Publication cancelled [chapter 8.9 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA.
2020-11-17	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES.
2021-03-09	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.