BRPI0716838A2 - combinaÇÕes de inibidores de histona deacetilase especÍfica de classe i com inibidores de proteosome - Google Patents

combinaÇÕes de inibidores de histona deacetilase especÍfica de classe i com inibidores de proteosome

Info

Publication number: BRPI0716838A2
Authority: BR; Brazil
Prior art keywords: inhibitors; class; combinations; histone deacetylase; specific histone
Prior art date: 2006-09-15

Application number

BRPI0716838-1A2A

Other languages

English (en)

Inventor

Janine Arts

Peter Willem Jan Hellemans

Michel Marie Francois Janicot

Martin John Page

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-15

Filing date

2007-09-11

Publication date

2013-10-01

2007-09-11 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2013-10-01 Publication of BRPI0716838A2 publication Critical patent/BRPI0716838A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0716838-1A2A 2006-09-15 2007-09-11 combinaÇÕes de inibidores de histona deacetilase especÍfica de classe i com inibidores de proteosome BRPI0716838A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06120742		2006-09-15
PCT/EP2007/059523 WO2008031820A2 (en)	2006-09-15	2007-09-11	Combinations of class-i specific histone deacetylase inhibitors with proteasome inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0716838A2 true BRPI0716838A2 (pt)	2013-10-01

Family

ID=39048007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0716838-1A2A BRPI0716838A2 (pt)	2006-09-15	2007-09-11	combinaÇÕes de inibidores de histona deacetilase especÍfica de classe i com inibidores de proteosome

Country Status (10)

Country	Link
US (1)	US20090270419A1 (pt)
EP (1)	EP2066328A2 (pt)
JP (1)	JP5230625B2 (pt)
CN (1)	CN101516375B (pt)
AU (1)	AU2007296259A1 (pt)
BR (1)	BRPI0716838A2 (pt)
CA (1)	CA2662432A1 (pt)
MX (1)	MX2009002926A (pt)
RU (1)	RU2456990C2 (pt)
WO (1)	WO2008031820A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7446109B2 (en) *	2002-03-13	2008-11-04	Janssen Pharmaceutica N.V.	Carbonylamino-derivatives as novel inhibitors of histone deacetylase
EA007099B1 (ru)	2002-03-13	2006-06-30	Янссен Фармацевтика Н. В.	Сульфонилпроизводные в качестве ингибиторов гистон-деацетилазы
ATE521592T1 (de)	2002-03-13	2011-09-15	Janssen Pharmaceutica Nv	Histone-deacetylase-inhibitoren
MXPA04008795A (es) *	2002-03-13	2004-11-26	Janssen Pharmaceutica Nv	Derivados de piperazinilo, piperidinilo y morfolino como novedosos inhibidores de la desacetilasa de histona.
UA86066C2 (ru) *	2004-07-28	2009-03-25	Янссен Фармацевтика Н.В.	Производные замещенного пропенилпиперазина как ингибиторы гистондеацетилазы
NZ552865A (en)	2004-07-28	2009-09-25	Janssen Pharmaceutica Nv	Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
ES2553178T3 (es)	2005-05-18	2015-12-04	Janssen Pharmaceutica N.V.	Derivados sustituidos de aminopropenil piperidina o morfolina como nuevos inhibidores de histona deacetilasa
DK1979326T3 (da)	2006-01-19	2013-01-07	Janssen Pharmaceutica Nv	Pyridin- og pyrimidinderivater som inhibitorer af histondeacetylase
JP5225104B2 (ja) *	2006-01-19	2013-07-03	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	新しい、ヒストンデアセチラーゼのインヒビターとしてのアミノフェニル誘導体
EP1979327A1 (en)	2006-01-19	2008-10-15	Janssen Pharmaceutica, N.V.	Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
CA2635015C (en)	2006-01-19	2014-06-03	Janssen Pharmaceutica N.V.	Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
US8691534B2 (en)	2006-12-29	2014-04-08	Celgene Corporation	Preparation of romidepsin
EP2117556A2 (en) *	2007-01-23	2009-11-18	Gloucester Pharmaceuticals, Inc.	Combination therapy comprising romidepsin and i.a. bortezomib
WO2009155135A1 (en) *	2008-06-18	2009-12-23	Alza Corporation	Composition comprising liposome-entrapped doxorubicin and methods of admnistration for treatment of multiple myeloma
WO2010001366A1 (en) *	2008-07-04	2010-01-07	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Piperazines derivatives as proteasome modulators
JP2015515279A (ja)	2012-04-19	2015-05-28	アセチロンファーマシューティカルズインコーポレイテッドＡｃｅｔｙｌｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	治療に反応する患者を同定するバイオマーカーおよびそのような患者の治療
SG10201913777XA (en)	2013-03-13	2020-03-30	Sanofi Sa	Compositions comprising anti-cd38 antibodies and carfilzomib
TN2017000554A1 (en) *	2015-07-29	2019-04-12	Novartis Ag	Novel combination for use in the treatment of cancer
CA3004587A1 (en) *	2015-11-06	2017-05-11	Accuitis Pharmaceuticals, Inc.	Use of proteasome inhibitors to treat ocular disorders
RU2677279C1 (ru) *	2018-04-13	2019-01-16	Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации	Способ профилактики диареи у пациентов с острым миелобластным лейкозом на фоне агранулоцитоза
CN120514861A (zh) *	2025-05-29	2025-08-22	中国人民解放军军事科学院军事医学研究院	Nedd8抑制剂在制备抗焦虑药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6083903A (en) *	1994-10-28	2000-07-04	Leukosite, Inc.	Boronic ester and acid compounds, synthesis and uses
KR20040090978A (ko) *	2002-03-13	2004-10-27	얀센 파마슈티카 엔.브이.	히스톤 디아세틸라제의 신규한 저해제로서의 설포닐-유도체
WO2007016532A2 (en) *	2005-08-02	2007-02-08	Novartis Ag	Mutations and polymorphisms of hdac4

2007
- 2007-09-11 MX MX2009002926A patent/MX2009002926A/es not_active Application Discontinuation
- 2007-09-11 JP JP2009527808A patent/JP5230625B2/ja not_active Expired - Fee Related
- 2007-09-11 US US12/441,236 patent/US20090270419A1/en not_active Abandoned
- 2007-09-11 AU AU2007296259A patent/AU2007296259A1/en not_active Abandoned
- 2007-09-11 EP EP07820128A patent/EP2066328A2/en not_active Withdrawn
- 2007-09-11 RU RU2009114167/15A patent/RU2456990C2/ru not_active IP Right Cessation
- 2007-09-11 CA CA002662432A patent/CA2662432A1/en not_active Abandoned
- 2007-09-11 WO PCT/EP2007/059523 patent/WO2008031820A2/en not_active Ceased
- 2007-09-11 CN CN2007800341790A patent/CN101516375B/zh not_active Expired - Fee Related
- 2007-09-11 BR BRPI0716838-1A2A patent/BRPI0716838A2/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
US20090270419A1 (en)	2009-10-29
WO2008031820A2 (en)	2008-03-20
EP2066328A2 (en)	2009-06-10
WO2008031820A3 (en)	2008-05-15
CA2662432A1 (en)	2008-03-20
JP2010503637A (ja)	2010-02-04
CN101516375B (zh)	2012-10-03
HK1135902A1 (en)	2010-06-18
CN101516375A (zh)	2009-08-26
AU2007296259A1 (en)	2008-03-20
JP5230625B2 (ja)	2013-07-10
RU2009114167A (ru)	2010-10-20
RU2456990C2 (ru)	2012-07-27
MX2009002926A (es)	2009-03-31

Publication	Publication Date	Title
BRPI0716838A2 (pt)	2013-10-01	combinaÇÕes de inibidores de histona deacetilase especÍfica de classe i com inibidores de proteosome
EP1991226A4 (en)	2012-01-25	Histone deacetylase INHIBITORS
EP2265590A4 (en)	2012-04-25	SELECTIVE HISTONDEACETYLASE HEMMER
BRPI0817860A2 (pt)	2019-09-24	inibidores de histona deacetilase
EP2010168A4 (en)	2011-06-01	Histone deacetylase INHIBITORS
EP1789381A4 (en)	2009-11-11	INHIBITORS OF HISTONE DEACETYLASE
EP2217588A4 (en)	2013-12-04	INHIBITORS OF HISTONE DEACETYLASE
EP1991247A4 (en)	2011-05-11	BIFUNCTIONAL HISTONDEACETYLASE INHIBITORS
ZA200906609B (en)	2010-05-26	Inhibitors of histone deacetylase
BRPI0916713A2 (pt)	2015-11-10	compostos inibidores de histona desacetilase de cicloalquilideno e heterocicloalquilideno
BRPI0719204A2 (pt)	2014-03-04	Inibidores de hdac
EP2134680A4 (en)	2012-03-07	Histone deacetylase INHIBITORS
EP1735319A4 (en)	2010-06-09	Histone deacetylase INHIBITORS
EP1755601A4 (en)	2009-12-02	HISTONE DEACETYLASE INHIBITORS
IL198263A0 (en)	2009-12-24	Hydroxamates as inhibitors of histone deacetylase
IL188692A0 (en)	2008-08-07	Histone deacetylase inhibitors
EP2049505A4 (en)	2010-12-22	ISOFORM SELECTIVE HDAC HEMMER
EP2007383A4 (en)	2010-09-15	HEMMER OF PROTEIN PRENYL TRANSFERASES
EP2231596A4 (en)	2012-06-06	INHIBITORS OF HISTONATE ACETYLASE
EP1771167A4 (en)	2010-04-21	Histone deacetylase INHIBITORS:
ATE495153T1 (de)	2011-01-15	Arylsulfonylpyrrolidine als 5-ht6-inhibitoren
EP2205563A4 (en)	2012-01-25	NEW HISTONDEACETYLASE INHIBITORS
DK1776358T3 (da)	2009-09-07	Substituerede propenylpiperazinderivater som nye inhibitorer af histondeacetylase
ZA201001972B (en)	2012-06-27	Novel teteahydrofusedpyridines as histone deacetylase inhibitors
DK1991718T3 (da)	2013-10-28	Korrosionsinhibitorer

Legal Events

Date	Code	Title	Description
2014-08-26	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 7A ANUIDADE.
2014-12-16	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2277 DE 26/08/2014.