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BRPI0612145A2 - tubulin inhibitor and process for its preparation - Google Patents

tubulin inhibitor and process for its preparation Download PDF

Info

Publication number
BRPI0612145A2
BRPI0612145A2 BRPI0612145-4A BRPI0612145A BRPI0612145A2 BR PI0612145 A2 BRPI0612145 A2 BR PI0612145A2 BR PI0612145 A BRPI0612145 A BR PI0612145A BR PI0612145 A2 BRPI0612145 A2 BR PI0612145A2
Authority
BR
Brazil
Prior art keywords
preparation
tubulin inhibitor
hemifumarate
tubulin
inhibitor
Prior art date
Application number
BRPI0612145-4A
Other languages
Portuguese (pt)
Inventor
Yanzhong Wu
Jean Schmid
Timothy John Doyle
Jay Thomas Afragola
David Michael Blum
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37074929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0612145(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0612145A2 publication Critical patent/BRPI0612145A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

INIBIDOR DE TUBULINA E PROCESSO PARA SUA PREPARAçãO. A invenção apresenta hemifumarato de 6-cloro-5-{2, 6-difluoro-4-[3- (metilamino) propóxi] fenil}-2-pirazin-2-il-N-[(1S)-2,2,2-trifluoro-1-metiletil] pirimidin-4-amina, que é um inibidor da tubulina utilizável no tratamento de câncer, e processos de preparação do dito hemifumarato.TUBULIN INHIBITOR AND PROCESS FOR PREPARATION. The invention features 6-chloro-5- {2,6-difluoro-4- [3- (methylamino) propoxy] phenyl} -2-pyrazin-2-yl-N - [(1S) -2,2 hemifumarate, 2-Trifluoro-1-methylethyl] pyrimidin-4-amine, which is a tubulin inhibitor usable in the treatment of cancer, and processes for preparing said hemifumarate.

BRPI0612145-4A 2005-06-13 2006-06-08 tubulin inhibitor and process for its preparation BRPI0612145A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69001605P 2005-06-13 2005-06-13
US80278106P 2006-05-24 2006-05-24
PCT/US2006/022574 WO2006138180A1 (en) 2005-06-13 2006-06-08 Tubulin inhibitor and process for its preparation

Publications (1)

Publication Number Publication Date
BRPI0612145A2 true BRPI0612145A2 (en) 2010-10-19

Family

ID=37074929

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0612145-4A BRPI0612145A2 (en) 2005-06-13 2006-06-08 tubulin inhibitor and process for its preparation

Country Status (12)

Country Link
EP (1) EP1891052A1 (en)
JP (1) JP2008543838A (en)
AR (1) AR054392A1 (en)
AU (1) AU2006259663A1 (en)
BR (1) BRPI0612145A2 (en)
CA (1) CA2610416A1 (en)
GT (1) GT200600257A (en)
MX (1) MX2007015718A (en)
PE (1) PE20070114A1 (en)
SV (1) SV2007002573A (en)
TW (1) TW200716613A (en)
WO (1) WO2006138180A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2499152B1 (en) 2009-11-12 2016-06-29 TUBE Pharmaceuticals GmbH Tubulin inhibitors
EP2903436B1 (en) * 2012-09-19 2019-07-17 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2017181974A1 (en) * 2016-04-20 2017-10-26 苏州苏领生物医药有限公司 Five-membered heterocyclic compound, preparation method therefor, pharmaceutical composition and use
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060098368A (en) * 2003-09-24 2006-09-18 와이어쓰 홀딩스 코포레이션 6-[(substituted) phenyl] triazolopyrimidine as anticancer agent
JP2007506746A (en) * 2003-09-24 2007-03-22 ワイス・ホールディングズ・コーポレイション 5-Arylpyrimidines as anticancer agents

Also Published As

Publication number Publication date
CA2610416A1 (en) 2006-12-28
SV2007002573A (en) 2007-01-03
AU2006259663A1 (en) 2006-12-28
JP2008543838A (en) 2008-12-04
EP1891052A1 (en) 2008-02-27
GT200600257A (en) 2007-02-14
PE20070114A1 (en) 2007-02-03
AR054392A1 (en) 2007-06-20
TW200716613A (en) 2007-05-01
MX2007015718A (en) 2008-02-21
WO2006138180A1 (en) 2006-12-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired