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BRPI0608185A2 - processo para redução do tamanho de partìcula de aripiprazol - Google Patents

processo para redução do tamanho de partìcula de aripiprazol

Info

Publication number
BRPI0608185A2
BRPI0608185A2 BRPI0608185-1A BRPI0608185A BRPI0608185A2 BR PI0608185 A2 BRPI0608185 A2 BR PI0608185A2 BR PI0608185 A BRPI0608185 A BR PI0608185A BR PI0608185 A2 BRPI0608185 A2 BR PI0608185A2
Authority
BR
Brazil
Prior art keywords
particle size
reducing
aripiprazole
aripiprazole particle
micronized
Prior art date
Application number
BRPI0608185-1A
Other languages
English (en)
Inventor
Guy Samburshi
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of BRPI0608185A2 publication Critical patent/BRPI0608185A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Quinoline Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

PROCESSOS PARA REDUçãO DO TAMANHO DE PARTìCULA DE ARIPIPRAZOL. Forma II de aripiprazol micronizado que tem um formato de partícula e é caracterizada por 90% ou mais das partículas terem um tamanho de partícula de aproximadamente 30 pim, e a Forma II de aripiprazol micronizado não ter mais de 10% por peso de aripiprazol do Tipo C, conforme determinado pela difração de raios X e processos para sua obtenção.
BRPI0608185-1A 2005-12-22 2006-12-22 processo para redução do tamanho de partìcula de aripiprazol BRPI0608185A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75346605P 2005-12-22 2005-12-22
PCT/US2006/048761 WO2007075871A2 (en) 2005-12-22 2006-12-22 Processes for reducing particle size of aripiprazole

Publications (1)

Publication Number Publication Date
BRPI0608185A2 true BRPI0608185A2 (pt) 2009-11-17

Family

ID=38218601

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608185-1A BRPI0608185A2 (pt) 2005-12-22 2006-12-22 processo para redução do tamanho de partìcula de aripiprazol

Country Status (7)

Country Link
US (1) US20070272777A1 (pt)
EP (1) EP1919453A2 (pt)
JP (1) JP2008537540A (pt)
BR (1) BRPI0608185A2 (pt)
IL (1) IL191286A0 (pt)
TW (1) TW200800202A (pt)
WO (1) WO2007075871A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE529409T1 (de) * 2003-12-16 2011-11-15 Teva Pharma Verfahren zur herstellung von kristallinen aripiprazolformen
US7714129B2 (en) 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
EP2036545A1 (en) * 2006-01-05 2009-03-18 Teva Pharmaceutical Industries Ltd. Aripiprazole tablets
EP1808165B1 (en) * 2006-01-05 2009-04-29 Teva Pharmaceutical Industries Ltd Dry formulations of aripiprazole
KR101408370B1 (ko) * 2012-06-26 2014-06-18 주식회사지씨비 아리피프라졸-유기산 공결정을 함유하는 제제 및 이의 제조 방법
CA2910665C (en) * 2013-04-30 2018-05-22 Otsuka Pharmaceutical Co., Ltd. Oral solid preparation comprising aripiprazole and method for producing oral solid preparation comprising aripiprazole
AR096131A1 (es) 2013-04-30 2015-12-09 Otsuka Pharma Co Ltd Preparado oral sólido que comprende aripiprazol y un método para producir un preparado oral sólido que comprende aripiprazol
CN105924393A (zh) * 2016-07-05 2016-09-07 陕西省食品药品检验所 一种阿立哌唑新晶型及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
CA2044706C (en) * 1990-06-15 2003-02-25 Michael Midler Jr. Crystallization method to improve crystal structure and size
US6221153B1 (en) * 1998-06-09 2001-04-24 Trevor Percival Castor Method for producing large crystals of complex molecules
IL151838A0 (en) * 2000-03-20 2003-04-10 Teva Pharma Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n- (4-methoxyphenyl)-3-chloropropionamide
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
DE60302139T3 (de) * 2003-01-09 2011-02-24 Otsuka Pharmaceutical Co., Ltd. Verfahren zur herstellung von aripiprazole
EP1606262A1 (en) * 2003-03-21 2005-12-21 Hetero Drugs Limited Novel crystalline forms of aripiprazole
US20060270683A1 (en) * 2003-04-25 2006-11-30 Lohray Braj B Polymorphs of aripiprazole
WO2005009990A1 (en) * 2003-07-25 2005-02-03 Hetero Drugs Limited Aripiprazole crystalline forms
US7166418B2 (en) * 2003-09-03 2007-01-23 Matsushita Electric Industrial Co., Ltd. Sulfonamide compound, polymer compound, resist material and pattern formation method
TWI371274B (en) * 2003-10-23 2012-09-01 Bristol Myers Squibb Co Process for making sterile aripiprazole of desired mean particle size
ATE529409T1 (de) * 2003-12-16 2011-11-15 Teva Pharma Verfahren zur herstellung von kristallinen aripiprazolformen
WO2006001846A1 (en) * 2004-02-05 2006-01-05 Teva Pharmaceutical Industries Ltd. Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril
US20050277650A1 (en) * 2004-04-20 2005-12-15 Sundaram Venkataraman Process for preparing aripirazole hydrate
DE102005048694A1 (de) * 2004-10-12 2006-05-18 Chemagis Ltd. Verbesserte Verfahren zur Herstellung von 7-Hydroxy-3,4-dihydro-2(1H)-quinolinon und dessen Verwendung in der Herstellung von Aripiprazol
DE102005048695A1 (de) * 2004-10-12 2006-05-18 Chemagis Ltd. Verfahren zur Herstellung und Reinigung von Carbostyrilverbindungen wie beispielsweise Aripiprazol und 7-(4-Halobutoxy)-3,4-dihydro-2(1H)-quinolinonen
WO2006097343A1 (en) * 2005-03-17 2006-09-21 Synthon B.V. Process of making crystalline type ii aripiprazole
CA2600542A1 (en) * 2005-03-17 2006-09-21 Synthon B.V. Pharmaceutical tablets of crystalline type ii aripiprazole

Also Published As

Publication number Publication date
TW200800202A (en) 2008-01-01
US20070272777A1 (en) 2007-11-29
JP2008537540A (ja) 2008-09-18
EP1919453A2 (en) 2008-05-14
WO2007075871A3 (en) 2008-04-03
IL191286A0 (en) 2009-08-03
WO2007075871A2 (en) 2007-07-05
WO2007075871A9 (en) 2007-08-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2211 DE 21/05/2013.