BRPI0607104A2 - additive for addition to a body wash, sunscreen additive composition, sunscreen additive for addition to a body wash, body wash, methods for preparing body wash, for protecting skin from sunlight and for doing business - Google Patents

Abstract

ADDITIVE FOR ADDITION TO A BODY WASH, COMPOSITION OF SUNSCREEN ADDITIVE, SOLAR PROTECTOR ADDITION FOR ADDING A BODY WASH, METHODS FOR PREPARING BODY WASH, TO PROTECT SUNSHINE SKIN AND SUNLIGHT SKIN. The invention encompasses body wash additives. The additive may contain a sunscreen. The additive may contain 2, 3 or more than three sunscreens. Optionally, one or more of the sunscreens may be encapsulated. The invention further encompasses methods of manufacturing and using additives and body wash containing an additive, for example an additive containing a sunscreen.

Description

"ADDITIVE FOR ADDITION TO A BODY WASH, COMPOSITION OF SOLAR PROTECTIVE ADDITIVE, ADDITIVE SOLAR DEPARTMENT FOR ADDITION TO A BODY WASH, CORPORAL WASH, METHODS TO PREPARE SUN SKIN" AND "SUNSHINE"

CROSS REFERENCE

This application claims the benefit of U.S. Conditional Patent Application No. 60 / 648,961 filed January 31, 2005, and U.S. Patent Application 111076.565; 11 / 076,089; 11 / 076,517; 11 / 076,088 and 11 / 076,507, all filed on March 8, 2005, all of which are incorporated herein by reference in their entirety.

Exposure to ultraviolet light, primarily through exposure to sunlight, produces several harmful effects including premature skin aging, loss of elasticity, wrinkling, drying and increased risk of developing skin cancer. Currently, various sunscreen products are marketed to protect against these harmful effects. All of these products contain agents known to filter out some of the sun's harmful rays embedded in creams, ointments, lotions, solutions or suspensions. Such products are applied just prior to anticipated early sun exposure, provide short-term protection and are removed by normal skin bathing, washing or peeling. Body wash soap has been used for years to remove oil due to its surfactant composition and associated charges. A normal soap contains both positive and negative charges. Although attempts have been made to combine sunscreens with soaps (ie, surfactants), none have provided an ideal combination of high sun protection factor (SPF) and long-lasting effect in a composition that maintains its integrity. Additives other than sunscreen are also potentially useful when applied in conjunction with a body wash, but few products currently utilize this potential. Current invention indicates these shortcomings.

SUMMARY OF THE INVENTION

The invention encompasses body wash containing an additive. The additive may contain a sunscreen. The invention further encompasses methods of manufacturing and using body washes containing an additive, for example an additive containing a sunscreen.

In one aspect, the invention provides a body wash containing an additive comprising a sunscreen, wherein upon simple application of the body wash to the skin and rinse, the skin is protected from sun light with an average SPF of at least about 15 ° C. In embodiments, the SPF of 15 is maintained for an average of at least about 4 hours after rinsing. In some embodiments, the sunscreen is encapsulated, for example, in sol-gel microcapsules. In some embodiments, the sunscreen is an organic sunscreen that is aminobenzoic acid, avobenzone, cinoxate, dioxibenzone, homosalate, menthyl anthranylate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padmate O, phenylbenzimidazol sulphonic acid sulphide, trolamine. In some embodiments, the sunscreen is a cinnamate derivative. In some embodiments, the additive contains 3 organic sunscreens. In some embodiments, the 3 organic sunscreens are selected from the group consisting of aminobenzoic acid, avobenzone, cinoxate, dioxibenzone, homosalate, menthyl anthranylate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padyto O, phenylbenzylisulfonic acid, sulfosulfonate of trolamine. Embodiments may further contain an inorganic sunscreen. In some embodiments, the sunscreen is selected from the group consisting of zinc oxide and titanium dioxide. In some embodiments, the sunscreen is a UVB absorbing sunscreen, and the composition also contains a UVA absorbing sunscreen and a physical blocking sunscreen, when the UVB absorbing sunscreen is selected from the group consisting of aminobenzoic acid, cinoxate dioxibenzone, homosalate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, sulfenic acid phenylbenzimidazole, sulisobenzone and trolamine salicylate; The UVA-absorbing sunscreen is selected from the group consisting of avobenzone and menthyl anthranilate and the physical blocking sunscreen is selected from the group consisting of titanium dioxide and zinc oxide. Embodiments may further contain a cationic polymer. In some embodiments, the cationic polymer is a polyquaternium. In some embodiments, the polyquattern is Polyquatern-4, -7, -11, -22, -27, -44, -51 or -64. In preferred embodiments, the cationic polymer is Polyquaternium-4. Embodiments may also contain a film former, a preservative and / or an antioxidant that is stable in sunlight exposure.

In another aspect, the invention provides a body wash containing an additive containing a sunscreen, where, after applying the body wash to the skin and rinse, the sunscreen penetrates an average of no more than 30 microns into the skin following application followed by the rinse. . In some embodiments of this aspect, after applying the body wash to the skin and rinse, the skin is protected from sunlight with an average SPF of at least about 15.

In another aspect, the invention provides a body wash comprising a UVA absorbing sunscreen, a UVB absorbing sunscreen, a physical blocking sunscreen, and a polymerocatonic. In some embodiments, the UVB-absorbing sunscreen is selected from the group consisting of aminobenzoic acid, cinoxate, dioxibenzone, homosalate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzone traminolate ; UVA-absorbing sunscreen is selected from the group consisting of avobenzone and menthyl anthranilate; The physical blocking sunscreen is selected from the group consisting of titanium dioxide and zinc oxide and the cationic polymer is a polyquattern. Polyquaternium-4, -7, -11, -22, -27, -44, -51 or -64. A preferred Polyquaternium is Polyquatern-4. Octyl methoxy cinnamate may be encapsulated, for example, in sol-gel microcapsules. Octyl ethoxycinnamate may be present in about 4.5 to 9%, octocrylene may be present in about 0.5 to 15%, avobenzone may be present in about 2 to 4% and titanium dioxide may be present in about 3 to 9%. Additionally, in Poliquaternium-4-containing embodiments, Polyquaternium-4 may be present in about 0.5 to 3%. In some embodiments, octyl methoxycinnamate is present in about 7.6%, octocrylene is present. In about 11.3%, an avobenzone is present in about 2.8% and titanium dioxide is present in about 6.5%. Additionally, in these embodiments which contain polyquaternium-4, Polyquaternium-4 may be present at about 2.8%. A film former may also be present, for example, about 1.5%. In this regard, the body wash according to claim may still contain a non-sunscreen active. In some embodiments, the non-sunscreen active is selected from the group consisting of steroidal anti-inflammatory actives, analgesic, antifungal, antibacterial and anti-parasitic actives, anti-allergenic, medicinal actives, rash medications, skin and dermatitis, insect repellent actives, antioxidants, hair growth promoter, hair bleaching agents, deodorant compounds and mixtures and combinations thereof. In some embodiments, at least one of the sunscreens is encapsulated, for example, in sol-gel microcapsules. In some embodiments, the cationic polymer is a polyquaternium. In some embodiments, the polyquaternium is polyquaternium-4, -7, -11, -22, -27, -44, -51 or -64. In preferred embodiments, the polymerocathionic is Polyquaternium-4. Embodiments may also contain a film former, a preservative and / or an antioxidant that is stable in sunlight exposure.

INCORPORATION BY REFERENCE

All publications and patent applications mentioned in this specification are incorporated herein by reference to the same extent as each individual publication or patent application is specifically and individually incorporated by reference.

DETAILED DESCRIPTION OF THE INVENTION

The present invention encompasses compositions containing one or more active ingredients (also referred to herein as "actives") which may be added to a body wash composition to provide an active / body wash combination. The invention also encompasses a body wash containing such an active ingredient. In some embodiments, the active ingredient is one or more sunscreens. The invention further encompasses methods of use and manufacture of the compositions and commercial methods.

As used in this, "body wash" covers all cleansing vehicles applied to the body. Exemplary forms of cleansing vehicles include, but are not limited to, liquid, bar, gel, foam, aerosol or pump spray, cream, lotion, stick, powder or incorporate a patch or towel. In addition, soap-free cleaners can also be used. Body wash can be manufactured in any suitable form of product. Thus, as used herein, "body wash" includes, but is not limited to, a soap that includes liquid and bar soap; a shampoo; a hair conditioner; a shower gel; including an exfoliating thinning gel; a sparkling bath product (e.g. gel, soap or lotion); a milk bath; a soap-free cleanser including a gel cleanser, a liquid cleanser and a cleanser bar; damp towels; body motion; a body spray, mist or gel; bath and tablet tablets (for example, bubble bath); a nail cream; a shower gel; a shower cream; a shaving cream; a shaving product, for example, a shaving cream, gel, foam or soap, an aftershave, an aftershave humidifier and combinations thereof and any other composition used for cleansing or post-cleansing application to the body, including skin and the hair. Especially useful as body wash in the invention are soaps, for example liquid soaps and bar soap soaps.

I. Compositions

In one aspect, the invention provides additives containing active ingredients when the additive is designed to be added to a body wash (for example, soap or shampoo). In some embodiments, the invention provides sunscreen compositions ("sunscreen additives") which may be added to a body wash preparation to impart sunscreen. In some embodiments, the invention provides a combination of a sunscreen additive and a body wash preparation ("sunscreen / body wash"). Thus, a sunscreen additive of the invention may be mixed with a conventional body wash; alternatively, the invention provides body wash with premixed sunscreen. In each case, sunscreen / bodywashing is generally applied in the same way as bodywashing alone and typically rinsed, with additive, for example, sunscreen protection being left on the skin after rinsing. In some cases, for example soap-free cleansers, body wash is applied without rinsing.

For sunscreen additives as part of a sunscreen / body wash, sunscreen protection after application and typically the rinse is, on average, greater than an SPF of 1, even around SPF 50. As used in this in the context of SPF, "mean SPF" is the SPF, determined as described herein, from about 5 to about 50 patients or about 5 to about 20 patients or about 5 to about 10 patients, when patients have, preferably type II skin. In some embodiments, the average SPF provided by the protetorsolar body wash after rinsing is from about 1 to about 50 or about 2 to about 50or about 2 to about 40 or about 2 to about 30 or so. about 2 to about 20 or about 2 to about 10 or about 2 to about 5 or about 5 about 25 or about 5 to about 20 or about 5 to about 15 or about 5 to about of 10. In some embodiments, the average SPF provided by body wash with sunscreen after rinsing is above fencing 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20. In some preferred embodiments, the mean post-rinse SPF is above about 2. In some preferred embodiments, the post-rinse SPF is above about In some preferred performing forms, the mean SPF after rinsing is above about 10.

In some preferred embodiments, the mean SPF after rinsing is above about 15. In some embodiments, the mean SPF provided by the sunscreen / body wash of the invention remains above about 1.2,3,4,5. , 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20, for an average of at least about 0.5, 1, 2, 3, 4 , 5, 6, 7, 8, 9, 10 or more than about 10 hours after rinsing. In some embodiments the average SPF provided by the sunscreen / body wash of the invention increases with each additional wash after a first wash, so that after a Second, Third, Fourth or Fifth wash, the SPF provided may be above about 2.4, 6, 8, 10, 15, 20, 25, 30, 40, 45 or more than about 45.

SPF is a commonly used photo protection measure of a sunscreen against erythema. This number is derived from one other parameter, the minimum erythema dose (MED). MED is defined as "the smallest exposure dose at a specified wavelength that will evoke a delayed erythema response". MED indicates the amount of radiation of energy on the skin and the responsiveness of the skin to radiation. The SPF of a particular photoprotector is obtained by dividing MED from protected skin by MED from unprotected skin. The higher the SPF, the more effective the sunburn prevention agent. The SPF value tells you how much longer a person can stay in the sun before they try 1 MED. For example, using a sunscreen with an SPF of 6 will allow an individual to remain in the sun six times longer before receiving 1 MED. Just as the SPF value of a sunscreen increases, so is less chance of developing tanning of the skin. Commercially available solar protection products typically have SPF values ranging from about 2 to 45.

Methods for measuring SPF are described, for example, by FDA monograph C.F.R. 21. One method for applying the sunscreen prior to measurement is as follows: the 50 cm2 square area of the test site with 10 ml of water released with a syringe. Apply test sample as per FDA monograph to area. Later work on the patient for 3 minutes to let the product absorb into the skin. Rinse the area for an additional 2 minutes with 20 ml of water. Lightly dry and leave 15 minutes before exposure to radiation as per FDA monograph. In some embodiments, after applying body wash containing the additive (eg, sunscreen) to the rinse skin, the additive (eg, sunscreen) ) penetrates an average of at least about 5 microns under the skin surface. In some embodiments, the additive penetrates an average of at least about 10, 15, 20, 25, 30, 40, 50, 60, 70, 80, 90, 100, 120 or 150 microns under the skin surface. In some embodiments, after applying the body wash containing the additive (eg, sunscreen) to the rinse skin, the additive (eg, sunscreen) penetrates an average of no more than about 30 microns under the surface. of the skin. In some embodiments, the additive penetrates an average of no more than about 50, 40, 30, 25, 20, 15, 10 or 5 microns under the skin surface. In some embodiments, after applying body wash containing the additive (eg, sunscreen) to the skin followed by rinsing, the additive (eg, sunscreen) penetrates an average of about 5 to about 50 or about 5 to about 40 or about 5 to about 30 or about 10 to about 40 or about 15 to about 40 or about 20 to about 40or about 5, 10, 15, 20, 25, 30, 25, 40, 45 or 50 microns under the surface of the skin. Depth of penetration can be tested by tape withdrawal methods as are well known in the art.

The sunscreen and sunscreen / body wash additives of the invention contain at least one sunscreen. In some embodiments, the sunscreen additives of the invention contain one, two, three or four or more than four sunscreens. In preferred embodiments, the sunscreen additives of the invention include three sunscreens. In other preferred embodiments, the sunscreen additives of the invention include four sunscreens. Sun protectors may be organic or inorganic. Sunscreens can be a UVA absorber, a UVB absorber, a physical blocker or any combination of these. In some embodiments one or more of the sunscreens is encapsulated. Various types of encapsulation may be used as described herein.

The compositions of the invention may include one or more actives which are not sunscreens when the composition is designed to be a body wash additive. In some compositions of the invention, the actives are provided in combination with one or more sunscreens, and in some compositions the actives are provided without sunscreen.

Additives, for example, sunscreen / body wash additives, for example sunscreen / body wash, may further include one or more components to provide a positive charge to the system to assist with protein binding and other skin-laden components. and / or hair, for example cationic polymeric agents. The cationic polymer may be, for example, a quaternium, for example, Polyquaternium.

The additives, for example, sunscreen / body wash additives, for example sunscreen / body wash, may further include a film former.

Other optional additive ingredients, for example sunscreen and body wash / additive, for example, body wash / body wash additives of the invention include preservatives, antioxidants, chelating agents, liquid hydrocarbon (e.g., similar to pentane), foaming agents (e.g., a cationic foaming agent), skin nourishing components, antibacterials, medicinal products and others as described below.

Additives, for example sunscreen additives, of the invention may be combined with any conventional body wash. The body wash composition with which the additive, for example sunscreen additive is combined may be any body wash known in the art or evident to a skilled person as described above. In embodiments when the additive is a non-sunscreen additive, the additive may be combined with any composition for topical application. In these embodiments, the additive is often encapsulated, for example, in sol-gel microcapsules.

In some embodiments the invention provides a additive, for example sunscreen additive, in combination with body lever composition to provide an additive / body wash, for example sunscreen / body wash composition. In these embodiments, the additive, for example sunscreen additives, of the invention is provided in combination with one or more surfactants. The surfactants may be cationic, anionic, nonionic, zwitterionic, amphoteric or any combination thereof. In preferred embodiments, the sunscreen / body wash compositions of the invention include at least one cationic surfactant.

A. Sunscreens

The sunscreen and sunscreen / body wash additives of the invention contain at least one sunscreen. Sunscreen may be organic or inorganic or a combination of both may be used. Sunscreens for use in the invention include UV absorbers or blockers (for example, many inorganic sunscreens are UV blockers). UV absorbers may be a UVB or UVA absorber (e.g., UVA I or UVA II absorber). In some embodiments, the sunscreen or sunscreen / body wash additives of the invention include an organic and an inorganic sunscreen. In some embodiments, the sunscreen or sunscreen / body wash additives of the invention include more than one organic sunscreen (e.g. at least one UVB absorber and at least one UVA absorber) and at least one inorganic sunscreen. In some embodiments, the sunscreen additives of the invention include only a physical blocking sunscreen, for example, detitanium dioxide. These embodiments may further contain a cationic polymer and / or a film former as well as any other components described herein as sunscreen additives.

Additional ingredients may include film builders, cationic polymers, antioxidants, preservatives and others as described herein. In some embodiments, the sunscreen or sunscreen / body wash additives of the invention include a sunscreen and an inorganic sunscreen. In some embodiments, the sunscreen or sunscreen / body wash additives of the invention include more than one organic sunscreen (e.g. at least one UVB absorber and at least one UVA absorber) and at least one inorganic protector solar.

In preferred embodiments, one or more of the sunscreens used in the invention are encapsulated.

Any sunscreen known in the art or evident to the skilled artisan can be used in the invention. The term "sunscreen" or "sunscreen agent" as used herein defines ultraviolet blocking compounds which exhibit absorption or blockage within the wavelength region between about 290 and 420 nm. Sun protectors can be classified into five groups based on their chemical structure: para-amino benzoates; salicylates; cinnamates; benzophenones and various chemicals including menthyl anthranilate and dedigaloyl trioleate. Inorganic sunscreens can also be used including titanium dioxide, zinc oxide, iron oxide and polymer particles such as polyethylene and polyamides.

Specific suitable sunscreens include, for example: p-aminobenzoic acid, its salts and derivatives (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic acid); Anthanilates (i.e. o-aminobenzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl and cyclohexenyl esters); Salicylates (amyl, phenyl, benzyl, menthyl, glyceryl and dipropylene glycol esters); Cinnamic acid derivatives (benzyl methyl esters, alpha-phenyl cinamonitrile; butyl cinnamoyl pyruvate); dehydroxycinnamic acid derivatives (umbeliferone, methylumbeliferone, methylaceto-umbeliferone); trihydroxycinnamic acid derivatives (esculetin, metilesculetin, dametin and glycosides, esculin and dafhina); Hydrocarbons (diphenylbutadiene, stilbene); Dibenzalacetone and benzalacetophenone; Naphtholsulfonates (sodium salts of 2-naphthol-3,3-disulfonic acids and 2-naphthol-6,8-disulfonic acids); dihydroxynaphthoic acid and its salts; o- and p-hydroxybiphenyldisulfonates; Coumarin derivatives (7-hydroxy, 7-methyl, 3-phenyl); Diazols (2-acetyl-3-bromoindazole, phenyl benzoxazole, methyl naphthoxalol, various aryl benzothiazoles); quinine salts (bisulfate, sulfate, chloride, oleate ethanate); quinoline derivatives (8-hydroxyquinoline, 2-phenylquinoline salts); hydroxy- or methoxy-substituted benzophenones; Uric and villuric acids; tannic acid and its derivatives (for example hexaethyl ether); (butylcarbityl) ether (6-propyl piperonyl); Hydroquinone; Benzophenones (Oxybenzene, Sulisobenzone, Dioxibenzone, Benzoresorcinol, 2,2 ', 4,4'-Tetrahydroxybenzophenone, 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone, Octabenzone; 4-Isopropylbenzoylmethane; Butylmethoxydibenzoylmethane; Ethipropylene and 4-ethylene titanium dioxide, iron oxide, zinc oxide and mixtures thereof Other cosmetically acceptable sunscreens and concentrations (weight percent of the total cosmetic protector solar composition) include diethanolamine methoxycinnamate (10% or less), ethyl- [ bis (hydroxypropyl)] aminobenzoate (5% or less), glyceryl aminobenzoate (3% or less), 4-isopropyl dibenzoylmethane (5% or less), 4-methylbenzylidene camphor (6% or less), dichlorophonic acid terephthalylidene ( 10% or less) and sulisobenzone (also called benzophenone-4, 10% or less).

In preferred embodiments, sunscreens are FDA approved or approved for use in the European Union. For example, FDA approved sunscreens may be used alone or preferably in combination. See, for example, U.S. Patent. 5,169,624; 5,543,136; 5,849,273; 5,904,917; 6,224,852; 6,217,852; eSegarin et al, Chapter Village, pages 189 of Cosmetics Science and Technology and Final Over-the-Counter Drug Products Monograph on Solar Protectors (Federal Register, 1999: 64: 27666-27963), all of which are incorporated herein by reference.

For example, for a product marketed in the United States, preferred cosmetically acceptable sunscreens and concentrations (reported as a percentage by weight of the total cosmetic sunscreen composition and referring to the final percentage of sunscreen after addition to body wash) include: aminobenzoic acid ( also known as paraaminobenzoic acid and PABA; 15% or less; an organic UVB absorbing protectorol), avobenzone (also called butyl methoxy dibenzoylmethane; 3% or less, sorbent UVA organic sunscreen), cinoxate (also called 2-ethoxyethyl p-methoxycinnamate; 3% or less, an organic UVB-absorbing sunscreen), dioxibenzone (also called benzophenone-8; 3% or less, an UVB- and UVA II-absorbing sunscreen), homosalate (15% or less, an organic-absorbing sunscreen) UVB), menthyl anthranilate (also called menthyl 2-aminobenzoate; 5% or less, an organic and absorbs UVA II), octocrylene (also called 2-ethylexyl-2-cyano-3,3-diphenylacrylate; 10% or less, an organic sunscreen that absorbs UVB), octyl methoxycinnamate (7.5% or less, an UVB-absorbing sunscreen), octyl salicylate (also called 2-ethylexylalicylate; 5% or less, a protector organic sunscreen UVB), oxybenzone (also called benzophenone-3; 6% or less, an organic sunscreen that absorbs UVB and UVA II), padimate O (also called octil dimethyl PABA; 8% or less, a sunscreen that absorbs UVB ), phenylbenzimidazole sulfonic acid (water soluble; 4% or less, a UVB-absorbing organic sunscreen), sulisobenzone (also called benzophenone-4; 10% or less, an UVB and UVA II-absorbing organic sunscreen) titanium (25% or less, an organic physical UVA and UVB blocker), detrolamine salicylate (also called triethanolamine salicylate; 12% or less, an UVB-absorbing organic sunscreen) and zinc oxide (25% or less, a blocker) physical the UVA and UVB).

For a product marketed in the European Union, cosmetically acceptable photoactive compounds and concentrations (reported as a percentage by weight of the total cosmetic sunscreen composition and referring to the final percentage of sunscreen after addition to body wash) include: PABA (5% or less ), camphor benzalkonomethsulfate (6% or less), homosalate (10% or less), benzophenone-3 (10% or less), phenylbenzimidazole sulfonic acid (8% or less, expressed as acid), terephthalene dicalphorphonic acid (10%) or less, expressed as acid), butyl methoxydibenzoyl methane (5% or less), camphor sulfonic acid benzylidene (6% or less, expressed as acid), octocrene (10% or less, expressed as acid), polyacrylamidomethyl benzylidene camphor (6% or less) , deoctyl methoxycinnamate (10% or less), PEG-25 PABA (10% or less), isoamyl p-methoxycinnamate (10% or less), ethylexyl triazone (5% or less), drometrizole trieloxane (15% or less) ), diethylhexyl butamido triazone (10% or less), 4-methylbenzylidene camphor (4% or less), 3-benzylidene camphor (2% or less), ethylhexyl salicylate (5% or less), ethylexyl dimethyl PABA (8%) or less), benzophenone-4 (5%, expressed as acid), methylene bis-benztriazolyl tetramethylbutylphenol (10% or less), disodium phenyldibenzimidazole tetrasulfonate (10% or less, expressed as acid), bis-ethylexyloxyphenol methoxyphenol triazine (10% or less) or less), methylenobisbenzotriazolyl tetramethylbutylphenol (10% or less, also known as TINOSORB M) and bisetylexyloxyphenol methoxyphenyl triazine (10% or less, also called TINOSORB S).

In some embodiments, the sunscreen or sunscreen / body wash additives of the invention include a long-lasting chromophoric silicon molecule, for example, PARASOL SLX (DSM Nutritional Products), which contains point-specific benzyl malonate chromophores. a polysiloxane chain. Thus, in some embodiments, the invention provides a protetorsolar or sunscreen / body wash additive containing a protetorsolar composition comprising a long chain silicone molecule with chromophores. For example, compositions of the invention include a composition containing octyl methoxycinnamate, octocrylene, avobenzone, detitanium dioxide and a chromophoric silicone long chain molecule. The silicone long-chain molecule can be used in about 0.5 to about 5% protector soluble additives or about 0.2 to about 2% sunscreen / body washes.

Inorganic UVA and UVB physical blockers useful in the invention further include iron oxide and polymeric particles such as those of polyethylene and polyamides.

In some embodiments, sunscreen and sunscreen sunscreen additives contain at least one active sunscreen that is cinnamate (eg Octylmethoxycinnamate (ethylhexylmethoxycinnamate), (available under the brand name PARSOL MCX), oxybenzone (eg benzophenone- 3- (2-Hydroxy-4-Methoxybenzophenone), avobenzone (4-tert-Butyl-4'-methoxydibenzoylmethane or PARSOL 1789), octyl (2-Ethylhexyl Salicylate) salicylate, 2-cyano-3,3-diphenylacrylate 2-ethylhexyl), methyl anthranilate and / or titanium dioxide or combinations thereof.

Sunscreen and sunscreen / body wash additives of the invention may, in some embodiments, contain as a sunscreen component only titanium dioxide. When detitanium dioxide is used in compositions of the invention, alone or in combination with other sunscreens, titanium dioxide may have an anatase, rutile or amorphous structure. Titanium dioxide particles may be uncoated or may be coated with a variety of materials including, but not limited to, aluminum compounds such as aluminum oxide, aluminum stearate, aluminum laurate and the like; phospholipids, such as comolecithin; silicone compounds and mixtures thereof. Various grades and forms of titanium dioxide are described in CTFA Cosmetic Ingredient Dictionary, Third Edition (1982), pp. 9-14. 318-319; U.S. Patent 4,820,508 to Wortzman, filed April 11, 1989 and World Patent No. WO 90/11067 issued to Elsom et al, published October 4, 1990; These three references are incorporated by reference herein in their entirety. Suitable grades of titanium dioxide for use in the compositions of the present invention are commercially available such as the MTda Tri-K Industries (Emerson, NJ) synchronized series. These micronized titanium dioxides, in general, have an average primary particle size ranging from about 10nm to about 50 nm. For example, titanium dioxide having an average primary particle size of about 15 nm is available under the brand names MT-150W (uncoated) and MT-100T (coated with stearic acid and aluminum compounds). Uncoated titanium dioxides having average primary particle sizes around 35 nm and around 50 nm are available under the brand names MT-500B and MT-600B, respectively. Other coated titanium dioxides having an average primary particle size around 15 nm include MT-100F (modified with stearic acid and iron hydroxide) and MT-100S (treated with lauric acid and aluminum hydroxide). Mixtures of two or more types and particle size variations of titanium dioxide may be used in the present invention.

A particularly preferred form of titanium dioxide is silica coated TiO 2. Such silica-coated Ti02 is available under T-AVO (Eusolex).

If a zinc compound is chosen as the sunscreen, some zinc-based compositions (eg Z-CoteTM HP1 [trademark SkinCeuticals]) provide zincomicrophin oxide coated with a dimethicone form. As expressed by the manufacturer, the dimethicone coating transforms the often granular and pasty zinc oxide particles into a uniform formulation that is transparent. The micronization of these particles achieves the important advantage of providing effective sunscreen without giving the appearance of white paint coated skin.

Also, it should be noted that in relation to inorganic blockers are Tioveil and Spectraveil (both from Tioxide Group). Tioveil includes products that are 40% dispersions of surface treated titanium dioxide in a range of cosmetic vehicles. Spectraveil includes products that are 60% dispersions of zinc oxide in a range of cosmetic vehicles. In certain variations, these products may be cell forming and may have advantageous uses herein.

In sunscreen additives, total sunscreens comprise about 0.1 to 50% or about 1 to 30% or about 1 to 25% or about 3 to 25% or about 5 to 25% or about 10%. 25% or about 15 to 25% or about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50% of the composition (all percentages in this composition are weight percent unless otherwise specified). way). In sunscreen / body wash compositions, total sunscreens may comprise from 0.05 to 30% or about 0.5 to 15% or about 0.5 to 12% or about 1.5 to 12% or about 2.5 to 12% or about 5 to 12% or about 7 to 12% or about 2.5, 5, 7.5, 10, 12.5, 15,20, 25, 30, 33, 35, 40, 45, 50 or more than 50% of the composition.

In some embodiments, a protective soluble additive invention includes octyl methoxycinnamate of about 4.5 to 9%, Octocrylene of about 0.5 to 15%, Avobenzone (e.g. PARSOL1789) of about 2 to 4. % and titanium dioxide from about 3 to 9%. In some embodiments, octyl methoxy cinnamate is encapsulated, for example, in amorphous silica. Such encapsulated octyl methoxy cinnamate is commercially available under the trademark UV PEARLS; about 20 to 40% Uv PEARLS provides about 4.5 to 9% octyl methoxy cinnamate. In some embodiments, a sunscreen additive of the invention includes about 7.6% octyl methoxycinnamate (in some embodiments, encapsulated as described, for example, in UV PEARLS where UV PEARLS is provided in about 33.3 %), About 11.3% octocrylene, about 2.8% Avobenzone (PARSOL 1789) and about 6.4% titanium dioxide. Sunscreen additives may further include a Polyquaternium, for example, Polyquaternium-4. In some embodiments, Polyquaternium-4 is present from about 0.5% to about 5%, in some embodiments, Polyquaternium-4 is present from about 2.8%. Sunscreen additives may further include a film former, which may comprise dimethicone and / or petrolatum and / or a preservative such as BHT. This sunscreen additive may be added to a conventional body wash formulation (e.g. SUAVEBodywash) at a ratio of about one part sunscreen additive to two parts body wash (w / w). Other ratios that are encompassed by the invention, for example, are about one part of sunscreen additive to about 0.2, 0.5, 0.7 1.0, 1.1, 1.2, 1.3, 1. , 4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1,2.2, 2.3, 2.4, 2.5, 2.6 2.7, 2.8, 2.9, 3.0, 3.2, 3.5, 3.7, 4.0, 4.2, 4.5, 4.7, 5.0, 6 0.7.0, 8.0, 9.0, 10, 12, 15, or 20 parts body wash (w / w).

It will be appreciated by those skilled in the art that various sunscreen additive ingredients may be added to the body wash all at once or in groups or separately. In some embodiments, the sunscreen additive comprises at least two components. For example, the first component may comprise all ingredients except an inorganic or physical blocking sunscreen and the second component may comprise inorganic or physical blocking sunscreen. The first component is added to the body wash with total mixture, then the second component is added. For example, in some embodiments, all ingredients except detitanium dioxide are mixed, then added to the body wash and then titanium dioxide is added (see Examples).

In some embodiments, the sunscreen additives of the invention include from about 0.1 to 7.5 weight percent octyl methoxy cinnamate, about 0.1 to 6 weight percent octyl salicylate, about 0.1 to 5 parts by weight of oxybenzone, about 1 to 10 weight percent of cationic surfactant, and about 0.01 to 1 weight percent of a quaternized compound. This composition may further include a film former. These compositions may further include from 0.01 to 1 weight percent of a preservative.

Encapsulation Sunscreens and other assets used in the invention may be encapsulated. One or more of the sunscreens used in the composition may be encapsulated; preferably all used sun shields are encapsulated. Active sunscreens can be encapsulated together or can be encapsulated separately, in any combination, in the same or different types of encapsulations. In general, encapsulation involves placing the sunscreen on, for example, a vein. Depending on the choice of gallbladder, the gallbladder may break open when applied without being limited in theory, it is thought that the gallbladder will break various types of encapsulation due to friction, temperature or pH of the skin or hair or some combination thereof. By choosing the appropriate capsule and system additives, the stability, durability and / or SPF provided by the sunscreen and sunscreen / body wash additives of the invention may be increased.

Any encapsulation media known in the art, including but not limited to liposomes, maltodextrin capsules, desilyl gels, siloxanes and the like may be used in the compositions of the invention. A cationic or cationic in dry powder form may also be used for encapsulate the sunscreen. Commercial embodiments of sunscreens or vehicles suitable for encapsulating sunscreens include CATEZOMES (Engelhard Corp.), EUSOLEX UV PEARLS (EMDBiosciences) and others known in the art. Suitable encapsulation methods for releasing benefit agents that are mixed with a body wash composition are well known in the art. See, for example, U.S. Patent 6,825,161; 6,436,375; 6,238,650; 6,468,509.6,362,146; 6,074,630; 5,455,048; 5,770,556; 5,955,409; 5,876,755; 4,803,195; 5,508,259; 4,749,501; 6,248,703; 5,476,660 and 4,904,524 and EPN Patent No. 0,254,447; 0.025.379 and 0.399.911.

A particularly preferred method of encapsulation is sol-gel encapsulation. This technique is described, for example, in U.S. Patent. 6,238,650; 6,436,375. 6,303,149 and 6,468,509. any or all sunscreens and / or other active ingredients of the inventive compositions may be encapsulated by such sol-gel encapsulation. Sol-gel granules may be prepared to have a surface charge, for example a cationic charge. This is advantageous in that otherwise water and insoluble components can be encapsulated within the microcapsules, which are then freely miscible in water, for example without the need for an emulsifying agent. For example, in some embodiments, a UVA absorber, a UVB absorber (e.g., octyl methoxycinnamate) and / or a physical blocker, for example titanium dioxide, is provided with an optionally sol-gel silica encapsulated. with additional ingredients containing PVP, Chlorphenesin and an antioxidant such as BHT. One commercial embodiment of such an encapsulation containing octyl methoxycinnamate, PVP, chlorphenesin eBHT, is available under the tradename EUSOLEX UV PEARLS (EMDBiosciences). Such an encapsulated sol-gel silica UVB absorber, for example octyl methoxycinnamate, may be used in a protector soluble additive at a concentration that results in a final UVB absorber concentration of from about 1% to about 40% or about 2% to about 20% or about 2% to about 10% or about 5% to about 10% or about 6%, 7%, 7.4%, 7.5%, 7.6%, 8% or 9%. The preferred final concentration is about 7.6%. In other embodiments, more than one sunscreen is encapsulated as the sol-gel silica encapsulated. In these embodiments, the final concentration of each sunscreen independently in the final sunscreen additive is from about 1% to about 40% or about 2% to about 20% or about 2% to about 10% or about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 7.5%, 8%, 9% or 10%. Sunscreens can be encapsulated together or separately or any combination of these. In some embodiments, the invention provides an additive for addition to a body wash that includes a sunscreen encapsulated in a sol-gel microcapsule and a polymerocatonic (described below). Other ingredients in these embodiments may include a film former, antioxidant, preservative, chelating agent, thickener, emollient and / or other active and inactive ingredients as described herein. In some embodiments where encapsulation, for example, sol-gel microencapsulation The micro-capsule composition, e.g., sol-gel microcapsule, may be varied to allow varying amounts of active, for example, sunscreen, microcapsule to be released. Microcapsules, for example, sol-gel microcapsules, may be prepared to experience no or minimal breakage when applied to the skin and when left on the skin. Alternatively, microcapsules, for example, sol-gel microcapsules, They can be prepared to experience varying degrees of breakage, on average, when applied to the skin and when left on the skin. In this way, microcapsules, for example, sol-gel microcapsules, may be prepared in order to experience about 0% break or break in the range of about 0.1, 0.5, 1, 2, 5, 10, 20, 30, 40, 50, 60, 70, 80 or 90% at about 0.5, 1, 2, 5.10, 20, 30, 40, 50, 60, 70, 80 or 90% after application (or application and rinse in case of one of a body wash containing asmicrocapsules). In addition, microcapsules may be formulated to break in response to conditions that occur on the skin, so that upon application, the microcapsules act to release their contents in a time-controlled or controlled release manner. Exemplary non-limiting skin or hair conditions which may vary with the user environment, the variation of which may trigger microcapsule breakage, include pH, temperature, friction, light or air exposure, pressure and others.

Other forms of immobilization or retention of sunscreen and other active components are also useful. For example, as an alternative to the use of chemical sunscreen agents, the inventive compositions may utilize an organic sunscreen such as octyl methoxycinnamate retained within a matrix. A commercial example of such a composition is found in SunCaps ™ (brand, SkinCeuticals) where the organic sunscreen molecules are evenly distributed throughout the particle.

B. Non-sunscreen Assets

In one aspect, the invention provides additives containing a non-sunscreen active ingredient when the additive is designed to be added to a composition for topical application, for example, a body wash. These actives may be used in combination with the sunscreens described above in a sunscreen or sunscreen / body wash additive or may be used separately, non-sunscreen compositions. In some embodiments, at least one of the assets is encapsulated. In another aspect, the invention provides the composition for topical application, for example, a body wash containing one or more such actives. These actives may be used in combination with the sunscreens described above in a sunscreen or sunscreen / body wash additive or may be used separately, non-sunscreen compositions.

Non-limiting examples of a non-sunscreen active in the compositions of the invention include sunless tanning actives, skin lightening actives, anti-acne actives, anti-wrinkle and anti-aging actives, vitamins, anti-inflammatory actives, anesthetic actives , analgesic actives, anti-pruritic actives, anti-microbial actives (eg antifungal, antibacterial and anti-parasitic), anti-viral, anti-allergenic, medicinal actives (eg rash medications, skin disease and dermatitis), anti-cellulite additives, insect repellent actives, antioxidants, hair growth promoters, hair growth inhibitors, hair bleaching agents, deodorant compounds and combinations thereof.

Sunless tanning assets include dihydroxyacetone (DHA); glyceryl aldehyde; tyrosine and tyrosine derivatives such as malthyl tyrosine, tyrosine glycosinate and ethyl tyrosine; phospho-DOPA, indole ederivates and mixtures thereof

Non-limiting examples of skin lightening actives include EMBLICA (also an antioxidant), monobenzone (a depigmenting agent), kojic acid, arbutin, ascorbic acid and derivatives thereof (eg, magnesium ascorbyl phosphate or ascorbyl sodium phosphate) and extracts (eg , blackberry extract, placental extract). Non-limiting Examples of skin whitening agents suitable for use herein also include those described in WO 95/34280, WO 95/07432 and WO 95/23780.

Vitamins may be included in the compositions of the present invention, examples include Vitamin A and derivatives thereof (including, for example, retinol, see anti-wrinkle actives), ascorbic acid (Vitamin C and derivatives), Vitamin B (e.g., riboflavin, vitamin B2), biotin, Vitamin D (all forms), Vitamin E and derivatives thereof, such as tocopheryl acetate, beta carotene, pantothenic acid and mixtures thereof.

Anti-acne actives include benzoyl peroxide, erythromycin, clindamycin phosphate, 5,7-dichloro-8-hydroxyquinoline, resorcinol, resorcinol acetate, salicylic acid, azelaic acid, long chain dicarboxylic acids, sulfur, zinc, various natural agents such as those derived from green tree and mixtures thereof. Other non-limiting examples of suitable anti-acne actives for use herein are described in U.S. Patent 5,607,980, the disclosure of which is incorporated herein by reference.

Anti-wrinkle skin actives include a variety of agents, often in combination, that prevent or treat wrinkle through a variety of actions. Many methods are used to reduce the appearance of facial wrinkles based on an understanding of the molecular basis of wrinkle formation. Such treatments include cosmetic products, drug therapy and surgical procedures. For example, many cosmetic products include hydroxy acids, which can stimulate collagen synthesis. Another common treatment utilizes retinol, retinoid, retinol palmitate, a vitamin A derivative (or its strongest written version Retin-A and Renova) which aids in the production of collagen. Retinoid-like bicyclic aromatic compounds, which are Useful compounds, in particular for preventing or treating various keratinization disorders, are described in EP 679 630. These compounds are particularly active in repairing or combating actinic or chronological aging of the skin, for example, as in anti-wrinkle products. Antioxidants such as vitamin C and E and coenzyme Q-10 are believed to neutralize free radicals that damage cells and cause aging and are used in wrinkle treatment. Recently, the FDA-approved botox usocosmetics (an extremely dilute form of botulinum toxin) to treat glabella expression lines. Thus a non-sunscreen active of the invention which are anti-aging or anti-wrinkling active may contain, alone or in combination, the above defined bicyclic aromatic compounds, other compounds having retinoid activity, free radicals, hydroxy or keto acid decontaminants or derivatives thereof. The term "free radical decontaminant" refers to, for example, atocopherol, superoxide dismutase, ubiquinol or certain metal chelating agents. Hydroxy acids include, for example, alpha-hydroxy acids, such as lactic acid and glycolic acid or beta-hydroxy acids, such as salicylic acid and salicylic acid derivatives, such as the octanoyl derivative; other hydroxy acids and keto acids include malic, citric, mandelic, tartaric or glyceric acids or salts, amides or esters.

Other anti-wrinkling agents and skin anti-aging agents useful in the invention include sulfur-containing D and L amino acids and their derivatives and salts, particularly those of N-acetyl, whose preferred example is N-acetyl-L-cysteine; thiols, for example ethanethiol; fat-soluble vitamins, ascorbyl palmitate, ceramides, pseudoceramides (e.g., pseudoceramides described in US Patent 5,198,210; 4,778,823; 4,985,547; 5,175,321, all of which are incorporated herein by reference), phospholipids (e.g. distearoyl lecithinphospholipid), fatty acids, fatty alcohols, cholesterol, plant sterols, phytic acid, lipoic acid; lysophosphatidic acid and skin peeling agents (e.g. phenol and others) and mixtures thereof, the preferred fatty acids are those having straight or branched alkyl chains containing from 12 to 20 carbon atoms. A particularly preferred fatty acid is linoleic acid as linoleic acid aids in light ultraviolet absorption and is also a vital component of pelenatural lipids. Other non-limiting examples of suitable anti-wrinkle actives for use herein are described in U.S. Patent 6,217,888, the disclosure of which is incorporated herein by reference.

Anti-inflammatory actives include steroidal, non-steroidal and other compounds.

Non-limiting examples of steroidal inflammatory agents suitable for use herein include corticosteroids such as hydrocortisone, hydroxytriamcinolone, alpha-methyl dexamethasone, dexamethasone phosphate, beclomethasone dipropionates, clobetasol valerate, desonide, deoxymethasone, deoxycethasone diacetate, deoxycethasone acetate diflorasone, dediflucortolone valerate, fluadrenolone, fluclorolone acetonide, fludrocortisone, flumetasone pivalate, fluosinolone acetonide, fluocinonide, flucortinabutylester, fluprednidone (fluprednilidene), trisulfonide cortodoxone, flucetonide, fludrocortisone, difluorosone diacetate, fluradrenolone, fludrocortisone, diflurosone diacetate, fluradrenolonaacetonide, medrisone, amcinafel, amcinafide, betamethasone and the balance of these esters, chloropred nisone, chlorprednisone acetate, clocortelone, clescinolone, dichlorisone, diflurprednato, flucloronide, flunisolide, fluorometalone, fluperolone, fluprednisolone, hydrocortisone valerate, cyclopentylpropionone, hydrocortisone predpretone, hydrocortisone, hydrocortisone be used. The preferred steroidal anti-inflammatory for use is hydrocortisone.

Non-steroidal inflammatory agents are also suitable for use herein as skin active agents in the inventive compositions. Non-limiting examples of non-steroidal inflammatory agents suitable for use herein include oxicams (e.g., piroxicam, isoxicam, tenoxicam, sudoxicam, CP-14,304); salicylates (e.g., aspirin, disalcid, benorylate, trilisate, safaprin, solprin, diflunisal, fendosal); acetic acid derivatives (e.g. diclofenac, fenclofenac, indometacin, sulindac, tolmetin, isoxepac, furofenac, thiopinac, zidometacin, acematacin, fentiazac, clindanac, oxepinac, felbinac, ketorolac); mechaenamic acid, e.g. , flufenamic, niflumic, tolfenamic); propionic acid derivatives (e.g., ibuprofen, naproxen, benoxaprofen, flurbiprofen, ketoprofen, fenoprofen, fenbufen, indopropfen, pirprofen, carprofen, oxaprozine pranoprofen, miroprofen, thioxaprofen, suprofen, alminoprofen, thiaprofen; pyrazoles (e.g., phenylbutazone, oxyphenbutazone, feprazone, azapropazone, trimetazone); and combinations thereof, as well as any dermatologically acceptable salts or esters thereof. COX-2 inhibitors are also suitable for use herein and include, but are not limited to, AZD 3582 (ASTRAZENECA and NicOx), Celecoxib (PHARMACIA Corp.) (4- [5- (4-Inethylphenyl) -3- ( trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfonamide), Meloxicam (BOEHRINGER INGELHEIM Pharmaceuticals) (4-hydroxy-2-methyl-N- (5-methyl-2-thiazolyl) -2H-1,2GW-4063 81 (GLAXOSMITHKLINE), Etoricoxib (MERCK & Co.), Rofecoxib (MERCK & Co.) (4- [4- (methylsulfonyl) phenyl] -3-phenyl-2 (5H) - furanone), Lumiracoxib (NOVARTISPharma AG), Valdecoxib (PHARMACIA Corp.) (4- (5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonamide) and Etodolac (WYETH Ayerst Laboratories) ((. + -.) 1,8-diethyl-1, 3,4,9-tetrahydropyran [3,4-b] acid).

Other non-limiting examples of suitable or similar anti-inflammatory drugs, other active agents on the skin include candelilla wax, bisabolol (eg, alpha bisabolol), aloe vera, plant sterols (eg phytosterol), Manjista (extracted from plants of the genus Rubia, particularly Rubia Cordifolia) and Guggal (extracted from plants of the genus Commiphora, particularly Commiphora Mukul), cola extract, chamomile, red clover extract, sea whip extract, anise oil, garlic oil, ginger extract, vasoconstrictors such as hydrochloride Phenylephrine and combinations thereof.

Other non-limiting examples of suitable anti-inflammatories or other similar active agents in the skin include Licorice family compounds (the plant genus Glicirriza glabra), including glycyrretic acid, glycyrrizic acid and derivatives thereof (for example, esters salts). Suitable salts of the foregoing compounds include methanose salts of ammonium. Suitable esters saturated or unsaturated esters include C2 -C24 acids, preferably C10 -C24, more preferably C16 -C24. Specific non-limiting examples of the foregoing include oil-soluble licorice extract, glycyrrizic and glycyrrhizinate glycyrrizinate alone monopotassium, dipotassium glycyrrizinate, 1-beta-glycyrretic acid, stearyl glycyrretinate and 3-stearyloxy-glycyrretinic acid, 3-succinyloxy-beta-glycyrretinate disodium and combinations of these.

Anesthetic actives include butamben picrate, lidocaine, xylocaine, benzocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mepivacaine, tetracaine, diclonin, hexylcaine, procaine, cocaine, ketamine, pramoxin and its pharmaceutically acceptable phenol.

Analgesic actives include diclonin hydrochloride, aloevera, fentanyl, capsaicin and others.

Anti-pruritic actives include dealclometasone dipropionate, betamethasone valerate and isopropyl myristate MSD.

Antimicrobial actives include antifungal, antibacterial and antiseptic compounds. Antifungal compounds include, but are not limited to, compounds such as antifungal iridazole. Specific antifungal agents include butocouazole nitrate nitrate, miconazole, econazole, ketoconazole, oxiconizole, haloprogin, clotrimazole to butenafen HCl, naphthym, terbinafine, cyclopirox and tolnaftate. Antibacterial and antiseptic compounds include phenol-TEA complex, mupirocin, triclosan, chlorocresol, chlorbutol, iodine, clindamycin, CAE (Anjinomoto Co., Inc., containing L-Cocoyl Arginine ethyl ester Carboxylic acid pyrrolidone salt ), povidone-iodine, polymixin b sulfate-bacitracin, zinc-neomycin sulfate-hydrocortisone, chloramphenicol, antiseptic methylbenzethonium chloride and erythromycin (eg benzalkonium chloride, benzethonium chloride, chlorhexidine glyconate, mafone acetate, nitrofur nitromersol and others may be included in the compositions of the invention Many deodorant compounds are also antimicrobial (see below) Anti-parasitics such as lindane may also be included.

Other examples of antimicrobial and antifungal actives useful in the compositions of the present invention include, but are not limited to, (3-lactam, quinolone, ciprofloxacin, norfloxacin, tetracycline, amikacin, ether 2,4,4'- trichloro-2,2-diphenylhydroxy, 3,4,4'-trichlorocarbanilide, phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, ethambutol, hexamidine isethionate, metronidazole, pentamidine, phenamidine metacycline, methenamine, minocycline, neomycin, netylmycin, paromomycin, streptomycin, tobramycin, miconazole, tetracycline clondride, erythromycin, zinc erythromycin, erythromycin stearate, amicacin sulfate hydrochloride hydrochloride, dehydrocholinate, hydrochloride chlorate dechorexidine, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, chlorine ethambutol hydrochloride, demetronidazole hydrochloride, pentamidine hydrochloride, gentamycin sulfate, decanamycin sulfate, lineomycin hydrochloride, metacycline hydrochloride, methenamine mandrate, minocycline hydrochloride, deneomycin sulfate, netylomycin sulphate, deomycin sulfate tobramycin sulfate, miconazole hydrochloride, deamanfadine hydrochloride, amanfadine sulfate, octopirox, parachlorometa xylenol, nystatin, tolnaftate, zinc pyrithione and clotrimazole.

Compositions of the invention may include antiviral agents. Suitable antiviral agents include, but are not limited to, metal salts (e.g. silver nitrate, copper sulfate, iron chloride, etc.) and organic acids (e.g. malic acid, salicylic acid, succinic acid, benzoic acid, etc.) in particular compositions which contain additional suitable antiviral ingredients include those described in the copending Ser. 09 / 421,084 (Beerse et al.); 09 / 421,131 (Biederman et al); 09 / 420,646 (Morgan et al.) And 09 / 421,179 (Page et al), each deposited on October 19, 1999.

Anti-allergenic agents include antihistamines. Antihistamines may be from Hi or H2 antagonists or other types of histamine release inhibitors. H 1 antagonists may be either sedating or non-sedating. Examples of Hiinc sedative antihistamines include diphenhydramine (Benadril), chlorpheniramine, tripelenamine, promethazine, clemastine, doxylamine, benadril etc. Examples of non-sedating antihistamines H1 include astemizole, terfenadine, loratadine etc. Examples of H2 antagonists include cimetadine, famotidine, nizatidine and eranitidine. Examples of histamine release inhibitors include chromoline.

Another additive useful in the invention may be a medicament for treating dermatological conditions such as dermatological conditions such as psoriasis, acne, eczema and other skin conditions due to disease, condition, accident and the like. Medicines include burn relief aids such as o-amino-p-toluenesulfonamide monoacetate; dermatitis relieving agent, such as active steroidal amino acidity, diflorasone diacetate and hydrocortisone; diaper rash relief agents such as methylbenzetonium chloride and the like; medicines for treating herpes such as 0 - [(2-hydroxyethoxy) methyl] guanine; psoriasis, seborrhea and scabicidal agents such as shale oil and derivatives thereof, elubiol, ketoconazole, coal tar and petrolatum distillates, salicylic acid, zinc pyrithione, selenium sulfide, hydrocortisone, sulfur, menthol, psoralen, depramoxin hydrochloride, antraline and methoxsalen; steroids such as 2- (acetyloxy) -9-fluoro-1 ', 2', 3 ', 4'-tetrahydro-11-hydroxypregna-1,4-diene [1,6,17-b] naphthalene-3, 20-dione and 21-chloro-9-fluoro-r, 2 ', 3', 4'-tetrahydro-1H-hydroxypregna-1,4-diene [16z, 17-b] naphthalene-3,20-dione and others including those that are anti-inflammatory. Other medicinal products include those useful in treating exposure to poison oak, poisonous herb, sumagrevenenoso and others. These include camphor, menthol, benzocaine, butambenpicrate, dibucaine, dibucaine hydrochloride, dimethisoquine hydrochloride, diclonine hydrochloride, lidocaine, methacresol, lidocaine hydrochloride, pramoxin hydrochloride, tetracaine hydrochloride, tetracaine alcohol hydrochloride juniper, phenol, sodium phenolate, resorcinol, diphenhydramine hydrochloride, tripelenamine hydrochloride, hydrocortisone, corticosteroid and hydrocortisone acetate. Any other medication capable of topical administration may also be incorporated into the composition of the present invention in an amount sufficient to perform its intended function.

Anticellulite actives include isobutylmethylxanthine, caffeine, theophylline, theobromine, aminophylline, yohimbine and mixtures thereof.

Examples of actives suitable for treating hair loss include, but are not limited to, potassium channel openers and peripheral deodorators such as minoxidyl, diazoxide and compounds such as N * -cyan-N- (tert-pentyl) -N'-3 -pyridinyl guanidine ("P-1075") as disclosed US Patent 5,244,664, which is incorporated herein by reference: vitamins such as vitamin E and vitamin C and derivatives thereof, such as vitamin E acetate and vitamin C palmitate; hormones such as erythropoietin, prostaglandins such as prostaglandin E1 and prostaglandin F2-alpha; fatty acids, such as oleic acid; diruretics, such as spironolactone; heat shock proteins ("HSP"), such as HSP 27 and HSP 72; calcium channel blockers such as verapamil HCL, nifedipine and diltiazemamiloride; immunosuppressive drugs such as comocyclosporin and Fk-506; alpha-reductase inhibitors such as finasteride, growth factors such as EGF, IGF and FGF; beta growth factor transformer; tumor necrosis factor; non-steroidal inflammatory agents such as benoxaprofen; retinoids such as tretinoin, cytokines such as IL-6, IL-1 alpha and IL-1 beta; cell adhesion molecules such as ICAM; glycorcorticoids such as betamethasone; botanical extracts such as aloe, clove, ginseng, rehmania, swertia, sweet orange, zantoxilum, serenoa repens (saw palm), hypoxis rooperi, nettle, pumpkin seed and rye pollen; other botanical extracts including red beet root, chrysanthemum, rosemary, burdock root and other activators of hair growth promoters which are disclosed in DE 4330597 which is incorporated herein in its entirety; homeopathic agents such as Kalium Phosforicum D2, Azadirachta indica D2 and Joborandi D1; genes against male cytokines, growth factors and standardized baldness; antifungals such as ketoconazole and elubiol antibiotics such as streptomycin; protein inhibitors such as cycloheximide; acetazolamide; benoxaprofen; cortisone; diltiazem: hexachlorobenzene; hydantoin; nifedipine; penicillamine; phenotaiazines, pinacidyl; psoralens, verapamil; zidovudine; alpha-glucosylated rutin has at least one of the following rutins: quercetin, isoquercitrin, hespedine, naringin and methylsperidine, and flavonoids and transglycosylated derivatives of these are all disclosed in JP 7002677, which is incorporated herein and mixtures thereof, the loss treatment agents include minoxidyl, 6- (1-piperdinyl) -2,4-pyrimidinediamine-3-oxide, N-cyan-N- (tert-pentyl) -N-3-pyridinyl guanidine, finasteride, retinoids and derivatives thereof, ketoconazole, elubiol or mixtures thereof.

Examples of suitable actives for use in inhibiting hair development include: serine proteases such as trypsin, vitamins such as alpha-tocophenol (vitamin E) and derivatives thereof such as tocophenol acetate and tocophenol palmitate; antineoplastic agents such as doxorubicin, cyclophosphamide, chlormetine, methotrexate, fluorouracil, vincristine, daunorubicin, bleomycin and hydroxycarbamide; anticoagulants such as heparin, heparinoids, coumaerins, detranes and indandiones; antithyroid drugs such as iodine, thiouracils and carbimazole; lithium and lithium carbonate; interferons, such as interferon alfa, interferon alfa-2a and interferon alfa-2b; retinoids such as retinol (vitamin A), isotretinoin: glucocorticoids such as betamethasone and dexamethasone; antihyperlipidemic drugs such as triparanol and clofibrate; thallium; mercury, albendazole; allopurinol; amiodarone; amphetamines; androgens broinocriptine; butyrophenones; carbamazepine; cholestyramine; cimetidine clofibrate; danazol; desipramine; dixirazine; ethambutol; etionamide, fluoxetine; gentamicin, gold salts; hydantoins; ibuprofen; impramine, immunoglobulins; indandions; indomethacin; intraconazole; levadopa maprotiline; methysergide; metoprolol; metyrapone; nadolol; nicotinic acid; potassium thiocyanate; propranolol; pyridostimine; salicylates; sulfasalazine terfenadine; thiamphenicol; thiouracils; trimethadione; troparanol; valproic acid and mixtures thereof. Hair growth inhibitors include serine proteases, retinol, isotretinoin, betamethoisone, alpha-tocophenol and derivatives thereof or mixtures thereof.

Examples of hair bleaching agents include perborate or persulfate salts.

Deodorant compounds include astringent salts and bioactive compounds. Astringent salts include organic or inorganic salts of aluminum, zirconium, zinc and mixtures thereof, the salad-astringent anion may be, for example, sulfate, chloride, chlorine hydroxide, alum, formate, lactate, benzyl sulfonate or phenyl sulfonate. Exemplary classes of antiperspirant astringent salts include aluminum halides, aluminum hydroxyalides, zirconium oxyalides, and tenirconium hydroxyalides and mixtures thereof, exemplary aluminum salts include aluminum chloride and aluminum hydroxyalides having the general formula Al2 (OH) xQyXH20, where Q is chlorine, bromine or iodine; x is from about 2 to about 5; x + y is about 6, where x and y are not necessarily integers and X is about 1 to about 6. Exemplary zirconium compounds include hydroxy zirconium salts and hydroxy zirconium salts, also referred to as zirconyl salts and zirconyl hydroxy salts and represented by the general empirical formula ZrO (OH) 2 -nz Lz, wherein z ranges from about 0.9 to about 2 and is not necessarily an integer; n is the valence of L; 2-nz is greater than or equal to 0; and L is selected from the group consisting of halides, nitrate, sulfamate, sulfate and mixtures thereof.

Exemplary deodorant compounds therefore include, but are not limited to, aluminum bromoidrate, potassium alum, sodium aluminum chloride hydroxide lactate, aluminum sulfate, aluminum chlorhydrate, aluminum zirconium tetrachloride comglycine, aluminum zirconium trichlorochloride octochloride trichloride , aluminum sesquichloroidrexate, aluminum sesquichloroidrex PG, aluminumchloroidrex PEG, aluminum zirconium octachloroidrex glycine complex, aluminum zirconium pentachloroidrex glycine complex, aluminum zirconium tetrachloroidrex glycine complex, aluminum zirconium trichloridexyrine chloride, aluminum chlorochloride , aluminum dichloroidrex PG, aluminum dichloroidrex PG, aluminum chloride, aluminum zirconium pentachloroidrate, numerous other useful antiperspirant compounds listed on CTFAHandbook on p. 56, incorporated herein by reference and mixtures thereof. In addition to the astringent salts, the deodorant compound may be bacteriostatic quaternary ammonium compound, such as, for example, cetyl trimethyl ammonium bromide, cetyl pyridinium chloride, debenzethonium chloride, diisobutylbenzoxyethoxyethyldimethylbenzyl chloride , sodium N-lauryl sarcosine, sodium N-polymethyl sarcosine, lauroyl sarcosine, N-myristyl glycine, potassium N-lauroyl sarcosine and stearyl trimethyl ammonium chloride or a bioactive compound or a carbonate or bicarbonate salt such as carbonates and alkali metal bicarbonates and ammonium and tetralkylammonium carbonates and bicarbonates. Other useful deodorant compounds include copper chlorophyllin complex, aluminum chloride, aluminum chloride hexahydrate, and benzethonium methyl chloride.

Antioxidants are also useful in the formulations of. Suitable typical antioxidants include propyl esters, gedic acid octodic and edodecyl esters, butylated hydroxyanisole (BHA, commonly purchased as a mixture of ortho and meta isomers), hydroxytoluene-butylated (BHT), nordihydroguaiaretic acid, Vitamin A, ascorbic acid, and ascorbic acid and fatty acid. , ascorbic acid derivatives (eg magnesium ascorbyl phosphate, ascorbyl sodium phosphate, ascorbyl sorbate), tocopherol, tocopherol acetate, other tocopherol esters, tocotrienols and their esters and 6-hydroxy-2,5,7 acid, 8-Tetramethylchroman-2-carboxylic (commercially available under the brand name TROLOX). Other suitable antioxidants include uric acid and its salts and alkyl esters, sorbic acid and its salts, lipoic acid, amines (e.g. N, N-diethylhydroxylamine, amino guanidine), sulfhydryl compounds (e.g. glutathione, N-acetyl cysteine ), fumaric dihydroxy acid and its salts, lycinapidolate, arginine pilolate, nordihydroguaiaretic acid, bioflavonoids, curcumin, lysine, methionine, proline, superoxide dismutase, silymarin, tea extracts, bark / grape seed extracts, melanin and extracts of crecin may be used.

Preferred antioxidants are photostable antioxidants. An exemplary photoestable antioxidant is marketed under the EMBLICA brand name by EMDChemicals. See, for example, U.S. Patent 6,831,191. Antioxidants, preferably photostable antioxidants (e.g. EMBLICA), may be included in sunscreen additives of from about 0.05 to about 5% or about 0.05 to about 2% or about 0.1%, 0.2%, 0.3% or 0.4% in sunscreen / body washes from about 0.02 to about 2% or about 0.02 to about 1% or about 0.04%, 0 .06%, 0.08%, 0.1%, 0.2% or 0.3%.

Insect repellents include the most widely used active agent for personal care products, N, N-Diethyl-m-toluamide, often referred to as "DEFT" and available as a concentrate containing at least about 95 percent DEET. Other synthetic chemical repellents include dimethyl phthalate, ethyl hexanediol, indalone, di-n-propylisocincoronate, bicycloepten, ethohydrofuraldehyde dicarboximide. Certain plant-derived materials may also have insect repellent activity, including citronella oil and other decitronella sources (including lemon grass oil), limonene, rosemary oil, and eucalyptus oil. The choice of an insect repellent for incorporation into compositions of the invention will often be influenced by the repellent odor. The amount of repellent used will depend on the choice of agent, DEFT is useful at high concentrations, such as about 15 percent or more, while some of the plant derived substances are typically used in much smaller amounts, such as 0.1 percent. or less.

The compositions of the present invention may contain a wide range of additional active components. The CTFA Cosmetic Ingredient Handbook, Seventh Edition, 1997 and the Eighth Edition, 2000, which are incorporated by reference in their entirety, describe a wide variety of active ingredients commonly used in skin care compositions, which are suitable for use in skin care compositions. Other topically active compounds are listed in Remington's Pharmaceutical Sciences, 20th Ed., Lippincott Williams & Witkins, Baltimore, MD (2000) (hereinafter Remington's), US Pharmacopeia and National Formulary, The United States Pharmacopeial Convention, Inc. ., Rockville, Md. and Physician's Desk Reference, Medical Economics Co., Inc., Oradell, N.J. incorporated herein by reference.

The active non-sunscreen may be supplied as is or in encapsulated form. Encapsulation is described for sunscreen additives, above, in addition to the encapsulated active, in some additive embodiments or composition for topical application containing the active further including cationic polymer, as described herein, as well as optionally a film former. a preservative and / or an antioxidant that is stable on exposure to sunlight. Other components may be as described herein. In some embodiments the additive or composition for topical application may comprise two, three, four, five, six, seven, eight, nine, ten or more than ten assets, each of which may be be encapsulated or unencapsulated in any combination.

In preferred embodiments, the active is encapsulated sol-gel microcapsules, such as sol-gel silica microcapsules. Such microcapsules are described in U.S. Patent 6,238,650; 6,436,375. 6,303,149 and 6,468,509. Accordingly, in some embodiments the invention provides an additive for addition to a composition for topical application when the additive comprises an encapsulated non-sunscreen active and optionally further comprises a cationic polymer. In other embodiments the invention provides the composition for topical application which contains an additive when the additive comprises a non-sunscreen encapsulated active and optionally further comprises a cationic polymer.

Other ingredients include film formers, antioxidants, preservatives and other ingredients as listed herein. The composition for topical application may be, for example, a body wash.

In some embodiments the invention provides microcapsules, for example, sol-gel microcapsules (e.g., as described in US Patent 6,238,650; 6,436,375. 6,303,149; and 6,468,509) which acts as a protective barrier. on the skin when used alone or as an additive in a body wash. In these embodiments, the sol-gel microcapsules may be used without any additional (i.e. empty) active ingredients providing a physical barrier or they may be used with additional encapsulated active ingredients that enhance their barrier function. For example, the microcapsules may contain substances that act to evaluate toxic agents (e.g. biological or chemical decombating agents) or radiation (e.g. alpha, beta or gamma radiation) partially or completely from penetration into the skin of the user. In some embodiments, the microcapsules may contain one or more radiation absorbing agents such as graphite, lead, tungsten and others known in the art or radiation reflecting agents such as ceramic droplets. Because microcapsules can be designed to experience minimal or no breakage when applied to the skin, as well as experience minimal skin penetration, it is possible to use the same toxic substances (eg lead) that provide a protective effect, as these substances will not release or will be released only in minimum quantities. The microcapsules will eventually be removed by repeated washing and / or normal peeling of the outer skin cell layers. Especially for agents used at once or very few exposures, as may occur with personnel engaged in fighting or countering terrorist attacks or in combat, the invention provides a means of releasing a last line of defense into the skin of personnel when assets used in the microcapsules may be used. Rum that is not suitable for long-term use, but is suitable for a limited number of applications to protect the user from a higher risk (eg microcapsule encapsulating lead protects against radiation attack).

Microcapsules, for example, sol-gel microcapsules, may be prepared in order to experience minimal or no breakage when applied to the skin, as is or in the form of a body wash. Alternatively, microcapsules, such as microcapsules. can be prepared to experience varying degrees of breakage, on average, when applied as is or in a body wash. In this way, microcapsules, for example, sol-gel microcapsules, can be prepared to experience about 0% break or break in the range of about 0.1, 0.5, 1, 2, 5, 10. , 20, 30, 40, 50, 60, 70, 80 or 90% about 0.5, 1, 2, 5, 10, 20, 30, 40, 50, 60, 70, 80 or 90% after application (or application or rinsing in the case of a body wash containing a body wash containing the microcapsules). In addition, microcapsules may be formulated to break in response to conditions occurring on the skin, so that upon application the microcapsules act to release their components in a time release or in a controlled manner. Non-limiting exemplary skin or capillary conditions that may vary with the user's environment, the variation of which may trigger breakage of the microcapsules, include pH, temperature, friction, light or air exposure, pressure and others.

C. Cationic Component C

In some embodiments the additives, for example sunscreen and sunscreen / body wash additives of the invention further include a cationic component. Without being bound by theory, it is thought that this component serves as a protein binder to provide a positive charge to promote binding of the composition to skin and hair proteins, thereby increasing retention of components, eg sunscreen, after rinsing. and during normal activities. This positive charge creates a strong affinity for aprotein in the hair or skin. Any means of communicating a positive can be used.

Preferred means are including one or more polymerscionics in the composition. Various cationic polymers may be used. Examples of cationic polymers are described in U.S. Patent Nos. 6,224,852; 3,816,616; 4,272,515; 4,298,494; 4,080,310; 4,048,301; 4,009,256 and 3,186,911. cationic polymers are commercially available, for example, from Union Carbide Corp. under the brand POLIMER JR., from Celanese-Stein Hall under the brand JAGUAR, from GAF Corporation under the brand Gafquatm and Merck & Co., Inc under the brand MERQUAT. Representatives are Merquat 100, a highly charged cationic dimethylammonium chloride homopolymer and Merquat ™ 550, a highly charged cationic copolymer prepared with dimethyldiallylammonium chloride and acrylamide. These materials are named in the CTFA dictionary as Quaternium 40 and Quaternium-41, respectively.

Especially preferred are polyquatterns. Quaternized material in powder form, not limited to polyquaterns, may also be used. Exemplary polyquatterns for use in the invention include Polyquaternium-4, -7, -11, -22, -37, -44, -51 and -64. Polyquaternium compounds are commercially available, for example, CELQUAT L-200 for Polyquaternium-4. In addition, exemplary Polyquatranes may be quaternized vinylpyrrolidone, methacrylamide, vinylimidiazole quaternized and / or vinyl caprolate quopolized polymers. These would all vary with different charge densities. We are mainly concerned with those with larger cationic charges. We have listed some of the new Polyquaterns at 68, 46.16. Without being bound by theory, it is thought that with the entrapment of the encapsulated (for example, the sunscreen activator inside the capsule) by its cationic component, rinsing is difficult and repays the active noun for the protein in the skin and hair.

Useful in some embodiments of the invention is a dry cationic component, as sold under the brand name CAE (AnjinomotoCo., Inc.), containing DL-pyrrolidone Carboxylic acid salt of L-Cocoyl Arginine ethyl ester, which is a cationic agent. useful for protein binding and provide an antimicrobial effect.

In some additive embodiments, for example sunscreen additives, the cationic component (e.g., polymerocationic) comprises about 0.1 to about 20% or about 0.1 to about 10% or about 0.5 to about 10% or about 1 to about 10% or about 0.5 to about 5% or about 0.5 to about 3% or about 1 to about 5% or about 1 to about 3% or about 1% of the total composition. In some embodiments, the cationic component is Polyquaternium-4; In some embodiments, Polyquaternium-4 is present at about 1%.

In some active / body wash embodiments, for example, sunscreen / body wash, the cationic component (e.g., cationic polymer) comprises from about 0.03 to about 7% or about 0.03 to about 4. % or about 0.2 to about 4% or about 0.3 to about 4% or about 0.2 to about 2% or about 0.3 to about 4% or about 0.3 to about about 1%, or about 0.3 or 0.4% of the total composition. In some embodiments, the cationic component is Polyquaternium-4; in some embodiments Polyquaternium-4 is present at about 0.33. %.

D. Film Formatters

In some embodiments, the compositions of the invention further include a component that provides a cell barrier system, typically a hydrophobic layer that serves to maintain residual protector sols after rinsing. Film barrier systems are well known in the art and include, without limitation, petrolatum, derivatives and silicon, and combinations thereof, carboxylic-ended polymers that become insoluble until neutralized are also useful. After being neutralized, they can act as film formers. Film formers also include emollient esters, lanolin derivatives (eg acetylated lanolines) and super fatty oils. Cell former are commercially available, for example, a preferred cell former is MOISTUREGUARD ™ which contains petrolatum, dimethicone, stearamidopropyl dimethylamine stearate and tocopheryl acetate available from Engelhard.

It may also be desirable to add acrylic copolymers to the formulations of the invention as film formers. An exemplary liquid acrylic copolymer formulation is DERMACRILA, marketed by National Starch and Chemical. Acrylic copolymers may be included in sunscreen additives from about 0.1 to about 5% or about 0.2 to about 3% or about 0.2%, 0.3%, 0.4% or 0.5% or in sunscreen / body washes from about 0.05 to about 2% or about 0.1 to about 1% or about 0.05%, 0.1%, 0.2% 0.3%, 0.4% or 0.5%.

A secondary film former may also be used, for example, keratin or other protein derivative in a amino acid complex such as cysteine.

The film former may be present in the sunscreen additive in the range of from about 0.1 to about 25% or about 1 to about 10% or about 2 to about 6% or about 3, 4 or 5%. . In some embodiments, the MoistureGuard film former is used at a concentration of about 4.2%. Equivalent film formers at equivalent concentrations may also be used.

As noted, some preparations may perform more than one function, for example inorganic blockers such as Tioveil and Spectraveil (both from Tioxide Group), in certain variations, may be film forming and may be advantageous uses herein.

In addition, many emollients may also perform a film-forming function wherein it provides a barrier to the skin. Thus, the compositions of the invention may include water-insoluble emollients which include fatty acids such as oleic and stearic; fatty acids such as cetyl and hexadecyl (ENJAY); esters such as diisopropyl adipate, C9 -C15 alcohols benzoic acid esters and deisononyl iso nonanoate; alkanes, such as mineral oil, silicones; such as dimethylpolysiloxane and ethers such as polyoxypropylene butyl ethers and polyoxypropylene ethoxy ethers. If a water-insoluble emollient is used, it may be in an amount of from about 2% to about 15% by weight and more preferably from about 4% to about 10%.

Other useful film formers include polyethylenes, such as those available from New Phase Technologies as PERFORMALENE 400, a polyethylene having a molecular weight of 400. Another suitable waterproofing agent is polyethylene 2000 (molecular weight 2000), which is available from New Phase Technologies. as PERFORMALENE 2000.

In addition, another synthetic / waterproof film-forming agent is also available from New Phase Technologies as PERFORMA V-825. Yet another film-forming / waterproofing agent is octadecene / MA copolymer

Additional film formers which may also be used within the structure of the invention include any film-forming chemistry known in the art. Accordingly, suitable additional film formers include acacia gum, cellulose derivatives, guar derivatives and all those given on pages 68-69 of C.T.F.A. CosmeticIngredient Handbook, First Edition, 1988, which is incorporated into this reference. Such film formers include acrylamide copolymer, acrylamide / sodium acrylate copolymer, acrylate / acrylamide copolymer, acrylate / ammonium methacrylate copolymer, acrylate copolymer, acrylate / diacetoneacrylamide acrylic copolymer, acrylic acid copolymer adipic / dimethylaminohydroxypropyl diethylenotnamine, adipic acid / epoxypropyl / dietlenotramine copolymer, albumin, allyl stearate copolymer / VA, aminoethyl acrylophosphate / acrylate copolymer, ammonium acrylate copolymer, vinyl ammonium copolymer, ammonium copolymer of AMPacrylates / diacetoneacrylamide, balm of Canada, balm of Oregon, balm of Peru, tolu balm, copolymer of benzoic acid / anhydridophthalic / pentaerythritol / neopentyl glycol / palmitic acid, benzoin extract, butadiene acrylate copolymer, burylated formaldehyde, butyl benzyl acid copolymer phthalic anhydride oic / trimethylolethane, maleic ethylene anhydride butyl ester, PVM / MA copolymer butyl ester, calcium carrageenan, PVM / MA calcium / copolymer, carboxymethyl hydroxyethyl cellulose, cellulose gum, colodion, copa, cornstarch copolymer / acrylamide / sodium acrylate, damar, diethylene glycolamine / epichlorohydrin / piperazine copolymer, DMJ-IF, dodecanedioic acid / cetearyl glycol alcohol copolymer, ethylcellulose, ethylene copolymer / ethylene malolide copolymer, ethylene copolymer vinyl acetate, PVM / MA ethyl ester, colodianoflexible, gamma benzoin, gutta-percha, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxyethyl ethyl cellulose, hydroxypropylceylulose, hydroxypropyl guar, hydroxypropyl methylcellulose, PVM / MA, maltod resin, isopropyl docopolymer, maltod resin / formaldehyde, methacryloyl ethyl betainel methacrylates copolymer, nitrocellulose, octyl copolymer rilamida / acrylates / butilaminoetilmetacrilato, copolymer deoctilacrilamida / acrylates, anhydride copolymer phthalic / glycerol / decanoatode glycidyl, phthalic copolymer / trimellitic / glycols, polyacrylamide, ácidopoliaciilarnidometilpropano sulfonic acid, polyacrylic acid, depolibutileno terephthalate, polychlorotrifluoroethylene, polietilacrilato, polyethylene, polyethylene tereftalatode, polyisobutene , Polyquatern-1, Polyquatern-2, Polyquatern-4, Polyquatern-5, Polyquatern-6, Polyquatnium-7, Polyquatern-8, Polyquatern-9, Polyquatnium-10, Polyquatnium-11, Polyquatnium-13 -14, Polyquaternium-15, polystyrene, polyvinyl acetate, polyvinyl alcohol, polyvinyl butyral, polyvinyl imidazolinium acetate, polyvinyl laurate, polyvinyl methyl ether, potassiocarragenin, PVM / MA copolymer, PVP, PVP copolymer / dimethyl copolymer, PVP copolymer / dimethyl copolymer eicosene, PVP / ethyl methacrylate / α copolymer methacrylic acid, PVP / hexadecene copolymer, PVP / VA copolymer, PVP / devinyl acetate / itaconic acid copolymer, rosin, serum albumin, shellac, sodium deacrylate copolymer, sodium carrageenan, sodium polymethacrylate , sodium polystyrene sulfonate, starch / acrylates / acrylamide copolymer, stearyl vinylaminoethyl ester, stearyl vinyl ether / anhydridomaleic copolymer, styrene / acrylate / acrylonitrile copolymer, styrene copolymer / styrene anhydride copolymer, styrene copolymer / PVP, sucrose benzoate / sucrose isobutyrateacetate / butyl benzyl phthalate, benzoate disaccharide / acetate sucrose / butyl benzyl phthalate / methyl methacrylate copolymer, sucrose benzoate / sucrose copolymer isobutyrate sulfate formaldehyde sulfonate, devinyl acetate / crotonates copolymer, vinyl acetate copolymer / crotonic acid, vinyl acetate copolymer / crotonic acid / methacryloxybenzophenon-1, vinyl deacetate copolymer / crotonic acid / vinyl neodecanoate and zein.

Additional film formers include those disclosed in U.S. Patent 6,838,419; 6,838,088; 6,780,422; 6,531,118 and 5,916,541, all of which are incorporated herein by reference

E. Other Components

A wide variety of additional components may be added to the compositions of the present invention as long as the components are selected to avoid any undesirable reaction with the primary components (e.g., one or more of the sunscreen agents) of the composition. The CTFA Cosmetic Ingredient Handbook, Seventh Edition, 1997 and Eighth Edition, 2000 (incorporated by reference in this), provides a broad source of possible cosmetic ingredients and pharmaceutical ingredients typically used in skin care compositions. Examples of such additional components include one or more of the following: Absorbents, abrasives, anti-solidifying agents, antifoam agents, binders, biological additives, buffering agents, fillers, chelating / sequestering agents (eg disodium EDTA), additives chemicals, dyes, cosmetic astringents, biocidascosmetics, denaturants, medicine astringents, emollients (including glycerin aloevera and Vitamins A, C and D [skin moisturizing and protective agents]), foam enhancers, fragrance components, gums, humectants / humidifiers ( including urea, guanidine, glycolic acid, polyhydroxy alcohols, such as sorbitol, glycerine, hexanotriol, propylene glycol, hexylene glycol and others, polyethylene glycol, amino acids, sugar and starch derivatives, D-panthenol, hyaluronic acid, lactamide monoethanolamine, acetamide monoethanolamine and mixtures thereof), hydrotropes, neutralizing agents, opacifying agents dyes and pigments, pH adjusters, plasticizers, preservatives, propellants, reducing agents, skin bleaching agents, skin protectors, solubilising agents and suspending agents (eg Carbomer 1382).

In some embodiments, the body wash additives and washings of the invention, for example sunscreen or sun shield / body wash additives include a preservative. Exemplary preservatives useful in the invention include citric acid, tartaric acid, phosphoric acid, iminodiacetic acid, nitrilotriacetic acid, hydroxyethyleneaminodiacetic acid and ethylenediaminetetraacetic acid and salts thereof, such as butyl paraben, methyl paraben and propylparaben; imidazolines (eg, imidiazolinylurea), triclosan, hydantoins (eg, dimethyloldimethylidantoin), isothiazolidinone compounds and mixtures thereof, commercially available preservatives include KATON CG and KATON CGII, which contain methylchlorisothiazolinone and methylisothiazolinone (Rohm and and). When present, the amount of preservative is in the range from 0.001 to 2%, preferably from 0.01 to 0.2%. In certain embodiments, the compositions of the invention include a chelating agent. Chelating agents are substances used to chelate or bond metal ions, such as with a heterocyclic ring structure such that the ion is maintained by the chemical bonds of each of the participating rings. Suitable chelating agents include ethylene diaminetetraacetic acid (EDTA), disodium EDTA, disodium calcium edetate, trisodium EDTA, tetrasodium EDTA and dipotassium EDTA. One or more chelating agents may optionally be included in the additives or body wash / additives in amounts ranging from about 0.001 to about 0.2 weight percent or about 0.01 weight percent.

thickening or gel-forming agents may be added as desired to adjust the texture and viscosity of the composition. Exemplary or gel forming agents may be selected from Carbopol ™ resins [e.g., 934, 971, 974, 980, 981] ePemulen ™ [TR-1 and TR-2] [both Carbopol ™ and Pemulen ™ are registered trademarks of BF Goodrich ], Noveon AA-1, ETD resins and Ultrez ™ resins [registered trademark, BF Goodrich]. In addition, carbomers should be useful for this purpose.

It may be desired to include a nonpolar wax. Examples of such useful waxes include ester waxes, diester waxes, hydrocarbon waxes, silicon waxes and triglyceride waxes and mixtures thereof.

Other components may include a hydrocarbonetoliquid (similar to pentane) and / or a dearginine and / or cysteine derived cationic foaming agent.

Additional optional ingredients which may be present in the composition include fragrance, pigments, antimicrobial materials such as triclocarban, triclosan, iodophores, diode formulations, phenolic compounds, for example hexachlorophene and bisbiguanides, for example chlorhexidene glyconate and others. See, for example, U.S. Patent No. 8,827,795; 6,517,854; 6,010,817; 5,173,216; 5,719,113; 5,259,984; 5,562,912; 5,629,006; 5,728,662; 5,767,163; 5,750,579; 5,591,442; 5,650,143; 5,772,640; and 4,478,821.

The components of the composition are generally mixed in water.

F. Surfactants and Body Washes

Compositions of the invention may be formulated as skin wash products, for example, bath gels, hand wash compositions or facial wash liquids; pre and post shave products; rinse, scrub and non-rinse products; hair wash and dental care products. Bath gels are particularly preferred forms of product.

It is desired to prepare a sunscreen / body wash composition, the sunscreen additives of the invention may be combined with other ingredients for the production of a body wash (e.g. a liquid or solid formulation). The sunscreen / body wash may include one or more surfactants. The use of surfactants and body washings is well known in the art. Any surfactant known in the art and appropriate for the body wash composition may be used. See, McCutcheon's Detergents & Emulsifiers, M.C.Publishing Co. (North American edition 1959); Schwartz, et al., SurfaceActive Agents, Their Chemistry and Technology, New York, IntersciencePublishers, 1949 and U.S. Patent 6,096,697; 4,741,855; 4,788,066; 5,104,646; 5,106,609; 2,658,072; 2,438,091; 2,528,378; 2,486,921; 2,486,922; 2,396,278; 2,979,465; 3,179,599; 5,322,643; 5,084,212; 3,332,880; 4,122,029; 4,265,878; 4,421,769; 3,929,678; 3,959,461; 4,387,090; 4,303,543 and 6,224,852 and British Patent Nos. 848,224 and 791,415. See also CTFACosmetic Ingredient Dictionary, 4th Edition 1991, pages 509-514 for various long chain alkyl cationic surfactants and Richmond, James M., Cationic Surfactants, Mareei Dekker, Inc., New York and Basel, 1990.

The surfactants may be cationic, anionic, nonionic, zwitterionic, amphoteric or any combination thereof.

Specific examples of anionic surfactants include those selected from the group consisting of alkyl and etheralkyl sulfates, sulfated monoglycerides, sulfonated olefins, alkyl aryl sulfonates, alkane primary sulfonates, dealkyl sulfosuecinates, acyl taurates, acyl isethionates, alkylglyceride sulfate esters , sulfonated fatty acids, alkyl phosphates, ethoxylated alkyl phosphates, acyl glutamates, acyl sarcosinates, alkyl sulfoacetates, acid peptides, alkyl ether carboxylates, acillactylates, anionic fluorine surfactants and combinations thereof, anionic surfactants can be used Effective in the present invention, specific examples of alkyl sulfates which may be used are sodium, ammonium, potassium, magnesium or TEA salts of lauryl sulfate or myristyl. Examples of alkyl ether sulfates which may be used include ammonium, sodium, magnesium or TEA laureth-3 sulfate.

Another suitable class of anionic surfactants are sulphated osmoglycerides of the form R 1 CO - 0 - CH 2 -C (OH) H - CH 2 O -SO 3 M, wherein R 1 is a branched or unbranched alkyl or branched group of about 8 to about 24 carbon atoms and M is a water-soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. An example of a sulphated monoglyceride is sodium cocomonoglyceride sulphate.

Other suitable anionic surfactants include deolefin sulfonates of the form R1SO3M, wherein R1 is a mono olefin having from about 12 to about 24 carbon atoms and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine. emonoethanolamine. An example of a sulfonated olefin is C14 / C16 sodium olefin sulfonate.

Other suitable anionic surfactants are linear alkylbenzene sulfonates of the form R'-C6H4-SO03M, wherein R1 is a saturated or unsaturated, branched or unbranched alkyl group of from about 8 to about 24 carbon atoms and M is a soluble cation. in water such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. An example of this anionic surfactant is sodium dodecylbenzene sulfonate.

Still other suitable anionic surfactants for the compositions of the present invention include the primary and secondary alkane sulfonates of the form R 1 OsM, wherein R 1 is a branched or unbranched saturated or unsaturated alkyl chain of from about 8 to about 24 atoms. of carbon and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. An example of a useful alkane sulfonate in this is alkali metal or ammonium C13 -C17 paraffin sulfonates.

Still other suitable anionic surfactants are alkyl sulfosuccinates, which include disodium N-octadecyl sulfosuccinate; lauryl sulfosuccinate diammonium; Tetrasodium N- (1,2-dicarboxyethyl) -N-octadecylsulfosuccinate; sodium sulfosuccinic acid diamyl ester; sodium sulfosuccinic acid dixyl ester and dioctyl sodium sulfosuccinic acid esters.

Also useful are taurates which are based on taurine. Examples of taurates include N-alkyltaurines, such as one prepared by the reaction of dodecylamine with sodium isethionate as detailed in U.S. Patent 2,658,072.

Another class of suitable anionic surfactants is acyl isethionates. Non-limiting examples of these acyl isethionates include ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate and mixtures thereof. Still other suitable anionic surfactants are R1-OCH2-C (OH) H-CH2- SO3, wherein R1 is a branched or unbranched saturated or unsaturated alkyl group of about 8 to about 24 carbon atoms and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. An example is sodium cocoglyceryl ether sulfonate.

Other suitable anionic surfactants include: R1-CH (SO4) -COOH sulfonated fatty acids and R1-CH (SO4) -CO-0-CH3 methylsulfonated esters, where R1 is a saturated or unsaturated, branched or branched alkyl group. unbranched from about 8 to about 24 carbon atoms (e.g., alpha sulfonated coconut fatty acid and methyl lauryl ester); phosphates, such as monoalkyl, dialkyl and trialkylphosphate salts formed by the reaction of phosphorus pentoxide with unamidified monohydric alcohols having from about 8 to about 24 carbon atoms (e.g., mono or dilauryl phosphate, ethoxylated monoalkyl phosphates, etc. ); acyl glutamates of the formula wherein R 1 is a branched or unbranched saturated or unsaturated alkyl or alkenyl group of about 8 to about 24 carbon atoms and M is a soluble cation in water (for example sodium lauroyl glutamate and cocoyl sodium glutamate); alkanoyl sarcosinates which correspond to the formula R1CON (CH3) -CH2CH2-CO202 wherein R1 is a saturated or unsaturated, branched or unbranched alkyl group of from about 10 to about 20 carbon atoms and M is a soluble cation in water (e.g. sodium lauroyl sarcosinate, sodium cocoyl sarcosinate and ammonium lauroyl sarcosinate); alkyl ether carboxylates corresponding to the formula R1- (OCH2CH2) x -OCH2-CO2 where R1 is a branched or unbranched saturated or unsaturated alkyl or alkenyl group of about 8 to about 24 carbon atoms, xedelalOeM is a soluble cation in water (e.g. sodium laureth carboxylate); acyl lactylates corresponding to the formula wherein R1 is a branched or unbranched saturated or unsaturated alkyl or alkenyl group of from about 8 to about 24 carbon atoms x is 3 and M is a water soluble cation (e.g. sodium cocoyl lactylate); carboxylates, non-limiting examples of which include sodium lauroyl carboxylate, sodium cocoyl carboxylate and ammonium lauryl carboxylate; anionic fluorotensive agents and natural soaps derived from the saponification of animal and vegetable fats and oils, examples of which include sodium laurate, sodium myristate, palmitate, stearate, tallow, cocoate.

Any counterion, M, can be used in the anionic surfactant. Preferably, the counter cation is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine and triethanolamine.

Nonlimiting examples of nonionic surfactants that may be included in the compositions of the present invention include those selected from the group consisting of alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides and mixtures thereof.

Alkyl glycosides and alkyl polyglycosides are also useful herein and may be broadly defined as condensation products of long chain alcohols, for example C8.3 alcohols, with sugars or starch or starch polymers, ie glycosides or polyglycosides. These compounds may be represented by the formula (S) -O-R wherein S is a sugar moiety such as glucose, fructose, mannose and galactose; n is an integer from about 1 to about 1000 and R is a Cs-30 alkyl group. Examples of long chain alcohols from which the alkyl group may be derived include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and the like. Preferred examples of these surfactants include those wherein S is a glucose moiety, R is a C8-20 alkyl group and n is an integer from about 1 to about 9. Commercially available examples of these surfactants include decyl polyglycoside (available as APG 325 CS by Henkel) and polyglycoside lauryl (available as APG 600CS and 625 CS by Henkel). Sucrose ester surfactants such as sucrose cocoate and sucrose laurate are also useful.

Other useful nonionic surfactants include polyhydroxy fatty acid amide surfactants, more specifically examples including glucosamides. Processes for the manufacture of polyhydroxy fatty acid amide-containing compositions are disclosed, for example, in Descriptive Report G.B. Pat. 809,060, published February 18, 1959, to Tomas Hedley & Co., Ltd .; U.S. Patent 2,965,576 issued to E. R. Wilson, filed December 20, 1960; U.S. Patent 2,703,798, issued to A. M. Schwartz, filed March 8, 1955; and U.S. Patent 1,985,424 issued to Piggott, filed December 25, 1934.

Other examples of nonionic surfactants include amine oxides. Amine oxides correspond to the general formula wherein R 1 contains an alkyl, alkenyl or monohydroxy alkyl radical of from about 8 to about 18 carbon atoms, from 0 to about 10 portions of ethylene oxide and from 0 to about 1 portion of glyceryl and R2 and R3 contain from about 1 to about 3 carbon atoms and from 0 to about 1 hydroxy group, for example methyl, ethyl, propyl, hydroxyethyl radicals or hydroxypropyl. The arrow in the formula is a conventional representation of a semipolar bond. Examples of amine oxides suitable for use in this invention include dimethyl dodecylamine oxide, oleyldi (2-hydroxyethyl) amine oxide, dimethyloctylamine oxide, dimethyl decylamine oxide, dimethyl tetradecylamine oxide, 3.6 oxide 9-trioxaeptadecyldiethylamine, di (2-hydroxyethyl) tetradecylamine oxide, 2-dodecoxyethyl dimethylamine oxide, 3-dodecoxy-2-hydroxypropyl) (3-hydroxypropyl) amine oxide, dimethylexadecylamine oxide.

The term "amphoteric surfactant" as used herein is also intended to encompass zwitterionic surfactants, which are well known to those skilled in the art as a sub-series of amphoteric surfactants.

A wide variety of amphoteric foaming surfactants may be used in the compositions of the present invention, particularly useful are those which are widely described as derivatives of aliphatic secondary and tertiary amines, preferably wherein nitrogen is in a cationic state, where aliphatic radicals may be present. be straight chain or branched and wherein one of the radicals contains an ionizable water solubilizing group, for example carboxy, sulfonate, sulfate, phosphate or phosphonate.

Non-limiting examples of amphoteric or zwitterionic surfactants are those selected from the group consisting of betaines, sultaines, hydroxysultaines, alkyliminoacetates, iminodialcanoates, aminoalkanoates and mixtures thereof.

Examples of betaines include higher alkyl betaines such as coco dimethyl carboxymethyl betaine, lauryl dimethyl carboxymethyl betaine, lauryl dimethyl carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine (available as Lonzaine 16SP from Lonza Corp.), lauryl bis- (2) -hydroxyethyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betaine, lauryl bis- (2-hydroxypropyl) alpha-carboxyethyl betaine, coco dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, lauryl bis- (2-hydroxyethyl) sulfopropyl betaine, amidobetaines and (wherein the RCONH (CH2) 3 radical is attached to the betaine nitrogen atom), oleyl betaine (available as Henkel amphoteric Velvetex OLB-50) and cocamidopropyl betaine (available as Henkel Velvetex BK-35 and BA-35).

Examples of sultaines and hydroxysultaines include materials such as cocamidopropyl hydroxysultaine (available as Mirataine CBS from Rhone-Poulenc).

Examples of amphoteric surfactants of the present invention include the following compounds: Cetyl dimethyl betaine (this material is also referred to as cetyl betaine CTFA); Cocamidopropyl betaine; Cocamidopropyl hydroxy sultaine. Examples of other useful amphoteric surfactants are alkyliminoacetates and iminodialanoates and aminoalkanoates of the formulas RN [(CH2) CO22] 2 and RNH (CH2) mCO2M where med4, R6 alkyl or alkenyl C1 -C22 and M is H, alkali metal, alkaline earth metal , ammonium or alkanolammonium. Also included are imidazolium and ammonium derivatives. Specific examples of suitable amphoteric surfactants include sodium 3-dodecyl aminopropionate, sodium 3-dodecylaminopropane sulfonate, N-higher alkyl aspartic acids such as those produced according to the disclosures of U.S. Patent 4,438,091; and products sold under the brand name "Miranol" and described in U.S. Patent 2,528,378. Other examples of useful amphoterics include amphoteric phosphates, such as coamidopropyl PG-dimonium chloride phosphate (commercially available as Monaquat PTC from Mona Corp.). Also useful are amphoacetates such as disodium lauroamphodiacetate, sodium lauroanfoacetate and mixtures thereof.

In preferred embodiments, the sunscreen / body wash of the invention includes at least one cationic surfactant. Many cationic surfactants are known in the art. Suitable cationic surfactants include, but are not limited to, fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof. Suitable fatty amines include monalkyl quaternary amines such as cetyltrimethylammonium bromide. Suitable quaternary amine is dialkylamidoethyl hydroxyethylammonium methosulfate. By way of example, the following may be mentioned: stearyldimentylbenzylammonium chloride; dodecyltrimethylammonium chloride; nonylbenzylethyldimethylammonium nitrate; tetradecylpyridinium bromide; laurylpyridinium chloride; cetylpyridinium chloride; laurylpyridinium chloride; laurylisoquinolinium bromide; tallow (hydrogenated) dimethyl ammonium chloride; dilauryldimethyl ammonium chloride; and stearalconium chloride.

Additional cationic surfactants are disclosed in U.S. Patent 4,303,543 see column 4, line 58 and column 5, lines 1 to 42, incorporated herein by reference. See also CTFA Cosmetic Ingredient Dictionary, 4th Edition 1991, pages 509-514 for various long chain alkyl cationic surfactants; incorporated herein by reference.

Total surfactants, eg cationic surfactant, may be present in sunscreen / body wash from about 0.1 to about 20% or from about 0.1 to about 10% or from about 0.1 to about 10%. about 5% or about 0.5 to about 5% or about 1 to about 10% or about 1 to about 5% or about 0.1 to about 2% or about about 1 to about 2%. In some embodiments, a sunscreen / body wash composition of the invention contains a surfactant, for example a cationic surfactant, of about 1%.

In addition to surfactants, other ingredients as described above for additives may be included in the additive / body wash. Any component known in the art or useful in body wash may be used.

In some embodiments, soap-free cleansers may be used in addition to or instead of soap / surfactants. For example, Oilatum® AD (trademark Stiefel Laboratories), Aquanil® (trademark Person & Covey, Inc.), Cetafil® (trademark Galderma Laboratories, Inc.) or SpectroDerm® (trademark Draxis Pharmaceutical Inc .) or equivalents thereof may be used as a soap-free component in the present invention. As mentioned above, the sunscreen additives of the invention may also be combined with conventional body wash compositions as well as hair shampoos and compositions. of skin care after washing. The proportions for addition and mixing are given above as well as in more detail below. An exemplary body wash that can be used with additives of the invention is exemplified by SUAVE Body Wash. Ingredients of a typical GENTLE Body Wash include: Water, Ammonium Lauryl Sulphate, Ammonium Laureth Sulphate, Cocamidopropyl Betaine, Fragrance, Glycerin,

10 Hydrolyzed Milk Protein & Honey Extract, PEG-10 Sunflower Glycerides, Cocamide MEA, Guar Hydroxypropylammonium Chloride, Acrylate Copolymer, PEG-5 Cocamide, Helianthus Anuus (Sunflower) Seed Oil or Soy Glycine Oil ( Doja), Tetrasodium EDTA, Propylene Glycol, Ammonium Chloride, Sodium Hydroxide, Methylchlorisothiazolinone, Methylisothiazolinone, Titanium Dioxide (Cl 77891) II. Preparation Methods

The compositions of the invention may be prepared by any suitable method. In a preferred method, a "Phase I," which is an "aqueous phase," is prepared by mixing the most water-soluble components of the composition. For example, Polyquaternium-4, a film former (e.g., in MOISTUREGUARD) and encapsulated sunscreen (e.g., UV PEARLS) can be mixed to uniform. A "Phase II," which is an "oil phase," is prepared by mixing the more hydrophobic components of the composition. For example, Avobenzone (e.g. PARSOL 1789) may be mixed with Octocrylene, with heating, until dissolved. Then Phase I and Phase II are combined with gentle stirring until a uniform composition is obtained (Phase III). Phase III may be further combined with the body wash composition (e.g., GENTLE body wash) and mixed until uniform. Another sunscreen, such as titanium dioxide, may be added to the Stage III / body wash composition and mixed until uniform. Alternatively, sunscreen may be added prior to addition to body wash or soap to provide a formulation-ready additive with body wash or soap. Use

Additives, for example, sunscreen additives of the invention are generally designed to be used in combination with body wash. Accordingly, the compositions of the invention are typically designed to be applied under wash. This feature facilitates use and may have additional benefits of being cumulative. The compositions of the present invention are readily applied during washing in a suitable or effective amount and may generally be applied to the entire body.

Shampoos can be applied specifically to the hair. A selected amount of the composition may be applied directly to the skin or may be used by intermediate application to a wash cloth, pad or sponge or other applicator. After lathering, removing dirt and crust from the skin can be washed off by rinsing with water leaving behind one or more of the additives, for example sunscreen components. Additives of the invention, for example sunscreen additives of the invention are also useful in shampoos and hair conditioners and after-wash lotions.

Thus, the methods of the invention include methods for protecting the skin from sunlight, comprising applying body wash comprising a sunscreen to the skin, wherein after applying body wash to the skin and rinse, the skin is protected from light. with an average SPF of at least about 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 or more than 20. In some preferred embodiments, the skin is protected from sunlight with an average SPF of at least about 2. In some preferred embodiments, the skin is protected from sunlight with an average SPF of at least about 2. 5. In some preferred embodiments, the skin is protected from sunlight with an average SPF of at least about 10. In some preferred embodiments, the skin is protected from sunlight with an average SPF of at least about 10. 15. In some embodiments, body wash is applied more than once; in such cases the SPF may be cumulative and may increase with the second wash, for example up to an average of more than 2, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45 or more than about 45. In some embodiments body wash is applied once a day. In some embodiments, body wash is applied more than once a day, for example 2, 3, 4 or more than 4 times a day. In some embodiments, body wash is applied every other day. In some embodiments, body wash is applied about 10, 8, 7, 6, 5, 4, 3, 2 or 1 time per week.

In these methods, the active additive, eg sunscreen, often does not penetrate beyond a certain level into the skin, typically due to encapsulation. Thus, in some embodiments of the methods of the invention, the active additive, e.g. sunscreen, does not penetrate more than about 10, 20, 25, 30, 35, 40, 45 or 50 microns into the skin with a wash. with the body wash containing the additive. In some embodiments, the active additive, for example sunscreen, does not penetrate more than about 10, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 120 or 150 microns on the skin, even with repeated washes.

In other embodiments the sunscreen or other additive is designed to penetrate the skin, thus in these embodiments the active additive, for example sunscreen, penetrates at least about 10, 20, 25, 30, 35. , 40, 45 or 50 microns in the skin with a body wash containing the additive. In some embodiments, the active additive, for example sunscreen, does not penetrate more than about 10, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 120 or 150 microns in the skin. In some embodiments this penetration occurs with a single wash and rinse. In some embodiments this penetration occurs with repeated washes and rinses.

Any additive described herein, for example sunscreen additives, generally as a body wash component, may be used in the methods of the invention. In some embodiments, the additive is an additive other than sunscreen and is encapsulated, for example, in the form of sol-gel microcapsules. In these embodiments, the additive may be used in combination with a non-body wash vehicle such as a skin lotion, gel, cream and the like as are well known in the art.

While it is generally preferred to use the compositions of the present invention in a manner similar to ordinary soap (i.e. wetting, applying the composition, rinsing), it is also envisaged that the composition may be used for application without wetting followed by removal, e.g. through towel rubbing. This is the case for soap free cleaners.

C. Commercial Methods

The invention also encompasses methods of doing business in the field of topical release of cosmetic products and transdermal release of pharmaceutical products using soap products, including soap and shampoo for daily use, such as release agents.

Consumers spend more than $ 30 billion annually on products that take advantage of topical and transdermal delivery methods. Despite huge growth in this area, there have been few major innovations. Most release methods still rely on lotions, creams or patches. By combining a cosmetic product or even a pharmaceutical regimen with activity as routine as washing or showering, the commercial methods of the invention capture a significant portion of the topical and transdermal delivery market. The products enable manufacturers of personal care products to secure a growing market share for cosmetic products, such as sunscreen, by intensifying existing product lines. These will also enable drug manufacturers to offer consumers more attractive ways to administer a pharmaceutical product under a prescription and to sell them freely.

Commercial methods of the invention comprise a business-doing method comprising marketing an additive for use with an existing body wash, wherein the additive, when combined with body wash, has an additional effect to the normal effect of soap or body wash. Commercial methods include methods that involve any of the additives described herein, including sunscreens, insect repellents, anti-acne medications, anti-wrinkle agents, deodorants and all others described herein. In some embodiments, the methods include marketing a sunscreen benefit agent (additive) for use with body wash, for example bar and liquid soaps and shampoos, to add the benefit of a sunscreen. The sunscreen may be any of the sunscreen additives described herein. This embodiment is designed to attract soap makers looking to expand the market for their products among the growing population of consumers concerned about skin cancer and wrinkles. In general, the benefit agent is marketed as a brand neutral additive for use with existing brands. In some cases, a standalone tag may be created.

Sunscreen or other benefit agents may be licensed as an additive, in both liquid and embarking soap forms, to personal care product manufacturers of all sizes to enhance and differentiate their product offering. The license may be exclusive or preferably non-exclusive. If exclusive, it may be exclusive in a defined geographic territory, for a defined period of time (often with an option to renew or right to first decline at the expiration of the period of time), for a defined type of skin care product or any combination of these. The methods also include providing one or more customers with an option to license or purchase the additive, usually for a defined period of time. As with licenses, such an option may be exclusive or non-exclusive. Alternatively, sunscreen or other benefit agent may be manufactured and supplied to personal care product manufacturers. Another alternative is to manufacture a standalone soap / body wash brand that includes the additive.

Another component of the commercial methods of the invention typically includes receiving payment to provide the additive, license or the like to the customer. It will be appreciated that "payment" may be any form of consideration, including monetary consideration. License payments typically take the form of a direct payment, royalty, license maintenance fees or some combination thereof. Also included in the payment options are participation in the company receiving the additive or license to the additive. It will be appreciated that any other consideration may also constitute payment in the commercial methods of the invention.

Commercial methods of the invention may further include manufacturing the additive and / or the additive / body wash. In some embodiments, different entities perform different aspects; for example, a first entity may manufacture the additive and the second entity may market and / or distribute it. In some embodiments, a single entity performs both manufacturing and marketing.

Commercial methods of the invention further include a method comprising the steps of: a) designating an additive for use in the personal care product; b) testing the additive for safety and efficacy in humans; c) organize the distribution and marketing of the additive. In some embodiments, steps a) and c) are performed by a first entity, typically a business entity, and step b) is performed by a second entity, such as the business entity or an academic entity. In some or these embodiments, step b) is performed as a joint venture between the two entities.

All publications and patent applications mentioned in this specification are hereby incorporated by reference to the same degree as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.

It will be apparent to one of ordinary skill in the art that many changes and modifications may be made to the disclosures herein without departing from the spirit or scope of the appended claims. EXAMPLES EXAMPLE 1

A sunscreen additive for addition to a body wash was prepared as follows: To 13.7 g of water was added 1 g of polyquaternium-4 (CELQUAT-200), 1.5 g of MOISTUREGUARD and 12 g of UV PEARLS. The mixture was stirred until uniform to produce Phase I. Separately 1 g of PARSOL 1789 was added to 4 g of Octocrylocene with heating and stirred until uniform to produce Phase II. Phase I and Phase II were combined with gentle to uniform agitation to produce Phase III, a sunscreen additive.

The Phase III sunscreen additive was added to 64.5 g of SUAVE Body Wash and stirred until uniform. Finally, 2.3 g of titanium dioxide was added with stirring. The final composition was a sunscreen / body wash.

EXAMPLE 2

The sunscreen / body wash from Example 1 was tested for SPF capacity as follows: 50 cm 2 test site was moistened with 10 ml of water released with a syringe. The test sample was applied as per C.F.R. 21 of the FDA to the area. The soap was worked on the patient for 3 minutes to allow the skin to absorb the product. The area was rinsed after an additional 2 minutes with 20 ml of water, then the area was wiped and left 15 minutes before radiation exposure as per the FDA monograph. The skin was exposed to UV radiation and MED was noted and compared with MED for untreated skin. Results are shown in the table below.

Table (Soap Method *)

<table> table see original document page 67 </column> </row> <table>

MED: Minimal Erythema Dose

I: Light source intensity

This Example demonstrates that sunscreen / body wash enhanced sun protection as measured by this protocol when compared to untreated skin by an average SPF of more than 18.

EXAMPLE 3

A sunscreen / body wash is prepared by mixing the following ingredients: 0.1 to 7.5 parts by weight of octyl methoxy cinnamate, 0.1 to 6 parts by weight of octyl salicylate, 0.1 to 5 parts by weight. oxybenzone, 1 to 10 parts by weight of cationic surfactant, 0.01 to 1 parts by weight of a quaternized compound and 0.01 to 1 parts by weight of a preservative.

EXAMPLE 4

A sunscreen / body wash is prepared by mixing the following ingredients:

Water 20 to 65%

Poliquat4 0.01 to 3.75%

Dimethicone 0.01 to 7%

Amorphous Silica Octylmethoxycinnamate

Petrolate 0.01 to 10%

0.01 to 20% Titanium Dioxide

Octocrylene 0.01 to 10%

Parsol 1789 (Avobenzone) 0.01 to 3%

Katon 0.01 to 2%

Generic Body Wash 5 to 99% EXAMPLE 5

Generic soap bases for shampoos, body washes, facial cleansers or specialty washes may consist of bases such as;

Water 45

Dermacril AQF 4.7

Poliquat4 3.8

Propyl Betaine Cocamido Unibetain BA-35 6

Ammonium Lauryl Sulfate Unipol A 24

Laureth Ammonium Sulfate Unipol EA-2 6

Dimethicone Moistureguard 10service 0.5

100

This base shows an example of adding a poliquat to highlight the benefits of SPF added in the mixtures mentioned in the art. Polyquat ranges in the base may range from 0.001% to 10% relative to the base to enhance the system. The addition of additional film formers may also enhance the additive, an example being Dermacril AQFtm Acrylate Copolymer. Specially carboxylated acrylates added at a level of 0.001% to 20% being hydrophobic offer substantial water resistance enabling the final product to be water resistant to a greater degree. These components can all be added to the soap-based formulation to create a synergistic effect with the additive.

EXAMPLE 6

50 patients were tested with the sunscreen / body wash of Example 1 of the invention for skin irritation. Patients bathed or washed as usual, then 0.2 ml or 0.2 g of test material was dispensed over a designated area of the patient's back and allowed to air dry. The procedure was completed nine consecutive times (Monday, Wednesday, and Friday for three consecutive weeks). Application areas were monitored for erythema and edema. Patients were then given a rest for 10 to 14 days followed by reapplication at another test site, equivalent to any of the original nine exposures.

No adverse reactions of any kind were observed during the course of this study.

EXAMPLE 7

A water resistance test was performed using the sunscreen / body wash of Example 1. According to the FDA's Monograph for Water Resistant and Very Water Resistant claims, the product sample was applied to patients' dry skin, then submerged in a Agitated bath for 40 or 80 minutes before measurement. The average SPF after 40 minutes of immersion was 12.45 and after 80 minutes of immersion was 10.35.

While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes and substitutions will now occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be used in the practice of the invention. It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents are thereby encompassed.

Claims (31)

1. Additive for addition to a body wash, characterized in that the additive comprises a sunscreen and in which, when the additive is combined with said body wash, after a simple application of the body wash to the skin and rinse the skin. It is protected from sunlight with an average SPF of at least about 15. 2. Additive for addition to a body wash, characterized in that the additive comprises a UVA absorbing sunscreen, a UVB absorbing sunscreen and a physical blocking sunscreen, wherein (i) the UVB absorbing sunscreen is selected from the group consisting of aminobenzoic acid, cinoxate, dioxibenzone, homosalate, octocrylene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzene and trolamine salicylate; (ii) the sunscreen that absorbs UVA is selected from the group consisting of avobenzene and methyl anthranilate; (iii.) The physical blocking sunscreen is selected from the group consisting of titanium dioxide and zinc oxide and where, when the additive is combined with said wash After a simple body wash is applied to the skin and rinse, the skin is protected from sunlight with an average SPF of at least about 2. 3. Additive for addition to a body wash, characterized in that the additive comprises a sunscreen and when, when the additive is combined with said body wash, after applying the body wash to the skin and rinse, the sunscreen penetrates no more than 50 microns into the skin after application followed by rinsing. 4. Sunscreen additive composition, characterized in that it is for addition to a body wash comprising a UVA absorbing sunscreen, a UVB absorbing sunscreen, a physical blocking sunscreen and a cationic polymer. Sunscreen additive for the addition to a body wash, characterized in that it comprises a first component comprising a first sunscreen and a cationic polymer and a second component comprising a second sunscreen, wherein the first component is The second component is added to the body wash separately. 6. Additive for addition to a body wash, characterized in that the additive comprises a sunscreen encapsulated in a sol-gel microcapsule and a cationic polymer. 7. Additive for addition to a body wash, characterized in that the additive comprises a non-sunscreen active which is encapsulated and a cationic polymer. 8. Body wash, characterized in that it comprises an additive comprising a sunscreen, where after a simple application of body wash to the skin and rinse, the skin is protected from sunlight with an average SPF of at least about 15 . 9. Body wash, characterized in that 20 comprises an additive comprising a sunscreen, whereby, after applying body wash to the skin and rinse, the sunscreen penetrates an average of no more than 30 microns into the skin after application followed by rinsing. 10. Body wash, characterized in that it comprises a UVA-absorbing sunscreen, a UVB-absorbing sunscreen, a physical blocking sunscreen and a cationic polymer. 11. Body wash, characterized in that it comprises an additive, wherein the additive comprises an encapsulated non-sunscreen active and further comprises a cationic polymer. Additive according to claims 1, 2, 3, 4, 5, 8, 9 and 10, characterized in that the sunscreen is encapsulated. Additive according to Claim 12, characterized in that the sunscreen is encapsulated in a sol-gel microcapsule. Additive according to claims 1, 2, 3, 8 and 9, characterized in that it further comprises a cationic polymer. An additive according to claims 4, 5, 6, 7, 10, 11 and 14, characterized in that the cationic polymer is a polyquaternium. An additive according to claim 15, characterized in that the cationic polymer is polyquaternium-4, -7, -11, -22, -27, -44, -51 or -64. An additive according to claim 16, characterized in that the cationic polymer is polyquaternium-4. Additive according to claims 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13 and 17, characterized in that it comprises a film former. Additive according to Claim 18, characterized in that the film former comprises petrolatum. Additive according to claim 12 or 13, characterized in that the additive further comprises a cationic polymer. Additive according to Claim 20, characterized in that the cationic polymer is a polyquaternium. Additive according to claim 21, characterized in that the cationic polymer is polyquaternium-4. Additive according to Claims 1, 3, 5, 6, 8, 9, 19 and 22, characterized in that the sunscreen is a UVB absorbing sunscreen and further comprises a UVA absorbing sunscreen. Additive according to Claim 23, characterized in that it comprises a physical blocking sunscreen. An additive according to claim 24, characterized in that (i.) The UVB-absorbing sunscreen is selected from the group consisting of aminobenzoic acid, cinoxate, dioxibenzone, homosalate, octocrene, octyl methoxycinnamate, octyl salicylate, oxybenzone, padimate O, phenylbenzimidazole sulfonic acid, sulisobenzene and trolamine salicylate; (ii.) UVA-absorbing sunscreen is selected from the group consisting of avobenzene and methyl anthranilate and (iii.) physical blocking sunscreen is selected from the group. which consists of titanium dioxide and zinc oxide. A method for preparing body wash comprising a sunscreen additive comprising a first component comprising a first sunscreen and a cationic polymer and a second component comprising a second sunscreen, characterized in that it comprises combining the first component with a body wash, then separately combine the second component with the body wash. 27. A method of protecting the skin from sunlight, characterized in that it comprises applying body wash comprising a sunscreen to the skin, wherein after applying body wash to the skin and rinse, the skin is protected from sunlight. sun with an average SPF of at least about 15. 28. A method of protecting the skin from sunlight, comprising applying a body wash comprising an additive comprising a sunscreen to the skin, wherein the sunscreen penetrates an average of no more than 30 microns into the skin. skin after application followed by rinsing. 29. A method of protecting the skin from sunlight, comprising applying a body wash to the skin, wherein the body wash comprises a UVA absorbing sunscreen, a UVB absorbing sunscreen, a physical blocking sunscreen and a cationic polymer. 30. Method of doing business, characterized in that it comprises: (a) providing an additive for the addition to a body wash 10 to a consumer and (b) receiving payment of said additive. 31. A method of doing business which comprises: (a) providing the consumer with a license for an additive for the addition to a body wash and (b) receiving payment for said license.