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BRPI0606146A2 - 6-Dimethylaminomethyl-1- (3-methoxyphenyl) -1,3-dihydroxycyclohexane phosphate salt compounds - Google Patents

6-Dimethylaminomethyl-1- (3-methoxyphenyl) -1,3-dihydroxycyclohexane phosphate salt compounds

Info

Publication number
BRPI0606146A2
BRPI0606146A2 BRPI0606146-0A BRPI0606146A BRPI0606146A2 BR PI0606146 A2 BRPI0606146 A2 BR PI0606146A2 BR PI0606146 A BRPI0606146 A BR PI0606146A BR PI0606146 A2 BRPI0606146 A2 BR PI0606146A2
Authority
BR
Brazil
Prior art keywords
dihydroxycyclohexane
dimethylaminomethyl
methoxyphenyl
phosphate salt
salt compounds
Prior art date
Application number
BRPI0606146-0A
Other languages
Portuguese (pt)
Inventor
Michael Gruss
Andreas Fischer
Wolfgang Hell
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of BRPI0606146A2 publication Critical patent/BRPI0606146A2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
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    • A61P23/02—Local anaesthetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P7/10—Antioedematous agents; Diuretics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTOS DE SAIS FOSFATO 6-DIMETILAMINOMETIL-1 -(3- METOXIFENIL)-1 ,3-DIHIDROXICICLOHEXANO. A invenção refere-se a compostos 6-dimetilaminometil-1 -(3-metoxifenil)-1 -3-d ih idroxiciclohexano na forma de sais fosfato, o procedimento para sua preparação e para o uso destes compostos em farmacêuticos.6-DIMETHYLAMYLOMYL-1- (3-METOXYPHENYL) -1,3-DIHYDROXYCYLOHEXANE Phosphate compounds. The invention relates to 6-dimethylaminomethyl-1- (3-methoxyphenyl) -1 -3-dihydroxycyclohexane compounds as phosphate salts, the procedure for their preparation and the use of these compounds in pharmaceuticals.

BRPI0606146-0A 2005-02-25 2006-02-21 6-Dimethylaminomethyl-1- (3-methoxyphenyl) -1,3-dihydroxycyclohexane phosphate salt compounds BRPI0606146A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005009217A DE102005009217A1 (en) 2005-02-25 2005-02-25 New phosphoric acid salts of 6-dimethylaminomethyl -1-(3-methoxyphenyl)-1,3-dihydroxycyclohexane useful to treat e.g. pain, migraine, depressions, neurodegenerative illnesses, cognitive illnesses, fear conditions and epilepsy
PCT/EP2006/001547 WO2006089707A1 (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds

Publications (1)

Publication Number Publication Date
BRPI0606146A2 true BRPI0606146A2 (en) 2009-06-02

Family

ID=36090780

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606146-0A BRPI0606146A2 (en) 2005-02-25 2006-02-21 6-Dimethylaminomethyl-1- (3-methoxyphenyl) -1,3-dihydroxycyclohexane phosphate salt compounds

Country Status (18)

Country Link
EP (1) EP1851191A1 (en)
JP (1) JP2008531510A (en)
KR (1) KR20070107162A (en)
CN (1) CN101137615A (en)
AR (1) AR053145A1 (en)
AU (1) AU2006218132B2 (en)
BR (1) BRPI0606146A2 (en)
CA (1) CA2598845A1 (en)
DE (1) DE102005009217A1 (en)
IL (1) IL185468A0 (en)
MX (1) MX2007010361A (en)
NO (1) NO20074673L (en)
NZ (1) NZ556338A (en)
PE (1) PE20061100A1 (en)
RU (1) RU2007135271A (en)
TW (1) TW200640840A (en)
WO (1) WO2006089707A1 (en)
ZA (1) ZA200708153B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615802C (en) 2005-07-07 2015-10-06 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs
DE102007022790A1 (en) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol for the treatment of pain in osteoarthritis
EP2477960A1 (en) * 2009-09-14 2012-07-25 Grünenthal GmbH Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (en) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexane compounds as intermediates for the preparation of pharmaceutical agents
DE10146275A1 (en) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Combination of selected opioids with muscarinic antagonists for the treatment of urinary incontinence
DE10333835A1 (en) * 2003-07-24 2005-03-10 Gruenenthal Gmbh Sustained-release drug containing 6-dimethylaminomethyl-1- (3-methoxy-phenyl) -cyclohexane-1,3-diol

Also Published As

Publication number Publication date
DE102005009217A1 (en) 2006-08-31
PE20061100A1 (en) 2007-01-04
AR053145A1 (en) 2007-04-25
JP2008531510A (en) 2008-08-14
CA2598845A1 (en) 2006-08-31
RU2007135271A (en) 2010-02-27
KR20070107162A (en) 2007-11-06
AU2006218132A1 (en) 2006-08-31
WO2006089707A1 (en) 2006-08-31
MX2007010361A (en) 2008-02-21
IL185468A0 (en) 2008-01-06
CN101137615A (en) 2008-03-05
AU2006218132B2 (en) 2011-10-06
NO20074673L (en) 2007-10-19
ZA200708153B (en) 2008-10-29
NZ556338A (en) 2009-11-27
TW200640840A (en) 2006-12-01
EP1851191A1 (en) 2007-11-07

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013.