BRPI0513135A - bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo - Google Patents
bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivoInfo
- Publication number
- BRPI0513135A BRPI0513135A BRPI0513135-9A BRPI0513135A BRPI0513135A BR PI0513135 A BRPI0513135 A BR PI0513135A BR PI0513135 A BRPI0513135 A BR PI0513135A BR PI0513135 A BRPI0513135 A BR PI0513135A
- Authority
- BR
- Brazil
- Prior art keywords
- libraries
- polynucleotide
- identifying
- producing
- electronic device
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title 2
- 108091033319 polynucleotide Proteins 0.000 title 2
- 239000002157 polynucleotide Substances 0.000 title 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
BIBLIOTECAS DE POLINUCLEOTìDEOS, MéTODO DE PRODUçãO DAS MESMAS, MéTODO DE IDENTIFICAçãO DE UM POLINUCLEOTìDEO, REGIãO DE LIGAçãO, MEIO ADEQUADO PARA USO EM UM, DISPOSITIVO ELETRÈNICO E DISPOSITIVO. Bibliotecas de anticorpo universais são descritas as quais são sintéticas e derivadas das seqüências de anticorpo humanas expressas, selecionadas conseqüentemente por certos critérios, por exemplo, que as seqüências sejam derivadas de anticorpos de ocorrência natural expressos em resposta a uma certa classe de antígenos (por exemplo, molécula pequena, polissacarídeo, peptídeo ou proteína) e tendo regiões CDR planejadas com relação a diversidade ideal. São também apresentados métodos para a produção e triagem de tais bibliotecas para o isolamento de produtos terapêuticos para o tratamento de doenças.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58593104P | 2004-07-06 | 2004-07-06 | |
| PCT/US2005/024002 WO2006014498A2 (en) | 2004-07-06 | 2005-07-06 | Universal antibody libraries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0513135A true BRPI0513135A (pt) | 2008-04-29 |
Family
ID=35787625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0513135-9A BRPI0513135A (pt) | 2004-07-06 | 2005-07-06 | bibliotecas de polinucleotìdeos, método de produção das mesmas, método de identificação de um polinucleotìdeo, região de ligação, meio adequado para uso em um, dispositivo eletrÈnico e dispositivo |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11674240B2 (pt) |
| EP (1) | EP1781680B8 (pt) |
| JP (1) | JP5143551B2 (pt) |
| BR (1) | BRPI0513135A (pt) |
| CA (1) | CA2572961C (pt) |
| ES (1) | ES2563491T3 (pt) |
| MX (1) | MX2007000103A (pt) |
| WO (1) | WO2006014498A2 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| AU2014200954B2 (en) * | 2006-10-02 | 2016-06-16 | Bioassets, Llc | Design and construction of diverse synthetic peptide and polypeptide libraries |
| WO2008042754A2 (en) | 2006-10-02 | 2008-04-10 | Sea Lane Biotechnologies, Llc | Design and construction of diverse synthetic peptide and polypeptide libraries |
| WO2008103474A1 (en) * | 2007-02-20 | 2008-08-28 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
| WO2009004066A2 (en) | 2007-07-03 | 2009-01-08 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating cdr and/or fr positions |
| EP2088432A1 (en) | 2008-02-11 | 2009-08-12 | MorphoSys AG | Methods for identification of an antibody or a target |
| JP5804521B2 (ja) | 2009-05-29 | 2015-11-04 | モルフォシス・アー・ゲー | コレクション及びその使用方法 |
| US20110053803A1 (en) * | 2009-08-26 | 2011-03-03 | Xin Ge | Methods for creating antibody libraries |
| WO2011047146A2 (en) | 2009-10-14 | 2011-04-21 | Centocor Ortho Biotech Inc. | Methods of affinity maturing antibodies |
| SG10201509257VA (en) | 2010-11-19 | 2015-12-30 | Morphosys Ag | A collection and methods for its use |
| BR112016012094A2 (pt) * | 2013-12-04 | 2017-09-26 | Chugai Pharmaceutical Co Ltd | moléculas de ligação a antígeno, cuja atividade de ligação a antígeno varia de acordo com a concentração de compostos e bibliotecas das ditas moléculas |
| WO2016114567A1 (ko) * | 2015-01-13 | 2016-07-21 | 이화여자대학교 산학협력단 | 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리 |
| US10548987B2 (en) | 2015-07-31 | 2020-02-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody-drug conjugates for targeting CD56-positive tumors |
| EP3293293A1 (en) * | 2016-09-08 | 2018-03-14 | Italfarmaco SpA | Hc-cdr3-only libraries with reduced combinatorial redundancy and optimized loop length distribution |
| CN111511768B (zh) * | 2017-11-20 | 2024-03-26 | 南特生物科学公司 | mRNA展示抗体文库和方法 |
| US11034951B2 (en) | 2017-11-20 | 2021-06-15 | Nantbio, Inc. | mRNA display antibody library and methods |
| KR102115300B1 (ko) | 2018-06-01 | 2020-05-26 | 재단법인 목암생명과학연구소 | 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법 |
| KR102736548B1 (ko) * | 2019-01-31 | 2024-12-02 | 난트바이오 인코포레이티드 | Mrna 디스플레이 항체 라이브러리 및 방법 |
| WO2021115468A1 (zh) * | 2019-12-13 | 2021-06-17 | 南京金斯瑞生物科技有限公司 | 一种构建抗体互补决定区文库的方法 |
| JP7809068B2 (ja) * | 2020-04-24 | 2026-01-30 | メモリアル スローン ケタリング キャンサー センター | Ｃｄ１９を標的とするキメラ抗原受容体およびその使用 |
| WO2021231237A2 (en) * | 2020-05-11 | 2021-11-18 | Augmenta Bioworks, Inc. | Antibodies for sars-cov-2 and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69112207T2 (de) | 1990-04-05 | 1996-03-28 | Roberto Chestnut Hill Mass. Crea | "walk-through"-mutagenese. |
| GB9015198D0 (en) * | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| IL102490A0 (en) | 1991-07-15 | 1993-01-14 | Wellcome Found | Production of antibodies |
| ES2136092T3 (es) * | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US20030194807A1 (en) | 1992-11-02 | 2003-10-16 | Roberto Crea | Walk-through mutagenesis |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
| US6352842B1 (en) | 1995-12-07 | 2002-03-05 | Diversa Corporation | Exonucease-mediated gene assembly in directed evolution |
| ATE498718T1 (de) | 2000-12-18 | 2011-03-15 | Dyax Corp | Gerichtete bibliotheken die genetisch verpackt sind |
| WO2002084277A1 (en) | 2001-04-17 | 2002-10-24 | Abmaxis, Inc. | Structure-based construction of human antibody library |
| US7117096B2 (en) | 2001-04-17 | 2006-10-03 | Abmaxis, Inc. | Structure-based selection and affinity maturation of antibody library |
| CA2482769C (en) | 2002-04-17 | 2013-10-08 | Roberto Crea | "doping" in walk-through mutagenesis |
| ATE438852T1 (de) | 2002-04-17 | 2009-08-15 | Bioren Inc | Universelle banken für immunoglobuline |
| CN1836041A (zh) | 2003-06-27 | 2006-09-20 | 比奥伦公司 | 浏览突变 |
-
2005
- 2005-07-06 ES ES05770048.6T patent/ES2563491T3/es not_active Expired - Lifetime
- 2005-07-06 MX MX2007000103A patent/MX2007000103A/es active IP Right Grant
- 2005-07-06 JP JP2007520478A patent/JP5143551B2/ja not_active Expired - Lifetime
- 2005-07-06 CA CA2572961A patent/CA2572961C/en not_active Expired - Lifetime
- 2005-07-06 BR BRPI0513135-9A patent/BRPI0513135A/pt not_active Application Discontinuation
- 2005-07-06 EP EP05770048.6A patent/EP1781680B8/en not_active Expired - Lifetime
- 2005-07-06 WO PCT/US2005/024002 patent/WO2006014498A2/en not_active Ceased
- 2005-07-06 US US11/571,710 patent/US11674240B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1781680B1 (en) | 2016-01-20 |
| EP1781680B8 (en) | 2016-05-18 |
| CA2572961A1 (en) | 2006-02-09 |
| CA2572961C (en) | 2016-08-16 |
| US20110245108A1 (en) | 2011-10-06 |
| WO2006014498A3 (en) | 2007-03-01 |
| ES2563491T3 (es) | 2016-03-15 |
| US11674240B2 (en) | 2023-06-13 |
| EP1781680A2 (en) | 2007-05-09 |
| JP5143551B2 (ja) | 2013-02-13 |
| MX2007000103A (es) | 2007-05-11 |
| WO2006014498A2 (en) | 2006-02-09 |
| EP1781680A4 (en) | 2008-04-02 |
| JP2008536473A (ja) | 2008-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07H 21/02 , C07H 21/00 , C12P 19/34 , C07K 1/00 Ipc: C07K 16/00 (2006.01) |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |