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BRPI0512286A - proteìnas quiméricas inibidoras da angiogênese e o uso - Google Patents

proteìnas quiméricas inibidoras da angiogênese e o uso

Info

Publication number
BRPI0512286A
BRPI0512286A BRPI0512286-4A BRPI0512286A BRPI0512286A BR PI0512286 A BRPI0512286 A BR PI0512286A BR PI0512286 A BRPI0512286 A BR PI0512286A BR PI0512286 A BRPI0512286 A BR PI0512286A
Authority
BR
Brazil
Prior art keywords
chimeric proteins
angiogenesis inhibiting
chimeric protein
inhibiting chimeric
recombinant
Prior art date
Application number
BRPI0512286-4A
Other languages
English (en)
Inventor
Jiangsu Zheng Liu
Original Assignee
Chengdu Kanghong Biotechnologi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Kanghong Biotechnologi filed Critical Chengdu Kanghong Biotechnologi
Publication of BRPI0512286A publication Critical patent/BRPI0512286A/pt
Publication of BRPI0512286B1 publication Critical patent/BRPI0512286B1/pt
Publication of BRPI0512286B8 publication Critical patent/BRPI0512286B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)

Abstract

PROTEìNAS QUIMéRICAS INIBIDORAS DA ANGIOGéNESE E O USO. A presente invenção é direcionada a seqüências de DNA codificando proteínas quiméricas recombinantes inibidoras da angiogênese per se, o uso farmacêutico das proteínas quiméricas, e a composição farmacêutica contendo a proteína recombinante e a formulação derivada.
BRPI0512286A 2004-06-08 2005-06-08 proteínas quiméricas inibidoras da angiogênese e o uso BRPI0512286B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200410044965.7 2004-06-08
CN200410044965 2004-06-08
PCT/CN2005/000802 WO2005121176A1 (en) 2004-06-08 2005-06-08 Angiogenesis-inhibiting chimeric protein and the use

Publications (3)

Publication Number Publication Date
BRPI0512286A true BRPI0512286A (pt) 2008-03-18
BRPI0512286B1 BRPI0512286B1 (pt) 2020-03-24
BRPI0512286B8 BRPI0512286B8 (pt) 2021-05-25

Family

ID=35503012

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512286A BRPI0512286B8 (pt) 2004-06-08 2005-06-08 proteínas quiméricas inibidoras da angiogênese e o uso

Country Status (13)

Country Link
US (2) US7750138B2 (pt)
EP (1) EP1767546B1 (pt)
JP (1) JP4680997B2 (pt)
KR (1) KR100897379B1 (pt)
AT (1) ATE548384T1 (pt)
BR (1) BRPI0512286B8 (pt)
CA (1) CA2569108C (pt)
DK (1) DK1767546T3 (pt)
ES (1) ES2381014T3 (pt)
PL (1) PL1767546T3 (pt)
PT (1) PT1767546E (pt)
RU (1) RU2355414C2 (pt)
WO (1) WO2005121176A1 (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2586459T (lt) 2005-03-25 2017-09-25 Regeneron Pharmaceuticals, Inc. Vegf antagonisto kompozicijos
CN100502945C (zh) * 2006-03-31 2009-06-24 成都康弘生物科技有限公司 Vegf受体融合蛋白在治疗眼睛疾病中的应用
US8216575B2 (en) * 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
HUE018715T2 (hu) 2006-06-16 2024-10-28 Regeneron Pharma Intravitreális beadásra alkalmas VEGF antagonista készítmények
CN101838329A (zh) * 2009-03-18 2010-09-22 嘉和生物药业有限公司 抗血管新生融合蛋白
KR101248912B1 (ko) * 2009-12-31 2013-03-29 한양대학교 산학협력단 항혈관신생 활성을 가지는 재조합 아데노바이러스
EP2663325A1 (en) 2011-01-13 2013-11-20 Regeneron Pharmaceuticals, Inc. Use of a vegf antagonist to treat angiogenic eye disorders
KR102288287B1 (ko) 2012-06-01 2021-08-11 노파르티스 아게 시린지
AU2012101677B4 (en) 2012-07-03 2012-12-20 Novartis Ag Device
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
WO2014203183A1 (en) 2013-06-20 2014-12-24 Novartis Ag Use of a vegf antagonist in treating macular edema
US20160129080A1 (en) 2013-06-20 2016-05-12 Aaron Osborne Treatment of polypoidal chroidal vasculopathy
WO2014203182A1 (en) 2013-06-20 2014-12-24 Novartis Ag Use of a vegf antagonist in treating choroidal neovascularisation
MX2016000384A (es) 2013-07-11 2016-04-29 Novartis Ag Uso de un antagonista de vegf en el tratamiento de trastornos coriorretinianos neovasculares y de permeabilidad en pacientes pediatricos.
MX2016000364A (es) 2013-07-12 2016-05-09 Ophthotech Corp Metodos para tratar o prevenir afecciones oftalmologicas.
PE20170142A1 (es) * 2014-01-25 2017-04-02 Chengdu Kanghong Biotechnologies Co Ltd Proteina de fusion que inhibe angiogenesis o crecimiento y uso de la misma
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US20180170979A1 (en) 2015-06-28 2018-06-21 Allgenesis Biotherapeutics Inc. Fusion proteins for inhibiting angiogenesis
TWI899515B (zh) 2015-08-04 2025-10-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
NZ783685A (en) 2015-12-30 2025-09-26 Kodiak Sciences Inc Antibodies and conjugates thereof
US11099185B2 (en) 2016-02-29 2021-08-24 Maintect Gmbh Predictive markers useful in the treatment of wet age-related macular degeneration
US20200188590A1 (en) 2017-06-08 2020-06-18 Novartis Ag Filling adapter and injection solution transferring system
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
AU2018290633B9 (en) * 2017-06-30 2021-04-01 Korea Advanced Institute Of Science And Technology Conjugate of VEGF-Grab protein and drug, and use thereof
CN110914293B (zh) 2017-07-06 2024-08-13 里珍纳龙药品有限公司 用于制备糖蛋白的细胞培养工艺
SG11202004268PA (en) 2017-11-30 2020-06-29 Regeneron Pharma Use of a vegf antagonist to treat angiogenic eye disorders
SG11202008242XA (en) 2018-03-02 2020-09-29 Kodiak Sciences Inc Il-6 antibodies and fusion constructs and conjugates thereof
CN118948760A (zh) 2018-05-10 2024-11-15 瑞泽恩制药公司 含有高浓度vegf受体融合蛋白的制剂
WO2021046245A1 (en) * 2019-09-04 2021-03-11 University Of Massachusetts Adeno-associated virus vector platform for delivery of kh902 (conbercept) and uses thereof
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CN115335529A (zh) * 2019-11-26 2022-11-11 马萨诸塞大学 用于递送kh902(康柏西普)的重组腺相关病毒及其用途
KR102727299B1 (ko) 2019-12-12 2024-11-08 노파르티스 아게 주입 장치 및 주입 용액 전달 시스템
CN115803009A (zh) 2020-05-08 2023-03-14 瑞泽恩制药公司 用于治疗眼病和癌症的vegf阱和微阱及方法
PH12023550015A1 (en) 2020-07-16 2024-03-11 Novartis Ag Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
IL300864A (en) * 2020-09-03 2023-04-01 Univ Massachusetts Adeno-associated virus for the administration of KH902 (Conversept) and its uses
LT4185318T (lt) 2021-05-17 2025-11-10 Prailginto atpalaidavimo, didelės dozės vegf antagonisto režimai, skirti akių angiogeninių sutrikimų gydymui
EP4145456A1 (en) 2021-09-06 2023-03-08 Bayer AG Prediction of a change related to a macular fluid
CN119365206A (zh) 2022-03-15 2025-01-24 瑞泽恩制药公司 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案
JP2023135646A (ja) 2022-03-15 2023-09-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 血管新生性眼障害の処置のための長期高用量ｖｅｇｆアンタゴニストレジメン
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition
JP2025529465A (ja) 2022-09-16 2025-09-04 チールー ファーマシューティカル カンパニー、リミテッド 安定な高濃度自己緩衝医薬組成物
US20250025531A1 (en) 2023-06-23 2025-01-23 Regeneron Pharmaceuticals, Inc. Extended, High Dose VEGF Antagonist Regimens for Treatment of Angiogenic Eye Disorders
WO2025217334A1 (en) 2024-04-09 2025-10-16 Regeneron Pharmaceuticals, Inc. Low concentration vegf receptor fusion protein containing formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021679A1 (en) * 1993-03-25 1994-09-29 Merck & Co., Inc. Inhibitor of vascular endothelial cell growth factor
US6020473A (en) * 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
US6100071A (en) * 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
CA2376379C (en) * 1999-06-08 2007-08-07 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US6833349B2 (en) * 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
WO2005046602A2 (en) * 2003-11-10 2005-05-26 Greenville Hospital System Vegf receptor antagonists
CN101134777A (zh) * 2006-08-31 2008-03-05 苏州思坦维生物技术有限责任公司 可拮抗血管内皮细胞生长因子的人源化的免疫球蛋白的制备方法及其组合应用

Also Published As

Publication number Publication date
US7750138B2 (en) 2010-07-06
EP1767546A4 (en) 2008-03-19
KR20070029204A (ko) 2007-03-13
US20080206238A1 (en) 2008-08-28
CA2569108C (en) 2012-08-21
RU2355414C2 (ru) 2009-05-20
KR100897379B1 (ko) 2009-05-14
RU2006146995A (ru) 2008-07-20
ATE548384T1 (de) 2012-03-15
EP1767546B1 (en) 2012-03-07
JP2008503243A (ja) 2008-02-07
ES2381014T3 (es) 2012-05-22
BRPI0512286B8 (pt) 2021-05-25
EP1767546A1 (en) 2007-03-28
JP4680997B2 (ja) 2011-05-11
PT1767546E (pt) 2012-03-20
BRPI0512286B1 (pt) 2020-03-24
US20100215655A1 (en) 2010-08-26
PL1767546T3 (pl) 2012-07-31
CA2569108A1 (en) 2005-12-22
WO2005121176A1 (en) 2005-12-22
DK1767546T3 (da) 2012-04-23

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