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BRPI0517803A - pirazolpirimidinas 1,4-substituìdas como inibidores de cinase - Google Patents

pirazolpirimidinas 1,4-substituìdas como inibidores de cinase

Info

Publication number
BRPI0517803A
BRPI0517803A BRPI0517803-7A BRPI0517803A BRPI0517803A BR PI0517803 A BRPI0517803 A BR PI0517803A BR PI0517803 A BRPI0517803 A BR PI0517803A BR PI0517803 A BRPI0517803 A BR PI0517803A
Authority
BR
Brazil
Prior art keywords
substituted
pyrazolpyrimidine
compound
kinase inhibitors
treatment
Prior art date
Application number
BRPI0517803-7A
Other languages
English (en)
Inventor
Niko Schmiedeberg
Pascal Furet
Patricia Imbach
Philipp Holzer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0517803A publication Critical patent/BRPI0517803A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

PIRAZOLPIRIMIDINAS 1,4-SUBSTITUìDAS COMO INIBIDORES DE CINASE. A presente invenção refere-se a compostos pirazolpirimidina 1,4- substituidos da fórmula (1), compostos farmacêuticos compreendendo um composto pirazolpirimidina 1,4-substituído, o uso de um composto pirazolpirimidina 1,4-substituído no tratamento ou ao seu uso na fabricação de uma formulação farmacêutica para o tratamento de uma doença que depende de atividade inadequada de uma proteína cinase, métodos de tratamento compreendendo administrar um composto pirazolpirimidina 1,4-substituído, métodos para a fabricação de um novo composto desta classe e novos intermediários e etapas parciais para sua síntese.
BRPI0517803-7A 2004-11-12 2005-11-10 pirazolpirimidinas 1,4-substituìdas como inibidores de cinase BRPI0517803A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425035A GB0425035D0 (en) 2004-11-12 2004-11-12 Organic compounds
PCT/EP2005/012045 WO2006050946A1 (en) 2004-11-12 2005-11-10 1,4 substituted pyrazolopyrimidines as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0517803A true BRPI0517803A (pt) 2008-10-21

Family

ID=33523649

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517803-7A BRPI0517803A (pt) 2004-11-12 2005-11-10 pirazolpirimidinas 1,4-substituìdas como inibidores de cinase

Country Status (15)

Country Link
US (1) US20080096868A1 (pt)
EP (1) EP1812441A1 (pt)
JP (1) JP2008519790A (pt)
KR (1) KR20070084191A (pt)
CN (1) CN101098873A (pt)
AR (1) AR051485A1 (pt)
AU (1) AU2005303965A1 (pt)
BR (1) BRPI0517803A (pt)
CA (1) CA2585660A1 (pt)
GB (1) GB0425035D0 (pt)
GT (1) GT200500325A (pt)
MX (1) MX2007005644A (pt)
RU (1) RU2007121846A (pt)
TW (1) TW200621783A (pt)
WO (1) WO2006050946A1 (pt)

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AR051485A1 (es) 2007-01-17
RU2007121846A (ru) 2008-12-20
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EP1812441A1 (en) 2007-08-01
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US20080096868A1 (en) 2008-04-24

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