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BRPI0509298A - composto, composição farmacêutica, métodos de inibir receptor h3 de histamina em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, obesidade, e um distúrbio ou doença, e, uso de um composto - Google Patents

composto, composição farmacêutica, métodos de inibir receptor h3 de histamina em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, obesidade, e um distúrbio ou doença, e, uso de um composto

Info

Publication number
BRPI0509298A
BRPI0509298A BRPI0509298-1A BRPI0509298A BRPI0509298A BR PI0509298 A BRPI0509298 A BR PI0509298A BR PI0509298 A BRPI0509298 A BR PI0509298A BR PI0509298 A BRPI0509298 A BR PI0509298A
Authority
BR
Brazil
Prior art keywords
compound
disorder
methods
receptor
obesity
Prior art date
Application number
BRPI0509298-1A
Other languages
English (en)
Inventor
Lisa Selsam Beavers
Don Richard Finley
Terry Patrick Finn
Robert Alan Gadski
Philip Arthur Hipskind
William Joseph Hornback
Cynthia Darshini Jesudason
Richard Todd Pickard
Takako Takakuwa
Grant Mathews Vaught
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0509298A publication Critical patent/BRPI0509298A/pt

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Otolaryngology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS DE INIBIR RECEPTOR H3 DE HISTAMINA EM UM MAMìFERO, PARA TRATAR OU PREVENIR UM DISTúRBIO DO SISTEMA NERVOSO, OBESIDADE, E UM DISTúRBIO OU DOENçA, E, USO DE UM COMPOSTO" A presente invenção descreve novos compostos de fórmula (I) ou sais farmaceuticamente aceitáveis dos mesmos, que tem atividade deantagonista ou agonista inverso de receptor H3 de histamina, assim como métodos para a preparação destes compostos. Em outra forma de realização, a invenção descreve composições farmacêuticas compreendendo compostos de fórmula (I) assim como métodos de usar os mesmos para o tratamento de obesidade, deficiências cognitivas, narcolepsia, e outras doenças relacionadas com o receptor H3 de histamina.
BRPI0509298-1A 2004-04-01 2005-03-25 composto, composição farmacêutica, métodos de inibir receptor h3 de histamina em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, obesidade, e um distúrbio ou doença, e, uso de um composto BRPI0509298A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55854204P 2004-04-01 2004-04-01
US61710104P 2004-10-08 2004-10-08
PCT/US2005/010240 WO2005097740A1 (en) 2004-04-01 2005-03-25 Histamine h3 receptor agents, preparation and therapeutic uses

Publications (1)

Publication Number Publication Date
BRPI0509298A true BRPI0509298A (pt) 2007-09-18

Family

ID=34964070

Family Applications (1)

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BRPI0509298-1A BRPI0509298A (pt) 2004-04-01 2005-03-25 composto, composição farmacêutica, métodos de inibir receptor h3 de histamina em um mamìfero, para tratar ou prevenir um distúrbio do sistema nervoso, obesidade, e um distúrbio ou doença, e, uso de um composto

Country Status (17)

Country Link
US (1) US7632857B2 (pt)
EP (1) EP1735278B1 (pt)
JP (1) JP4777974B2 (pt)
CN (1) CN1960969B (pt)
AT (1) ATE454372T1 (pt)
AU (1) AU2005230881B9 (pt)
BR (1) BRPI0509298A (pt)
CA (1) CA2561628C (pt)
CY (1) CY1109860T1 (pt)
DE (1) DE602005018758D1 (pt)
DK (1) DK1735278T3 (pt)
ES (1) ES2337376T3 (pt)
MX (1) MXPA06011167A (pt)
PL (1) PL1735278T3 (pt)
PT (1) PT1735278E (pt)
SI (1) SI1735278T1 (pt)
WO (1) WO2005097740A1 (pt)

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PT1735278E (pt) 2010-03-09
EP1735278A1 (en) 2006-12-27
PL1735278T3 (pl) 2010-06-30
EP1735278B1 (en) 2010-01-06
CA2561628C (en) 2012-05-08
AU2005230881B2 (en) 2011-03-31
WO2005097740A1 (en) 2005-10-20
MXPA06011167A (es) 2007-01-25
US20070208024A1 (en) 2007-09-06
JP2007530698A (ja) 2007-11-01
DK1735278T3 (da) 2010-04-12
AU2005230881B9 (en) 2011-08-25
CY1109860T1 (el) 2014-09-10
US7632857B2 (en) 2009-12-15
JP4777974B2 (ja) 2011-09-21
AU2005230881A1 (en) 2005-10-20
CA2561628A1 (en) 2005-10-20
SI1735278T1 (sl) 2010-05-31
DE602005018758D1 (de) 2010-02-25
CN1960969A (zh) 2007-05-09
CN1960969B (zh) 2012-03-28
ATE454372T1 (de) 2010-01-15
ES2337376T3 (es) 2010-04-23

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