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BRPI0507917A - método para preparação de éteres de arila - Google Patents

método para preparação de éteres de arila

Info

Publication number
BRPI0507917A
BRPI0507917A BRPI0507917-9A BRPI0507917A BRPI0507917A BR PI0507917 A BRPI0507917 A BR PI0507917A BR PI0507917 A BRPI0507917 A BR PI0507917A BR PI0507917 A BRPI0507917 A BR PI0507917A
Authority
BR
Brazil
Prior art keywords
optically active
compound
aryl ethers
preparing aryl
formula
Prior art date
Application number
BRPI0507917-9A
Other languages
English (en)
Inventor
Mateusz Cebula
Kevin Edward Henegar
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0507917A publication Critical patent/BRPI0507917A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/02—Preparation of ethers from oxiranes
    • C07C41/03—Preparation of ethers from oxiranes by reaction of oxirane rings with hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

MéTODO PARA PREPARAçãO DE éTERES DE ARILA A presente invenção refere-se a um método enatiosseletivo para a preparação de um composto de fórmula (IV): epoxidação assimétrica de um composto e fórmula (I) onde R¬ 1¬ e são como definidos acima, com um agente oxidante na presença de um composto opticamente ativo,para gerar um epóxido opticamente ativo onde R¬ 1¬ e m são como definidos acima, seguido de (b) reação de um epóxido opticamente ativo com um derivado de fenol na presença de uma base; onde o método é realizado sem isolamento do composto opticamente ativo.
BRPI0507917-9A 2004-02-20 2005-02-08 método para preparação de éteres de arila BRPI0507917A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54649504P 2004-02-20 2004-02-20
PCT/IB2005/000315 WO2005082824A1 (en) 2004-02-20 2005-02-08 Method for the preparation of aryl ethers

Publications (1)

Publication Number Publication Date
BRPI0507917A true BRPI0507917A (pt) 2007-07-10

Family

ID=34910781

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507917-9A BRPI0507917A (pt) 2004-02-20 2005-02-08 método para preparação de éteres de arila

Country Status (15)

Country Link
US (2) US20050187399A1 (pt)
EP (1) EP1730094A1 (pt)
JP (1) JP2007523153A (pt)
KR (1) KR100796913B1 (pt)
CN (1) CN1922124A (pt)
AR (1) AR047689A1 (pt)
AU (1) AU2005217217B2 (pt)
BR (1) BRPI0507917A (pt)
CA (1) CA2556063A1 (pt)
IL (1) IL177212A0 (pt)
NO (1) NO20063537L (pt)
RU (1) RU2330012C2 (pt)
TW (2) TW200922916A (pt)
WO (1) WO2005082824A1 (pt)
ZA (1) ZA200606355B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104086431A (zh) * 2014-07-21 2014-10-08 天津药物研究院药业有限责任公司 一种甲磺酸瑞波西汀中间体的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL56369A (en) * 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
IL63433A (en) * 1980-08-06 1986-04-29 Univ Leland Stanford Junior Method of asymmetrical epoxidation
GB8419683D0 (en) * 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane
GB2167407B (en) * 1984-11-22 1988-05-11 Erba Farmitalia Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof
IL78187A (en) * 1985-04-04 1991-05-12 Massachusetts Inst Technology Catalytic asymmetric epoxidation
US4900847A (en) * 1985-04-04 1990-02-13 Massachusetts Institute Of Technology Catalytic asymmetric epoxidation
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
TR200101885T2 (tr) * 1998-12-29 2002-01-21 Pharmacia & Upjohn Company Aril eterler hazırlamak için yöntem.

Also Published As

Publication number Publication date
IL177212A0 (en) 2006-12-10
RU2006129937A (ru) 2008-02-27
AU2005217217A1 (en) 2005-09-09
KR100796913B1 (ko) 2008-01-22
TW200922916A (en) 2009-06-01
RU2330012C2 (ru) 2008-07-27
US20050187399A1 (en) 2005-08-25
NO20063537L (no) 2006-09-01
ZA200606355B (en) 2008-01-30
CN1922124A (zh) 2007-02-28
AR047689A1 (es) 2006-02-01
TW200609208A (en) 2006-03-16
KR20060130179A (ko) 2006-12-18
WO2005082824A1 (en) 2005-09-09
AU2005217217B2 (en) 2008-03-06
JP2007523153A (ja) 2007-08-16
US20090198080A1 (en) 2009-08-06
CA2556063A1 (en) 2005-09-09
EP1730094A1 (en) 2006-12-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: RFERENTE A 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.