BRPI0507886A - método de purificação de albumina compreendendo uma etapa de nanofiltração, solução e composição para uso terapêutico contendo-o - Google Patents
método de purificação de albumina compreendendo uma etapa de nanofiltração, solução e composição para uso terapêutico contendo-oInfo
- Publication number
- BRPI0507886A BRPI0507886A BRPI0507886-5A BRPI0507886A BRPI0507886A BR PI0507886 A BRPI0507886 A BR PI0507886A BR PI0507886 A BRPI0507886 A BR PI0507886A BR PI0507886 A BRPI0507886 A BR PI0507886A
- Authority
- BR
- Brazil
- Prior art keywords
- solution
- composition
- purification method
- therapeutic use
- use containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
MéTODO DE PURIFICAçãO DE ALBUMINA COMPREENDENDO UMA ETAPA DE NANOFILTRAçãO, SOLUçãO E COMPOSIçãO PARA USO TERAPêUTICO CONTENDO-O. A invenção se refere a um método de purificação de albumina compreendendo uma etapa que consiste em submeter uma solução aquosa de albumina, de concentração 15 g/L a 80 g/L e de pH de não menos do que 7, para uma nanofiltração em uma faixa de temperatura de entre 15 C a 55 C. A invenção ser refere igualmente a uma solução aquosa de albumina viralmente segura suscetível de ser obtida usando o método inventivo, no qual os sítios de transportes e de fixação dos princípios ativos terapêuticos da albumina são disponíveis e uma composição de albumina para uso terapêutico obtida por um tratamento de adaptação da dita solução de albumina para um uso clínico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0402001A FR2866890B1 (fr) | 2004-02-27 | 2004-02-27 | Procede de purification d'albumine comprenant une etape de nanofiltration, solution et composition a usage therapeutique la contenant |
| PCT/FR2005/000416 WO2005090402A1 (fr) | 2004-02-27 | 2005-02-23 | Procede de purificaton d’albumine comprenant une etape de nanofiltration, solution et composition a usage therapeutique la contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0507886A true BRPI0507886A (pt) | 2007-08-07 |
Family
ID=34834103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0507886-5A BRPI0507886A (pt) | 2004-02-27 | 2005-02-23 | método de purificação de albumina compreendendo uma etapa de nanofiltração, solução e composição para uso terapêutico contendo-o |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20070161122A1 (pt) |
| EP (1) | EP1718673B1 (pt) |
| JP (2) | JP4979571B2 (pt) |
| AT (1) | ATE373014T1 (pt) |
| AU (1) | AU2005223418B2 (pt) |
| BR (1) | BRPI0507886A (pt) |
| CA (1) | CA2557174C (pt) |
| CY (1) | CY1107082T1 (pt) |
| DE (1) | DE602005002461T2 (pt) |
| DK (1) | DK1718673T3 (pt) |
| ES (1) | ES2294696T3 (pt) |
| FR (1) | FR2866890B1 (pt) |
| IL (1) | IL177286A (pt) |
| PL (1) | PL1718673T3 (pt) |
| PT (1) | PT1718673E (pt) |
| WO (1) | WO2005090402A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2866890B1 (fr) * | 2004-02-27 | 2008-04-04 | Lab Francais Du Fractionnement | Procede de purification d'albumine comprenant une etape de nanofiltration, solution et composition a usage therapeutique la contenant |
| FR2887883B1 (fr) | 2005-06-29 | 2007-08-31 | Lab Francais Du Fractionnement | Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines |
| FR2894831B1 (fr) | 2005-12-16 | 2008-02-15 | Lab Francais Du Fractionnement | Colle biologique exempte de thrombine et son utilisation comme medicament. |
| ES2294976B1 (es) * | 2007-11-12 | 2008-12-16 | Grifols, S.A. | "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion". |
| JP6189751B2 (ja) | 2010-12-30 | 2017-08-30 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | 病原体不活性化剤としてのグリコール |
| FR3004451B1 (fr) * | 2013-04-11 | 2015-12-11 | Lab Francais Du Fractionnement | Procede de preparation d'une solution de proteine c viralement securisee par une double etape de nanofiltration |
| US20180028593A1 (en) * | 2014-03-21 | 2018-02-01 | Boreal Invest | Terminal nanofiltration of solubilized protein compositions for removal of immunogenic aggregates |
| FR3040882A1 (fr) * | 2015-09-10 | 2017-03-17 | Lab Francais Du Fractionnement | Composition liquide d'albumine humaine a usage therapeutique |
| CA3169955A1 (en) * | 2020-01-30 | 2021-08-05 | Fresenius Medical Care Holdings, Inc. | Techniques for modelling and optimizing dialysis toxin displacer compounds |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| US12151045B2 (en) | 2020-12-28 | 2024-11-26 | Davol Inc. | Reactive dry powdered hemostatic materials comprising a protein and a multifunctionalized modified polyethylene glycol based crosslinking agent |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
| FR2672604B1 (fr) * | 1991-02-07 | 1995-05-05 | Pasteur Merieux Serums Vacc | Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue. |
| US5849874A (en) * | 1991-07-12 | 1998-12-15 | Gist-Brocades, N.V. | Process for the purification of serum albumin |
| US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| JPH06279296A (ja) * | 1993-03-25 | 1994-10-04 | Asahi Chem Ind Co Ltd | 血漿分画製剤中から蛋白質会合物の除去方法 |
| SE9500724D0 (sv) * | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
| US6210683B1 (en) * | 1997-09-05 | 2001-04-03 | Merck & Co., Inc. | Stabilizers containing recombinant human serum albumin for live virus vaccines |
| JP4798832B2 (ja) * | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | ヒト血清アルブミン多量体の除去方法 |
| ATE331735T1 (de) * | 2000-10-24 | 2006-07-15 | Chemo Sero Therapeut Res Inst | Verfahren zur monomerisierung von humanen serumalbumin-polymeren |
| US6806355B2 (en) * | 2001-08-14 | 2004-10-19 | Statens Serum Institut | Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product |
| DE10211632A1 (de) * | 2002-03-15 | 2003-10-09 | Aventis Behring Gmbh | Verfahren zur Abtrennung von Viren aus einer Proteinlösung durch Nanofiltration |
| WO2004089402A1 (ja) * | 2003-04-09 | 2004-10-21 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | アルブミン製剤の製造方法 |
| FR2866890B1 (fr) * | 2004-02-27 | 2008-04-04 | Lab Francais Du Fractionnement | Procede de purification d'albumine comprenant une etape de nanofiltration, solution et composition a usage therapeutique la contenant |
-
2004
- 2004-02-27 FR FR0402001A patent/FR2866890B1/fr not_active Expired - Lifetime
-
2005
- 2005-02-23 PT PT05731028T patent/PT1718673E/pt unknown
- 2005-02-23 DK DK05731028T patent/DK1718673T3/da active
- 2005-02-23 DE DE602005002461T patent/DE602005002461T2/de not_active Expired - Lifetime
- 2005-02-23 AU AU2005223418A patent/AU2005223418B2/en not_active Ceased
- 2005-02-23 JP JP2007500249A patent/JP4979571B2/ja not_active Expired - Fee Related
- 2005-02-23 EP EP05731028A patent/EP1718673B1/fr not_active Expired - Lifetime
- 2005-02-23 PL PL05731028T patent/PL1718673T3/pl unknown
- 2005-02-23 BR BRPI0507886-5A patent/BRPI0507886A/pt active Search and Examination
- 2005-02-23 ES ES05731028T patent/ES2294696T3/es not_active Expired - Lifetime
- 2005-02-23 WO PCT/FR2005/000416 patent/WO2005090402A1/fr not_active Ceased
- 2005-02-23 US US10/589,825 patent/US20070161122A1/en not_active Abandoned
- 2005-02-23 CA CA2557174A patent/CA2557174C/fr not_active Expired - Lifetime
- 2005-02-23 AT AT05731028T patent/ATE373014T1/de active
-
2006
- 2006-08-03 IL IL177286A patent/IL177286A/en not_active IP Right Cessation
-
2007
- 2007-12-12 CY CY20071101575T patent/CY1107082T1/el unknown
-
2011
- 2011-12-21 JP JP2011280288A patent/JP2012102115A/ja active Pending
-
2015
- 2015-02-02 US US14/611,460 patent/US9611311B2/en not_active Expired - Lifetime
-
2017
- 2017-02-27 US US15/443,884 patent/US10562957B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005090402A1 (fr) | 2005-09-29 |
| ES2294696T3 (es) | 2008-04-01 |
| US9611311B2 (en) | 2017-04-04 |
| PL1718673T3 (pl) | 2008-03-31 |
| US20170166626A1 (en) | 2017-06-15 |
| ATE373014T1 (de) | 2007-09-15 |
| CA2557174A1 (fr) | 2005-09-29 |
| US20150152162A1 (en) | 2015-06-04 |
| JP2012102115A (ja) | 2012-05-31 |
| FR2866890B1 (fr) | 2008-04-04 |
| DK1718673T3 (da) | 2008-01-14 |
| DE602005002461D1 (de) | 2007-10-25 |
| FR2866890A1 (fr) | 2005-09-02 |
| US20070161122A1 (en) | 2007-07-12 |
| JP2007535495A (ja) | 2007-12-06 |
| CA2557174C (fr) | 2013-04-30 |
| DE602005002461T2 (de) | 2008-06-12 |
| AU2005223418B2 (en) | 2008-12-18 |
| IL177286A (en) | 2012-08-30 |
| EP1718673B1 (fr) | 2007-09-12 |
| JP4979571B2 (ja) | 2012-07-18 |
| IL177286A0 (en) | 2006-12-10 |
| CY1107082T1 (el) | 2012-10-24 |
| AU2005223418A1 (en) | 2005-09-29 |
| EP1718673A1 (fr) | 2006-11-08 |
| US10562957B2 (en) | 2020-02-18 |
| PT1718673E (pt) | 2007-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |