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BRPI0506488A - ensaio de citotoxicidade - Google Patents

ensaio de citotoxicidade

Info

Publication number
BRPI0506488A
BRPI0506488A BRPI0506488-0A BRPI0506488A BRPI0506488A BR PI0506488 A BRPI0506488 A BR PI0506488A BR PI0506488 A BRPI0506488 A BR PI0506488A BR PI0506488 A BRPI0506488 A BR PI0506488A
Authority
BR
Brazil
Prior art keywords
cytotoxicity assay
cytotoxicity
methods
flow cytometry
relates
Prior art date
Application number
BRPI0506488-0A
Other languages
English (en)
Inventor
Pamela Dunn
Liwei He
Laszlo Radvanyi
Marie-Danielle Salha
Original Assignee
Sanofi Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Pasteur Inc filed Critical Sanofi Pasteur Inc
Publication of BRPI0506488A publication Critical patent/BRPI0506488A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"ENSAIO DE CITOTOXICIDADE". A presente invenção refere-se a métodos para a detecção de atividade de CTL usando-se citometria de fluxo para detectar clivagem de enzimas relacionadas com citotoxicidade.
BRPI0506488-0A 2004-01-23 2005-01-21 ensaio de citotoxicidade BRPI0506488A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53899304P 2004-01-23 2004-01-23
PCT/US2005/001993 WO2005090990A2 (en) 2004-01-23 2005-01-21 Cytotoxicity assay

Publications (1)

Publication Number Publication Date
BRPI0506488A true BRPI0506488A (pt) 2007-02-13

Family

ID=34966212

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506488-0A BRPI0506488A (pt) 2004-01-23 2005-01-21 ensaio de citotoxicidade

Country Status (11)

Country Link
EP (1) EP1706744A2 (pt)
JP (1) JP2007522447A (pt)
KR (1) KR20070001930A (pt)
CN (1) CN101065669A (pt)
AU (1) AU2005224597A1 (pt)
BR (1) BRPI0506488A (pt)
CA (1) CA2559394A1 (pt)
IL (1) IL176938A0 (pt)
MX (1) MXPA06008336A (pt)
WO (1) WO2005090990A2 (pt)
ZA (1) ZA200605715B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013126720A2 (en) * 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Compositions and methods for the assessment of target cancer cell resistance to car engineered t cell killing
TWI718992B (zh) 2014-07-21 2021-02-21 瑞士商諾華公司 使用cll-1嵌合抗原受體治療癌症
EP3172237A2 (en) 2014-07-21 2017-05-31 Novartis AG Treatment of cancer using humanized anti-bcma chimeric antigen receptor
JP6604975B2 (ja) * 2015-02-09 2019-11-13 株式会社ライフアートビレッジ 免疫細胞療法のためのペプチドスクリーニング方法
CN105547971B (zh) * 2016-01-08 2018-05-01 首都医科大学附属北京友谊医院 细胞毒性t细胞脱颗粒的流式细胞术检测方法
CN105445171B (zh) * 2016-01-08 2018-03-02 首都医科大学附属北京友谊医院 自然杀伤细胞脱颗粒的流式细胞术检测方法
EP3806962A1 (en) 2018-06-13 2021-04-21 Novartis AG Bcma chimeric antigen receptors and uses thereof
US20250035613A1 (en) * 2021-12-06 2025-01-30 WuXi Biologics Ireland Limited 3d bioassays to measure antibody-dependent cell-mediated cytotoxicity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030211548A1 (en) * 2002-01-29 2003-11-13 Oncolmmunin, Inc. Visualization and quantitiation of cellular cytotoxicity using cell-permeable fluorogenic protease substrates and caspase activity indicator markers
US20070154464A1 (en) * 2003-11-14 2007-07-05 Jerome Keith R Methods for screening for agents capable of modulating t lymphocyte function in response to a herpes simplex virus-infected cell

Also Published As

Publication number Publication date
IL176938A0 (en) 2006-12-10
EP1706744A2 (en) 2006-10-04
KR20070001930A (ko) 2007-01-04
WO2005090990A2 (en) 2005-09-29
MXPA06008336A (es) 2007-04-17
AU2005224597A1 (en) 2005-09-29
CN101065669A (zh) 2007-10-31
CA2559394A1 (en) 2005-09-29
WO2005090990A3 (en) 2007-01-11
ZA200605715B (en) 2007-04-25
JP2007522447A (ja) 2007-08-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2094 DE 22/02/2011.