BRPI0506148A - preparação farmacêutica para o tratamento de choque - Google Patents
preparação farmacêutica para o tratamento de choqueInfo
- Publication number
- BRPI0506148A BRPI0506148A BRPI0506148-2A BRPI0506148A BRPI0506148A BR PI0506148 A BRPI0506148 A BR PI0506148A BR PI0506148 A BRPI0506148 A BR PI0506148A BR PI0506148 A BRPI0506148 A BR PI0506148A
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- moiety
- peptide
- pharmaceutical preparation
- bbeta
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 238000002635 electroconvulsive therapy Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 2
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- 102000008790 VE-cadherin Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 108010018828 cadherin 5 Proteins 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"PREPARAçãO FARMACêUTICA PARA O TRATAMENTO DE CHOQUE". A invenção refere-se ao uso de um peptídeo da fórmula geral I, em que R~ 1~ e R~ 2~, sendo iguais ou diferentes, denotam hidrogênio, uma porção de hidrocarboneto saturado ou insaturado compreendendo de 1 a 10, em particular de 1 a 3, átomos de carbono, Z~ 1~ denota uma porção de histidina ou prolina, Z~ 2~ denota uma porção de arginina, uma porção de peptídeo ou uma porção de proteína compreendendo uma porção de arginina inicial, em particular compreendendo de 2 a 30 aminoácidos, peptídeo este que tem a propriedade biológica de emparelhar o motivo de ligação de VE-caderina indutível na cadeia B<225> (isto é, B<225>~ 15-42~) da fibrina humana, para a preparação de uma preparação farmacêutica para o tratamento de choque.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0108704A AT414097B (de) | 2004-06-25 | 2004-06-25 | Pharmazeutische zubereitung zur behandlung von schock |
| AT0004005A AT501263B1 (de) | 2005-01-13 | 2005-01-13 | Pharmazeutische zubereitung zur behandlung von schock |
| PCT/AT2005/000228 WO2006000007A1 (de) | 2004-06-25 | 2005-06-24 | Verwendung von peptiden, die aus der a alpha oder der b beta kette des humanen fibrinogens abgeleitet wurden, zur behandlung von schock |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0506148A true BRPI0506148A (pt) | 2006-10-24 |
Family
ID=35058593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0506148-2A BRPI0506148A (pt) | 2004-06-25 | 2005-06-24 | preparação farmacêutica para o tratamento de choque |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20080249006A1 (pt) |
| EP (1) | EP1691827B1 (pt) |
| JP (1) | JP2008503503A (pt) |
| AT (1) | ATE439856T1 (pt) |
| AU (1) | AU2005256121B2 (pt) |
| BR (1) | BRPI0506148A (pt) |
| CA (1) | CA2544676A1 (pt) |
| CY (1) | CY1109631T1 (pt) |
| DE (1) | DE502005007926D1 (pt) |
| DK (1) | DK1691827T3 (pt) |
| EA (1) | EA008799B1 (pt) |
| ES (1) | ES2331958T3 (pt) |
| HR (1) | HRP20090618T1 (pt) |
| IL (1) | IL173969A (pt) |
| NZ (1) | NZ545634A (pt) |
| PL (1) | PL1691827T3 (pt) |
| PT (1) | PT1691827E (pt) |
| SI (1) | SI1691827T1 (pt) |
| WO (1) | WO2006000007A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT502987A1 (de) * | 2005-12-23 | 2007-07-15 | Fibrex Medical Res & Dev Gmbh | Pharmazeutische zusammensetzung zur behandlung von hämorrhagischem schock und seinen folgeerscheinungen |
| US7799758B2 (en) * | 2006-02-23 | 2010-09-21 | Ikaria Development Subsidiary Two, LLC | Peptides and peptide derivatives as well as pharmaceutical compositions containing the same |
| WO2007095659A1 (de) * | 2006-02-23 | 2007-08-30 | Fibrex Medical Research & Development Gmbh | Peptide und peptid-derivate, herstellun derselben sowie deren verwendung zur herstellung eines therapeutisch und/oder präventiv wirkenden arzneimittels |
| JP2009527503A (ja) * | 2006-02-23 | 2009-07-30 | ファイブレックス メディカル リサーチ アンド デベロップメント ゲーエムベーハー | ペプチドおよびペプチド誘導体、それらの製造ならびに治療上および／または予防上使用可能な医薬組成物を調製するためのそれらの使用 |
| JP2010540892A (ja) * | 2007-09-24 | 2010-12-24 | ファイブレックス メディカル リサーチ アンド デベロップメント ゲーエムベーハー | 抗炎症活性を有する化合物をスクリーニングする方法 |
| JP5410997B2 (ja) * | 2008-01-31 | 2014-02-05 | 則行 川村 | うつ病およびうつ状態のマーカーおよびそれを用いた検出・診断 |
| US7884074B2 (en) | 2008-05-15 | 2011-02-08 | Ikaria Development Subsidiary Two, LLC | Compounds and methods for prevention and/or treatment of inflammation using the same |
| US8088890B2 (en) * | 2008-09-26 | 2012-01-03 | Fibrex Medical Research & Development Gmbh | Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition |
| WO2010043444A2 (en) * | 2008-10-15 | 2010-04-22 | Fibrex Medical Research & Development Gmbh | Pharmaceutical preparation for the treatment and/or prevention of ischemia/reperfusion injury and the sequels thereof |
| US12128102B2 (en) | 2016-03-08 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Constrained conditionally activated binding proteins |
| PE20212205A1 (es) | 2017-09-08 | 2021-11-18 | Maverick Therapeutics Inc | Proteinas de union condicionalmente activadas restringidas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| DE19729591A1 (de) * | 1997-07-10 | 1999-02-11 | Therasorb Medizinische Systeme | Mittel zur Behandlung und/oder Prophylaxe von Mikrozirkulationsstörungen |
| DE50114771D1 (de) * | 2000-12-12 | 2009-04-23 | Fibrex Medical Res & Dev Gmbh | Peptide und/oder Proteine sowie ihre Verwendung zur Herstellung eines therapeutischen und/oder präventiven Arzneimittels |
| EP1420778B1 (en) * | 2001-03-06 | 2006-11-22 | Dorian Bevec | Use of mek inhibitors for treating virus induced hemorrhagic shock or fever |
| US7799758B2 (en) * | 2006-02-23 | 2010-09-21 | Ikaria Development Subsidiary Two, LLC | Peptides and peptide derivatives as well as pharmaceutical compositions containing the same |
-
2005
- 2005-06-24 SI SI200530842T patent/SI1691827T1/sl unknown
- 2005-06-24 US US10/596,103 patent/US20080249006A1/en not_active Abandoned
- 2005-06-24 WO PCT/AT2005/000228 patent/WO2006000007A1/de not_active Ceased
- 2005-06-24 DK DK05752350T patent/DK1691827T3/da active
- 2005-06-24 PT PT05752350T patent/PT1691827E/pt unknown
- 2005-06-24 HR HR20090618T patent/HRP20090618T1/hr unknown
- 2005-06-24 EA EA200600561A patent/EA008799B1/ru not_active IP Right Cessation
- 2005-06-24 DE DE502005007926T patent/DE502005007926D1/de not_active Expired - Lifetime
- 2005-06-24 AT AT05752350T patent/ATE439856T1/de active
- 2005-06-24 CA CA002544676A patent/CA2544676A1/en not_active Abandoned
- 2005-06-24 JP JP2007516870A patent/JP2008503503A/ja active Pending
- 2005-06-24 BR BRPI0506148-2A patent/BRPI0506148A/pt not_active IP Right Cessation
- 2005-06-24 EP EP05752350A patent/EP1691827B1/de not_active Expired - Lifetime
- 2005-06-24 PL PL05752350T patent/PL1691827T3/pl unknown
- 2005-06-24 ES ES05752350T patent/ES2331958T3/es not_active Expired - Lifetime
- 2005-06-24 AU AU2005256121A patent/AU2005256121B2/en not_active Ceased
- 2005-06-24 NZ NZ545634A patent/NZ545634A/en not_active IP Right Cessation
-
2006
- 2006-02-27 IL IL173969A patent/IL173969A/en not_active IP Right Cessation
-
2009
- 2009-11-13 CY CY20091101198T patent/CY1109631T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200600561A1 (ru) | 2006-08-25 |
| AU2005256121A8 (en) | 2008-08-21 |
| DE502005007926D1 (de) | 2009-10-01 |
| WO2006000007A1 (de) | 2006-01-05 |
| AU2005256121B2 (en) | 2011-03-03 |
| CY1109631T1 (el) | 2014-08-13 |
| ATE439856T1 (de) | 2009-09-15 |
| ES2331958T3 (es) | 2010-01-21 |
| PT1691827E (pt) | 2009-11-23 |
| IL173969A (en) | 2011-06-30 |
| SI1691827T1 (sl) | 2010-01-29 |
| CA2544676A1 (en) | 2006-01-05 |
| HK1093308A1 (zh) | 2007-03-02 |
| IL173969A0 (en) | 2006-07-05 |
| HRP20090618T1 (hr) | 2010-01-31 |
| EA008799B1 (ru) | 2007-08-31 |
| AU2005256121A1 (en) | 2006-04-27 |
| NZ545634A (en) | 2009-09-25 |
| EP1691827A1 (de) | 2006-08-23 |
| DK1691827T3 (da) | 2009-12-14 |
| US20080249006A1 (en) | 2008-10-09 |
| JP2008503503A (ja) | 2008-02-07 |
| PL1691827T3 (pl) | 2010-01-29 |
| EP1691827B1 (de) | 2009-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DA 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013. |