[go: up one dir, main page]

BRPI0417833A - benzofuran derivatives which may be used for the prophylaxis or treatment of 5-ht6 receptor-related disorders - Google Patents

benzofuran derivatives which may be used for the prophylaxis or treatment of 5-ht6 receptor-related disorders

Info

Publication number
BRPI0417833A
BRPI0417833A BRPI0417833-5A BRPI0417833A BRPI0417833A BR PI0417833 A BRPI0417833 A BR PI0417833A BR PI0417833 A BRPI0417833 A BR PI0417833A BR PI0417833 A BRPI0417833 A BR PI0417833A
Authority
BR
Brazil
Prior art keywords
receptor
related disorders
treatment
prophylaxis
benzofuran derivatives
Prior art date
Application number
BRPI0417833-5A
Other languages
Portuguese (pt)
Inventor
Gary Johansson
Peter Brandt
Bjoern M Nilsson
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0303480A external-priority patent/SE0303480D0/en
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of BRPI0417833A publication Critical patent/BRPI0417833A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

"NOVOS DERIVADOS DE BENZOFURANO, OS QUAIS PODEM SER USADOS NA PROFILAXIA OU TRATAMENTO DE DISTúRBIOS RELACIONADOS COM O RECEPTOR 5-HT6". A presente invenção refere-se a compostos de fórmula (I): onde P, R¬ 3¬, w~ 1~ e W~ 2~ são como descritos no relatório descritivo, a composições farmacêuticas compreendendo os compostos, a processos para sua preparação, bem como ao uso dos compostos para a preparação de um medicamento contra distúrbios relacionados ao receptor 5-HT~ 6~."NEW BENZOFURAN DERIVATIVES, WHICH CAN BE USED FOR PROPHYLAXY OR TREATMENT OF 5-HT6 RECEPTOR RELATED DISORDERS". The present invention relates to compounds of formula (I): where P, R 3, w 1 and W 2 are as described in the specification, pharmaceutical compositions comprising the compounds, processes for their preparation. as well as the use of the compounds for the preparation of a medicament against 5-HT 6 receptor-related disorders.

BRPI0417833-5A 2003-12-19 2004-12-20 benzofuran derivatives which may be used for the prophylaxis or treatment of 5-ht6 receptor-related disorders BRPI0417833A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0303480A SE0303480D0 (en) 2003-12-19 2003-12-19 Benzofuranes
US54965204P 2004-03-03 2004-03-03
PCT/SE2004/001949 WO2005058858A1 (en) 2003-12-19 2004-12-20 Novel benzofuran derivatives, which can be used in prophylaxis or treatment of 5-ht6 receptor-related disorder

Publications (1)

Publication Number Publication Date
BRPI0417833A true BRPI0417833A (en) 2007-04-17

Family

ID=34703499

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417833-5A BRPI0417833A (en) 2003-12-19 2004-12-20 benzofuran derivatives which may be used for the prophylaxis or treatment of 5-ht6 receptor-related disorders

Country Status (9)

Country Link
EP (1) EP1694663A1 (en)
KR (1) KR20060127886A (en)
AU (1) AU2004299438A1 (en)
BR (1) BRPI0417833A (en)
CA (1) CA2545506A1 (en)
EA (1) EA010298B1 (en)
IL (1) IL175960A0 (en)
NO (1) NO20062923L (en)
WO (1) WO2005058858A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
WO2006062481A1 (en) * 2004-12-09 2006-06-15 Biovitrum Ab New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders .
WO2007108744A2 (en) * 2006-03-17 2007-09-27 Astrazeneca Ab Novel quinazolines as 5-ht6 modulators
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
EP2069359B1 (en) 2006-08-21 2014-11-12 Genentech, Inc. Aza-benzothiophenyl compounds and methods of use
HU230761B1 (en) * 2007-05-30 2018-03-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság New benzofuran derivatives as selective inhibitors of 5-ht6 and process for their preparation
RU2509078C2 (en) 2008-07-01 2014-03-10 Дженентек, Инк. Bicyclic heterocycles as mek kinase inhibitors
US8492427B2 (en) 2008-07-01 2013-07-23 Genentech, Inc. Isoindolones derivatives as MEK kinase inhibitors and methods of use
EP2310372B1 (en) 2008-07-09 2012-05-23 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
EP2346847B1 (en) * 2008-09-17 2013-05-15 Suven Life Sciences Limited Aryl sulfonamide amine compounds and their use as 5-ht6 ligands
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
JP2013503135A (en) 2009-08-26 2013-01-31 サノフイ Novel crystalline heteroaromatic fluoroglycoside hydrate, pharmaceutical comprising the compound and use thereof
CN102648188A (en) * 2009-12-08 2012-08-22 诺瓦提斯公司 Heterocyclic sulfonamide derivatives
EP2516445B1 (en) * 2009-12-22 2015-03-11 Cephalon, Inc. Tricyclic derivatives and their pharmaceutical use and compositions
EP2683701B1 (en) 2011-03-08 2014-12-24 Sanofi Oxathiazine derivatives substituted with benzyl or heteromethylene groups, method for their preparation, their usage as medicament, medicament containing same and its use
EP2683700B1 (en) 2011-03-08 2015-02-18 Sanofi Tetra-substituted oxathiazine derivatives, method for their preparation, their usage as medicament and medicament containing same and its use
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120051A1 (en) 2011-03-08 2012-09-13 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
WO2012120057A1 (en) 2011-03-08 2012-09-13 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120055A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2376A1 (en) * 1996-12-19 2002-12-28 Smithkline Beecham Plc New sulfonamide derivatives process for their preparation and pharmaceutical compositions containing them.
GB9926302D0 (en) * 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
EP1401813B1 (en) * 2001-06-07 2007-02-07 F. Hoffman-la Roche AG New indole derivatives with 5-ht6 receptor affinity
WO2002100822A1 (en) * 2001-06-11 2002-12-19 Biovitrum Ab Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes
EP1414442A1 (en) * 2001-08-07 2004-05-06 Smithkline Beecham Plc 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
BR0311952A (en) * 2002-06-20 2005-04-19 Biovitrum Ab New compounds useful for treating obesity, type ii diabetes and snc disorders

Also Published As

Publication number Publication date
NO20062923L (en) 2006-06-22
KR20060127886A (en) 2006-12-13
EA010298B1 (en) 2008-08-29
WO2005058858A1 (en) 2005-06-30
CA2545506A1 (en) 2005-06-30
EP1694663A1 (en) 2006-08-30
AU2004299438A1 (en) 2005-06-30
EA200601194A1 (en) 2006-10-27
IL175960A0 (en) 2006-10-05

Similar Documents

Publication Publication Date Title
BRPI0417833A (en) benzofuran derivatives which may be used for the prophylaxis or treatment of 5-ht6 receptor-related disorders
BRPI0407253A (en) Heterocyclyl-3-sulfonylindazoles as ligands 5-hydroxytryptamine-6 process for their preparation, their uses in the preparation of a pharmaceutical composition and a pharmaceutical composition comprising said compounds
BRPI0507877A (en) formamide derivatives, pharmaceutical composition, use thereof and combination
SE0302760D0 (en) New compounds
BRPI0409109A (en) new compounds
BR0214343A (en) 11 - Beta - Hydroxy Steroid Dehydrogenase Inhibitors Type 1
NO20033181L (en) Substituted alkylamine derivatives and methods of use
BR0307429A (en) Compound, use thereof, pharmaceutical composition, and method for treating h3 histamine receptor related disorders or diseases
BRPI0108395B8 (en) pyrrolopyrimidinone derivatives, preparation and use processes
BRPI0414514A (en) use of a compound, compound, and pharmaceutical compositions
NO20076638L (en) New 8-sulfonylamino-3-amino-substituted chroman or tetrahydronaphthalene derivatives modulating the 5HT6 receptor
BRPI0409227B8 (en) "compound, pharmaceutical composition, use of a compound and process for the preparation of a compound of formula (i)"
BRPI0408681A (en) compounds, pharmaceutical compositions, use of a 1,2,3,4-tetrahydroisoquinoline derivative, method for treating or preventing disease, process for the manufacture of pharmaceutical compositions, and use of one or more compounds
BR0212008A (en) Use of a compound or a salt, solvate or prodrug thereof, a pharmaceutical composition, a compound or a salt, solvate or prodrug thereof and process for the preparation thereof
BRPI0418099A (en) compounds, pharmaceutical composition, and use of a compound
BR0312000A (en) Compounds, pharmaceutical compositions, method for treating or prophylaxis of diseases, and use of the compounds
BR0315580A (en) Methylene Urea Derivatives
BRPI0417376A (en) compounds, process for the manufacture thereof, pharmaceutical compositions comprising them, method for treating and / or prophylaxis of diseases that are associated with cb1 receptor modulation and their use
BRPI0507085A (en) sulfonamide derivatives, pharmaceutical composition, uses, processes for preparation and combination
BRPI0413353A (en) pharmaceutical composition containing water soluble drug
BRPI0113162B8 (en) non-imidazole aryloxyalkylamine compounds and pharmaceutical composition comprising said compounds
BR0314314A (en) 4-Pyrrolidine-phenyl-benzyl ether derivatives
BRPI0410660A (en) 2-amino-pyridine derivatives as ß2 adrenoreceptor agonists
BRPI0409498A (en) use of a compound, pharmaceutical formulation, compound, pharmaceutical composition, and process for preparing a compound
BRPI0512974A (en) New Hydantoin Derivatives for the Treatment of Obstructive Airway Diseases

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: BIOVITRUM AB (PUBL) (SE)

Free format text: ALTERADO DE: BIOVITRUM AB

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.