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BRPI0417145A - delta-amine-gamma-hydroxy-Omega-aryl-alkanoic acid amides and use as renin inhibitors - Google Patents

delta-amine-gamma-hydroxy-Omega-aryl-alkanoic acid amides and use as renin inhibitors

Info

Publication number
BRPI0417145A
BRPI0417145A BRPI0417145-4A BRPI0417145A BRPI0417145A BR PI0417145 A BRPI0417145 A BR PI0417145A BR PI0417145 A BRPI0417145 A BR PI0417145A BR PI0417145 A BRPI0417145 A BR PI0417145A
Authority
BR
Brazil
Prior art keywords
hydroxy
amine
acid amides
delta
aryl
Prior art date
Application number
BRPI0417145-4A
Other languages
Portuguese (pt)
Inventor
Holger Sellner
Gerhard Gross
Juergen Klaus Maibaum
Sylvain Cottens
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0417145A publication Critical patent/BRPI0417145A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"AMIDAS DE áCIDO DELTA-AMINA-GAMA-HIDRóXI-ÈMEGA-ARIL-ALCANóICO E USO COMO INIBIDORES DE RENINA". A presente invenção refere-se a novas amidas de ácido <sym>-amina<sym>-hidróxi-<sym>-arila alcanóico da fórmula (I) ou um sal do mesmo farmaceuticamente aceitável."DELTA-AMINE-HYDROXY-EMEGA-ARYL-ALKANIC ACID AMIDES AND USE AS RENINE INHIBITORS". The present invention relates to novel <sym> -amine <sym> -hydroxy-<sym> -alkanoic acid amides of formula (I) or a pharmaceutically acceptable salt thereof.

BRPI0417145-4A 2003-12-01 2004-11-30 delta-amine-gamma-hydroxy-Omega-aryl-alkanoic acid amides and use as renin inhibitors BRPI0417145A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0327839.7A GB0327839D0 (en) 2003-12-01 2003-12-01 Organic compounds
PCT/EP2004/013589 WO2005054177A1 (en) 2003-12-01 2004-11-30 Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides and use as renin inhibitors

Publications (1)

Publication Number Publication Date
BRPI0417145A true BRPI0417145A (en) 2007-03-06

Family

ID=29798109

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417145-4A BRPI0417145A (en) 2003-12-01 2004-11-30 delta-amine-gamma-hydroxy-Omega-aryl-alkanoic acid amides and use as renin inhibitors

Country Status (11)

Country Link
US (1) US20070142475A1 (en)
EP (1) EP1692095A1 (en)
JP (1) JP2007512382A (en)
KR (1) KR20060121119A (en)
CN (1) CN1914153B (en)
AU (1) AU2004295093B2 (en)
BR (1) BRPI0417145A (en)
CA (1) CA2546682A1 (en)
GB (1) GB0327839D0 (en)
RU (1) RU2425027C2 (en)
WO (1) WO2005054177A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2580862A1 (en) * 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
GB2431653A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
GB2431641A (en) * 2005-10-25 2007-05-02 Novartis Ag Alternative synthesis of aryl-octanoyl amide compounds
EP1911762A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Amino alcohols and their use as renin inhibitors
US20100137403A1 (en) * 2008-07-10 2010-06-03 Scott Malstrom Method for enhancing cognition or inhibiting cognitive decline

Family Cites Families (35)

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US4889861A (en) 1982-12-21 1989-12-26 Ciba-Geigy Corp. Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
US4617307A (en) 1984-06-20 1986-10-14 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4559332A (en) 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
CA1334092C (en) 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5594021A (en) 1993-05-20 1997-01-14 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
DE69033469T2 (en) 1989-06-14 2000-09-07 Smithkline Beecham Corp., Philadelphia Imidazoalkenoic acid
DE3924506A1 (en) * 1989-07-25 1991-01-31 Hoechst Ag New poly:hydroxy:amide derivs.
FR2652087B1 (en) 1989-09-15 1993-10-15 Bioprojet Ste Civile AMINO ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS.
IL96942A (en) * 1990-01-31 1995-01-24 Abbott Lab Pharmaceutical composition comprising a renin inhibitor amide derivative
PH30484A (en) 1990-02-19 1997-05-28 Ciba Geigy Acy compounds pharmaceutical composition containing said compound and method of use thereof
IE910913A1 (en) 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
FI112942B3 (en) 1991-02-21 2012-03-13 Daiichi Sankyo Co Ltd Process for the preparation of 4 '- (1H-imidazol-1-ylmethyl) -1,1'-biphenyl derivatives useful for treating and preventing high blood pressure
RU2086544C1 (en) 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity
DE4121975A1 (en) 1991-07-03 1993-01-07 Basf Ag THERMOPLASTIC MOLDING MATERIALS BASED ON POLYCARBONATES, STYROL / ACRYLNITRILE POLYMERISATES AND POLYOLEFINS
JPH0532602A (en) * 1991-07-26 1993-02-09 Terumo Corp Naphthylmethylamine derivative and renin inhibitor containing the same
TW226375B (en) 1991-10-24 1994-07-11 American Home Prod
JPH06199891A (en) * 1992-09-18 1994-07-19 Japan Tobacco Inc Alcohol derivative having renin inhibitory activity and use thereof
HU9503067D0 (en) 1993-04-27 1995-12-28 Smithkline Beecham Corp Endotheline receptor antagonists
US5508272A (en) 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
AU675870B2 (en) 1993-08-18 1997-02-20 Msd K.K. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
US5659065A (en) * 1994-04-18 1997-08-19 Novartis Corporation Alpha-aminoalkanoic acids and reduction products
US5606078A (en) * 1994-04-18 1997-02-25 Ciba-Geigy Corporation 3,5-Disubstituted tetrahydrofuran-2-ones
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
ATE219077T1 (en) 1994-08-19 2002-06-15 Abbott Lab ENDOTHELIN ANTAGONIST
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
DE19533023B4 (en) 1994-10-14 2007-05-16 Basf Ag New carboxylic acid derivatives, their preparation and use
TW313568B (en) 1994-12-20 1997-08-21 Hoffmann La Roche
WO1997022595A1 (en) 1995-12-20 1997-06-26 Yamanouchi Pharmaceutical Co., Ltd. Arylethenesulfonamide derivatives and drug composition containing the same
IT1277737B1 (en) 1995-12-28 1997-11-12 Zambon Spa TIOLIC DERIVATIVES FOR METALLOPEPTIDASE INHIBITIVE ACTIVITY
AU1319697A (en) 1996-01-23 1997-08-20 Shionogi & Co., Ltd. Process for producing oleanolic acid analogs by culturing hairy root
PL329077A1 (en) 1996-04-04 1999-03-15 Banyu Pharma Co Ltd Method of treating cardiac insufficiency by means of endotelin antagonists
US8168616B1 (en) * 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
ES2274847T3 (en) * 2000-12-14 2007-06-01 Speedel Pharma Ag PROCESS TO PREPARE ARILOCTANOIL-AMIDAS.
CN102260188A (en) * 2003-11-26 2011-11-30 诺瓦提斯公司 organic compounds

Also Published As

Publication number Publication date
KR20060121119A (en) 2006-11-28
AU2004295093A1 (en) 2005-06-16
RU2425027C2 (en) 2011-07-27
CN1914153A (en) 2007-02-14
RU2006123314A (en) 2008-01-20
JP2007512382A (en) 2007-05-17
GB0327839D0 (en) 2003-12-31
EP1692095A1 (en) 2006-08-23
AU2004295093B2 (en) 2008-08-14
CA2546682A1 (en) 2005-06-16
CN1914153B (en) 2011-06-08
US20070142475A1 (en) 2007-06-21
WO2005054177A1 (en) 2005-06-16

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]