BRPI0409393A8 - composto, composição farmacêutica, e, métodos para modulação de atividade de receptor de quimiocina em um mamífero, para tratamento, melhora, controle ou redução do risco de um distúrbio ou doença inflamatório e imunorregulatório, e de artrite reumatóide - Google Patents
composto, composição farmacêutica, e, métodos para modulação de atividade de receptor de quimiocina em um mamífero, para tratamento, melhora, controle ou redução do risco de um distúrbio ou doença inflamatório e imunorregulatório, e de artrite reumatóideInfo
- Publication number
- BRPI0409393A8 BRPI0409393A8 BRPI0409393A BRPI0409393A BRPI0409393A8 BR PI0409393 A8 BRPI0409393 A8 BR PI0409393A8 BR PI0409393 A BRPI0409393 A BR PI0409393A BR PI0409393 A BRPI0409393 A BR PI0409393A BR PI0409393 A8 BRPI0409393 A8 BR PI0409393A8
- Authority
- BR
- Brazil
- Prior art keywords
- rheumatoid arthritis
- chemokine receptor
- inflammatory
- ameliorating
- mammal
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 230000004957 immunoregulator effect Effects 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 2
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010003645 Atopy Diseases 0.000 abstract 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 abstract 1
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 abstract 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 206010012434 Dermatitis allergic Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 125000004622 benzoxazinyl group Chemical group O1NC(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
"composto, composição farmacêutica, e, métodos para modulação de atividade de receptor de quimiocina em um mamífero para tratamento, melhora, controle ou redução do risco de um distúrbio ou doença inflamatório e imunorregulatório, e de artrite reumatóide". compostos ciclopentila ligados a um grupo benzoxazinila através de uma porção amido utilizando o nitrogênio de anel da benzoxazina e ainda substituído com uma porção heterocíclica, estes compostos representados pela fórmula (i), que são usados para modular o receptor de quimiocina ccr-2 para evitar ou tratar distúrbios e doenças inflamatórios e imunorregulatórios, doenças alérgicas, condições atópicas incluindo rinite alérgica, dermatite, conjuntivite, e asma, assim como patologias autoimunes, como artrite reumatóide e aterosclerose; e composições farmacêuticas compreendendo estes compostos e o uso destes compostos e composições.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46311103P | 2003-04-15 | 2003-04-15 | |
| PCT/US2004/011281 WO2004092124A2 (en) | 2003-04-15 | 2004-04-09 | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0409393A BRPI0409393A (pt) | 2006-04-18 |
| BRPI0409393A8 true BRPI0409393A8 (pt) | 2018-05-08 |
Family
ID=33300038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409393A BRPI0409393A8 (pt) | 2003-04-15 | 2004-04-09 | composto, composição farmacêutica, e, métodos para modulação de atividade de receptor de quimiocina em um mamífero, para tratamento, melhora, controle ou redução do risco de um distúrbio ou doença inflamatório e imunorregulatório, e de artrite reumatóide |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7700591B2 (pt) |
| EP (1) | EP1615699B1 (pt) |
| JP (1) | JP4440257B2 (pt) |
| KR (1) | KR20060003353A (pt) |
| CN (1) | CN1802187B (pt) |
| AT (1) | ATE461929T1 (pt) |
| AU (1) | AU2004231087B2 (pt) |
| BR (1) | BRPI0409393A8 (pt) |
| CA (1) | CA2521950C (pt) |
| CY (1) | CY1110155T1 (pt) |
| DE (1) | DE602004026166D1 (pt) |
| DK (1) | DK1615699T3 (pt) |
| ES (1) | ES2342776T3 (pt) |
| IS (1) | IS8056A (pt) |
| MX (1) | MXPA05011160A (pt) |
| NO (1) | NO20055376L (pt) |
| NZ (1) | NZ543287A (pt) |
| PL (1) | PL1615699T3 (pt) |
| PT (1) | PT1615699E (pt) |
| RU (1) | RU2301802C2 (pt) |
| SI (1) | SI1615699T1 (pt) |
| WO (1) | WO2004092124A2 (pt) |
| ZA (1) | ZA200507796B (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007518799A (ja) * | 2004-01-20 | 2007-07-12 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性モジュレーターとしての２，６−二置換ピペリジン |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| EP1855673A4 (en) * | 2005-01-06 | 2008-03-12 | Merck & Co Inc | MEDICAL COMBINATION THERAPY AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| WO2007053498A1 (en) | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of ccr2 |
| KR101176697B1 (ko) | 2006-04-20 | 2012-08-23 | 에프. 호프만-라 로슈 아게 | 케모카인 수용체의 다이아제판 유도체 조절자 |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| MX2010005916A (es) * | 2007-11-30 | 2010-06-11 | Noxxon Pharma Ag | Acidos nucleicos de enlace mcp-1 y uso de los mismos. |
| KR100904535B1 (ko) * | 2009-03-09 | 2009-06-29 | 한세이엔씨(주) | 교량의 박스거더 내부 안전진단장치 |
| RU2011141794A (ru) | 2009-03-17 | 2013-04-27 | Дайити Санкио Компани, Лимитед | Амидное производное |
| EP2417131A4 (en) * | 2009-04-07 | 2014-08-27 | Astrazeneca Ab | ISOXAZOL-3 (2H) -ONE ANALOGUE AS THERAPEUTIC |
| UA107938C2 (en) * | 2009-08-12 | 2015-03-10 | Syngenta Participations Ag | Heterocycles with microbicidal properties |
| US9040526B2 (en) | 2010-02-09 | 2015-05-26 | Bristol-Myers Squibb Company | Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity |
| CN103694220A (zh) * | 2013-12-30 | 2014-04-02 | 张磊 | 新型吡唑-3-甲酸酯及合成方法 |
| RU2564440C1 (ru) * | 2014-06-03 | 2015-10-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | 3-ароил-2-гидрокси-2-(2-оксоциклоалкил)пирроло[2,1-с][1,4]бензоксазин-1,4(2н)-дионы, проявляющие анальгетическую активность, и способ их получения |
| ES2708344T3 (es) * | 2015-01-16 | 2019-04-09 | Bayer Cropscience Ag | Procedimiento para la preparación de hidrocloruro de 4-cianoperidina |
| BR112017018991B1 (pt) * | 2015-03-05 | 2022-02-15 | Bayer Cropscience Aktiengesellschaft | Processo para preparação de hidrocloreto de piperidina-4-carbotioamida |
| MA42133A (fr) * | 2015-05-21 | 2021-06-02 | Chemocentryx Inc | Modulateurs du ccr2 |
| BR112018001264B1 (pt) | 2015-07-23 | 2022-04-19 | Huntsman Advanced Materials Americas Llc | Composição curável, processo para produção de uma composição curável, artigo curado, e, método para produção de um prepreg ou towpreg. |
| BR112020005284A2 (pt) | 2017-09-25 | 2020-09-24 | Chemocentryx, Inc. | terapia de combinação usando um antagonista do receptor de quimiocina 2 (ccr2) e um inibidor de pd-1/pd-l1 |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| IL275898B2 (en) | 2018-01-08 | 2025-05-01 | Chemocentryx Inc | Methods for treating solid tumors with CCR2 antagonists |
| KR20220106998A (ko) | 2019-11-27 | 2022-08-01 | 스미토모 파마 가부시키가이샤 | 시클로알킬 우레아 유도체 |
| US11352357B2 (en) * | 2019-11-27 | 2022-06-07 | Sumitomo Dainippon Pharma Co., Ltd. | Cycloalkylurea derivative |
| CN116730855B (zh) * | 2023-08-08 | 2023-10-20 | 苏州开元民生科技股份有限公司 | 3-氨基-4-氯苯甲酸十六酯的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3647804A (en) | 1970-02-27 | 1972-03-07 | Upjohn Co | Cycloalkanecarboxamides |
| US3772308A (en) | 1972-06-02 | 1973-11-13 | Lilly Co Eli | Cyclopentanecetamides and cyclopentaneacetonitriles |
| US5631363A (en) * | 1992-11-13 | 1997-05-20 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| GB9812037D0 (en) | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| AU5473400A (en) * | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| JP2004529113A (ja) | 2001-03-07 | 2004-09-24 | ファイザー・プロダクツ・インク | ケモカイン受容体活性のモジュレーター |
| RU2199537C1 (ru) * | 2001-08-08 | 2003-02-27 | Пермский государственный университет | Триазиламиды 4-арил-2-гидрокси-4-оксо-3-(2-оксо-3,4-дигидро-2h-1,4-бензоксазинил)-2-бут еновой кислоты, проявляющие противовоспалительную активность |
| EP1501507B1 (en) * | 2002-04-29 | 2008-05-28 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| EP1501803B1 (en) * | 2002-04-29 | 2008-08-13 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
| WO2004110376A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Ccr-2 antagonists for treatment of neuropathic pain |
| US20070238723A1 (en) * | 2004-10-15 | 2007-10-11 | Goble Stephen D | Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors |
| EP1855673A4 (en) * | 2005-01-06 | 2008-03-12 | Merck & Co Inc | MEDICAL COMBINATION THERAPY AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATION |
-
2004
- 2004-04-08 NZ NZ543287A patent/NZ543287A/en not_active IP Right Cessation
- 2004-04-08 PT PT04759458T patent/PT1615699E/pt unknown
- 2004-04-08 KR KR1020057019690A patent/KR20060003353A/ko not_active Ceased
- 2004-04-08 RU RU2005135432/05A patent/RU2301802C2/ru not_active IP Right Cessation
- 2004-04-08 CA CA002521950A patent/CA2521950C/en not_active Expired - Fee Related
- 2004-04-08 AU AU2004231087A patent/AU2004231087B2/en not_active Ceased
- 2004-04-09 MX MXPA05011160A patent/MXPA05011160A/es active IP Right Grant
- 2004-04-09 JP JP2006509950A patent/JP4440257B2/ja not_active Expired - Fee Related
- 2004-04-09 WO PCT/US2004/011281 patent/WO2004092124A2/en not_active Ceased
- 2004-04-09 PL PL04759458T patent/PL1615699T3/pl unknown
- 2004-04-09 DK DK04759458.5T patent/DK1615699T3/da active
- 2004-04-09 AT AT04759458T patent/ATE461929T1/de active
- 2004-04-09 CN CN2004800160753A patent/CN1802187B/zh not_active Expired - Fee Related
- 2004-04-09 EP EP04759458A patent/EP1615699B1/en not_active Expired - Lifetime
- 2004-04-09 BR BRPI0409393A patent/BRPI0409393A8/pt not_active Application Discontinuation
- 2004-04-09 DE DE602004026166T patent/DE602004026166D1/de not_active Expired - Lifetime
- 2004-04-09 ES ES04759458T patent/ES2342776T3/es not_active Expired - Lifetime
- 2004-04-09 SI SI200431410T patent/SI1615699T1/sl unknown
-
2005
- 2005-05-13 US US11/129,512 patent/US7700591B2/en not_active Expired - Lifetime
- 2005-09-27 ZA ZA200507796A patent/ZA200507796B/xx unknown
- 2005-09-29 IS IS8056A patent/IS8056A/is unknown
- 2005-11-14 NO NO20055376A patent/NO20055376L/no not_active Application Discontinuation
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2010
- 2010-06-24 CY CY20101100581T patent/CY1110155T1/el unknown
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