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BRPI0409200A - microesferas compreendendo isótopos radioativos terapêuticos e de diagnóstico - Google Patents

microesferas compreendendo isótopos radioativos terapêuticos e de diagnóstico

Info

Publication number
BRPI0409200A
BRPI0409200A BRPI0409200-7A BRPI0409200A BRPI0409200A BR PI0409200 A BRPI0409200 A BR PI0409200A BR PI0409200 A BRPI0409200 A BR PI0409200A BR PI0409200 A BRPI0409200 A BR PI0409200A
Authority
BR
Brazil
Prior art keywords
radioisotope
therapeutic
atomic number
microspheres
diagnostic
Prior art date
Application number
BRPI0409200-7A
Other languages
English (en)
Inventor
Alexander Schwarz
James A Krom
Original Assignee
Biosphere Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosphere Medical Inc filed Critical Biosphere Medical Inc
Publication of BRPI0409200A publication Critical patent/BRPI0409200A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

"MICROESFERAS COMPREENDENDO ISóTOPOS RADIOATIVOS TERAPêUTICOS E DE DIAGNóSTICO". Um aspecto da presente invenção refere-se a uma microesfera impregnada com um radioisótopo que emite partículas <225> terapêuticas e um radioisótopo que emite radiação <sym> de diagnóstico; onde o número atómico do primeiro radioisótopo não é o mesmo o número atómico do segundo radioisótopo. Em uma modalidade preferida, a microesfera é composta de vidro impregnado com ¬ 90¬Y como a fonte das emissões de <225> terapêutica e ¬ 198¬Au como a fone de emissões de <sym> de diagnóstico. Um outro aspecto da presente invenção refere-se à preparação de uma microesfera impregnada com um radioisótopo que emite partículas <225> terapêuticas e um radioisótopo que emite radiação <sym> de diagnóstico; onde o número atómico do primeiro radioisótopo não é o mesmo que o número atómico do segundo radioisótopo. Em uma modalidade preferida, uma microesfera de vidro contendo ¬ 90¬Y e ¬ 198¬Au é preparada através de ativação de nêutron de uma microesfera de vidro compreendendo vidro, ¬ 89¬Y e ¬ 197¬Au. Um outro aspecto da presente invenção referese à administração a um mamífero de uma quantidade terapeuticamente eficaz de microesferas impregnadas com um radioisótopo de emissão de <225> e um radioisótopo de emissão de <sym>; onde o número atómico do primeiro radioisótopo não é o mesmo o número atómico do segundo radioisótopo. Em uma modalidade preferida, as ditas microesferas são administradas ao paciente através de um cateter.
BRPI0409200-7A 2003-04-04 2004-03-08 microesferas compreendendo isótopos radioativos terapêuticos e de diagnóstico BRPI0409200A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/407,144 US20040197264A1 (en) 2003-04-04 2003-04-04 Microspheres comprising therapeutic and diagnostic radioactive isotopes
PCT/US2004/007061 WO2005035005A1 (en) 2003-04-04 2004-03-08 Microspheres comprising therapeutic and diagnostic radioactive isotopes

Publications (1)

Publication Number Publication Date
BRPI0409200A true BRPI0409200A (pt) 2006-03-28

Family

ID=33097488

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409200-7A BRPI0409200A (pt) 2003-04-04 2004-03-08 microesferas compreendendo isótopos radioativos terapêuticos e de diagnóstico

Country Status (9)

Country Link
US (1) US20040197264A1 (pt)
EP (2) EP2574347B1 (pt)
JP (1) JP2006522123A (pt)
KR (1) KR20060057527A (pt)
CN (1) CN1798580B (pt)
AU (1) AU2004279286A1 (pt)
BR (1) BRPI0409200A (pt)
CA (1) CA2520144C (pt)
WO (1) WO2005035005A1 (pt)

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WO2013011984A1 (ja) * 2011-07-21 2013-01-24 国立大学法人名古屋大学 蛍光プローブ及びその製造方法
RU2485059C1 (ru) * 2011-10-14 2013-06-20 Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации Способ получения микросфер для радиотерапии
ES2762214T3 (es) * 2011-10-21 2020-05-22 Betaglue Tech S P A Compuesto antitumoral y proceso de producción relativo
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EP2968165B1 (en) 2013-03-13 2023-09-13 Biosphere Medical, Inc. Compositions and associated methods for radioisotope-binding microparticles
US10384078B2 (en) * 2013-10-15 2019-08-20 Ip Liberty Vision Corporation Polymeric radiation-sources
US9827444B2 (en) * 2013-10-15 2017-11-28 Ip Liberty Vision Corporation Radioactive epoxy in ophthalmic brachytherapy
US20150105605A1 (en) * 2013-10-15 2015-04-16 Ip Liberty Vision Corporation Radioactive glass source in ophthalmic brachytherapy
SG10201914111XA (en) 2014-03-20 2020-03-30 Samumed Llc 5-substituted indazole-3-carboxamides and preparation and use thereof
CN107206112B (zh) * 2014-11-26 2021-01-01 Abk生物医学公司 放射性栓塞颗粒
CN105472428B (zh) * 2015-11-18 2019-02-26 华为技术有限公司 一种用于播放频道节目的方法和设备
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CN108090279B (zh) * 2017-12-15 2021-01-08 中国科学院合肥物质科学研究院 基于杂化lkmc和okmc模拟纳米结构核材料辐照损伤的方法
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TWI728280B (zh) * 2018-11-21 2021-05-21 白金科技股份有限公司 放射微球、其製備方法及放射性填充物組成物
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Also Published As

Publication number Publication date
CA2520144C (en) 2012-12-11
CN1798580B (zh) 2010-10-13
JP2006522123A (ja) 2006-09-28
HK1093319A1 (en) 2007-03-02
EP2574347A2 (en) 2013-04-03
EP1615671B1 (en) 2014-05-21
US20040197264A1 (en) 2004-10-07
AU2004279286A1 (en) 2005-04-21
KR20060057527A (ko) 2006-05-26
EP1615671A4 (en) 2009-07-22
WO2005035005A1 (en) 2005-04-21
EP2574347A3 (en) 2013-07-03
EP1615671A1 (en) 2006-01-18
EP2574347B1 (en) 2018-05-16
CA2520144A1 (en) 2005-04-21
CN1798580A (zh) 2006-07-05

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time