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BRPI0408876A - derivado de indazol, composição farmacêutica, agentes anti-tumoral e terapêutico, uso do derivado de indazol ou do seu sal farmaceuticamente aceitável, e, métodos para tratar de tumor, para tratar de leucemia, para tratar de mieloma ou linfoma, para tratar de carcinoma sólido e para tratar de cáncer - Google Patents

derivado de indazol, composição farmacêutica, agentes anti-tumoral e terapêutico, uso do derivado de indazol ou do seu sal farmaceuticamente aceitável, e, métodos para tratar de tumor, para tratar de leucemia, para tratar de mieloma ou linfoma, para tratar de carcinoma sólido e para tratar de cáncer

Info

Publication number
BRPI0408876A
BRPI0408876A BRPI0408876-0A BRPI0408876A BRPI0408876A BR PI0408876 A BRPI0408876 A BR PI0408876A BR PI0408876 A BRPI0408876 A BR PI0408876A BR PI0408876 A BRPI0408876 A BR PI0408876A
Authority
BR
Brazil
Prior art keywords
treating
substituted
unsubstituted
tumor
indazole derivative
Prior art date
Application number
BRPI0408876-0A
Other languages
English (en)
Inventor
Yoshihisa Ohta
Fumihiko Kanai
Shinji Nara
Yutaka Kanda
Hiroshi Umehara
Yukimasa Shiotsu
Tomoki Naoe
Hitoshi Kiyoi
Keiko Kawashima
Hiromi Ando
Motoki Miyama
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of BRPI0408876A publication Critical patent/BRPI0408876A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADO DE INDAZOL, COMPOSIçãO FARMACêUTICA, AGENTES ANTI-TUMORAL E TERAPêUTICO, USO DO DERIVADO DE INDAZOL OU DO SEU SAL FARMACEUTICAMENTE ACEITáVEL, E, MéTODOS PARA TRATAR DE TUMOR, PARA TRATAR DE LEUCEMIA, PARA TRATAR DE MIELOMA OU LINFOMA, PARA TRATAR DE CARCINOMA SóLIDO E PARA TRATAR DE CáNCER". Derivados de indazol representados pela fórmula geral (I) ou seus sais farmacologicamente aceitáveis: (I) em que R¬ 1¬ é CONR¬ 1a¬R¬ 1b¬ (R¬ 1a¬ e R¬ 1b¬ São , cada um independentemente, hidrogênio, alquila inferior, arila, aralquila ou um grupo heterocíclico, ou R¬ 1a¬ e R¬ 1b¬ juntos com o átomo de nitrogênio adjacente podem formar um grupo heterocíclico) ou coisa parecida; e R¬ 2¬ é hidrogênio, CONR¬ 2a¬R¬ 2b¬ (em que R¬ 2a¬ e R¬ 2b¬ São como definido para R¬ 1a¬ e R¬ 1b¬), NR¬ 2c¬R¬ 2d¬ (em que R¬ 2c¬ e R¬ 2d¬ São, cada um independentemente, hidrogênio, alquila inferior, alcanoíla inferior, aroíla, heteroaroíla, aralquila, alquilsulfonila ou arilsulfonila) ou coisa parecida.
BRPI0408876-0A 2003-07-30 2004-07-30 derivado de indazol, composição farmacêutica, agentes anti-tumoral e terapêutico, uso do derivado de indazol ou do seu sal farmaceuticamente aceitável, e, métodos para tratar de tumor, para tratar de leucemia, para tratar de mieloma ou linfoma, para tratar de carcinoma sólido e para tratar de cáncer BRPI0408876A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003203508 2003-07-30
PCT/JP2004/011287 WO2005012257A1 (ja) 2003-07-30 2004-07-30 インダゾール誘導体

Publications (1)

Publication Number Publication Date
BRPI0408876A true BRPI0408876A (pt) 2006-04-11

Family

ID=34113614

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408876-0A BRPI0408876A (pt) 2003-07-30 2004-07-30 derivado de indazol, composição farmacêutica, agentes anti-tumoral e terapêutico, uso do derivado de indazol ou do seu sal farmaceuticamente aceitável, e, métodos para tratar de tumor, para tratar de leucemia, para tratar de mieloma ou linfoma, para tratar de carcinoma sólido e para tratar de cáncer

Country Status (15)

Country Link
US (2) US7470717B2 (pt)
EP (1) EP1652842B1 (pt)
JP (1) JP4335212B2 (pt)
KR (1) KR20060119705A (pt)
CN (1) CN100390149C (pt)
AT (1) ATE553092T1 (pt)
AU (1) AU2004260756B2 (pt)
BR (1) BRPI0408876A (pt)
CA (1) CA2518950A1 (pt)
EA (1) EA010165B1 (pt)
ES (1) ES2384568T3 (pt)
MX (1) MXPA05011420A (pt)
NO (1) NO20055333L (pt)
WO (1) WO2005012257A1 (pt)
ZA (1) ZA200509952B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003076400A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. New inhibitors of histone deacetylase
WO2003076395A1 (en) 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
ES2307909T3 (es) 2002-03-13 2008-12-01 Janssen Pharmaceutica Nv Derivados de piperazinil, piperidinil y morfolinil como nuevos inhidbidores de la histona deacetilasa.
JP4725945B2 (ja) 2002-03-13 2011-07-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのスルホニルアミノ誘導体
CA2518950A1 (en) * 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. Indazole derivatives
NZ552865A (en) 2004-07-28 2009-09-25 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
CA2596527C (en) * 2005-01-27 2013-02-12 Kyowa Hakko Kogyo Co., Ltd. Igf-1r inhibitors
US7759491B2 (en) * 2005-04-28 2010-07-20 Kyowa Hakko Kirin Co., Ltd. Method for producing indazol-3-ylmethyl phosphonium salt
US8138198B2 (en) 2005-05-18 2012-03-20 Angibaud Patrick Rene Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
AU2006307918B2 (en) * 2005-10-27 2012-06-21 Janssen Pharmaceutica N.V. Squaric acid derivatives as inhibitors of histone deacetylase
CA2631874C (en) 2006-01-19 2014-11-18 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
EP1979326B1 (en) 2006-01-19 2012-10-03 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
ES2327972T3 (es) 2006-01-19 2009-11-05 Janssen Pharmaceutica, N.V. Derivados de aminofenil como nuevos inhibidores de histona deacetilasa.
JP5137849B2 (ja) 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体
CN101484427A (zh) 2006-06-30 2009-07-15 协和发酵麒麟株式会社 Abl激酶抑制剂
WO2008001886A1 (en) 2006-06-30 2008-01-03 Kyowa Hakko Kirin Co., Ltd. Aurora inhibitor
JPWO2008020606A1 (ja) * 2006-08-16 2010-01-07 協和発酵キリン株式会社 血管新生阻害剤
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
KR20090116794A (ko) 2007-03-05 2009-11-11 교와 핫꼬 기린 가부시키가이샤 의약 조성물
KR20090115866A (ko) 2007-03-05 2009-11-09 교와 핫꼬 기린 가부시키가이샤 의약 조성물
WO2008114812A1 (ja) * 2007-03-19 2008-09-25 Kyowa Hakko Kirin Co., Ltd. Jak阻害剤
WO2009143404A1 (en) * 2008-05-23 2009-11-26 Wyeth Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression
CN103804382A (zh) * 2012-11-05 2014-05-21 韩文毅 一类治疗湿疹的化合物及其用途
CN103804306A (zh) * 2012-11-12 2014-05-21 韩文毅 一类治疗糖尿病的化合物及其用途
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
CN108366984A (zh) 2015-09-22 2018-08-03 灰色视觉公司 用于治疗眼部病症的化合物和组合物
CA3056923A1 (en) 2017-03-23 2018-09-27 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
JP2020519585A (ja) 2017-05-10 2020-07-02 グレイバグ ビジョン インコーポレイテッド 医学療法のための延長放出マイクロ粒子及びその懸濁液
WO2019051396A1 (en) * 2017-09-08 2019-03-14 President And Fellows Of Harvard College SMALL MOLECULE INHIBITORS OF EBOLA VIRUSES AND LASSA FEVER, AND METHODS OF USE THEREOF
US11566004B2 (en) 2018-07-23 2023-01-31 Celgene Quanticel Research, Inc. Process for the preparation of bromodomain inhibitor

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0232059A (ja) * 1988-07-18 1990-02-01 Kyowa Hakko Kogyo Co Ltd インダゾール誘導体
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
US7238853B2 (en) 2000-07-14 2007-07-03 Unicrop Ltd Molecular mechanisms for gene containment in plants
US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US20050009876A1 (en) 2000-07-31 2005-01-13 Bhagwat Shripad S. Indazole compounds, compositions thereof and methods of treatment therewith
US6982274B2 (en) 2001-04-16 2006-01-03 Eisai Co., Ltd. 1H-indazole compound
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
AU2003289287A1 (en) * 2002-12-03 2004-06-23 Kyowa Hakko Kogyo Co., Ltd. Jnk inhibitor
CA2518950A1 (en) * 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. Indazole derivatives

Also Published As

Publication number Publication date
JP4335212B2 (ja) 2009-09-30
EP1652842A1 (en) 2006-05-03
WO2005012257A1 (ja) 2005-02-10
ZA200509952B (en) 2006-09-27
ES2384568T3 (es) 2012-07-09
EA200600333A1 (ru) 2006-06-30
ATE553092T1 (de) 2012-04-15
MXPA05011420A (es) 2005-12-12
EP1652842B1 (en) 2012-04-11
CN1777590A (zh) 2006-05-24
US7470717B2 (en) 2008-12-30
EA010165B1 (ru) 2008-06-30
EP1652842A4 (en) 2008-10-01
US7919517B2 (en) 2011-04-05
US20070117856A1 (en) 2007-05-24
AU2004260756B2 (en) 2010-03-25
CA2518950A1 (en) 2005-02-10
NO20055333L (no) 2005-11-11
JPWO2005012257A1 (ja) 2006-09-14
KR20060119705A (ko) 2006-11-24
US20090082348A1 (en) 2009-03-26
AU2004260756A1 (en) 2005-02-10
CN100390149C (zh) 2008-05-28

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: KYOWA HAKKO KIRIN CO., LTD. (JP)

Free format text: NOME ALTERADO DE: KYOWA HAKKO KOGYO CO., LTD.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.