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BRPI0408518A - combination therapy comprising nemorubicin and a cyclooxygenase-2 inhibitor - Google Patents

combination therapy comprising nemorubicin and a cyclooxygenase-2 inhibitor

Info

Publication number
BRPI0408518A
BRPI0408518A BRPI0408518-3A BRPI0408518A BRPI0408518A BR PI0408518 A BRPI0408518 A BR PI0408518A BR PI0408518 A BRPI0408518 A BR PI0408518A BR PI0408518 A BRPI0408518 A BR PI0408518A
Authority
BR
Brazil
Prior art keywords
inhibitor
nemorubicin
cyclooxygenase
combination therapy
cox
Prior art date
Application number
BRPI0408518-3A
Other languages
Portuguese (pt)
Inventor
Maria Cristina Geroni
Maria Adele Pacciarini
Antonino Suarato
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of BRPI0408518A publication Critical patent/BRPI0408518A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"TERAPIA COMBINADA COMPREENDENDO NEMORUBICIN E UM INIBIDOR DE CICLOOXIGENASE-2". A presente invenção refere-se ao uso de um derivado de morfolinil antraciclina, um sal farmaceuticamente aceitável ou metabólito do mesmo, para a preparação de um medicamento em combinação com um inibidor de Cox-2, para uso simultâneo, separado ou seqüencial em tratamento de câncer, e a composições ou unidades embaladas compreendendo um derivado de morfolinil antraciclina e um inibidor de Cox-2."COMBINED THERAPY UNDERSTANDING NEMORUBICIN AND A CYCLOOXYGENASE-2 INHIBITOR". The present invention relates to the use of a morpholinyl anthracycline derivative, a pharmaceutically acceptable salt or metabolite thereof, for the preparation of a medicament in combination with a Cox-2 inhibitor for simultaneous, separate or sequential use in the treatment of cancer, and packaged compositions or units comprising a morpholinyl anthracycline derivative and a Cox-2 inhibitor.

BRPI0408518-3A 2003-03-18 2004-03-04 combination therapy comprising nemorubicin and a cyclooxygenase-2 inhibitor BRPI0408518A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03075780 2003-03-18
PCT/EP2004/050251 WO2004082689A1 (en) 2003-03-18 2004-03-04 Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor

Publications (1)

Publication Number Publication Date
BRPI0408518A true BRPI0408518A (en) 2006-03-07

Family

ID=33016930

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408518-3A BRPI0408518A (en) 2003-03-18 2004-03-04 combination therapy comprising nemorubicin and a cyclooxygenase-2 inhibitor

Country Status (6)

Country Link
EP (1) EP1605951A1 (en)
AU (1) AU2004222527A1 (en)
BR (1) BRPI0408518A (en)
CA (1) CA2519310A1 (en)
MX (1) MXPA05009849A (en)
WO (1) WO2004082689A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
ES2655243T3 (en) 2008-04-11 2018-02-19 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
EP2277884B1 (en) * 2008-04-11 2017-08-23 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
ES2532635T3 (en) 2008-07-15 2015-03-30 Genentech, Inc. Anthracycline conjugates, process for its preparation and its use as antitumor compounds
RU2563638C2 (en) 2010-12-02 2015-09-20 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Method of obtaining morpholinylanthracycline derivatives
WO2016040825A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
WO2016051389A1 (en) * 2014-10-03 2016-04-07 Engeneic Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0434960T3 (en) * 1989-12-19 1996-10-14 Pharmacia Spa Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates
GB2296495B (en) * 1994-12-23 1998-04-15 Erba Carlo Spa Anthracycline derivatives
PL350291A1 (en) * 1998-12-23 2002-12-02 Searle & Co Method of using a cyclooxygenase-2 inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
GB9909925D0 (en) * 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives

Also Published As

Publication number Publication date
CA2519310A1 (en) 2004-09-30
MXPA05009849A (en) 2005-12-06
EP1605951A1 (en) 2005-12-21
WO2004082689A1 (en) 2004-09-30
AU2004222527A1 (en) 2004-09-30

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]