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BRPI0407690A - and methods for treating endometriosis and for treating uterine leiomyoma - Google Patents

and methods for treating endometriosis and for treating uterine leiomyoma

Info

Publication number
BRPI0407690A
BRPI0407690A BRPI0407690-7A BRPI0407690A BRPI0407690A BR PI0407690 A BRPI0407690 A BR PI0407690A BR PI0407690 A BRPI0407690 A BR PI0407690A BR PI0407690 A BRPI0407690 A BR PI0407690A
Authority
BR
Brazil
Prior art keywords
treating
methods
endometriosis
uterine leiomyoma
treat
Prior art date
Application number
BRPI0407690-7A
Other languages
Portuguese (pt)
Inventor
David Michael Remick
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2003/003349 external-priority patent/WO2004009086A1/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0407690A publication Critical patent/BRPI0407690A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO, E, MéTODOS PARA TRATAR ENDOMETRIOSE E PARA TRATAR LEIOMIOMA UTERINO". A presente invenção refere-se a hidrocloreto de 1-(4-(2-piperidiniletóxi)fenóxi)-2-(4-metanossulfonilfenil)-6-hidroxinafta leno não-solvatado cristalino, útil como um modulador de receptor de estrogênio seletivo."COMPOUND AND METHODS TO TREAT ENDOMETRIOSIS AND TO TREAT UTERINE LEIOMYOMA". The present invention relates to crystalline unsolvated 1- (4- (2-piperidinylethoxy) phenoxy) -2- (4-methanesulfonylphenyl) -6-hydroxynaphthalene hydrochloride useful as a selective estrogen receptor modulator.

BRPI0407690-7A 2003-02-25 2004-01-21 and methods for treating endometriosis and for treating uterine leiomyoma BRPI0407690A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45023303P 2003-02-25 2003-02-25
PCT/IB2003/003349 WO2004009086A1 (en) 2002-07-22 2003-07-16 Selective estrogen receptor modulators containing a phenylsulfonyl group
PCT/US2004/000020 WO2004075894A1 (en) 2003-02-25 2004-01-21 Crystalline non-solvated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride

Publications (1)

Publication Number Publication Date
BRPI0407690A true BRPI0407690A (en) 2006-03-01

Family

ID=32929435

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407690-7A BRPI0407690A (en) 2003-02-25 2004-01-21 and methods for treating endometriosis and for treating uterine leiomyoma

Country Status (8)

Country Link
EP (1) EP1601356A1 (en)
AU (1) AU2004216258B2 (en)
BR (1) BRPI0407690A (en)
CA (1) CA2512663A1 (en)
HR (1) HRP20050675A2 (en)
MX (1) MXPA05009098A (en)
NO (1) NO20054400L (en)
WO (1) WO2004075894A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1713770A1 (en) * 2004-01-29 2006-10-25 Eli Lilly And Company Selective estrogen receptor modulators
CN101262847B (en) 2005-09-12 2010-11-24 埃科特莱茵药品有限公司 Stable pharmaceutical compositions comprising pyrimidine-sulfonamides
MX2010001837A (en) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd DERIVATIVES OF 4-PYRIMIDINASULFAMIDA.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501441B1 (en) 1994-09-20 2009-03-10 Eli Lilly And Company Naphthyl compounds, intermediates, processes, compositions, and methods
US6703407B1 (en) 1994-09-20 2004-03-09 Eli Lilly And Company Benzofuran compounds, compositions, and methods
US5484798A (en) 1994-09-20 1996-01-16 Eli Lilly And Company Benzothiopene compounds, compositions, and method of inhibiting restenosis
US5998401A (en) 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
US5510357A (en) 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US5929090A (en) 1997-09-12 1999-07-27 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods
DE60327931D1 (en) * 2002-07-22 2009-07-23 Lilly Co Eli SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYL SULPHONYL GROUP

Also Published As

Publication number Publication date
NO20054400L (en) 2005-09-22
WO2004075894A1 (en) 2004-09-10
MXPA05009098A (en) 2005-11-17
HRP20050675A2 (en) 2005-10-31
AU2004216258B2 (en) 2006-10-19
EP1601356A1 (en) 2005-12-07
AU2004216258A1 (en) 2004-09-10
CA2512663A1 (en) 2004-09-10

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE AS 6A, 7A E 8A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012.