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BRPI0407658A - derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico - Google Patents

derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico

Info

Publication number
BRPI0407658A
BRPI0407658A BRPI0407658-3A BRPI0407658A BRPI0407658A BR PI0407658 A BRPI0407658 A BR PI0407658A BR PI0407658 A BRPI0407658 A BR PI0407658A BR PI0407658 A BRPI0407658 A BR PI0407658A
Authority
BR
Brazil
Prior art keywords
act
acid derivatives
receptor modulators
hydrates
salts
Prior art date
Application number
BRPI0407658-3A
Other languages
English (en)
Inventor
Yasushi Kohno
Kiyoaki Tanaka
Kazuhiko Kuriyama
Wataru Hori
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of BRPI0407658A publication Critical patent/BRPI0407658A/pt

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    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
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    • C07C47/00—Compounds having —CHO groups
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
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    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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  • Health & Medical Sciences (AREA)
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Abstract

"DERIVADOS DE áCIDO AMINOFOSFÈNICO, SEUS SAIS E HIDRATOS QUE ATUAM COMO MODULADORES DE RECEPTOR DE S1P E AGENTE FARMACêUTICO". Derivados de ácido aminofosfónico (como 2-amino-5-¢4-(3-benziloxifeniltio)-2-clorofenil!-2-metilpentilfosfonato monoéster) são representados pela seguinte fórmula geral (1): e que agem como eficazes moduladores de receptor de S1P ao mesmo tempo em que causam menos efeitos colaterais.
BRPI0407658-3A 2003-02-18 2004-02-18 derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico BRPI0407658A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003039269 2003-02-18
PCT/JP2004/001783 WO2004074297A1 (ja) 2003-02-18 2004-02-18 アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤

Publications (1)

Publication Number Publication Date
BRPI0407658A true BRPI0407658A (pt) 2006-02-21

Family

ID=32905163

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407658-3A BRPI0407658A (pt) 2003-02-18 2004-02-18 derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico

Country Status (17)

Country Link
US (2) US7456157B2 (pt)
EP (2) EP2172472B1 (pt)
JP (1) JP4564918B2 (pt)
KR (1) KR101005171B1 (pt)
CN (1) CN100344638C (pt)
AT (1) ATE504590T1 (pt)
AU (1) AU2004213297B2 (pt)
BR (1) BRPI0407658A (pt)
CA (1) CA2515574C (pt)
CY (1) CY1111529T1 (pt)
DE (1) DE602004032118D1 (pt)
DK (1) DK1602660T3 (pt)
ES (1) ES2360394T3 (pt)
MX (1) MXPA05008760A (pt)
PT (1) PT1602660E (pt)
SI (1) SI1602660T1 (pt)
WO (1) WO2004074297A1 (pt)

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KR101003877B1 (ko) * 2002-09-19 2010-12-30 교린 세이야꾸 가부시키 가이샤 아미노알코올 유도체와 그 부가염 및 면역 억제제
SI1602660T1 (sl) * 2003-02-18 2011-06-30 Kyorin Seiyaku Kk Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P
US7638637B2 (en) 2003-11-03 2009-12-29 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
RU2396982C2 (ru) * 2004-07-16 2010-08-20 Киорин Фармасьютикал Ко., Лтд. Эффективный способ использования лекарственных средств и способ предотвращения выраженности побочных эффектов
MX2007001661A (es) 2004-08-13 2007-04-23 Praecis Pharm Inc Metodos y composiciones para modular la actividad del receptor de esfingosina -1 fosfato (sip).
US20060223866A1 (en) * 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
ES2563034T3 (es) * 2004-10-12 2016-03-10 Kyorin Pharmaceutical Co., Ltd. Procedimiento para producir hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol e hidratos del mismo, e intermedios para la producción de los mismos
JP2008522977A (ja) 2004-12-06 2008-07-03 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン＝１−リン酸のアリールアミドアナログ
SG165364A1 (en) * 2005-09-09 2010-10-28 Novartis Ag Treatment of autoimmune diseases
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