BRPI0407400A - derivados do ácido 10,10-dialquil prostanóico como agentes para o abaixamento de pressão intra-ocular - Google Patents
derivados do ácido 10,10-dialquil prostanóico como agentes para o abaixamento de pressão intra-ocularInfo
- Publication number
- BRPI0407400A BRPI0407400A BRPI0407400-9A BRPI0407400A BRPI0407400A BR PI0407400 A BRPI0407400 A BR PI0407400A BR PI0407400 A BRPI0407400 A BR PI0407400A BR PI0407400 A BRPI0407400 A BR PI0407400A
- Authority
- BR
- Brazil
- Prior art keywords
- agents
- intraocular pressure
- prostanoic acid
- acid derivatives
- glaucoma
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DO áCIDO 10,10-DIALQUIL PROSTANóICO COMO AGENTES PARA O ABAIXAMENTO DA PRESSãO INTRAOCULAR". A presente invenção proporciona um método para o tratamento da hipertensão ocular ou glaucoma, que compreende a administração a um animal que tenha hipertensão ocular ou glaucoma, de uma quantidade terapeuticamente eficaz de um composto representado pela fórmula geral (I), na qual a linha pontilhada indica a presença ou a ausência de uma ligação, a borda interrompida indica a configuração a (para baixo) e o triângulo sólido indica a configuração <225> (para cima); B é uma ligação covalente simples, dupla ou tripla; n é 0 a 6; X é CH~ 2~, S OU O; Y é qualquer sal farmaceuticamente aceitável de CO~ 2~H ou CO~ 2~R, CONR~ 2~, CONHCH~ 2~CH~ 2~OH, CON(CH~ 2~CH~ 2~OH)~ 2~, CH~ 2~OR, P(O)(OR)~ 2~, CONRSO~ 2~R, SONR~ 2~, ou a fórmula (Ia) na qual R é H, C~ 1-6~ alquila ou C~ 2-6~ alquenila; R¬ 2¬ e R¬ 3¬ são C~ 1-6~ alquila linear que podem ser o mesmo ou diferentes, e podem estar ligados um com o outro de tal forma que eles formem um anel que incorpora o carbono ao qual eles estão ligados comumente.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/365,369 US6875787B2 (en) | 2003-02-11 | 2003-02-11 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| US10/772,720 US20040235958A1 (en) | 2003-02-11 | 2004-02-04 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| PCT/US2004/003433 WO2004071428A2 (en) | 2003-02-11 | 2004-02-06 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0407400A true BRPI0407400A (pt) | 2006-02-21 |
Family
ID=32871611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0407400-9A BRPI0407400A (pt) | 2003-02-11 | 2004-02-06 | derivados do ácido 10,10-dialquil prostanóico como agentes para o abaixamento de pressão intra-ocular |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1608309B1 (pt) |
| JP (1) | JP5319065B2 (pt) |
| KR (1) | KR101077461B1 (pt) |
| AU (1) | AU2004211936B2 (pt) |
| BR (1) | BRPI0407400A (pt) |
| CA (1) | CA2515631C (pt) |
| MX (1) | MXPA05008431A (pt) |
| NO (1) | NO334659B1 (pt) |
| NZ (1) | NZ541352A (pt) |
| PL (1) | PL209130B1 (pt) |
| RU (1) | RU2336081C2 (pt) |
| WO (1) | WO2004071428A2 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855226B2 (en) * | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| EP1805139A2 (en) * | 2004-10-26 | 2007-07-11 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| AU2012200514B2 (en) * | 2005-03-17 | 2014-03-06 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| WO2008041054A1 (en) | 2006-10-02 | 2008-04-10 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
| CN105566192B (zh) * | 2006-10-02 | 2019-01-22 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的前列腺素及相关化合物的前药 |
| US8455547B2 (en) * | 2008-02-05 | 2013-06-04 | Allergan, Inc. | Substituted cyclopentanes having prostaglandin activity |
| US7732443B2 (en) * | 2008-03-18 | 2010-06-08 | Yariv Donde | Therapeutic substituted cyclopentanes |
| BRPI0912193A2 (pt) * | 2008-05-09 | 2015-10-06 | Allergan Inc | compostos terapêuticos. |
| BR112012008959A2 (pt) | 2009-10-14 | 2019-09-24 | Gemmus Pharma Inc | tratamento de terapia de combinação para infecções virais |
| KR20130130694A (ko) * | 2010-07-30 | 2013-12-02 | 알러간, 인코포레이티드 | 피부 재생을 위한 화합물과 방법 |
| WO2012024376A1 (en) * | 2010-08-17 | 2012-02-23 | Allergan, Inc. | Ep2 or ep4 agonists for treating corneal haze |
| BR112016002789A2 (pt) | 2013-08-09 | 2017-11-21 | Ardelyx Inc | compostos e métodos para inibir transporte de fosfato |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117014A (en) * | 1976-01-09 | 1978-09-26 | Abbott Laboratories | Prostaglandin derivatives |
| JPS59101458A (ja) * | 1982-12-01 | 1984-06-12 | Nippon Iyakuhin Kogyo Kk | 新規なチアプロスタグランジン誘導体及びその製法 |
| JPS632972A (ja) * | 1986-06-20 | 1988-01-07 | Nippon Iyakuhin Kogyo Kk | 新規プロスタグランジンｅ↓１誘導体及びその製法 |
| US4994274A (en) * | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| US5034413A (en) * | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| US5462968A (en) * | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
| US6410591B1 (en) * | 2001-05-08 | 2002-06-25 | Allergan Sales, Inc. | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| CA2450466C (en) * | 2001-06-14 | 2011-07-05 | Allergan, Inc. | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
-
2004
- 2004-02-06 RU RU2005129072/04A patent/RU2336081C2/ru active
- 2004-02-06 KR KR1020057014697A patent/KR101077461B1/ko not_active Expired - Fee Related
- 2004-02-06 NZ NZ541352A patent/NZ541352A/en not_active IP Right Cessation
- 2004-02-06 JP JP2006503371A patent/JP5319065B2/ja not_active Expired - Lifetime
- 2004-02-06 AU AU2004211936A patent/AU2004211936B2/en not_active Ceased
- 2004-02-06 BR BRPI0407400-9A patent/BRPI0407400A/pt not_active Application Discontinuation
- 2004-02-06 MX MXPA05008431A patent/MXPA05008431A/es active IP Right Grant
- 2004-02-06 WO PCT/US2004/003433 patent/WO2004071428A2/en not_active Ceased
- 2004-02-06 PL PL378421A patent/PL209130B1/pl unknown
- 2004-02-06 EP EP04709028A patent/EP1608309B1/en not_active Expired - Lifetime
- 2004-02-06 CA CA2515631A patent/CA2515631C/en not_active Expired - Fee Related
-
2005
- 2005-08-01 NO NO20053715A patent/NO334659B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2515631A1 (en) | 2004-08-26 |
| KR20050101202A (ko) | 2005-10-20 |
| AU2004211936B2 (en) | 2008-09-11 |
| PL378421A1 (pl) | 2006-04-03 |
| EP1608309A2 (en) | 2005-12-28 |
| EP1608309B1 (en) | 2012-07-11 |
| JP2006517587A (ja) | 2006-07-27 |
| CA2515631C (en) | 2013-08-20 |
| RU2005129072A (ru) | 2006-02-27 |
| AU2004211936A1 (en) | 2004-08-26 |
| JP5319065B2 (ja) | 2013-10-16 |
| WO2004071428A2 (en) | 2004-08-26 |
| RU2336081C2 (ru) | 2008-10-20 |
| PL209130B1 (pl) | 2011-07-29 |
| MXPA05008431A (es) | 2005-10-19 |
| WO2004071428A3 (en) | 2005-11-10 |
| NO334659B1 (no) | 2014-05-12 |
| NZ541352A (en) | 2007-12-21 |
| NO20053715D0 (no) | 2005-08-01 |
| KR101077461B1 (ko) | 2011-10-26 |
| NO20053715L (no) | 2005-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 11, 13, 22 E 25 DA LPI |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |