BRPI0407301A - Use of a combination, pharmaceutical composition, kit, and method for treating cancer in a warm-blooded animal such as a human. - Google Patents
Use of a combination, pharmaceutical composition, kit, and method for treating cancer in a warm-blooded animal such as a human.Info
- Publication number
- BRPI0407301A BRPI0407301A BR0407301-0A BRPI0407301A BRPI0407301A BR PI0407301 A BRPI0407301 A BR PI0407301A BR PI0407301 A BRPI0407301 A BR PI0407301A BR PI0407301 A BRPI0407301 A BR PI0407301A
- Authority
- BR
- Brazil
- Prior art keywords
- cpt
- human
- combination
- warm
- kit
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 10
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 2
- 230000005865 ionizing radiation Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 230000001603 reducing effect Effects 0.000 abstract 2
- 230000008728 vascular permeability Effects 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"USO DE UMA COMBINAçãO, COMPOSIçãO FARMACêUTICA, KIT, E, MéTODO PARA O TRATAMENTO DE CâNCER EM UM ANIMAL DE SANGUE QUENTE TAL COMO UM SER HUMANO". A presente invenção diz respeito a um método para a produção de um efeito de redução antiangiogênica e/ou de permeabilidade vascular em um animal de sangue quente tal como um ser humano, que opcionalmente está sendo tratado com radiação ionizante, particularmente um método para o tratamento de um câncer, particularmente um câncer envolvendo um tumor sólido, que compreende um de: a administração de ZD6474 em combinação com 5-FU; a administração de ZD6474 em combinação com CPT- 11; e a administração de ZD6474 em combinação com 5-FU e CPT-11; a uma composição farmacêutica compreendendo um de: ZD6474 e 5-FU; ZD6474 e CPT-11; e ZD6474 e 5-FU e CPT-11; a um produto combinado compreendendo um de: ZD6474 e 5-FU; ZD6474 e CPT-11; e ZD6474 e 5FU e CPT- 11, para o uso em um método de tratamento de um corpo humano ou animal por terapia; a um kit compreendendo um de: ZD6474 e 5-FU; ZD6474 e CPT-11; e ZD6474 e 5-FU e CPT-11; para o uso de um de: ZD6474 e 5-FU; ZD6474 e CPT-11; e ZD6474 e 5-FU e CPT-11, na fabricação de um medicamento para o uso na produção de um efeito de redução antiangiogênica e/ou de permeabilidade vascular em um animal de sangue quente tal como um ser humano que opcionalmente está sendo tratado com radiação ionizante."USE OF A COMBINATION, PHARMACEUTICAL COMPOSITION, KIT, AND METHOD FOR TREATMENT OF CANCER IN A HOT BLOOD ANIMAL LIKE A HUMAN". The present invention relates to a method for producing an antiangiogenic reducing and / or vascular permeability effect in a warm-blooded animal such as a human being, which is optionally being treated with ionizing radiation, particularly a method for treating from a cancer, particularly a cancer involving a solid tumor, comprising one of: administering ZD6474 in combination with 5-FU; administration of ZD6474 in combination with CPT-11; and administering ZD6474 in combination with 5-FU and CPT-11; a pharmaceutical composition comprising one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11; to a combined product comprising one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5FU and CPT-11, for use in a method of therapy of a human or animal body; a kit comprising one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11; for the use of one of: ZD6474 and 5-FU; ZD6474 and CPT-11; and ZD6474 and 5-FU and CPT-11, in the manufacture of a medicament for use in producing an antiangiogenic reducing effect and / or vascular permeability in a warm-blooded animal such as a human being optionally treated with ionizing radiation.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0303289A GB0303289D0 (en) | 2003-02-13 | 2003-02-13 | Combination therapy |
| GB0314100A GB0314100D0 (en) | 2003-06-18 | 2003-06-18 | Combination therapy |
| GB0316184A GB0316184D0 (en) | 2003-07-10 | 2003-07-10 | Combination therapy |
| PCT/GB2004/000550 WO2004071397A2 (en) | 2003-02-13 | 2004-02-11 | Combination therapy of zd6474 with 5-fu or/and cpt-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0407301A true BRPI0407301A (en) | 2006-02-07 |
Family
ID=35745214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0407301-0A BRPI0407301A (en) | 2003-02-13 | 2004-02-11 | Use of a combination, pharmaceutical composition, kit, and method for treating cancer in a warm-blooded animal such as a human. |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI0407301A (en) |
-
2004
- 2004-02-11 BR BR0407301-0A patent/BRPI0407301A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |
|
| B25B | Requested transfer of rights rejected |
Owner name: ASTRAZENECA AB (SE) |