BRPI0312001B1 - Processo para produção de n-(2,6-dimetil-fenil)-2-piperazin-1-il-acetamida - Google Patents

Processo para produção de n-(2,6-dimetil-fenil)-2-piperazin-1-il-acetamida Download PDF

Info

Publication number: BRPI0312001B1
Authority: BR; Brazil
Prior art keywords: xylidine; dimethyl; phenyl; piperazine; piperazin
Prior art date: 2002-06-24

Application number

BRPI0312001-5A

Other languages

English (en)

Portuguese (pt)

Other versions

BR0312001A (pt

Inventor

Michel Joseph Maurice Andre Guillaume

Jozef Ludo Jan Cuypers

Ivan Joseph Maria Vervest

Stefan Marcel Herman Leurs

Dirk De Smaele

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-24

Filing date

2003-06-19

Publication date

2015-04-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29797257&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0312001(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-06-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-03-22 Publication of BR0312001A publication Critical patent/BR0312001A/pt

2015-04-07 Publication of BRPI0312001B1 publication Critical patent/BRPI0312001B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0312001-5A 2002-06-24 2003-06-19 Processo para produção de n-(2,6-dimetil-fenil)-2-piperazin-1-il-acetamida BRPI0312001B1 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02077749		2002-06-24
PCT/EP2003/050241 WO2004000824A1 (en)	2002-06-24	2003-06-19	Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide

Publications (2)

Publication Number	Publication Date
BR0312001A BR0312001A (pt)	2005-03-22
BRPI0312001B1 true BRPI0312001B1 (pt)	2015-04-07

Family

ID=29797257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0312001-5A BRPI0312001B1 (pt)	2002-06-24	2003-06-19	Processo para produção de n-(2,6-dimetil-fenil)-2-piperazin-1-il-acetamida

Country Status (12)

Country	Link
US (1)	US8541578B2 (de)
EP (1)	EP1517900B1 (de)
JP (1)	JP4846234B2 (de)
CN (1)	CN1326846C (de)
AT (1)	ATE432267T1 (de)
AU (1)	AU2003255511B2 (de)
BR (1)	BRPI0312001B1 (de)
CA (1)	CA2487141C (de)
DE (1)	DE60327765D1 (de)
ES (1)	ES2326800T3 (de)
IL (1)	IL165916A (de)
WO (1)	WO2004000824A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101747294B (zh) *	2008-12-10	2011-09-28	上海医药工业研究院	一种n-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺的纯化方法
EP3782992A1 (de) *	2015-03-10	2021-02-24	Unichem Laboratories Limited	Neuartiges verfahren zur herstellung von ranolazin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US458129A (en) *		1891-08-18		papin
GB840358A (en)	1957-10-11	1960-07-06	British Drug Houses Ltd	Improvements in or relating to the manufacture of n-mono-substituted piperazines
US3953448A (en) *	1972-12-07	1976-04-27	Delmar Chemicals Limited	Piperazino-anilido compounds
IT1054961B (it) *	1976-01-23	1981-11-30	Corvi Camillo Spa	Derivati della piperazina adatti come agenti anti ulcera
US4567264A (en)	1983-05-18	1986-01-28	Syntex (U.S.A.) Inc.	Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4558129A (en) *	1983-05-18	1985-12-10	Syntex (U.S.A.) Inc.	Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
CA2101311A1 (en) *	1992-07-31	1994-02-01	Neelakantan Balasubramanian	Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
AU6167696A (en) *	1995-06-07	1996-12-30	Dade Chemistry Systems Inc.	Preparation of immunogens and other conjugates of drugs
NZ321575A (en)	1995-10-30	1999-05-28	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

2003
- 2003-06-19 WO PCT/EP2003/050241 patent/WO2004000824A1/en not_active Ceased
- 2003-06-19 JP JP2004514875A patent/JP4846234B2/ja not_active Expired - Fee Related
- 2003-06-19 CN CNB038146673A patent/CN1326846C/zh not_active Expired - Lifetime
- 2003-06-19 ES ES03760705T patent/ES2326800T3/es not_active Expired - Lifetime
- 2003-06-19 US US10/518,887 patent/US8541578B2/en not_active Expired - Fee Related
- 2003-06-19 BR BRPI0312001-5A patent/BRPI0312001B1/pt not_active IP Right Cessation
- 2003-06-19 DE DE60327765T patent/DE60327765D1/de not_active Expired - Lifetime
- 2003-06-19 CA CA2487141A patent/CA2487141C/en not_active Expired - Lifetime
- 2003-06-19 AU AU2003255511A patent/AU2003255511B2/en not_active Expired
- 2003-06-19 EP EP03760705A patent/EP1517900B1/de not_active Expired - Lifetime
- 2003-06-19 AT AT03760705T patent/ATE432267T1/de not_active IP Right Cessation
2004
- 2004-12-22 IL IL165916A patent/IL165916A/en active IP Right Grant

Also Published As

Publication number	Publication date
DE60327765D1 (de)	2009-07-09
US20050240018A1 (en)	2005-10-27
ATE432267T1 (de)	2009-06-15
WO2004000824A1 (en)	2003-12-31
JP2005530837A (ja)	2005-10-13
BR0312001A (pt)	2005-03-22
AU2003255511A1 (en)	2004-01-06
AU2003255511B2 (en)	2009-02-05
CA2487141C (en)	2011-08-02
ES2326800T3 (es)	2009-10-20
CN1662517A (zh)	2005-08-31
IL165916A (en)	2012-12-31
EP1517900A1 (de)	2005-03-30
JP4846234B2 (ja)	2011-12-28
HK1081966A1 (zh)	2006-05-26
CA2487141A1 (en)	2003-12-31
US8541578B2 (en)	2013-09-24
CN1326846C (zh)	2007-07-18
IL165916A0 (en)	2006-01-15
EP1517900B1 (de)	2009-05-27

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Legal Events

Date	Code	Title	Description
2011-03-09	B15K	Others concerning applications: alteration of classification	Free format text: PARA INT.CL: C07D 295/14, C07D 295/15, C07D 295/00, A61P 23/00 Ipc: C07D 295/15 (2011.01)
2011-03-15	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2014-10-07	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2014-12-09	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2015-04-07	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/04/2015, OBSERVADAS AS CONDICOES LEGAIS.
2024-04-09	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 21A ANUIDADE.
2024-07-23	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2779 DE 09-04-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.