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BRPI0314038B8 - anticorpo humano isolado, molécula de ácido nucleico isolada, vetor, uso de um anticorpo, e, composição farmacêutica - Google Patents

anticorpo humano isolado, molécula de ácido nucleico isolada, vetor, uso de um anticorpo, e, composição farmacêutica

Info

Publication number
BRPI0314038B8
BRPI0314038B8 BRPI0314038A BR0314038A BRPI0314038B8 BR PI0314038 B8 BRPI0314038 B8 BR PI0314038B8 BR PI0314038 A BRPI0314038 A BR PI0314038A BR 0314038 A BR0314038 A BR 0314038A BR PI0314038 B8 BRPI0314038 B8 BR PI0314038B8
Authority
BR
Brazil
Prior art keywords
antibody
pharmaceutical composition
vector
nucleic acid
acid molecule
Prior art date
Application number
BRPI0314038A
Other languages
English (en)
Other versions
BRPI0314038B1 (pt
BR0314038A (pt
Inventor
Witte Alison
Varnum Brian
Vezina Chris
Martin Frank
Elliott Gary
Huang Haichun
Qian Xueming
Original Assignee
Amgen Inc
Squibb & Sons Llc
Medarex Inc
Medarex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Squibb & Sons Llc, Medarex Inc, Medarex Llc filed Critical Amgen Inc
Publication of BR0314038A publication Critical patent/BR0314038A/pt
Publication of BRPI0314038B1 publication Critical patent/BRPI0314038B1/pt
Publication of BRPI0314038B8 publication Critical patent/BRPI0314038B8/pt

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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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Abstract

anticorpo humano isolado, método de tratar uma doença mediada com il-1 em um paciente, composição farmacêutica, cadeias pesada e leve, e, método de mapeamento de epitopo de um antígeno selecionado. descreve-se anticorpos que interagem com receptor de tipo 1 de interleucina-1 (il-1r1). descreve-se métodos de tratar doenças mediadas com il-1 mediante administração de uma quantidade farmaceuticamente eficaz de anticorpos para il-1r1. métodos de detectar a quantidade de il-1r1 em uma amostra utilizando-se anticorpos para il-1r1.
BRPI0314038A 2002-09-06 2003-09-05 anticorpo humano isolado, molécula de ácido nucleico isolada, vetor, uso de um anticorpo, e, composição farmacêutica BRPI0314038B8 (pt)

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US40871902P 2002-09-06 2002-09-06
PCT/US2003/027978 WO2004022718A2 (en) 2002-09-06 2003-09-05 Therapeutic human anti-il-1r1 monoclonal antibody

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