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BRPI9707889B8 - composto e seus sais, composição farmacêutica, utilização do composto. - Google Patents

composto e seus sais, composição farmacêutica, utilização do composto.

Info

Publication number
BRPI9707889B8
BRPI9707889B8 BRPI9707889A BR9707889A BRPI9707889B8 BR PI9707889 B8 BRPI9707889 B8 BR PI9707889B8 BR PI9707889 A BRPI9707889 A BR PI9707889A BR 9707889 A BR9707889 A BR 9707889A BR PI9707889 B8 BRPI9707889 B8 BR PI9707889B8
Authority
BR
Brazil
Prior art keywords
compound
salts
pharmaceutical composition
group
cells
Prior art date
Application number
BRPI9707889A
Other languages
English (en)
Other versions
BR9707889A (pt
BR9707889B1 (pt
Inventor
Jean-Marie Lehn
Jean-Pierre Vigneron
Pierre Lehn
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26232562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9707889(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9602604A external-priority patent/FR2745569B1/fr
Priority claimed from FR9609557A external-priority patent/FR2751972B1/fr
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Publication of BR9707889A publication Critical patent/BR9707889A/pt
Publication of BR9707889B1 publication Critical patent/BR9707889B1/pt
Publication of BRPI9707889B8 publication Critical patent/BRPI9707889B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composto e seus sais, composição farmacêutica, utilização do composto e método de transferência de ácido nucléico para células. a presente invenção se refere a novos derivados de amidínio de fórmula na qual: r1 representa um derivado do colesterol ou um grupamento alquila amino-nr'r", r2 e r3 representam, independentemente um do outro, um átomo de hidrogênio ou um grupamento de fórmula ii na qual r4 e r5 representam, independentemente um do outro, um átomo de hidrogênio ou um grupamento de fórmula iii. a presente invenção concerne ainda a composições farmacêuticas correspondentes, úteis notadamente em terapia gênica, para a transferência de genes terapêuticos para as células.
BRPI9707889A 1996-03-01 1997-02-28 composto e seus sais, composição farmacêutica, utilização do composto. BRPI9707889B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9602604A FR2745569B1 (fr) 1996-03-01 1996-03-01 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications
FR9602604 1996-03-01
FR9609557 1996-07-30
FR9609557A FR2751972B1 (fr) 1996-07-30 1996-07-30 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications
PCT/FR1997/000364 WO1997031935A1 (fr) 1996-03-01 1997-02-28 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications

Publications (3)

Publication Number Publication Date
BR9707889A BR9707889A (pt) 2000-01-04
BR9707889B1 BR9707889B1 (pt) 2010-03-23
BRPI9707889B8 true BRPI9707889B8 (pt) 2016-11-08

Family

ID=26232562

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9707889A BRPI9707889B8 (pt) 1996-03-01 1997-02-28 composto e seus sais, composição farmacêutica, utilização do composto.

Country Status (18)

Country Link
US (2) US6143729A (pt)
EP (1) EP0888379B1 (pt)
JP (1) JP4271260B2 (pt)
KR (1) KR19990087372A (pt)
AT (1) ATE198599T1 (pt)
AU (1) AU723998B2 (pt)
BR (1) BRPI9707889B8 (pt)
CZ (1) CZ295225B6 (pt)
DE (1) DE69703878T2 (pt)
DK (1) DK0888379T3 (pt)
ES (1) ES2154453T3 (pt)
GR (1) GR3035205T3 (pt)
HU (1) HU228072B1 (pt)
IL (1) IL125926A (pt)
NO (1) NO311806B1 (pt)
PT (1) PT888379E (pt)
SK (1) SK283575B6 (pt)
WO (1) WO1997031935A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884430B1 (en) * 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
FR2763943B1 (fr) * 1997-05-28 1999-07-09 Rhone Poulenc Rorer Sa Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
FR2777017B1 (fr) * 1998-04-02 2002-08-23 Rhone Poulenc Rorer Sa Nouveaux agents de transfert d'acides nucleiques, compositions les contenant et leurs applications
WO1999051581A1 (fr) * 1998-04-02 1999-10-14 Aventis Pharma S.A. Nouveaux agents de transfert d'acides nucleiques, compositions les contenant et leurs applications
DE10109898A1 (de) * 2001-02-21 2002-09-05 Novosom Gmbh Lipide mit veränderlicher Ladung
WO2002092558A1 (fr) * 2001-05-14 2002-11-21 Gencell S.A. Derives lipidiques de polythiouree
FR2824557B1 (fr) * 2001-05-14 2003-08-29 Aventis Pharma Sa Derives lipidiques de polythiouree
FR2829136B1 (fr) 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
ES2635247T3 (es) 2002-01-17 2017-10-03 Alfa Laval Corporate Ab Evaporador sumergido que comprende un intercambiador de calor de placas y una carcasa cilíndrica en la que está dispuesto el intercambiador de calor de placas
WO2006118283A1 (ja) * 2005-04-28 2006-11-09 Nippon Soda Co., Ltd. 新規なグアニジン化合物、製造方法及びそれらを含有する殺菌性組成物
US20100035974A1 (en) * 2006-10-04 2010-02-11 Centre National De La Recherche Scientifique (Cnrs Compositions comprising a sirna and lipidic 4,5-disubstituted 2-deoxystreptamine ring aminoglycoside derivatives and uses thereof
EP2350296A4 (en) * 2008-11-17 2013-04-03 Enzon Pharmaceuticals Inc BRANCHED CATIONIC LIPIDS FOR THE SYSTEM FOR INTRODUCING NUCLEIC ACIDS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
NZ276975A (en) * 1993-11-24 1998-04-27 Megabios Corp Guanidine based amphiphiles and their use in liposomes for delivering genetic material intracellularly
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5811406A (en) * 1995-06-07 1998-09-22 Regents Of The University Of California Dry powder formulations of polynucleotide complexes

Also Published As

Publication number Publication date
AU723998B2 (en) 2000-09-07
NO983691D0 (no) 1998-08-12
KR19990087372A (ko) 1999-12-27
JP2000506136A (ja) 2000-05-23
BR9707889A (pt) 2000-01-04
ATE198599T1 (de) 2001-01-15
CZ277298A3 (cs) 1998-12-16
DE69703878D1 (de) 2001-02-15
ES2154453T3 (es) 2001-04-01
IL125926A0 (en) 1999-04-11
AU1930497A (en) 1997-09-16
HU228072B1 (en) 2012-09-28
EP0888379A1 (fr) 1999-01-07
SK118298A3 (en) 1999-02-11
HUP9902465A3 (en) 2009-10-28
US6143729A (en) 2000-11-07
CZ295225B6 (cs) 2005-06-15
WO1997031935A1 (fr) 1997-09-04
JP4271260B2 (ja) 2009-06-03
NO311806B1 (no) 2002-01-28
DK0888379T3 (da) 2001-01-29
EP0888379B1 (fr) 2001-01-10
US6316422B1 (en) 2001-11-13
KR100452062B1 (pt) 2005-04-08
DE69703878T2 (de) 2001-04-26
HUP9902465A1 (hu) 1999-12-28
BR9707889B1 (pt) 2010-03-23
NO983691L (no) 1998-08-12
SK283575B6 (sk) 2003-09-11
IL125926A (en) 2004-09-27
PT888379E (pt) 2001-05-31
GR3035205T3 (en) 2001-04-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]

Free format text: DEFERIDO, COM RESSALVA NO QUE INCIDIR NO ART. 10, INCISO VIII DA LPI 9279/96.

B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: A FIM DE ATENDER A PETICAO DE EXPEDICAO DE CARTA PATENTE NO 018090028337/SP DE 29/05/2009, QUEIRA O INTERESSADO APRESENTAR A DEVIDA PROCURACAO.

B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: REFERENTE A RPI 2017 DE 01/09/2009 CODIGO DO DESPACHO (6.7), POR TER SIDO INDEVIDO.

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2010, OBSERVADAS AS CONDICOES LEGAIS. RESSALVANDO O QUE INCIDIR NO ART. 10 (VIII) DA LPI 9279/96.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI-52400.68486/2013 ORIGEM: JUIZO DA 25A VARA FEDERAL DE SAO PAULO PROCESSO NO 0017574-93.2013.4.03.6100 ACAO DE NULIDADE DE PATENTE AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: BAYER SAS, CENTELION E CENTELION S.A., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MERCK SERONO S.A. E SAMJIN PHARMACEUTICAL CO. LTD.

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI-52400.068486/2013 SECAO JUDICIARIA DE SAO PAULO - 25A VARA FEDERAL CIVEL DE SAO PAULO PROCESSO NO0017574-93.2013.403.6100 AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: BAYER SAS, CENTELION, CENTELION S.A, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MERCK SERONO S.A E SAMJIN PHARMACEUTICAL CO. LTDA DECISAO: JULGO PROCEDENTE O PEDIDO FORMULADO PARA DECLARAR A NULIDADE PARCIAL DAS PATENTES PI 9607583-0, PI 9610511-9, PI 9707889-1 E PI 9604907-3 E DETERMINO A RETIFICACAO DOS RESPECTIVOS PRAZOS DE VIGENCIA DE MODO A OBSERVAR A O DISPOSTO NO PARAGRAFO UNICO DO ARTIGO 229 DA LEI NO 9.279-96, EM INTERPRETACAO CONJUNTA COM O CAPUT DO ARTIGO 40 DO MESMO DIPLOMA.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2046 DE 23/03/2010, QUANTO AO PRAZO DE VALIDADE POR DETERMINACAO DA 25A VARA CIVEL FEDERAL DE SAO PAULO, PROC. 0017574-93.2013.403.6100 - ACAO ORDINARIA - INPI 52400.068486/2013-05.

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI NO 52400.009771/2015-48 PROCESSO JUDICIAL: 0017574-93.2013.4.03.6100 NUP: 00848.000050/2015-10 (REF. 0017574-93.2013.4.03.6100) PARECER DE FORCA EXECUTORIA N. 00012/2020/EEFIN NAP/EEFINSP/PGF/AGU INTERESSADOS: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E OUTROS DECISAO: O JUIZO DA 25A VARA CIVEL FEDERAL DE SAO PAULO JULGOU O PEDIDO PARCIALMENTE PROCEDENTE, PARA DECLARAR A NULIDADE PARCIAL DAS PATENTES PI 9607583-0, PI 9610511-9, E PI 9707889-1, ADEQUANDO AS PATENTES AOS ARTIGOS 229, P. U., E 40, CAPUT, DA LEI N. 9.279-96. ESTA DECISAO FOI POSTERIORMENTE CONFIRMADA PELO TRF DA 3A REGIAO, COM TRANSITO EM JULGADO EM 23 DE JULHO DE 2019.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 28/12/2017.