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BR9916320A - Bisamido polibiguanidas e uso das mesmas para desinfetar lentes de contato e preservar composições farmacêuticas - Google Patents

Bisamido polibiguanidas e uso das mesmas para desinfetar lentes de contato e preservar composições farmacêuticas

Info

Publication number
BR9916320A
BR9916320A BR9916320-9A BR9916320A BR9916320A BR 9916320 A BR9916320 A BR 9916320A BR 9916320 A BR9916320 A BR 9916320A BR 9916320 A BR9916320 A BR 9916320A
Authority
BR
Brazil
Prior art keywords
polybiguanide
contact lenses
pharmaceutical compositions
bisamido
bisamides
Prior art date
Application number
BR9916320-9A
Other languages
English (en)
Inventor
Joonsup Park
Nathaniel D Mcqueen
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of BR9916320A publication Critical patent/BR9916320A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A61L12/142—Polymeric biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Patente de Invenção:<B>''BISAMIDO POLIBIGUANIDAS E USO DAS MESMAS PARA DESINFETAR LENTES DE CONTATO E PRESERVAR COMPOSIçõES FARMACêUTICAS''<D>. A presente invenção refere-se a novas bisamido polibiguanidas e seu uso como agentes antimicrobianos em composições farmacêuticas.Também está descrito um método de síntese das bisamido polibiguanidas. As bisamido polibiguanidas são úteis na preservação de composições farmacêuticas, particularmente composições oftálmicas e auriculares e composições para tratamento de lentes de contato. Os compostos são especialmente úteis para desinfetar/limpar lentes de contato.
BR9916320-9A 1998-12-18 1999-12-17 Bisamido polibiguanidas e uso das mesmas para desinfetar lentes de contato e preservar composições farmacêuticas BR9916320A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11297198P 1998-12-18 1998-12-18
PCT/US1999/030208 WO2000035861A1 (en) 1998-12-18 1999-12-17 Bis-amido polybiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BR9916320A true BR9916320A (pt) 2001-08-14

Family

ID=22346862

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916320-9A BR9916320A (pt) 1998-12-18 1999-12-17 Bisamido polibiguanidas e uso das mesmas para desinfetar lentes de contato e preservar composições farmacêuticas

Country Status (7)

Country Link
US (1) US6316669B1 (pt)
EP (1) EP1140804A1 (pt)
JP (1) JP2002532462A (pt)
AU (1) AU2195800A (pt)
BR (1) BR9916320A (pt)
CA (1) CA2352076A1 (pt)
WO (1) WO2000035861A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002056895A2 (en) * 2001-01-18 2002-07-25 Genzyme Corporation Ionene polymers and their use in treating mucositis
US7923469B2 (en) 2001-04-30 2011-04-12 Allergen, Inc. Compositions including vitamin-based surfactants and methods for using same
US20050042712A1 (en) * 2003-08-22 2005-02-24 Advanced Medical Optics, Inc. Methods, compositions and instruments to predict antimicrobial or preservative activity
US7897553B2 (en) * 2006-10-23 2011-03-01 Bausch & Lomb Incorporated Biguanide composition with low terminal amine
US8093352B2 (en) * 2008-08-05 2012-01-10 Alcon Research, Ltd. Polyalkylene oxide polyquaternary ammonium biocides
CN101962442B (zh) * 2009-07-21 2013-03-27 铜陵高聚生物科技有限公司 一种盐酸聚六亚甲基双胍的制备方法
CN102993057B (zh) * 2012-12-04 2014-09-17 甘肃省化工研究院 1,6-双氰基胍基己烷的合成方法
AU2015229452B2 (en) 2014-03-12 2021-07-15 University Of Virginia Patent Foundation Compositions and methods for treating eye infections and disease
CN108084434B (zh) * 2017-12-04 2020-07-03 辽宁科技大学 一种由废酸碱液制备聚六亚甲基单胍盐酸盐的方法
CN110078913B (zh) * 2019-05-29 2021-08-24 湖南雪天精细化工股份有限公司 一种聚六亚甲基双胍盐酸盐的制备方法
CN110218314B (zh) * 2019-05-30 2021-09-17 甘肃泰升化工科技有限公司 聚六亚甲基双胍盐酸盐的合成工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799988A (en) * 1969-04-02 1974-03-26 Taiho Pharmaceutical Co Ltd {107 -guanidino acid diamide derivatives and manufacturing the same
US4891423A (en) * 1989-03-20 1990-01-02 Stockel Richard F Polymeric biguanides
US4954636A (en) 1989-07-03 1990-09-04 Gaf Chemicals Corporation Antimicrobial polymeric bisbiguanides
US5149524A (en) 1991-01-03 1992-09-22 Rohm And Haas Company Antimicrobial polymeric quaternary ammonium salts
TW203128B (en) 1992-06-17 1993-04-01 Ciba Geigy Ag The protection method for hard and soft contact lens
US5573726A (en) 1993-09-22 1996-11-12 Alcon Laboratories, Inc. Use of amidoamines in ophthalmic compositions
US5741886A (en) 1995-09-19 1998-04-21 Stockel; Richard F. End-capped polymeric biguanides
GB9606868D0 (en) 1996-04-01 1996-06-05 Waverley Pharma Ltd Disinfectant solutions
JP2001504246A (ja) 1996-11-13 2001-03-27 ボシュ アンド ロム インコーポレイテッド コンタクトレンズを消毒するためにビス（ビグアニド）が増強された抗菌効力を提供する組成物および方法
EP0938344B1 (en) 1996-11-13 2002-02-20 Bausch & Lomb Incorporated Method for providing rapid disinfection of contact lenses
US5882687A (en) 1997-01-10 1999-03-16 Allergan Compositions and methods for storing contact lenses

Also Published As

Publication number Publication date
EP1140804A1 (en) 2001-10-10
JP2002532462A (ja) 2002-10-02
WO2000035861A1 (en) 2000-06-22
CA2352076A1 (en) 2000-06-22
AU2195800A (en) 2000-07-03
US6316669B1 (en) 2001-11-13

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O E 7O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.