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BR9915900A - Compound, pharmaceutical composition, and process for treating or inhibiting disorders associated with smooth muscle contraction. - Google Patents

Compound, pharmaceutical composition, and process for treating or inhibiting disorders associated with smooth muscle contraction.

Info

Publication number
BR9915900A
BR9915900A BR9915900-7A BR9915900A BR9915900A BR 9915900 A BR9915900 A BR 9915900A BR 9915900 A BR9915900 A BR 9915900A BR 9915900 A BR9915900 A BR 9915900A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
smooth muscle
disorders associated
muscle contraction
Prior art date
Application number
BR9915900-7A
Other languages
Portuguese (pt)
Inventor
Schuyler A Antane
John A Butera
Joseph R Lennox
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR9915900A publication Critical patent/BR9915900A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSO PARA TRATAR OU INIBIR DISTúRBIOS ASSOCIADOS COM CONTRAçãO DA MUSCULATURA LISA" Compostos de Fórmulas (I) e (II): onde R~ 1~, R~ 2~, R~ 3~, X, Y e Z são como definidos na especificação compostos estes úteis no tratamento de distúrbios associados com contração de musculatura lisa via modulação por canal de potássio."COMPOUND, PHARMACEUTICAL COMPOSITION, AND, PROCESS TO TREAT OR INHIBIT DISTURBANCES ASSOCIATED WITH SMOOTH MUSCULATURE CONTRACTION" Compounds of Formulas (I) and (II): where R ~ 1 ~, R ~ 2 ~, R ~ 3 ~, X, Y and Z are as defined in the specification compounds which are useful in the treatment of disorders associated with smooth muscle contraction via potassium channel modulation.

BR9915900-7A 1998-12-04 1999-12-03 Compound, pharmaceutical composition, and process for treating or inhibiting disorders associated with smooth muscle contraction. BR9915900A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20577098A 1998-12-04 1998-12-04
PCT/US1999/028619 WO2000034285A2 (en) 1998-12-04 1999-12-03 Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers

Publications (1)

Publication Number Publication Date
BR9915900A true BR9915900A (en) 2001-08-21

Family

ID=22763580

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915900-7A BR9915900A (en) 1998-12-04 1999-12-03 Compound, pharmaceutical composition, and process for treating or inhibiting disorders associated with smooth muscle contraction.

Country Status (7)

Country Link
EP (1) EP1135393A2 (en)
JP (1) JP2002531569A (en)
CN (1) CN1333774A (en)
AU (1) AU2163600A (en)
BR (1) BR9915900A (en)
CA (1) CA2350590A1 (en)
WO (1) WO2000034285A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005287038B2 (en) * 2004-09-20 2012-02-02 Janssen Pharmaceutica N.V. Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
KR100659498B1 (en) 2005-03-10 2006-12-20 애니젠 주식회사 Benzopuroindole Potassium Channel Initiator
ATE478863T1 (en) 2005-07-14 2010-09-15 Irm Llc HETEROTETRACYCLIC COMPOUNDS AS TPOMIMETICA
JP6091445B2 (en) * 2013-02-07 2017-03-08 富士フイルム株式会社 Organic thin film transistor, organic semiconductor thin film and organic semiconductor material
AU2016215432B2 (en) 2015-02-02 2020-07-30 Valo Early Discovery, Inc. 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as HDAC inhibitors
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
CN106632360A (en) * 2016-09-27 2017-05-10 上海道亦化工科技有限公司 Compound based on benzofuroindole and organic electroluminescent device thereof
CN109942545A (en) * 2019-04-15 2019-06-28 中国药科大学 Potassium ion competitive acid blocker containing indole structure and its preparation method and use
US12227523B2 (en) 2021-01-14 2025-02-18 Samsung Display Co., Ltd. Luminescence device and polycyclic compound for luminescence device

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8902273D0 (en) * 1989-06-22 1989-06-22 Univ Cincinnati INDENOINDOLE COMPOUNDS I
SE8902274D0 (en) * 1989-06-22 1989-06-22 Univ Cincinnati INDENOIDOLE COMPOUNDS II
EP0447703A1 (en) * 1990-03-20 1991-09-25 The Wellcome Foundation Limited Hetero polycyclic biocidal compounds, their synthesis and intermediates therefor,formulations containing them and their use in medicine

Also Published As

Publication number Publication date
WO2000034285A2 (en) 2000-06-15
CN1333774A (en) 2002-01-30
JP2002531569A (en) 2002-09-24
WO2000034285A3 (en) 2000-11-16
CA2350590A1 (en) 2000-06-15
EP1135393A2 (en) 2001-09-26
AU2163600A (en) 2000-06-26

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired