[go: up one dir, main page]

BR9915611A - Benzo [de] isoquinolina-1,3-dionas substituìdas - Google Patents

Benzo [de] isoquinolina-1,3-dionas substituìdas

Info

Publication number
BR9915611A
BR9915611A BR9915611-3A BR9915611A BR9915611A BR 9915611 A BR9915611 A BR 9915611A BR 9915611 A BR9915611 A BR 9915611A BR 9915611 A BR9915611 A BR 9915611A
Authority
BR
Brazil
Prior art keywords
benzo
diones
substituted isoquinoline
substituted
isoquinoline
Prior art date
Application number
BR9915611-3A
Other languages
English (en)
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Peter Raddatz
Zhengdong Wu
Daljit Dhanoa
Richard Soll
James Rinker
Todd Graybill
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9915611A publication Critical patent/BR9915611A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: <B>"BENZO[DE]ISOQUINOLINA-1,3-DIONAS SUBSTITUìDAS"<D>. Novos compostos da fórmula I em que R, R¹, R² e i têm os significados indicados na reivindicação 1 da Patente, e seus sais e solvatos como antagonistas de IbIX de glicoproteína.
BR9915611-3A 1998-11-25 1999-11-09 Benzo [de] isoquinolina-1,3-dionas substituìdas BR9915611A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19940998A 1998-11-25 1998-11-25
US40099299A 1999-09-21 1999-09-21
PCT/EP1999/008560 WO2000031039A1 (en) 1998-11-25 1999-11-09 Substituted benzo[de]isoquinoline-1,3-diones

Publications (1)

Publication Number Publication Date
BR9915611A true BR9915611A (pt) 2001-08-14

Family

ID=26894739

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915611-3A BR9915611A (pt) 1998-11-25 1999-11-09 Benzo [de] isoquinolina-1,3-dionas substituìdas

Country Status (15)

Country Link
EP (1) EP1133475A1 (pt)
JP (1) JP2002530379A (pt)
CN (1) CN1328549A (pt)
AR (1) AR029152A1 (pt)
AU (1) AU1504900A (pt)
BR (1) BR9915611A (pt)
CA (1) CA2351348A1 (pt)
CZ (1) CZ20011792A3 (pt)
HU (1) HUP0104469A3 (pt)
ID (1) ID29425A (pt)
MX (1) MXPA01005228A (pt)
NO (1) NO20012543D0 (pt)
PL (1) PL347766A1 (pt)
SK (1) SK7012001A3 (pt)
WO (1) WO2000031039A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0104236D0 (en) 2001-02-21 2001-04-11 Clariant Int Ltd New dye compounds
GB0104240D0 (en) 2001-02-21 2001-04-11 Clariant Int Ltd Copolymer composition having pigment like properties
GB0419850D0 (en) * 2004-09-07 2004-10-13 Angeletti P Ist Richerche Bio Therapeutic agents
US8097725B2 (en) * 2004-12-03 2012-01-17 Roche Diagnostics Operations, Inc. Luminescent indicator dye and optical sensor
WO2012115945A1 (en) * 2011-02-21 2012-08-30 The Board Of Regents Of The University Of Texas System Viral inhibitors
CN103848787A (zh) * 2012-12-06 2014-06-11 中国科学院大连化学物理研究所 一种荧光探针及其在可逆检测次氯酸中的应用
WO2014149198A1 (en) * 2013-03-15 2014-09-25 Alumend, Llc Compositions and methods of using the compositions for plaque softening
CN107417616A (zh) * 2013-05-01 2017-12-01 中央研究院 治疗β‑地中海贫血和镰状细胞病的方法和组合物
CN110650946A (zh) * 2017-05-19 2020-01-03 株式会社同仁化学研究所 荧光化合物及应用该化合物的自噬检测试剂
CN111253368B (zh) * 2018-11-30 2020-12-25 沈阳药科大学 一类稳定氮氧自由基修饰的萘酰亚胺类化合物及其应用
CN111777557B (zh) * 2020-07-28 2022-11-22 中国科学院上海有机化学研究所 以芳香联苯烯为骨架的新型抗肿瘤先导化合物及其应用
CN113087702B (zh) * 2021-03-29 2022-07-12 苏州大学 一种多功能过氯乙烯衍生物及其制备方法与应用
WO2023166531A1 (en) * 2022-03-04 2023-09-07 Jawaharlal Nehru Centre For Advanced Scientific Research Amyloid and associated pathology modulators and methods thereof
CA3265669A1 (en) * 2022-08-22 2024-02-29 Jawaharlal Nehru Centre For Advanced Scientific Research TAU LIQUID-LIQUID PHASE SEPARATION MODULATORS AND ASSOCIATED PROCESSES

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2360705A1 (de) * 1973-12-06 1975-06-26 Hoechst Ag Wasserunloesliche verbindungen, verfahren zu ihrer herstellung und ihre verwendung als farbstoffe
US4200752A (en) * 1978-02-16 1980-04-29 Bertelson Robert C 4-Disubstituted amino, N-substituted naphthalimide dyestuffs
JPS54160977A (en) * 1978-06-09 1979-12-20 Kawasaki Steel Corp Functioning speed changing method by means of operating lever
GB2183667B (en) * 1985-10-29 1989-11-22 Univ Brunel Preparation of amino-1;8-naphthalimides.
DE3614414A1 (de) * 1986-04-29 1987-11-05 Knoll Ag Neue benzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
US5308773A (en) * 1992-11-16 1994-05-03 Microbiomed Corp. Non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium
DE19505941A1 (de) * 1995-02-21 1996-08-22 Bayer Ag 1,8-Naphthalimid-Derivate, Verfahren zur Herstellung und ihre Verwendung als Zwischenprodukte
NZ335291A (en) * 1996-10-21 2001-02-23 Allelix Biopharma Neurotrophin antagonist compositions

Also Published As

Publication number Publication date
CZ20011792A3 (cs) 2001-09-12
SK7012001A3 (en) 2001-11-06
EP1133475A1 (en) 2001-09-19
HUP0104469A2 (hu) 2002-04-29
MXPA01005228A (es) 2002-06-21
NO20012543L (no) 2001-05-23
AR029152A1 (es) 2003-06-18
HUP0104469A3 (en) 2003-06-30
ID29425A (id) 2001-08-30
WO2000031039A1 (en) 2000-06-02
JP2002530379A (ja) 2002-09-17
AU1504900A (en) 2000-06-13
CA2351348A1 (en) 2000-06-02
NO20012543D0 (no) 2001-05-23
CN1328549A (zh) 2001-12-26
PL347766A1 (en) 2002-04-22

Similar Documents

Publication Publication Date Title
BR9915611A (pt) Benzo [de] isoquinolina-1,3-dionas substituìdas
BR0114020A (pt) 4-amino-quinazolinas
BR0215042A (pt) fenil-naftalenos substituìdos como agentes estrogênicos
BR9915648A (pt) Benzo [de] isoquinolina-1,3-dionas substituìdas
BR9814592A (pt) &#34;compostos azopolicìclicos condensados com arila&#34;
DK0889876T3 (da) Meta-substituerede phenylensulfonamidderivater
BR9916111A (pt) Derivados de fenilglicina
BR9901111A (pt) Corantes contendo derivados de diamino-benzeno bem como derivados de diamino-benzeno
BR9901491A (pt) 7-hetero-biciclo [2.2.1] - heptanos.
BR0014311A (pt) Quinazolinonas
ATE350036T1 (de) Tetrahydroquinolin-derivate
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
ES2134755T3 (es) Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion.
BR9916798A (pt) 4-arilamino, 4-arilóxi e 4-ariltio diarilaminas e seus derivados como inibidores seletivos de mek
BR0110024A (pt) Derivados de ecteinascidina antitumorais
BR0014294A (pt) Quinazolinonas
BR9909486A (pt) Compostos calcilìticos
TR199801268T2 (xx) Ta�ikinin antagonistleri olarak 3-Azetidinilalkilpiperidinler veya pirolidinler.
BR9910032A (pt) Tienopirimidinas
YU11401A (sh) Lokalne farmaceutske kompozicije koje sadrže nimesulid
BR9909548A (pt) Fenilpiridazinonas substituìdas
BR0009211A (pt) Derivados de resorcinol
EA200100517A1 (ru) Антагонисты 5ht1 для антидепрессантной терапии
BR9912307A (pt) Inibidores fkbp
BR0114021A (pt) 4-amino-quinazolinas

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.