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BR9915604A - Peptìdios inibidores de tgfbeta1 - Google Patents

Peptìdios inibidores de tgfbeta1

Info

Publication number
BR9915604A
BR9915604A BR9915604-0A BR9915604A BR9915604A BR 9915604 A BR9915604 A BR 9915604A BR 9915604 A BR9915604 A BR 9915604A BR 9915604 A BR9915604 A BR 9915604A
Authority
BR
Brazil
Prior art keywords
tgfbeta1
inhibitory peptides
peptides
compositions
inhibitory
Prior art date
Application number
BR9915604-0A
Other languages
English (en)
Other versions
BR9915604B1 (pt
Inventor
Ignacio Jose Ezquerro Saenz
Juan Jose Lasarte Sagastibelza
Jesus Prieto Valtuena
Francisco Borras Cuesta
Original Assignee
Inst Cientifico Tecnol Navarra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Cientifico Tecnol Navarra filed Critical Inst Cientifico Tecnol Navarra
Publication of BR9915604A publication Critical patent/BR9915604A/pt
Publication of BR9915604B1 publication Critical patent/BR9915604B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>PEPTìDIOS INIBIDORES DE TGFBETA1''<D>. Peptídios sintéticos antagonistas obtidos de TGFß1 ou de seus receptores no organismo, que podem ser usados, como tais ou como as seq³ências genéticas que os codificam e os sistemas recombinantes que os expressem, na produção de composições úteis para o tratamento de doenças hepáticas e mais particularmente em casos de fibrose. Essas composições podem incluir opcionalmente mimótopos de referidos peptídios ativos.
BRPI9915604-0A 1998-11-24 1999-11-23 peptÍdios antagonistas de inibidores de tgf-beta1 e seu uso. BR9915604B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP9802465 1998-11-24
ES009802465A ES2146552B1 (es) 1998-11-24 1998-11-24 Peptidos inhibidores de tgf/31
PCT/ES1999/000375 WO2000031135A1 (es) 1998-11-24 1999-11-23 PEPTIDOS INHIBIDORES DE TGFβ1

Publications (2)

Publication Number Publication Date
BR9915604A true BR9915604A (pt) 2001-08-07
BR9915604B1 BR9915604B1 (pt) 2011-07-26

Family

ID=8305903

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9915604-0A BR9915604B1 (pt) 1998-11-24 1999-11-23 peptÍdios antagonistas de inibidores de tgf-beta1 e seu uso.

Country Status (16)

Country Link
US (2) US7057013B1 (pt)
EP (1) EP1132403B1 (pt)
JP (5) JP3836677B2 (pt)
CN (1) CN1203091C (pt)
AT (1) ATE322505T1 (pt)
AU (1) AU767498B2 (pt)
BR (1) BR9915604B1 (pt)
CA (1) CA2352537C (pt)
CY (1) CY1105616T1 (pt)
DE (1) DE69930763T2 (pt)
DK (1) DK1132403T3 (pt)
ES (2) ES2146552B1 (pt)
PT (1) PT1132403E (pt)
RU (1) RU2232771C2 (pt)
SI (1) SI1132403T1 (pt)
WO (1) WO2000031135A1 (pt)

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US7723473B2 (en) * 1997-06-19 2010-05-25 St. Louis University Peptide antagonists of TGF-beta family members and therapeutic uses thereof
JP2002087938A (ja) * 2000-09-11 2002-03-27 Shiseido Co Ltd 養毛剤及びそのスクリーニング方法
EP1534737A4 (en) * 2002-04-29 2007-10-31 Univ Saint Louis PEPTIDANTAGONISTS OF MEMBERS OF THE TGF BETA FAMILY AND THEIR THERAPEUTIC APPLICATION
US8158589B2 (en) * 2003-08-22 2012-04-17 Proyecto Biomedicine Cima, S.L. Peptides with the capacity to bind to transforming growth factor β1 (TGF-β1)
ES2304069B1 (es) * 2003-08-22 2009-08-12 Proyecto De Biomedicina Cima, S.L. Peptidos con capacidad de unirse al factor transformante de crecimiento beta 1 (tgf-b1).
RU2420307C2 (ru) * 2005-10-24 2011-06-10 Проекто Де Биомедисина Сима, С.Л. ПРИМЕНЕНИЕ ИНГИБИРУЮЩИХ TGF-бета1 ПЕПТИДОВ ДЛЯ ПРИГОТОВЛЕНИЯ МОДУЛИРУЮЩЕГО ИММУННЫЙ ОТВЕТ АГЕНТА
CA2627298A1 (en) * 2005-10-24 2007-05-03 Proyecto De Biomedicina Cima, S.L. Use of tgf-.beta.1 inhibitor peptides in the preparation of an immune response modulating agent
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ES2327088B1 (es) * 2007-08-20 2010-07-26 Proyecto De Biomedicina Cima S.L. Combinaciones terapeuticas para el tratamiento de las metastasis.
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CN102159219B (zh) 2008-09-16 2015-06-24 圣路易斯大学 提高转化生长因子-β信号发送的方法
AU2010210033A1 (en) 2009-02-05 2011-08-04 Digna Biotech, S.L. Pharmaceutical compositions comprising TGF- beta1 inhibitor peptides
ES2347627B1 (es) 2009-03-06 2011-10-10 Isdin, S.A. Peptido para el tratamiento profilactico o terapeutico de tumores de la piel en estadios iniciales.
KR100983182B1 (ko) * 2009-08-14 2010-09-20 (주)엔솔테크 신규 펩타이드 및 그 용도
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SG183356A1 (en) * 2010-02-18 2012-09-27 Univ California INTEGRIN aVß8 NEUTRALIZING ANTIBODY
CN102898508B (zh) * 2011-08-12 2014-04-30 北京大学第一医院 封闭TGF-β受体或IL-10受体的多肽、其药物组合物及其用途
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CU24181B1 (es) * 2012-11-09 2016-04-25 Ct De Inmunología Molecular POLIPÉPTIDOS DERIVADOS DEL TGFß
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EP3174550B1 (en) * 2014-08-01 2020-01-29 The Brigham and Women's Hospital, Inc. Methods and compositions relating to treatment of pulmonary arterial hypertension
CN107073042A (zh) 2014-09-03 2017-08-18 布里格海姆妇女医院公司 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法
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CN116327952A (zh) 2015-08-04 2023-06-27 阿塞勒隆制药公司 用于治疗骨髓增生性病症的方法
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US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
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Also Published As

Publication number Publication date
CA2352537A1 (en) 2000-06-02
CA2352537C (en) 2011-11-15
RU2232771C2 (ru) 2004-07-20
DE69930763T2 (de) 2006-11-30
US7528226B2 (en) 2009-05-05
US20070014767A1 (en) 2007-01-18
JP2007186519A (ja) 2007-07-26
PT1132403E (pt) 2006-07-31
CN1203091C (zh) 2005-05-25
JP2009040796A (ja) 2009-02-26
EP1132403A1 (en) 2001-09-12
AU767498B2 (en) 2003-11-13
JP4002287B2 (ja) 2007-10-31
CY1105616T1 (el) 2010-07-28
ATE322505T1 (de) 2006-04-15
JP2002530431A (ja) 2002-09-17
JP4068654B2 (ja) 2008-03-26
EP1132403B1 (en) 2006-04-05
DE69930763D1 (en) 2006-05-18
CN1328569A (zh) 2001-12-26
JP4272255B2 (ja) 2009-06-03
JP2008056685A (ja) 2008-03-13
ES2146552B1 (es) 2001-04-16
JP3836677B2 (ja) 2006-10-25
BR9915604B1 (pt) 2011-07-26
AU1507700A (en) 2000-06-13
ES2262349T3 (es) 2006-11-16
JP4237807B2 (ja) 2009-03-11
SI1132403T1 (sl) 2006-08-31
ES2146552A1 (es) 2000-08-01
WO2000031135A1 (es) 2000-06-02
US7057013B1 (en) 2006-06-06
JP2006241166A (ja) 2006-09-14
DK1132403T3 (da) 2006-08-14

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