[go: up one dir, main page]

BR9914206A - Ceto-amidas heterocìclicas 2-substituìdas úteis para tratar a perda de cabelos em mamìferos - Google Patents

Ceto-amidas heterocìclicas 2-substituìdas úteis para tratar a perda de cabelos em mamìferos

Info

Publication number
BR9914206A
BR9914206A BR9914206-6A BR9914206A BR9914206A BR 9914206 A BR9914206 A BR 9914206A BR 9914206 A BR9914206 A BR 9914206A BR 9914206 A BR9914206 A BR 9914206A
Authority
BR
Brazil
Prior art keywords
nothing
mammals
useful
alkyl
hair loss
Prior art date
Application number
BR9914206-6A
Other languages
English (en)
Inventor
John Mcmillan Mciver
Charles Raymond Degenhardt
David Joseph Eickhoff
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9914206A publication Critical patent/BR9914206A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Indole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"CETO-AMIDAS HETEROCìCLICAS 2-SUBSTITUìDAS úTEIS PARA TRATAR A PERDA DE CABELOS EM MAMìFEROS". A presente invenção descreve compostos inovadores (fórmula (I)), onde W é selecionado entre nada, hidrogênio, e alquila inferior; A é selecionado entre nada e alquila; X e Y são, cada um, independentemente, selecionados entre C (O), P (O), N, O, e S, onde (i) quando X é C (O), então R~ 3~ é nada e Y é selecionado entre N, O, e S, (ii) quando X é P (O), então R~ 3~ é nada e Y é selecionado no grupo que consiste de N e O; (iii) quando X é N, então R~ 3~ é selecionado entre hidrogênio, alquila, e aril-alquila, Y é C (O), e R~ 2~ é nada; e onde os substituintes R~ 1~ até R~ 10~ são aqui definidos, e composições que são particularmente úteis para tratar perda pilosa em mamíferos, inclusive deter e/oureverter perda pilosa e promover o crescimento piloso. Os presentes compostos e composições podem ser úteis também para uma série de distúrbios, inclusive, por exemplo, resistência a múltiplos medicamentos, vírus da imunodeficiência humana (HIV), lesão cardíaca, e distúrbios neurológicos, e podem ser úteis para controlar parasitas e induzir imunossupressão.
BR9914206-6A 1998-09-30 1999-09-24 Ceto-amidas heterocìclicas 2-substituìdas úteis para tratar a perda de cabelos em mamìferos BR9914206A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10244998P 1998-09-30 1998-09-30
PCT/US1999/022211 WO2000018733A1 (en) 1998-09-30 1999-09-24 Heterocyclic 2-substituted ketoamides useful for treating hair loss in mammals

Publications (1)

Publication Number Publication Date
BR9914206A true BR9914206A (pt) 2001-07-03

Family

ID=22289908

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914206-6A BR9914206A (pt) 1998-09-30 1999-09-24 Ceto-amidas heterocìclicas 2-substituìdas úteis para tratar a perda de cabelos em mamìferos

Country Status (7)

Country Link
US (2) US6307049B1 (pt)
EP (1) EP1117640A1 (pt)
JP (1) JP2002525355A (pt)
CN (1) CN1320116A (pt)
AU (1) AU6263599A (pt)
BR (1) BR9914206A (pt)
WO (1) WO2000018733A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6387500A (en) * 1999-08-05 2001-03-05 Procter & Gamble Company, The Multivalent exocyclic diketo compounds
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6809093B2 (en) * 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US20020119979A1 (en) * 2000-10-17 2002-08-29 Degenhardt Charles Raymond Acyclic compounds and methods for treating multidrug resistance
DOP2002000332A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US7251711B2 (en) * 2002-05-28 2007-07-31 Micron Technology, Inc. Apparatus and methods having a command sequence
US20090117067A1 (en) * 2007-11-07 2009-05-07 Baltimore Janice D Hair Product
US7479291B1 (en) * 2007-11-07 2009-01-20 Janice D Baltimore Hair product
WO2010009166A1 (en) 2008-07-14 2010-01-21 Gilead Colorado, Inc. Oxindolyl inhibitor compounds
CA2729909A1 (en) 2008-07-14 2010-01-21 Gilead Sciences, Inc. Imidazolyl pyrimidine inhibitor compounds
US8124764B2 (en) 2008-07-14 2012-02-28 Gilead Sciences, Inc. Fused heterocyclyc inhibitor compounds
BRPI0916713A2 (pt) 2008-07-28 2015-11-10 Gilead Science Inc compostos inibidores de histona desacetilase de cicloalquilideno e heterocicloalquilideno
US8258316B2 (en) 2009-06-08 2012-09-04 Gilead Sciences, Inc. Alkanoylamino benzamide aniline HDAC inhibitor compounds
KR20120024722A (ko) 2009-06-08 2012-03-14 길리애드 사이언시즈, 인코포레이티드 시클로알킬카르바메이트 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
TWI633091B (zh) 2011-10-14 2018-08-21 Bristol-Myers Squibb Company 作為因子ｘｉａ抑制劑之經取代四氫異喹啉化合物
US9108951B2 (en) 2011-10-14 2015-08-18 Bristol-Myers Squibb Company Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors
IN2014CN02805A (pt) 2011-10-14 2015-07-03 Bristol Myers Squibb Co
CN102627654B (zh) * 2012-05-08 2013-11-27 山东大学 含异山梨醇结构单元的hiv-1蛋白酶抑制剂及其制备方法与应用
WO2014059214A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
SI2906551T1 (en) 2012-10-12 2018-05-31 Bristol-Myers Squibb Company Crystalline forms of a factor xia inhibitor
EP2906552B1 (en) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
US9738655B2 (en) 2013-03-25 2017-08-22 Bristol-Myers Squibb Company Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors
BR112016015717B1 (pt) 2014-01-31 2023-04-04 Bristol-Myers Squibb Company Compostos macrociclos com grupos p2' heterocíclicos como inibidores do fator xia, composição farmacêutica compreendendo os referidos compostos e uso dos mesmos
NO2760821T3 (pt) 2014-01-31 2018-03-10
JP6526796B2 (ja) 2014-09-04 2019-06-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｆｘｉａ阻害剤であるジアミドマクロ環
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
RS62861B1 (sr) 2016-02-04 2022-02-28 Takeda Pharmaceuticals Co Supstituisano piperidin jedinjenje i njegova upotreba
CN110590535A (zh) * 2019-10-12 2019-12-20 重庆医药高等专科学校 用二氧化硒氧化芳香乙酮制备芳香乙醛酸的方法
KR20230035031A (ko) 2020-06-05 2023-03-10 킨네이트 바이오파마 인크. 섬유아세포 성장 인자 수용체 키나아제의 억제제

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070361A (en) 1977-04-21 1978-01-24 E. R. Squibb & Sons, Inc. Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof
US5162362A (en) 1980-08-30 1992-11-10 Hoechst Aktiengesellschaft Octahydroindole-2-carboxylic acids
DE3177311D1 (de) 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
US4950649A (en) 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
CN86101850A (zh) 1985-03-22 1987-02-04 森得克斯(美国)有限公司 N，n′-二烷基胍基二肽的制造方法与用途
EP0251164B1 (en) 1986-06-25 1992-12-16 Kazuo Achiwa New chiral phosphinopyrrolidine compounds and their use for asymetric synthesis of optically active compounds
JPH0717601B2 (ja) 1986-08-26 1995-03-01 日本化薬株式会社 インドリン類の製造方法
KR960004900B1 (ko) 1986-09-10 1996-04-17 신텍스(유.에스.에이.) 인코포레이티드 디아민의 선택적 아미딘화 방법
KR0159766B1 (ko) 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
GB8929070D0 (en) 1989-12-22 1990-02-28 Fujisawa Pharmaceutical Co Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
US5037819A (en) 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5192773A (en) 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
US5338755A (en) 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
EP0474126B1 (en) 1990-09-04 1997-03-19 Fujisawa Pharmaceutical Co., Ltd. Ointments containing tricyclic compound
HU217621B (hu) 1991-05-09 2000-03-28 Vertex Pharmaceuticals Inc. Eljárás új glioxaloil-pipekolinsav-észterek, származékaik és az ezeket tartalmazó gyógyszerkészítmények előállítására
US5723459A (en) 1991-05-09 1998-03-03 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
US5620971A (en) 1991-05-09 1997-04-15 Vertex Pharmaceuticals Incorporated Biologically active acylated amino acid derivatives
MX9202466A (es) 1991-05-24 1994-06-30 Vertex Pharma Compuestos inmunosupresores novedosos.
CA2091194A1 (en) 1992-04-08 1993-10-09 Richard D. Connell 2-oxo-ethyl derivatives as immunosuppressants
NZ314207A (en) 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
US5385918A (en) 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
US5686469A (en) 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
EP0610745A3 (en) 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
ATE172985T1 (de) 1993-02-09 1998-11-15 Bayer Ag Sulfonamidaminomethylenderivate als immunsuppressiva
JPH06256317A (ja) 1993-03-03 1994-09-13 Kyowa Hakko Kogyo Co Ltd 新規ベンゾイミダゾール誘導体
MY110603A (en) 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
EP0715619A4 (en) 1993-08-23 1997-03-19 Immunex Corp Inhibitors of tnf-alpha secretion
US5610165A (en) 1994-02-17 1997-03-11 Merck & Co., Inc. N-acylpiperidine tachykinin antagonists
US5744485A (en) 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
IL115685A (en) 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5543423A (en) 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
US5670504A (en) 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
US5726184A (en) 1995-05-19 1998-03-10 Vertex Pharmaceuticals Incorporated Tetralin compounds with improved MDR activity
US5614547A (en) 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5696135A (en) 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
WO1998006340A1 (en) 1995-06-07 1998-02-19 Prescott Marvin A Method and apparatus for preventing adhesion and colonization of bacteria in medical devices
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
EP0851760A4 (en) 1995-08-31 1998-11-25 Smithkline Beecham Corp INTERLEUKIN CONVERSION ENZYME AND APOPTOSIS
GB9521322D0 (en) 1995-10-17 1995-12-20 Sandoz Ltd Organic compounds
US5801197A (en) 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
DE69637307T2 (de) 1995-11-28 2008-02-28 Cephalon, Inc. Aus d-aminosäuren abgeleitete cystein-und serinproteasehemmer
EE9800172A (et) 1995-12-06 1998-12-15 Astra Pharmaceuticals Limited Ühendid
WO1997021100A1 (en) 1995-12-07 1997-06-12 The Scripps Research Institute Hiv protease inhibitors
IL124559A (en) 1995-12-08 2004-07-25 Agouron Pharma Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use
WO1997031898A1 (en) 1996-02-28 1997-09-04 Ariad Gene Therapeutics, Inc. Synthetic derivatives of rapamycin as multimerizing agents for chimeric proteins with immunophilin-derived domains
US5717092A (en) 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity
EP0927161B1 (en) 1996-08-28 2002-10-16 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
CZ62699A3 (cs) 1996-08-28 1999-07-14 The Procter & Gamble Company Heterocyklické inhibitory metaloproteinas
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5786378A (en) 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
US5840736A (en) 1996-11-13 1998-11-24 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5811434A (en) 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
WO1998022432A1 (en) 1996-11-18 1998-05-28 Yamanouchi Pharmaceutical Co., Ltd. Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same
ZA9711121B (en) 1996-12-13 1998-06-23 Handelman Joseph H Reduction of hair growth.
WO1998027069A1 (en) 1996-12-17 1998-06-25 Fujisawa Pharmaceutical Co., Ltd. Piperazine compounds as inhibitors of mmp or tnf
US5721256A (en) 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds
WO1998050348A1 (en) 1997-05-09 1998-11-12 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6121280A (en) 1998-03-24 2000-09-19 Pfizer Inc. Azabicyclic rotomase inhibitors
AU760663B2 (en) 1998-06-03 2003-05-22 Gpi Nil Holdings, Inc. Small molecule sulfonamide hair growth compositions and uses
AU767155B2 (en) 1998-06-03 2003-10-30 Gpi Nil Holdings, Inc. Small molecule pipecolic acid derivative hair growth compositions and uses
EP1083875A1 (en) 1998-06-03 2001-03-21 GPI NIL Holdings, Inc. Small molecule carbamate or urea hair growth compositions and uses

Also Published As

Publication number Publication date
WO2000018733A1 (en) 2000-04-06
JP2002525355A (ja) 2002-08-13
EP1117640A1 (en) 2001-07-25
US20010012895A1 (en) 2001-08-09
CN1320116A (zh) 2001-10-31
AU6263599A (en) 2000-04-17
US6307049B1 (en) 2001-10-23

Similar Documents

Publication Publication Date Title
BR9914206A (pt) Ceto-amidas heterocìclicas 2-substituìdas úteis para tratar a perda de cabelos em mamìferos
BRPI0416212A (pt) derivado de piridazinona, composição farmacêutica, uso do derivado, método para o tratamento de um sujeito afligido com uma condição ou doença susceptìvel de melhora pela inibição de fosfodiesterase 4 e produto de combinação
DE59712501D1 (de) 1-benzyl-3-(substituiertes-hetaryl)-kondensierten pyrazol-derivaten zur behandlung von erkrankungen des herz-kreislaufsystems und des zentralnervensystems
BR0113039A (pt) Composto ou um seu sal ou solvato fisiologicamente aceitável, uso do mesmo, composição farmacêutica, formulação farmacêutica em aerossol, método para o tratamento de um indivìduo humano ou animal com uma condição antiinflamatória e/ou alérgica, e, processo para preparar um composto
BRPI0313942C1 (pt) derivados de benzimidazol úteis como agentes antiproliferativos, seus processos de preparação, composição farmacêutica compreendendo os mesmos e usos dos referidos compostos nas preparações de composições farmacêuticas
BR0215429A (pt) Composto de fórmula i e seus usos, métodos de inibição da atividade e método de inibição da ativação de um receptor de monoamina, métodos de tratamento, método de identificação de polimorfismo genético e método de identificação de paciente
MA31766B1 (fr) Composés organiques
ATE381935T1 (de) Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen
BR0211206A (pt) Derivados de 8-metóxi-(1,2,4)triazolo(1, 5-a)piridina e seus usos como ligantes do receptor de adenosina
EA200400466A1 (ru) Производные пиперазина с антагонистической активностью к рецептору ccr1
DE68914292D1 (de) Zusammensetzung zur Behandlung von ischämischen Störungen in Organen.
ES2153491T3 (es) Derivados de quinazolina.
BR9714063A (pt) Composto, processo para a preparação e uso do mesmo, composição farmacêutica, e, processos para preparação da mesma, para executar a imunossupressão e para tratar ou reduzir o risco de uma doença reversìvel, obstrutiva das vias aéreas
AR029025A1 (es) Derivados de adenosina n6 heterociclicos 5' modificados, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de un medicamento
AR014554A1 (es) Compuestos polipeptidos, utiles para el tratamiento de infecciones microbianas, procedimiento para prepararlos, composiciones y medicamentos quelos incluyen y el uso de dichos compuestos y metodo para el tratamiento profilactico y terapeutico de infecciones
BR9807950A (pt) Composto, composição farmacêutica, uso de um composto, e, processos para tratar ou reduzir o risco de doenças ou condições humanas, o risco de doença inflamatória o risco da dor e para a preparação de um composto
BG108180A (en) Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases
BR0208353A (pt) Compostos de diidropirimidina substituìdos com ciano e seu uso para tratar doenças
ATE556712T1 (de) A2a antagonisten zur behandlung von motorischen störungen
BR9914207A (pt) Ceto-amidas 2-substituìdas
BR0016430A (pt) Método para o tratamento e/ou prevenção da tosse em um animal de sangue quente, uso de um composto, composto, e, composição farmacêutica
BR9914208A (pt) Sulfonamidas heterocìclicas 2-substituìdas
AR026470A1 (es) Un compuesto de pirazolpirazina, proceso para prepararlo, las composiciones farmaceuticas que lo contienen y su preparacion, y el uso de dichos compuestospara la preparacion de medicamentos.
ATE267816T1 (de) Tan-1057 derivate
ATE161725T1 (de) Verwendung von phosphatdiestern zur behandlung von erkrankungen der retina

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61Q 7/00 (2006.01), A61K 8/41 (2006.0