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BR9913855A - 1-2-3-4- tetrahidroquinolinas substituìdas na posição 2 e substituìdas na posição 4 com amino como inibidores de cetp - Google Patents

1-2-3-4- tetrahidroquinolinas substituìdas na posição 2 e substituìdas na posição 4 com amino como inibidores de cetp

Info

Publication number
BR9913855A
BR9913855A BR9913855-7A BR9913855A BR9913855A BR 9913855 A BR9913855 A BR 9913855A BR 9913855 A BR9913855 A BR 9913855A BR 9913855 A BR9913855 A BR 9913855A
Authority
BR
Brazil
Prior art keywords
cholesterol
substituted
inhibitors
amino
levels
Prior art date
Application number
BR9913855-7A
Other languages
English (en)
Inventor
Michael Paul Deninno
George Tetteh Magnus-Aryitey
Roger Benjamin Ruggeri
Ronald Thure Wester
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9913855A publication Critical patent/BR9913855A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Patente de Invenção: <B>"1,2,3,4-TETRAHIDROQUINOLINAS SUBSTITUìDAS NA POSIçãO 2 E SUBSTITUìDAS NA POSIçãO 4 COM AMINO COMO INIBIDORES DE CETP"<D>. Inibidores da proteína de transferência do éster de colesterol de fórmula I, pró-droga dos mesmos, ou um sal farmaceuticamente aceitável do dito composto ou da dita pró-droga, composições farmacêuticas que contêm tais inibidores e uso de tais inibidores para elevar certos níveis de lipídios do plasma, incluindo lipoproteína de alta densidade-colesterol, e para baixar certos níveis de outros lipídios do plasma, tais como LDL-colesterol e triglicerídios e, em concordância, para tratar doenças que são exarcebadas por baixos níveis de HDL-colesterol e/ou altos níveis de LDL-colesterol e triglicerídios, tais como aterosclerose e doenças cardiovasculares em alguns mamíferos, incluindo seres humanos.
BR9913855-7A 1998-09-17 1999-09-10 1-2-3-4- tetrahidroquinolinas substituìdas na posição 2 e substituìdas na posição 4 com amino como inibidores de cetp BR9913855A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10092798P 1998-09-17 1998-09-17
PCT/IB1999/001534 WO2000017165A1 (en) 1998-09-17 1999-09-10 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines as cetp inhibitors

Publications (1)

Publication Number Publication Date
BR9913855A true BR9913855A (pt) 2001-07-24

Family

ID=22282246

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913855-7A BR9913855A (pt) 1998-09-17 1999-09-10 1-2-3-4- tetrahidroquinolinas substituìdas na posição 2 e substituìdas na posição 4 com amino como inibidores de cetp

Country Status (50)

Country Link
US (2) US6140343A (pt)
EP (1) EP1114032B1 (pt)
JP (1) JP3561474B2 (pt)
KR (1) KR100422286B1 (pt)
CN (2) CN1515259A (pt)
AP (1) AP1345A (pt)
AR (1) AR030523A1 (pt)
AT (1) ATE268324T1 (pt)
AU (1) AU747715B2 (pt)
BG (1) BG65101B1 (pt)
BR (1) BR9913855A (pt)
CA (1) CA2344248C (pt)
CO (1) CO5290250A1 (pt)
CR (1) CR6306A (pt)
CU (1) CU23053A3 (pt)
CZ (1) CZ2001954A3 (pt)
DE (1) DE69917790T2 (pt)
DK (1) DK1114032T3 (pt)
DZ (1) DZ2891A1 (pt)
EA (1) EA005761B1 (pt)
EE (1) EE200100167A (pt)
ES (1) ES2221420T3 (pt)
GC (1) GC0000108A (pt)
GE (1) GEP20032973B (pt)
GT (1) GT199900147A (pt)
HK (1) HK1039938A1 (pt)
HR (1) HRP20010200B1 (pt)
HU (1) HUP0103512A3 (pt)
ID (1) ID27838A (pt)
IL (1) IL141388A0 (pt)
IS (1) IS2278B (pt)
MA (1) MA26689A1 (pt)
MY (1) MY121405A (pt)
NO (1) NO319781B1 (pt)
NZ (1) NZ509837A (pt)
OA (1) OA11651A (pt)
PA (1) PA8481201A1 (pt)
PE (1) PE20001054A1 (pt)
PL (1) PL198124B1 (pt)
PT (1) PT1114032E (pt)
SI (1) SI1114032T1 (pt)
SK (1) SK3532001A3 (pt)
SV (1) SV1999000150A (pt)
TN (1) TNSN99170A1 (pt)
TR (1) TR200100780T2 (pt)
TW (1) TW502022B (pt)
UA (1) UA70960C2 (pt)
WO (1) WO2000017165A1 (pt)
YU (1) YU18101A (pt)
ZA (1) ZA200101745B (pt)

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