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BR9913225A - New isoxazolinone antibacterial agents - Google Patents

New isoxazolinone antibacterial agents

Info

Publication number
BR9913225A
BR9913225A BR9913225-7A BR9913225A BR9913225A BR 9913225 A BR9913225 A BR 9913225A BR 9913225 A BR9913225 A BR 9913225A BR 9913225 A BR9913225 A BR 9913225A
Authority
BR
Brazil
Prior art keywords
new
antibacterial agents
isoxazolinone
isoxazolinone antibacterial
isoxazolinones
Prior art date
Application number
BR9913225-7A
Other languages
Portuguese (pt)
Inventor
Lawrence B Snyder
Zhizhen Zheng
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR9913225A publication Critical patent/BR9913225A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"NOVOS AGENTES ANTIBACTERIANOS DE ISOXAZOLINONA" Esta invenção descreve derivados de isoxazolinona, que possuem atividade antibacteriana e são úteis no tratamento de doenças bacterianas. Mais particularmente, são proporcionadas novas isoxazolinonas tendo a fórmula geral na qual A e R~ 1~ são como descritos no relatório descritivo."NEW ISOXAZOLINONE ANTIBACTERIAL AGENTS" This invention describes isoxazolinone derivatives, which have antibacterial activity and are useful in the treatment of bacterial diseases. More particularly, new isoxazolinones are provided having the general formula in which A and R ~ 1 ~ are as described in the specification.

BR9913225-7A 1998-08-24 1999-08-23 New isoxazolinone antibacterial agents BR9913225A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9757498P 1998-08-24 1998-08-24
PCT/US1999/019265 WO2000010566A1 (en) 1998-08-24 1999-08-23 Novel isoxazolinone antibacterial agents

Publications (1)

Publication Number Publication Date
BR9913225A true BR9913225A (en) 2001-05-22

Family

ID=22264103

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913225-7A BR9913225A (en) 1998-08-24 1999-08-23 New isoxazolinone antibacterial agents

Country Status (22)

Country Link
EP (1) EP1107756A4 (en)
JP (1) JP2002523369A (en)
KR (1) KR20010072945A (en)
CN (1) CN1314813A (en)
AR (1) AR020250A1 (en)
AU (1) AU748750B2 (en)
BR (1) BR9913225A (en)
CA (1) CA2341271A1 (en)
CO (1) CO5160266A1 (en)
CZ (1) CZ2001669A3 (en)
HU (1) HUP0103433A3 (en)
ID (1) ID27690A (en)
IL (1) IL141542A0 (en)
NO (1) NO20010916L (en)
NZ (1) NZ509867A (en)
PE (1) PE20001063A1 (en)
PL (1) PL346267A1 (en)
TR (1) TR200100672T2 (en)
TW (1) TW572757B (en)
UY (1) UY25677A1 (en)
WO (1) WO2000010566A1 (en)
ZA (1) ZA200101505B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
JP2002020366A (en) * 2000-07-05 2002-01-23 Sumitomo Seika Chem Co Ltd Method for producing alkylthiophenylacetic acid
PE20030044A1 (en) 2000-11-17 2003-02-09 Upjohn Co BICYCLE ISOXAZOLINONES OF FORMULA I
PE20020689A1 (en) 2000-11-17 2002-08-03 Upjohn Co OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE
US6861433B2 (en) * 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes
JP2004518677A (en) 2000-12-21 2004-06-24 ファルマシア・アンド・アップジョン・カンパニー Antibacterial quinolone derivatives and their use to treat bacterial infections
ES2180456B1 (en) * 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. SUBSTITUTED ISOXAZOLS AND ITS USE AS ANTIBIOTICS.
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
JP2005512975A (en) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ Isoxazoline derivatives useful as antibacterial agents
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
EP1554273A1 (en) * 2002-10-10 2005-07-20 Pharmacia & Upjohn Company LLC Antimicrobial 1-aryl dihydropyridone compounds
CA2515311A1 (en) * 2003-02-07 2004-08-19 Warner-Lambert Company Llc Antibacterial agents
DE602004014361D1 (en) 2003-04-30 2008-07-24 Morphochem Ag Komb Chemie USE OF OXAZOLIDINONE CHINOLIN HYBRID ANTIBIOTICS FOR THE TREATMENT OF ANTHRAX AND OTHER INFECTIONS
WO2005070904A2 (en) * 2003-06-03 2005-08-04 Rib-X Pharmaceutical, Inc. Sulfonamide compounds and methods of making and using the same
TWI454465B (en) 2003-06-03 2014-10-01 Melinta Therapeutics Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
JP2007500707A (en) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド Biarylheterocyclic amines, amides and sulfur-containing compounds and methods for making and using the compounds
DE10340485B4 (en) * 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Process for the preparation of oxazolidinone-quinolone hybrids
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1713785A1 (en) 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
JP2007516263A (en) 2003-12-18 2007-06-21 モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー Oxazolidinone-quinolone hybrid antibiotic
WO2005082900A2 (en) * 2004-01-28 2005-09-09 Pharmacia & Upjohn Company Llc Oxazolidinone amidoximes as antibacterial agents
ATE496914T1 (en) 2005-06-08 2011-02-15 Rib X Pharmaceuticals Inc METHOD FOR SYNTHESIS OF TRIAZOLES
AT503354B1 (en) * 2006-02-22 2008-07-15 Dsm Fine Chem Austria Gmbh METHOD FOR THE PRODUCTION OF 3,4-DISUBSTITUTED PHENYL ACETIC ACIDS, AND NEW INTERMEDIATE COMPOUNDS
JP4518066B2 (en) * 2006-10-25 2010-08-04 宇部興産株式会社 Dialkoxynitrile derivative and process for producing the same
CN110423610B (en) * 2019-08-29 2023-05-12 浙江理工大学 A fluorescent probe for detecting two-photon mercury ions and its preparation method and use method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2045049A1 (en) * 1970-09-11 1972-03-23 Dr Karl Thomae GmbH, 7950 Biberach New Nitrofurandenvate and processes for their production
US4000155A (en) * 1975-12-11 1976-12-28 Eli Lilly And Company Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
DE69316240T2 (en) * 1992-12-08 1998-05-20 Upjohn Co PHENYLOXAZOLIDINONE DERIVATIVES SUBSTITUTED BY A TROPON GROUP AS AN ANTIBACTERIAL AGENT
DK0863890T3 (en) * 1995-09-15 2003-03-24 Upjohn Co 5-amidomethyl alfa, beta-saturated and unsaturated 3-aryl-butyrolacetone antibacterial agents
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
US5990136A (en) * 1996-08-21 1999-11-23 Pharmacia & Upjohn Company Isoxazoline derivatives useful as antimicrobials

Also Published As

Publication number Publication date
EP1107756A1 (en) 2001-06-20
PL346267A1 (en) 2002-01-28
NO20010916D0 (en) 2001-02-23
HUP0103433A3 (en) 2002-08-28
KR20010072945A (en) 2001-07-31
NZ509867A (en) 2003-08-29
TR200100672T2 (en) 2001-07-23
ZA200101505B (en) 2002-02-22
CZ2001669A3 (en) 2001-08-15
TW572757B (en) 2004-01-21
UY25677A1 (en) 2001-08-27
AU748750B2 (en) 2002-06-13
NO20010916L (en) 2001-04-10
PE20001063A1 (en) 2000-12-24
AU5783399A (en) 2000-03-14
ID27690A (en) 2001-04-19
IL141542A0 (en) 2002-03-10
EP1107756A4 (en) 2003-02-26
HUP0103433A2 (en) 2002-01-28
AR020250A1 (en) 2002-05-02
CN1314813A (en) 2001-09-26
WO2000010566A1 (en) 2000-03-02
JP2002523369A (en) 2002-07-30
CO5160266A1 (en) 2002-05-30
CA2341271A1 (en) 2000-03-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1919 DE 16/10/2007.