[go: up one dir, main page]

BR9912817A - Therapeutic composition based on isoflavonoids to be used in the treatment of tumors by cytotoxic agents - Google Patents

Therapeutic composition based on isoflavonoids to be used in the treatment of tumors by cytotoxic agents

Info

Publication number
BR9912817A
BR9912817A BR9912817-9A BR9912817A BR9912817A BR 9912817 A BR9912817 A BR 9912817A BR 9912817 A BR9912817 A BR 9912817A BR 9912817 A BR9912817 A BR 9912817A
Authority
BR
Brazil
Prior art keywords
tumors
treatment
cytotoxic agents
isoflavonoids
therapeutic composition
Prior art date
Application number
BR9912817-9A
Other languages
Portuguese (pt)
Inventor
Francis Darro
Robert Kiss
Armand Frydman
Original Assignee
Lafon Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lafon Labor filed Critical Lafon Labor
Publication of BR9912817A publication Critical patent/BR9912817A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçãO TERAPêUTICA à BASE DE ISOFLAVONóIDES DESTINADA A SER UTILIZADA NO TRATAMENTO DOS TUMORES POR AGENTES CITOTóXICOS"<D>. A presente invenção se refere a uma composição que tem uma atividade sobre a proliferação de células clonogenes em tumores, e que compreende uma quantidade terapeuticamente eficaz de um isoflavonóide ou de um composto análogo de tipo cromona, notadamente de um composto escolhido dentre os compostos de fórmula (I) na qual: R~ 1~, R~ 2~, R~ 3~ e R~ 4~, R~ 5~ e R~ 6~ são tais como definidos na reivindicação (2). Essa composição é destinada a ser utilizada no tratamento dos tumores por agentes citotóxicos.Invention Patent: <B> "THERAPEUTIC COMPOSITION ON THE BASIS OF ISOFLAVONOIDS INTENDED TO BE USED IN THE TREATMENT OF TUMORS BY CYTOToxic Agents" <D>. The present invention relates to a composition which has an activity on the proliferation of clonogen cells in tumors, and which comprises a therapeutically effective amount of an isoflavonoid or a chromone-type analog compound, notably a compound chosen from the compounds of formula (I) in which: R ~ 1 ~, R ~ 2 ~, R ~ 3 ~ and R ~ 4 ~, R ~ 5 ~ and R ~ 6 ~ are as defined in claim (2). This composition is intended to be used in the treatment of tumors by cytotoxic agents.

BR9912817-9A 1998-07-15 1999-07-13 Therapeutic composition based on isoflavonoids to be used in the treatment of tumors by cytotoxic agents BR9912817A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9809059A FR2781154B1 (en) 1998-07-15 1998-07-15 THERAPEUTIC COMPOSITION BASED ON ISOFLAVONOIDS FOR USE IN THE TREATMENT OF TUMORS WITH CYTOTOXIC AGENTS
PCT/FR1999/001715 WO2000003707A1 (en) 1998-07-15 1999-07-13 Therapeutic composition based on flavonoids for use in the treatment of tumours with cytotoxic agents

Publications (1)

Publication Number Publication Date
BR9912817A true BR9912817A (en) 2001-05-08

Family

ID=9528649

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912817-9A BR9912817A (en) 1998-07-15 1999-07-13 Therapeutic composition based on isoflavonoids to be used in the treatment of tumors by cytotoxic agents

Country Status (11)

Country Link
EP (1) EP1096929A1 (en)
JP (1) JP2002520357A (en)
KR (1) KR20020006510A (en)
CN (1) CN1139383C (en)
AU (1) AU761417B2 (en)
BR (1) BR9912817A (en)
CA (1) CA2337256A1 (en)
EA (1) EA200100141A1 (en)
FR (1) FR2781154B1 (en)
IL (1) IL140580A0 (en)
WO (1) WO2000003707A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2136233C (en) 1992-05-19 2004-03-30 Graham Edmund Kelly Health supplements containing phyto-oestrogens, analogues or metabolites thereof
AUPO203996A0 (en) 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
US6146668A (en) 1997-04-28 2000-11-14 Novogen, Inc. Preparation of isoflavones from legumes
AUPP260798A0 (en) 1998-03-26 1998-04-23 Novogen Research Pty Ltd Treatment of medical related conditions with isoflavone containing extracts of clover
AUPQ266199A0 (en) * 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AUPR363301A0 (en) 2001-03-08 2001-04-05 Novogen Research Pty Ltd Dimeric isoflavones
PL205635B1 (en) * 2001-04-09 2010-05-31 Inst Farmaceutyczny Novel derivatives of genistein and pharmacological agents containing such derivatives
WO2003075943A2 (en) * 2002-03-06 2003-09-18 The Medical Research And Education Trust Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol
AU2002951833A0 (en) 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
DE10337863A1 (en) 2003-08-18 2005-03-17 Merck Patent Gmbh Use of chromene-4-one derivatives
CA2590048C (en) 2007-05-23 2013-07-16 Institut National De La Recherche Scientifique Cytosine nucleoside analogs and isoflavones and uses thereof
CN106265669A (en) * 2016-08-04 2017-01-04 大连理工大学 Drug combination of daidzein and 10‑hydroxycamptothecin and its application
CN113842387A (en) * 2021-11-19 2021-12-28 大连理工大学盘锦产业技术研究院 Pharmaceutical composition of 10-hydroxycamptothecin and biochanin A and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0617304B2 (en) * 1982-09-09 1994-03-09 理化学研究所 Anti-cancer drug
US5506211A (en) * 1994-05-09 1996-04-09 The Uab Research Foundation Genistein for use in inhibiting osteroclasts
US5824702A (en) * 1996-06-07 1998-10-20 Mount Sinai School Of Medicine Of The City University Of New York Genistein as a preventive against ultraviolet induced skin photodamage and cancer
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
JP2829387B2 (en) * 1996-09-13 1998-11-25 農林水産省四国農業試験場長 Composition for promoting lipolysis in fat cells
GB9621757D0 (en) * 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
US5733926A (en) * 1996-12-13 1998-03-31 Gorbach; Sherwood L. Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions

Also Published As

Publication number Publication date
FR2781154A1 (en) 2000-01-21
CA2337256A1 (en) 2000-01-27
CN1312712A (en) 2001-09-12
KR20020006510A (en) 2002-01-19
AU761417B2 (en) 2003-06-05
WO2000003707A1 (en) 2000-01-27
CN1139383C (en) 2004-02-25
AU4628299A (en) 2000-02-07
JP2002520357A (en) 2002-07-09
EP1096929A1 (en) 2001-05-09
EA200100141A1 (en) 2001-06-25
IL140580A0 (en) 2002-02-10
FR2781154B1 (en) 2001-09-07

Similar Documents

Publication Publication Date Title
BR9912073A (en) Pharmaceutical compositions comprising 2-quinolones
BR9814340A (en) Indole derivatives as factor xa inhibitors
BR9911488A (en) Compound, use of it, pharmaceutical composition, and processes for the treatment or prophylaxis of inflammatory diseases, and for the preparation of a compound
BRPI0409227B8 (en) &#34;compound, pharmaceutical composition, use of a compound and process for the preparation of a compound of formula (i)&#34;
BR0010555A (en) Neuraminidase Inhibitors
BR9912817A (en) Therapeutic composition based on isoflavonoids to be used in the treatment of tumors by cytotoxic agents
BR9812095A (en) Indole compounds as cox-2 inhibitors
PT896533E (en) PENTAFLUOROBENZENOSULFONAMIDAS AND ANALOGOS
ID27178A (en) COMPOUND AMINOSICLOHEXIC COMPOUNDS AND ITS USE
BR9713465A (en) Cytically substituted amine metallotprotease inhibitors
NO20020725L (en) cell adhesion inhibitor
BR9307451A (en) Compound, pharmaceutical composition and compound manufacturing process
EE200100558A (en) A triaryl acid derivative, a pharmaceutical composition comprising it, and a compound for therapeutic use
BR9707064A (en) New 19-nor-pregnene derivatives
ES2172580T3 (en) 1,3-OXATIOLANS SUBSTITUTED WITH ANTIVIRICAL PROPERTIES.
AR026064A1 (en) OXABISPIDINE COMPOUNDS, PHARMACEUTICAL FORMULATION, USE OF THESE COMPOUNDS FOR THE MANUFACTURE OF MEDICINES, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS, AND INTERMEDIARIES.
ES2149305T3 (en) SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE PROCEDURES.
BR9609653A (en) Pharmaceutical compounds and compositions containing the same
BRPI0408240A (en) compound, use of a compound and pharmaceutical composition
GT199900154A (en) PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PARKINSON, ADHD AND MICROADENOMAS DISEASE.
AR012878A1 (en) A COMPOUND DERIVED FROM 5&#39;-DEOXICITIDINE, ITS USE, A PROCESS TO MANUFACTURE IT, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT, AND A KIT THAT INCLUDES SUCH COMPOSITION.
BR9908125A (en) Compound, dimeric compound, pharmaceutical composition, use of the compound, process comprising inhibiting cancer cells, and, therapeutic process
BR0212353A (en) Compound, pharmaceutical composition, and use of a compound
BR0001201A (en) (Poly) thiaalkinoic compound, cosmetic composition, use of a cosmetic composition, use of a compound and pharmaceutical composition
BR0311491A (en) Compound, Pharmaceutical Composition, Use of a Compound, and, Therapeutic Method to Treat Cancer in a Mammal

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A,8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.