BR9911324A - Combinações terapêuticas de moduladores de receptor (seletivo) de estrogênio (serm) e secretagogos de hormÈnio do crescimento (ghs) para o tratamento de fragilidade músculo-esqueletal - Google Patents
Combinações terapêuticas de moduladores de receptor (seletivo) de estrogênio (serm) e secretagogos de hormÈnio do crescimento (ghs) para o tratamento de fragilidade músculo-esqueletalInfo
- Publication number
- BR9911324A BR9911324A BR9911324-4A BR9911324A BR9911324A BR 9911324 A BR9911324 A BR 9911324A BR 9911324 A BR9911324 A BR 9911324A BR 9911324 A BR9911324 A BR 9911324A
- Authority
- BR
- Brazil
- Prior art keywords
- fragility
- compositions
- ghs
- serm
- modulators
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 102000015694 estrogen receptors Human genes 0.000 title 1
- 108010038795 estrogen receptors Proteins 0.000 title 1
- 239000003324 growth hormone secretagogue Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 4- (2-pyrrolidin-1-yl-ethoxy) -phenyl Chemical group 0.000 abstract 1
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 abstract 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 229940047889 isobutyramide Drugs 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 abstract 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>''COMBINAçõES TERAPêUTICAS DE MODULADORES DE RECEPTOR (SELETIVO) DE ESTROGêNIO (SERM) E SECRETAGOGOS DE HORMÈNIO DO CRESCIMENTO (GHS) PARA O TRATAMENTO DE FRAGILIDADE MúSCULO-ESQUELETAL''<D>. Esta invenção refere-se a composições de combinações farmacêuticas e a métodos que contenham (-)-cis-6-fenil-5-(4-(2-pirrolidin-1-il-etóxi)-fenil)-5,6,7,8-tetra-hidronaftale n-2-ol ou um sal farmaceuticamente aceitável dos mesmos e 2-amino-N-(2-(3a(R)-benzil-2-metil-3-oxo-2,3,3a,4,6,7-hexahidro-pira zolo-[4,3-c]piridin-5-il)-1-(R)-benziloximetil-2-oxo-etil)-iso-butiramida ou um sal farmaceuticamente aceitável da mesma, métodos para a utilização de tais composições e kits que contenham tais composições. As composições são úteis para o tratamento de fragilidade músculo-esqueletal, incluindo a osteoporose, a fratura osteoporótica, a fraca massa óssea, a fragilidade e a fraca massa muscular.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8946998P | 1998-06-16 | 1998-06-16 | |
| PCT/IB1999/001117 WO1999065486A1 (en) | 1998-06-16 | 1999-06-16 | Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9911324A true BR9911324A (pt) | 2001-04-03 |
Family
ID=22217825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9911324-4A BR9911324A (pt) | 1998-06-16 | 1999-06-16 | Combinações terapêuticas de moduladores de receptor (seletivo) de estrogênio (serm) e secretagogos de hormÈnio do crescimento (ghs) para o tratamento de fragilidade músculo-esqueletal |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1087764A1 (pt) |
| JP (1) | JP2002518326A (pt) |
| KR (1) | KR20010052852A (pt) |
| CN (1) | CN1301160A (pt) |
| AP (1) | AP9901582A0 (pt) |
| AR (1) | AR018869A1 (pt) |
| AU (1) | AU4054799A (pt) |
| BG (1) | BG105041A (pt) |
| BR (1) | BR9911324A (pt) |
| CA (1) | CA2335134A1 (pt) |
| CO (1) | CO5070587A1 (pt) |
| EA (1) | EA200001186A1 (pt) |
| GT (1) | GT199900087A (pt) |
| HN (1) | HN1999000097A (pt) |
| HR (1) | HRP20000859A2 (pt) |
| HU (1) | HUP0102505A3 (pt) |
| ID (1) | ID27599A (pt) |
| IL (1) | IL138630A0 (pt) |
| IS (1) | IS5691A (pt) |
| MA (1) | MA26652A1 (pt) |
| NO (1) | NO20006312L (pt) |
| OA (1) | OA11505A (pt) |
| PA (1) | PA8475901A1 (pt) |
| PE (1) | PE20000646A1 (pt) |
| PL (1) | PL344981A1 (pt) |
| SK (1) | SK18912000A3 (pt) |
| TN (1) | TNSN99124A1 (pt) |
| TR (1) | TR200003544T2 (pt) |
| WO (1) | WO1999065486A1 (pt) |
| ZA (1) | ZA993975B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000047735A2 (en) * | 1999-02-08 | 2000-08-17 | Mcgill University | NON-HUMAN TRANSGENIC ANIMAL WHOSE GERM CELLS AND SOMATIC CELLS CONTAIN A KNOCKOUT MUTATION IN DNA ENCODING ORPHAN NUCLEAR RECEPTOR ERRalpha |
| DE60124616T2 (de) | 2000-05-08 | 2007-09-13 | Pfizer Products Inc., Groton | Enzymatische Spaltung von selektiven Modulatoren des Östrogenrezeptors |
| IL145106A0 (en) * | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
| JP2004507502A (ja) * | 2000-08-30 | 2004-03-11 | ファイザー・プロダクツ・インク | 成長ホルモン分泌促進物質のための徐放性製剤 |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| WO2006024931A2 (en) * | 2004-08-31 | 2006-03-09 | Pfizer Products Inc. | Therapeutic combinations comprising a selective estrogen receptor modulator and a selective androgen receptor modulator |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| ES2604943T3 (es) | 2007-02-09 | 2017-03-10 | Ocera Therapeutics, Inc. | Moduladores macrocíclicos del receptor de la grelina y procedimientos de uso de los mismos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA51676C2 (uk) * | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція |
| TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| HN1996000101A (es) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
-
1999
- 1999-06-15 HN HN1999000097A patent/HN1999000097A/es unknown
- 1999-06-15 PA PA19998475901A patent/PA8475901A1/es unknown
- 1999-06-15 PE PE1999000528A patent/PE20000646A1/es not_active Application Discontinuation
- 1999-06-15 ZA ZA9903975A patent/ZA993975B/xx unknown
- 1999-06-15 AP APAP/P/1999/001582A patent/AP9901582A0/en unknown
- 1999-06-15 AR ARP990102848A patent/AR018869A1/es not_active Application Discontinuation
- 1999-06-16 TN TNTNSN99124A patent/TNSN99124A1/fr unknown
- 1999-06-16 ID IDW20002627A patent/ID27599A/id unknown
- 1999-06-16 CN CN99806237A patent/CN1301160A/zh active Pending
- 1999-06-16 MA MA25628A patent/MA26652A1/fr unknown
- 1999-06-16 PL PL99344981A patent/PL344981A1/xx not_active Application Discontinuation
- 1999-06-16 HR HR20000859A patent/HRP20000859A2/hr not_active Application Discontinuation
- 1999-06-16 WO PCT/IB1999/001117 patent/WO1999065486A1/en not_active Ceased
- 1999-06-16 GT GT199900087A patent/GT199900087A/es unknown
- 1999-06-16 JP JP2000554366A patent/JP2002518326A/ja active Pending
- 1999-06-16 EP EP99923802A patent/EP1087764A1/en not_active Withdrawn
- 1999-06-16 BR BR9911324-4A patent/BR9911324A/pt not_active Application Discontinuation
- 1999-06-16 KR KR1020007014186A patent/KR20010052852A/ko not_active Ceased
- 1999-06-16 HU HU0102505A patent/HUP0102505A3/hu unknown
- 1999-06-16 EA EA200001186A patent/EA200001186A1/ru unknown
- 1999-06-16 TR TR2000/03544T patent/TR200003544T2/xx unknown
- 1999-06-16 CO CO99037622A patent/CO5070587A1/es unknown
- 1999-06-16 SK SK1891-2000A patent/SK18912000A3/sk unknown
- 1999-06-16 IL IL13863099A patent/IL138630A0/xx unknown
- 1999-06-16 AU AU40547/99A patent/AU4054799A/en not_active Abandoned
- 1999-06-16 CA CA002335134A patent/CA2335134A1/en not_active Abandoned
-
2000
- 2000-10-20 OA OA1200000290A patent/OA11505A/en unknown
- 2000-10-27 IS IS5691A patent/IS5691A/is unknown
- 2000-12-11 BG BG105041A patent/BG105041A/xx unknown
- 2000-12-12 NO NO20006312A patent/NO20006312L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20000646A1 (es) | 2000-08-05 |
| CO5070587A1 (es) | 2001-08-28 |
| TR200003544T2 (tr) | 2001-04-20 |
| ID27599A (id) | 2001-04-12 |
| MA26652A1 (fr) | 2004-12-20 |
| OA11505A (en) | 2004-05-07 |
| EP1087764A1 (en) | 2001-04-04 |
| GT199900087A (es) | 2000-12-07 |
| PA8475901A1 (es) | 2000-05-24 |
| TNSN99124A1 (fr) | 2005-11-10 |
| SK18912000A3 (sk) | 2001-10-08 |
| KR20010052852A (ko) | 2001-06-25 |
| NO20006312D0 (no) | 2000-12-12 |
| ZA993975B (en) | 2000-12-15 |
| PL344981A1 (en) | 2001-11-19 |
| HN1999000097A (es) | 1999-11-03 |
| HUP0102505A3 (en) | 2002-12-28 |
| CN1301160A (zh) | 2001-06-27 |
| AU4054799A (en) | 2000-01-05 |
| WO1999065486A1 (en) | 1999-12-23 |
| BG105041A (en) | 2001-08-31 |
| IS5691A (is) | 2000-10-27 |
| HRP20000859A2 (en) | 2001-04-30 |
| NO20006312L (no) | 2000-12-12 |
| EA200001186A1 (ru) | 2001-06-25 |
| JP2002518326A (ja) | 2002-06-25 |
| AR018869A1 (es) | 2001-12-12 |
| CA2335134A1 (en) | 1999-12-23 |
| AP9901582A0 (en) | 1999-06-30 |
| HUP0102505A2 (hu) | 2001-11-28 |
| IL138630A0 (en) | 2001-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |