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BR9909981A - Soluções de mitoxantrona estáveis - Google Patents

Soluções de mitoxantrona estáveis

Info

Publication number
BR9909981A
BR9909981A BR9909981-0A BR9909981A BR9909981A BR 9909981 A BR9909981 A BR 9909981A BR 9909981 A BR9909981 A BR 9909981A BR 9909981 A BR9909981 A BR 9909981A
Authority
BR
Brazil
Prior art keywords
stable
solutions
stable mitoxantrone
solution
mitoxantrone solutions
Prior art date
Application number
BR9909981-0A
Other languages
English (en)
Inventor
Katrin Moschner
Mario Weingart
Michael Pieroth
Wolfgang Morick
Elisabeth Wolf-Heuss
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of BR9909981A publication Critical patent/BR9909981A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Patente de Invenção: <B>"SOLUçõES DE MITOXANTRONA ESTáVEIS"<D>. é descrita uma solução de mitoxantrona estável, que para a estabilização contém 0,001 até 0,15% de edetato de sódio. A solução injetável é isenta de compostos sulfeto e evita seus efeitos colaterais na aplicação parenteral.
BR9909981-0A 1998-04-27 1999-04-01 Soluções de mitoxantrona estáveis BR9909981A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19818802A DE19818802A1 (de) 1998-04-27 1998-04-27 Stabile Mitoxantron-Lösungen
PCT/EP1999/002290 WO1999055375A1 (de) 1998-04-27 1999-04-01 Stabile mitoxantron-lösungen

Publications (1)

Publication Number Publication Date
BR9909981A true BR9909981A (pt) 2000-12-26

Family

ID=7865948

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909981-0A BR9909981A (pt) 1998-04-27 1999-04-01 Soluções de mitoxantrona estáveis

Country Status (17)

Country Link
US (1) US6143795A (pt)
EP (1) EP1073469B1 (pt)
JP (1) JP2002512981A (pt)
CN (1) CN1195548C (pt)
AR (1) AR018198A1 (pt)
AT (1) ATE282431T1 (pt)
AU (1) AU744502B2 (pt)
BG (1) BG64767B1 (pt)
BR (1) BR9909981A (pt)
CA (1) CA2270004C (pt)
CO (1) CO5021217A1 (pt)
DE (2) DE19818802A1 (pt)
HU (1) HUP0102075A3 (pt)
NZ (1) NZ507407A (pt)
RU (1) RU2219917C2 (pt)
TW (1) TWI224003B (pt)
WO (1) WO1999055375A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
EP2368553B1 (en) 2003-04-08 2014-12-31 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
CN102397561B (zh) * 2011-09-26 2013-03-06 沈阳药科大学 米托蒽醌作为淋巴示踪剂的应用
JP5589110B1 (ja) * 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
CN107149592B (zh) * 2017-06-23 2019-10-08 沈阳天邦药业有限公司 具有淋巴靶向功能的生物自组装纳米晶注射剂及制备方法
CN113730603B (zh) * 2020-05-27 2023-01-24 深圳华润九创医药有限公司 米托蒽醌制剂在制备诊治与甲状腺切除相关的疾病的药物中的应用
CN114601791B (zh) * 2020-12-08 2023-09-19 成都倍特药业股份有限公司 一种盐酸米托蒽醌液体制剂及其制备方法
CN114732807A (zh) * 2022-03-27 2022-07-12 苏州大学 米托蒽醌在制备预防或治疗急性移植物抗宿主病药物中的应用
CN120168664A (zh) * 2023-12-20 2025-06-20 深圳华润九创医药有限公司 米托蒽醌在制备淋巴示踪剂中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248291A (en) * 1963-08-19 1966-04-26 Hoffmann La Roche Stabilized thioxanthene derivatives and method of using the same
EP0236822B1 (en) * 1986-03-07 1990-12-27 American Cyanamid Company Stable injectable pharmaceutical formulation for 1,4-dihydroxy-5,8-bis((2-(hydroxyethylamino)-ethyl)amino)anthraquinone, dihydrochloride
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
DE3825374A1 (de) * 1988-07-26 1990-02-01 Schwendener Reto Dipl Apotheke Komplex aus mindestens einer lipophilen saeure und mitoxantron und/oder bisantren
AU5680994A (en) * 1992-12-10 1994-07-04 Abbott Laboratories Stabilized catecholamine solutions
RU2093158C1 (ru) * 1996-02-23 1997-10-20 Онкологический научный центр РАМН Противоопухолевое средство
FR2758264B1 (fr) * 1997-01-16 1999-03-26 Charles Dumontet Compositions medicamenteuses contenant de l'edta ou un de ses derives pour la prevention de la toxicite cutanee et sous-cutanee des anthracyclines et de leurs derives

Also Published As

Publication number Publication date
EP1073469A1 (de) 2001-02-07
JP2002512981A (ja) 2002-05-08
CN1298310A (zh) 2001-06-06
HK1036012A1 (en) 2001-12-21
CO5021217A1 (es) 2001-03-27
CN1195548C (zh) 2005-04-06
AU744502B2 (en) 2002-02-28
HUP0102075A3 (en) 2002-10-28
CA2270004A1 (en) 1999-10-27
RU2219917C2 (ru) 2003-12-27
NZ507407A (en) 2002-08-28
WO1999055375A1 (de) 1999-11-04
HUP0102075A2 (hu) 2002-05-29
BG104850A (en) 2001-05-31
AU3522599A (en) 1999-11-16
TWI224003B (en) 2004-11-21
CA2270004C (en) 2004-06-01
DE19818802A1 (de) 1999-10-28
DE59911099D1 (de) 2004-12-23
BG64767B1 (bg) 2006-03-31
US6143795A (en) 2000-11-07
AR018198A1 (es) 2001-10-31
ATE282431T1 (de) 2004-12-15
EP1073469B1 (de) 2004-11-17

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, COM BASE NOS ARTIGOS 8O E 13 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.