BR9907893A - Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 - Google Patents
Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1Info
- Publication number
- BR9907893A BR9907893A BR9907893-7A BR9907893A BR9907893A BR 9907893 A BR9907893 A BR 9907893A BR 9907893 A BR9907893 A BR 9907893A BR 9907893 A BR9907893 A BR 9907893A
- Authority
- BR
- Brazil
- Prior art keywords
- avermectins
- proportion
- drives
- ratio
- streptomyces avermitilis
- Prior art date
Links
- 241001468227 Streptomyces avermitilis Species 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000005660 Abamectin Substances 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 229940058299 avermectines Drugs 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Patente de Invenção: <B>"GENE DE STREPTOMYCES AVERMITILIS QUE DIRIGE A PROPORçãO DE AVERMECTINAS B2:B1"<D>. A presente invenção refere-se a moléculas polinucleotídicas que compreendem seq³ências nucleotídicas que condificam um produto gene AveC, moléculas polinucleotídicas essas que podem ser usadas para alterarem a proporção ou quantidade de avermectinas da classe 2:1 produzidas em culturas de fermentação de S. avermitilis. A presente invenção refere-se ainda a vetores, células hospedeiras e cepas mutantes de S. avermitilis nas quais o gene AveC tenha sido inativado ou mutado de maneira a mudar a proporção ou quantidade de avermectinas da classe 2:1 produzidas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 | |
| PCT/IB1999/000130 WO1999041389A1 (en) | 1998-02-13 | 1999-01-25 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9907893A true BR9907893A (pt) | 2000-11-14 |
Family
ID=22120706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9907893-7A BR9907893A (pt) | 1998-02-13 | 1999-01-25 | Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (pt) |
| JP (2) | JP2002503473A (pt) |
| KR (3) | KR20040053390A (pt) |
| CN (2) | CN1297485A (pt) |
| AP (1) | AP9901463A0 (pt) |
| AR (1) | AR018085A1 (pt) |
| AU (1) | AU752343C (pt) |
| BG (1) | BG64911B1 (pt) |
| BR (1) | BR9907893A (pt) |
| CA (2) | CA2521289A1 (pt) |
| CO (1) | CO5070698A1 (pt) |
| DZ (1) | DZ2720A1 (pt) |
| EA (1) | EA003905B1 (pt) |
| GT (1) | GT199900014A (pt) |
| HN (1) | HN1999000008A (pt) |
| HR (1) | HRP20000539A2 (pt) |
| HU (1) | HUP0100784A3 (pt) |
| IL (2) | IL137610A0 (pt) |
| IS (1) | IS5567A (pt) |
| MA (1) | MA24760A1 (pt) |
| NO (1) | NO20004044L (pt) |
| NZ (2) | NZ505676A (pt) |
| OA (1) | OA11449A (pt) |
| PA (1) | PA8467601A1 (pt) |
| PE (1) | PE20000352A1 (pt) |
| PL (1) | PL194270B1 (pt) |
| SK (1) | SK11722000A3 (pt) |
| TN (1) | TNSN99017A1 (pt) |
| TW (1) | TW585910B (pt) |
| WO (1) | WO1999041389A1 (pt) |
| YU (1) | YU50900A (pt) |
| ZA (1) | ZA991138B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002503473A (ja) * | 1998-02-13 | 2002-02-05 | ファイザー・プロダクツ・インク | Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子 |
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| EA200200056A1 (ru) | 1999-08-12 | 2002-06-27 | Пфайзер Продактс Инк. | Ген streptomyces avermitilis, направляющий соотношение авермектинов b2:b1 |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| CN1630712B (zh) | 2002-02-12 | 2011-09-28 | 辉瑞产品公司 | 指导b2:b1除虫菌素比例的除虫链霉菌基因 |
| CN107338210B (zh) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | 一种阿维链霉菌合成培养基及其发酵液的制备方法 |
| CN111269296B (zh) * | 2020-03-06 | 2021-11-05 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (pt) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| DE3881147T2 (de) * | 1987-10-23 | 1993-09-02 | Pfizer | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. |
| JPH0747171B2 (ja) * | 1988-09-20 | 1995-05-24 | 株式会社東芝 | 圧延機の設定方法および装置 |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| DE69023036T2 (de) * | 1989-03-31 | 1996-06-13 | Merck & Co Inc | Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung. |
| JP2888586B2 (ja) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法 |
| FI942725L (fi) * | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| JP2002503473A (ja) * | 1998-02-13 | 2002-02-05 | ファイザー・プロダクツ・インク | Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子 |
-
1999
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/ja active Pending
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/pt not_active Application Discontinuation
- 1999-01-25 IL IL13761099A patent/IL137610A0/xx unknown
- 1999-01-25 EA EA200000758A patent/EA003905B1/ru not_active IP Right Cessation
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Ceased
- 1999-01-25 YU YU50900A patent/YU50900A/sh unknown
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/ko not_active Ceased
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 CN CN99805027A patent/CN1297485A/zh active Pending
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/ko not_active Ceased
- 1999-01-25 NZ NZ505676A patent/NZ505676A/xx unknown
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-25 HR HR20000539A patent/HRP20000539A2/hr not_active Application Discontinuation
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/hu not_active Application Discontinuation
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/ko not_active Expired - Fee Related
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/zh active Pending
- 1999-01-25 PL PL99342468A patent/PL194270B1/pl not_active IP Right Cessation
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/sk unknown
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/es unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/es unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/es unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/es not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/zh active
- 1999-02-10 MA MA25460A patent/MA24760A1/fr unknown
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/xx active
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/fr unknown
- 1999-02-11 AR ARP990100571A patent/AR018085A1/es unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/es unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/xx unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/is unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 NO NO20004044A patent/NO20004044L/no not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/bg unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Nur et al. | Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas) | |
| Lai et al. | Structure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureus | |
| CA2240334A1 (en) | Thermostable dna polymerase from thermoanaerobacter thermohydrosulfuricus and mutant enzymes thereof with exonuclease activity removed | |
| DeAngelis | Enzymological characterization of the Pasteurella multocida hyaluronic acid synthase | |
| BR0003943A (pt) | Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma | |
| EP0717777A4 (en) | SALMONELLA VACCINE | |
| EP0792375A4 (en) | ENZYMACTIVE DNA MOLECULES | |
| Carey et al. | Human apurinic/apyrimidinic endonuclease is processive | |
| Denoya et al. | Mono-and dimethylating activities and kinetic studies of the ermC 23 S rRNA methyltransferase | |
| YU47886B (sh) | Postupak za dobijanje novih sojeva s. avermitilis | |
| Wickner et al. | Deoxyribonucleic Acid Polymerase II of Escherichia coli: II. STUDIES OF THE TEMPLATE REQUIREMENTS AND THE STRUCTURE OF THE DEOXYRIBONUCLEIC ACID PRODUCT | |
| BR9907893A (pt) | Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 | |
| BR0013093A (pt) | Gene de streptomyces avermitilis que regula a proporção de avermectinas b2:b1 | |
| CY1112491T1 (el) | Γονιδιο streptomyces avermitilis που ελεγχει την αναλογια αβερμεκτινων β2:β1 | |
| BR0013119A (pt) | Gene de streptomyces avermitilis que regula a proporção de avermectinas b2:bl | |
| Garrity et al. | Deoxyribonucleic acid base composition in the taxonomy of Staphylococcus | |
| Lanéelle et al. | Biological and Chemical Bases for the Reclassification of Brevibacterium vitarumen (Bechdel et al.) Breed (Approved Lists, 1980) as Corynebacterium vitarumen (Bechdel et al.) comb. nov. and Brevibacterium liquefaciens Okabayashi and Masuo (Approved Lists, 1980) as Corynebacterium liquefaciens (Okabayashi and Masuo) comb. nov. | |
| BR9405235A (pt) | DNA isolado e purificado,polinucleotídeo recombinante,célula hospedeira,substância proteinácea tendo atividade frutosiltransferase e processos para produzir uma substância proteinácea tendo atividade frutosiltransferase e para produzir frutooligossacarídeos e/ou frutanos | |
| Ludden et al. | Reversible ADP-ribosylation of dinitrogenase reductase in a nifD-mutant of Rhodospirillum rubrum | |
| Öhrlein et al. | Transferase-catalyzed synthesis of non-natural oligosaccharide-libraries (SLea-and SLex-analogues) | |
| Cacace et al. | Thermophilicity and thermostability of RNA polymerases from two strains of Caldariella acidophila, an extremely thermo-acidophilic bacterium | |
| Tsuda | ADENOSINE TRIPHOSPHATE REQUIREMENT FOR A DEOXYRIBONUCLEASE REACTION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A E 7A ANUIDADES |
|
| B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 22 DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |